I-Spermidine trihydrochloride ne-spermidine yizinhlanganisela ezimbili ezithole ukunakwa okuphawulekayo emkhakheni we-biomedicine.Lezi zinhlanganisela zihileleke ezinqubweni ezihlukahlukene zomzimba futhi zibonise imiphumela ethembisayo ekukhuthazeni ukuguga okunempilo nokuphila isikhathi eside.Kulesi sihloko, sizohlola isayensi ngemuva kwe-spermidine trihydrochloride ne-spermidine futhi sinikeze ukuqhathanisa okuphelele phakathi kwalokhu kokubili.
I-Spermidine trihydrochloride iyinhlanganisela encibilikayo emanzini esithole ukunakwa okuningi emkhakheni wezempilo nokuphila kahle.Ingowomndeni wama-polyamines, ama-molecule e-organic avela ngokwemvelo kuzo zonke izinto eziphilayo.Ama-Polyamine adlala indima ebalulekile ezinqubweni ezihlukahlukene zamaselula, okuhlanganisa ukukhula kwamangqamuzana, ukuhlukaniswa, nokufa kwamangqamuzana.Ukwengeza, i-spermidine trihydrochloride itholakale inezinhlobonhlobo zezinzuzo zezempilo ezingaba khona, okuhlanganisa ikhono lokuvuselela i-autophagy, ukuvikela ubuchopho, nokukhuthaza impilo yenhliziyo.Njengoba ucwaningo luqhubeka, amandla aphelele e-spermidine trihydrochloride angase acace.Nakuba i-spermidine trihydrochloride ikhona kweminye imithombo yokudla, njengegciwane likakolweni, ubhontshisi wesoya, noshizi osekhulile, ukudla okungokwemvelo kungase kunganele ukufeza amazinga afanele.Kulokhu, ukwesekwa kuba yinketho esebenzayo.
Enye yezinzuzo eziphawuleka kakhulu ze-spermidine trihydrochloride indima yayo ku-autophagy, inqubo yeselula enesibopho sokususa izingxenye ezilimele futhi ikhuthaze ukuvuselelwa kweseli.I-Autophagy idlala indima ebalulekile ekugcineni impilo nokusebenza kwamaseli.Ngokuthuthukisa i-autophagy, i-spermidine trihydrochloride isiza ukuqeda izinto ezinobuthi namaprotheni alimele, ngaleyo ndlela yehlise ingozi yezifo ze-neurodeergenerative njenge-Alzheimer's kanye ne-Parkinson.
Ucwaningo oluningana lubonise ukuthi i-spermidine trihydrochloride inomphumela omuhle empilweni yenhliziyo nemithambo yegazi.Kuye kwaboniswa ukuthuthukisa ukusebenza kwenhliziyo, ukunciphisa ukucindezeleka kwegazi nokuvimbela izifo ezihlobene nenhliziyo.I-Spermidine trihydrochloride ikhuthaza i-vasodilation, ithuthukise ukugeleza kwegazi, futhi inciphise ingozi ye-atherosclerosis.Ngokugcina isimiso senhliziyo esinempilo, singaba nomthelela omkhulu ekuphileni okude, okunempilo.
Ngaphezu kwalokho, i-spermidine trihydrochloride nayo inezindawo ezinamandla zokulwa ne-antioxidant.Ukucindezeleka okwenziwe nge-oxidative okubangelwa ukungalingani phakathi kwama-radicals mahhala nama-antioxidants emzimbeni kuyimbangela enkulu yokuguga kanye nezifo ezihlukahlukene ezingapheli.Ngokuqeda ama-radicals mahhala ayingozi, i-spermidine trisalt isiza ukulwa nengcindezi ye-oxidative, ngaleyo ndlela inciphise ubungozi bezinkinga zempilo ezihlobene nobudala njengomdlavuza, isifo sikashukela kanye nokuvuvukala.
Eminyakeni yamuva nje, abacwaningi bathole ukuxhumana phakathi kwe-spermidine trihydrochloride kanye nemiphumela engaba khona ekukhuthazeni ukuphila isikhathi eside.Izifundo ezinhlobonhlobo zezinto eziphilayo, ezihlanganisa izikelemu, izimpukane namagundane, zibonise ukuthi ukwengezwa nge-spermidine trihydrochloride kwandisa isikhathi sokuphila futhi kuthuthukisa impilo yonke.Nakuba ucwaningo olwengeziwe ludingeka ukuze kuqondwe ngokugcwele umthelela walo ekuphileni isikhathi eside komuntu, lokhu okutholakele kunesithembiso esikhulu se-spermidine trihydrochloride njengenhlanganisela evimbela ukuguga.
Kubalulekile ukuqaphela ukuthi ukufakwa kwe-spermidine trihydrochloride kufanele kwenziwe ngokuqapha futhi ngaphansi kokuqondisa kochwepheshe bezempilo.Njenganoma yisiphi isengezo, umthamo kanye nokusebenzisana okungenzeka nemithi kufanele kucatshangelwe ngokucophelela.
Kokubili i-spermidine trihydrochloride ne-spermidine angamalungu omndeni we-polyamine futhi adlala indima ebalulekile ezinqubweni ezihlukahlukene zomzimba emzimbeni.Nakuba babelana ngokufana emiphumeleni yabo yezempilo, kukhona futhi umehluko omkhulu phakathi kwe-spermidine trihydrochloride ne-spermidine.
●Okunye ukufana okuyinhloko phakathi kwe-spermidine trihydrochloride ne-spermidine yikhono labo lokukhuthaza i-autophagy, inqubo yeselula ebhekene nokususwa kwezingxenye ezilimele noma ezingasebenzi.I-Autophagy idlala indima ebalulekile ekugcineni impilo yamaselula futhi iye yathinteka ezifweni ezihlukahlukene ezihlobene neminyaka, kuhlanganise nezifo ze-neurodegenerative kanye ne-cardiovascular.Kokubili i-spermidine trihydrochloride kanye ne-spermidine kuboniswe ukuthi yenze i-autophagy, okungenzeka yehlise ingozi yalezi zifo ezihlobene nobudala.
●Enye inzuzo yezempilo eyabiwe yi-spermidine trihydrochloride kanye ne-spermidine amandla abo okuthuthukisa impilo yenhliziyo nemithambo yegazi.Ucwaningo luye lwabonisa ukuthi lezi zinhlanganisela zingathuthukisa ukusebenza kwenhliziyo, ukunciphisa umfutho wegazi, futhi zivimbele ukwakheka kwe-plaque emithanjeni yegazi.Le miphumela kucatshangwa ukuthi ixhunywe ngokusebenzisa ikhono lokukhuthaza i-autophagy futhi ikhuthaze ukukhiqizwa kwe-nitric oxide, i-molecule eyinhloko ekugcineni ukugeleza kwegazi okujwayelekile nokuvimbela ukuthuthukiswa kwesifo senhliziyo.
●Ngenkathi i-spermidine trihydrochloride kanye ne-spermidine behlanganyela izinzuzo zezempilo ezifanayo, futhi banomehluko obalulekile.Umehluko osobala kakhulu indlela yabo yokuphatha.I-Spermidine trihydrochloride iwuhlobo lokwenziwa lwe-spermidine oluvame ukusetshenziswa njengesengezo sokudla.Ngakolunye uhlangothi, i-spermidine iyinhlanganisela yemvelo etholakala emithonjeni yokudla ehlukahlukene, njengobhontshisi wesoya, amakhowe noshizi osekhulile.Lo mehluko ungathinta i-bioavailability kanye nemiphumela emibi engaba khona yalezi zinhlanganisela.
●Ukwengeza, amandla aphelele e-spermidine trihydrochloride ne-spermidine angase ahluke.Njengoba i-spermidine trihydrochloride iwuhlobo olugxile kakhulu lwe-spermidine, ingase inikeze imiphumela enamandla kakhulu ngemithamo ephansi kunemithombo yemvelo ye-spermidine.Kodwa-ke, ucwaningo olwengeziwe luyadingeka ukuze kutholwe ukuthi lo mehluko ekusebenzeni kahle uhumusha yini umehluko omkhulu ezinzuzweni zabo zezempilo.
●Ukwengeza, i-spermidine trihydrochloride ne-spermidine zingahluka ekuzinzeni nasekuphileni kweshalofu.Njengenhlanganisela yokwenziwa, i-spermidine trihydrochloride ngokuvamile izinzile futhi ineshelufu ende yokuphila kune-spermidine, engase yonakale ngokushesha okukhulu.Lo mehluko ungase uthinte ukugcinwa kanye nokwakhiwa kwemikhiqizo equkethe lezi zinhlanganisela.
I-Spermidine trihydrochloride iyinhlanganisela yokwenziwa etholakala ku-spermidine.I-Autophagy iyinqubo ebalulekile yeselula eyehlisa isithunzi futhi isebenzise kabusha izingxenye zamaselula ezingadingekile noma ezingasebenzi.Idlala indima ebalulekile ekugcineni i-homeostasis yamaselula nokuvimbela ukunqwabelana kwama-molecule alimele.Ngakolunye uhlangothi, i-senescence yeselula iyisimo esingenakuguqulwa sokuboshwa kokukhula okwenzeka ekuphenduleni ukucindezeleka okuhlukahlukene futhi kuhlotshaniswa nokuguga kanye nezifo ezihlobene nobudala.
Ucwaningo lwakamuva lubonise ukuthi i-spermidine kanye ne-trihydrochloride ephuma kuyo inamandla okulawula i-autophagy kanye ne-cell senescence.I-Spermidine iyi-polyamine eyenzeka ngokwemvelo ekhona kuwo wonke amangqamuzana aphilayo lapho ihileleke ezinkambisweni ezihlukahlukene zezinto eziphilayo ezihlanganisa ukukhula kwamangqamuzana, amandla kanye nokuvuselelwa kwezicubu.Ngokukhuthaza i-autophagy, i-spermidine iboniswe ukuthi inemiphumela engaba khona yokulwa nokuguga.
Enye yezindlela eziyinhloko lapho i-spermidine ne-spermidine trihydrochloride isebenza ngokusebenza kwe-autophagy.I-Autophagy ibangelwa ukwakheka kwezakhiwo ezinama-membrane amabili ezibizwa ngokuthi ama-autophagosomes, agibela izingxenye zamaselula ezihloselwe ukucekelwa phansi.Le nqubo ilawulwa uchungechunge lwezakhi zofuzo ezihlobene ne-autophagy (ATGs) kanye nezindlela ezihlukahlukene zokubonisa.
Ucwaningo luye lwabonisa ukuthi i-spermidine ne-spermidine trihydrochloride yandisa ukwakheka kwe-autophagosome futhi ithuthukise ukugeleza kwe-autophagic.Lokhu kubangela ukususwa kwamaprotheni kanye nama-organelles alimele, ukukhuthaza impilo yeselula nokuvimbela ukuqala kokuguga.Ukwengeza, i-spermidine iboniswe ukuthi isebenze isilawuli esiyinhloko se-autophagy, indlela ye-mTOR, ngaleyo ndlela ithuthukise umsebenzi we-autophagic.
Eminyakeni yamuva nje, i-spermidine trihydrochloride idonse ukunaka okuningi ngezinzuzo zayo zezempilo ezingaba khona kanye nezakhiwo zokulwa nokuguga.Nakuba i-spermidine trihydrochloride ingatholakala ngemithombo yokudla, kunezindlela zokwandisa amazinga ayo emzimbeni ngokwemvelo.
Enye yezindlela eziphumelela kakhulu zokwandisa amazinga akho e-spermidine trihydrochloride ukudla okunomsoco.Ukudla okufana negciwane likakolweni, ubhontshisi wesoya, amakhowe, nezinhlobo ezithile zikashizi kuqukethe inani eliphezulu lale nhlanganisela.Ukufaka lokhu kudla ekudleni kwakho kwansuku zonke kungasiza ekuqinisekiseni ukuthi uthola i-spermidine trihydrochloride eyanele.Kubalulekile ukuqaphela ukuthi ukupheka nokucubungula kunganciphisa amazinga e-spermidine trihydrochloride kulokhu kudla, ngakho-ke kungcono ukukhetha ukudla okusha nokugaywe kancane.
Ukuzila ukudla okungapheli, umkhuba wokudla ohlanganisa ukuhamba ngebhayisikili phakathi komjikelezo wokuzila nokudla, kutholakale futhi ukwandisa amazinga e-spermidine trihydrochloride emzimbeni.Ucwaningo lubonisa ukuthi ukuzila ukudla okungenani amahora angu-16 kukhuthaza ukukhiqizwa kwe-spermidine trihydrochloride, ekhuthaza i-autophagy futhi ithuthukise impilo yeselula.Kodwa-ke, kufanelekile ukubonisana nochwepheshe bezempilo ngaphambi kokufaka noma yiluphi uhlobo lokuzila ukudla esimisweni sakho, ikakhulukazi uma unezimo zezempilo ezingaphansi.
Izithasiselo zingenye inketho yokwandisa amazinga e-spermidine trihydrochloride ngokwemvelo.Izithako ze-Spermidine ziza ngezindlela eziningi, njengama-capsules noma i-powder, futhi zingatholakala ezitolo zezempilo noma ku-intanethi.Lapho ukhetha isithasiselo, kubalulekile ukukhetha uhlobo oluthembekile olunikeza umkhiqizo wekhwalithi.Ukubonisana nochwepheshe bezokunakekelwa kwempilo kungasiza futhi ukulungisa umthamo ngokwezidingo zomuntu ngamunye.
Ngaphezu kokulungiswa kokudla, indlela yokuphila enempilo ingase futhi isekele ukwanda kwemvelo kwe-spermidine trihydrochloride.Ukuzivocavoca okuvamile, amasu okulawula ingcindezi njengokuzindla noma i-yoga, nokulala ngokwanele konke kuxhunyaniswe nokusebenza okuthuthukisiwe kwezempilo nokusebenza kwamaselula.Le mikhuba ingakhuphula ngokungaqondile amazinga e-spermidine trihydrochloride emzimbeni.
Isikhathi sokuthumela: Jun-27-2023
