Ososayensi bathole ukuthi njengoba sikhula, i-mitochondria yethu iyancipha kancane kancane futhi ikhiqize amandla amancane. Lokhu kungaholela ezifweni ezihlobene nobudala njengezifo ze-neurodeergenerative, isifo senhliziyo, nokunye.
Urolithin A
I-Urolithin A iyi-metabolite yemvelo ene-antioxidant ne-antiproliferative effects. Izazi zokudla okunomsoco ezivela eNyuvesi yaseNova Southeastern e-United States ziye zathola ukuthi ukusebenzisa i-urolithin A njengokungenelela kokudla kungabambezela inqubo yokuguga futhi kuvimbele ukuthuthukiswa kwezifo ezihlobene nobudala.
I-Urolithin A (UA) ikhiqizwa amagciwane ethu amathumbu ngemva kokudla ama-polyphenols atholakala ekudleni okunjengamahalananda, ama-strawberry, nama-walnuts. Ukwengezwa kwe-UA kumagundane aneminyaka ephakathi kwenza ama-sirtuin asebenze futhi kukhulisa i-NAD+ namazinga wamandla eselula. Okubalulekile, i-UA ikhonjiswe ukuthi isusa i-mitochondria eyonakele emisipheni yomuntu, ngaleyo ndlela ithuthukisa amandla, ukumelana nokukhathala, nokusebenza kwezemidlalo. Ngakho-ke, ukwesekwa kwe-UA kungase kwandise isikhathi sokuphila ngokuphikisana nokuguga kwemisipha.
I-Urolithin A ayiveli ngokuqondile ekudleni, kodwa izinhlanganisela ezifana ne-ellagic acid ne-ellagitannins equkethwe kumantongomane, amapomegranati, amagilebhisi namanye amajikijolo azokhiqiza i-urolithin A ngemva kokufakwa kwe-metabolized microorganisms emathunjini.
I-Spermidine
I-Spermidine iwuhlobo lwemvelo lwe-polyamine oluthole ukunakwa eminyakeni yamuva nje ngenxa yamandla ayo okwandisa isikhathi sokuphila nokwandisa impilo. Njenge-NAD+ ne-CoQ10, i-spermidine iyi-molecule eyenzeka ngokwemvelo eyehla ngokuya ngeminyaka. Ngokufanayo ne-UA, i-spermidine ikhiqizwa amagciwane ethu amathumbu futhi ibangele i-mitophagy - ukususwa kwe-mitochondria engenampilo, eyonakele. Ucwaningo lwamagundane lubonisa ukuthi ukwesekwa kwe-spermidine kungavikela isifo senhliziyo nokuguga kokuzala kwabesifazane. Ukwengeza, i-spermidine yokudla (etholakala ekudleni okuhlukahlukene okuhlanganisa i-soy nezinhlamvu) ithuthukise inkumbulo kumagundane. Kudingeka ucwaningo olwengeziwe ukuze kutholwe ukuthi lokhu okutholakele kungenziwa yini kubantu.
Inqubo evamile yokuguga inciphisa ukugcwala kwezinhlobo zemvelo ze-spermidine emzimbeni, ngokocwaningo olushicilelwe ku-Scientific Reports ngabacwaningi base-Kyoto Prefectural University of Medicine eJapane. Kodwa-ke, lesi simo asizange sibonwe kubantu abaneminyaka eyikhulu;
I-Spermidine ingathuthukisa i-autophagy.
Ukudla okunokuqukethwe okuphezulu kwe-spermidine kufaka phakathi: ukudla kukakolweni, i-kelp, amakhowe e-shiitake, amantongomane, i-bracken, i-purslane, njll.
i-curcumin
I-Curcumin iyinhlanganisela esebenzayo ku-turmeric ene-anti-inflammatory and antioxidant properties.
Izazi zesayensi yezinto eziphilayo zokuhlola ezivela e-Polish Academy of Sciences zithole ukuthi i-curcumin inganciphisa izimpawu zokuguga futhi ibambezele ukuqhubeka kwezifo ezihlobene nobudala lapho amangqamuzana e-senescent ehileleka ngokuqondile, ngaleyo ndlela andise isikhathi sokuphila.
Ngaphezu kwe-turmeric, ukudla okuphezulu ku-curcumin kuhlanganisa: i-ginger, i-garlic, u-anyanisi, upelepele omnyama, lwesinaphi kanye ne-curry.
Izithako ze-NAD+
Lapho kune-mitochondria, kune-NAD+ (nicotinamide adenine dinucleotide), i-molecule edingekayo ukuze kukhuliswe ukukhiqizwa kwamandla. I-NAD+ ngokwemvelo yehla ngokukhula, okubonakala kuhambisana nokwehla okuhlobene nobudala emsebenzini we-mitochondrial. Lesi ngesinye sezizathu ezenza ukuthi ama-booster e-NAD+ afana ne-NR (Nicotinamide Ribose) athuthukiswe ukuze kubuyiselwe amazinga e-NAD+.
Ucwaningo lubonisa ukuthi ngokuphromotha i-NAD+, i-NR ingathuthukisa ukukhiqizwa kwamandla e-mitochondrial futhi ivimbele ukucindezelwa okuhlobene nobudala. I-NAD+ precursor supplements ingase ithuthukise ukusebenza kwemisipha, impilo yobuchopho, kanye ne-metabolism ngenkathi ilwa nezifo ze-neurodeergenerative. Ukwengeza, banciphisa ukuzuza kwesisindo, bathuthukise ukuzwela kwe-insulin, futhi benze amazinga e-lipid abejwayelekile, njengokwehlisa i-cholesterol ye-LDL.
Isikhathi sokuthumela: Jul-24-2024
