Izithasiselo Ezi-4 Eziphezulu Zokulwa Nokuguga Zokuthuthukisa Impilo Ye-Mitochondrial: Yisiphi Esinamandla Kakhulu?

Ososayensi bathole ukuthi njengoba siguga, i-mitochondria yethu iyancipha kancane kancane futhi ikhiqize amandla amancane. Lokhu kungaholela ezifweni ezihlobene nokuguga njengezifo eziwohlokayo zemizwa, isifo senhliziyo, nokuningi.

I-Urolithin A

I-Urolithin A iyi-metabolite yemvelo enemiphumela yokulwa nokuguga kanye neyokuvimbela ukwanda. Izazi zokudla ezivela eNova Southeastern University e-United States zithole ukuthi ukusebenzisa i-urolithin A njengendlela yokudla kungabambezela inqubo yokuguga futhi kuvimbele ukuthuthukiswa kwezifo ezihlobene nokuguga.
I-Urolithin A (UA) ikhiqizwa yibhaktheriya yethu yamathumbu ngemuva kokudla ama-polyphenol atholakala ekudleni okufana namapomegranate, ama-strawberry, nama-walnuts. Ukwengezwa kwe-UA kumagundane aneminyaka ephakathi nendawo kuvuselela ama-sirtuin futhi kwandisa amazinga e-NAD+ kanye namandla eseli. Okubalulekile, i-UA iboniswe ukuthi isusa i-mitochondria eyonakele emisipheni yabantu, ngaleyo ndlela ithuthukise amandla, ukumelana nokukhathala, kanye nokusebenza kwezemidlalo. Ngakho-ke, ukwengezwa kwe-UA kungandisa isikhathi sokuphila ngokulwa nokuguga kwemisipha.
I-Urolithin A ayiveli ngqo ekudleni, kodwa izinto ezifana ne-ellagic acid kanye ne-ellagitannins eziqukethwe kumantongomane, amapomegranati, amagilebhisi kanye namanye amajikijolo zizokhiqiza i-urolithin A ngemva kokuguqulwa yizinto ezincane zamathumbu.

I-Spermidine

I-Spermidine iwuhlobo lwemvelo lwe-polyamine oluye lwathola ukunakwa eminyakeni yamuva ngenxa yamandla alo okwandisa isikhathi sokuphila nokwandisa isikhathi sempilo. Njenge-NAD+ ne-CoQ10, i-spermidine iyi-molecule eyenzeka ngokwemvelo encipha ngokuguga. Ngokufanayo ne-UA, i-spermidine ikhiqizwa amabhaktheriya ethu esiswini futhi ibangela i-mitophagy - ukususwa kwe-mitochondria engaphili kahle, eyonakele. Izifundo zamagundane zibonisa ukuthi ukwengezwa kwe-spermidine kungavikela ezifweni zenhliziyo nokuguga kokuzala kwabesifazane. Ngaphezu kwalokho, i-spermidine yokudla (etholakala ekudleni okuhlukahlukene okuhlanganisa i-soy kanye nokusanhlamvu) ithuthukise inkumbulo emagundwini. Ucwaningo olwengeziwe luyadingeka ukuze kutholakale ukuthi lokhu okutholakele kungaphindaphindwa yini kubantu.
Inqubo evamile yokuguga inciphisa ukugcwala kwezinhlobo zemvelo ze-spermidine emzimbeni, ngokusho kocwaningo olushicilelwe kuyi-Scientific Reports ngabacwaningi baseKyoto Prefectural University of Medicine eJapane. Kodwa-ke, lesi simo asikaze sibonwe kubantu abaneminyaka eyikhulu;
I-Spermidine ingakhuthaza i-autophagy.
Ukudla okunokuqukethwe okuphezulu kwe-spermidine kufaka phakathi: ukudla kukakolweni ophelele, i-kelp, amakhowe e-shiitake, amantongomane, i-bracken, i-purslane, njll.

i-curcumin
I-Curcumin iyinhlanganisela esebenzayo ku-turmeric enezakhiwo zokulwa nokuvuvukala kanye ne-antioxidant.
Izazi zezinto eziphilayo zokuhlola ezivela ePolish Academy of Sciences zithole ukuthi i-curcumin inganciphisa izimpawu zokuguga futhi ilibazise ukuqhubeka kwezifo ezihlobene nokuguga lapho amangqamuzana asebekhulile ehileleke khona ngqo, ngaleyo ndlela yandise isikhathi sokuphila.
Ngaphezu kwe-turmeric, ukudla okune-curcumin eningi kufaka phakathi: ijinja, ugalikhi, u-anyanisi, upelepele omnyama, i-mustard kanye ne-curry.

Izithasiselo ze-NAD+
Lapho kukhona i-mitochondria, kukhona i-NAD+ (nicotinamide adenine dinucleotide), i-molecule edingekayo ukuze kwandiswe ukukhiqizwa kwamandla. I-NAD+ iyancipha ngokwemvelo ngokuguga, okubonakala kuhambisana nokwehla kokusebenza kwe-mitochondrial okuhlobene nobudala. Lesi ngesinye sezizathu ezenza ukuthi ama-booster e-NAD+ njenge-NR (Nicotinamide Ribose) athuthukiswe ukuze kubuyiselwe amazinga e-NAD+.
Ucwaningo lubonisa ukuthi ngokukhuthaza i-NAD+, i-NR ingathuthukisa ukukhiqizwa kwamandla e-mitochondrial futhi ivimbele ukucindezeleka okuhlobene nokuguga. Izithako zokwengeza ze-NAD+ zingathuthukisa ukusebenza kwemisipha, impilo yobuchopho, kanye nokusetshenziswa kwe-metabolism ngenkathi zilwa nezifo eziwohlokayo. Ngaphezu kwalokho, zinciphisa ukukhuluphala, zithuthukisa ukuzwela kwe-insulin, futhi zijwayele amazinga e-lipid, njengokwehlisa i-cholesterol ye-LDL.