Ingabe usohambweni lwezempilo futhi ufuna izithasiselo zokuthuthukisa impilo yakho engokomzimba nengqondo? Ungabheki ngaphezu kwe-7,8-dihydroxyflavone supplements. I-7,8-Dihydroxyflavone iyi-flavonoid etholakala ezitshalweni ezithile futhi iye yacwaningwa ngezinzuzo zayo zezempilo ezingaba khona. Ucwaningo lubonisa ukuthi i-7,8-dihydroxyflavone ine-neuroprotective, anti-inflammatory, kanye ne-antioxidant, okwenza kube isengezo sezempilo esithembisayo. Uma ubheke ukuthatha uhambo lwakho lwezempilo luye kwelinye izinga, cabanga ukufaka isithasiselo esingu-7,8-dihydroxyflavone ohlelweni lwakho lwansuku zonke.
Ngakho yini ngempela7,8-dihydroxyflavone? I-7,8-DHF iyi-flavonoid etholakala kwezinye izitshalo nemifino. Itholwe ngenkathi kuseshwa i-molecule elingisa ukusebenza kwe-brain-derived neurotrophic factor (BDNF), i-molecule encane eyenza isamukeli esithile sisebenze okuthiwa i-tropomyosin-related kinase B (TrkB) ngoba i-peptide isebenza kule receptor, ebizwa ngokuthi ubuchopho- derived neurotrophic factor (BDNF), ayikwazi ukusetshenziswa ngenxa ye-malabsorption yobuchopho.
I-7,8-DHF itholwe iyilingisa elinamandla le-BDNF, yenza ngendlela efanayo ku-TrkB. Lokhu kusho ukuthi i-7,8-DHF ngokwethiyori ingakhiqiza imiphumela efanayo ebuchosheni njenge-BDNF, futhi ngokwethiyori ingaba usizo kakhulu ngokwezokwelapha ngenxa yokumuncwa kwayo okungcono kanye nekhono lokuwela umgoqo wegazi nobuchopho.
Ngenxa yekhono layo lokuvuselela ama-TrkB receptors, ama-TrkB receptors adlala indima ebalulekile ekukhuleni nasekuphileni kwama-neurons ebuchosheni. Uma ama-receptors e-TrkB evuliwe, ama-neurons ajwayele ukuzwa ukukhula nokuvikelwa. Lokhu kukhula kuvame ukuthinta ama-dendrites ama-neuron, adlulela kuma-synapse ukuze axhumane nama-neurons alandelayo, futhi i-7,8-DHF iboniswe ukukhuthaza ukukhula kwalawa ma-dendrites abe ama-synapses, okusiza ukubuyisela izilwane Ukuxhumana phakathi kwama-neurons kumodeli yokuqonda kwengqondo. nqaba.
Ucwaningo oluningi luphakamisa ukuthi i-7,8-DHF ingase ibe namandla okuthuthukisa ukufunda nenkumbulo, ivimbele izifo ze-neurodegenerative, futhi isekele ngisho nempilo yemizwa nempilo yomzwelo. Lokhu okutholakele kubangele ukwanda kwentshisekelo kuzithasiselo ze-7,8-dihydroxyflavone njengezinye izindlela zemvelo zokusekela impilo yobuchopho.
Abantu abaningi baphendukela ezithasiselweni ze-7,8-dihydroxyflavone ukuze basekele umsebenzi wabo wokuqonda, ikakhulukazi njengoba bekhula noma bebhekana nezinselele ezihlobene nenkumbulo nokugxilisa ingqondo. Umqondo weukusebenzisa izinhlanganisela zemvelo ukusekela impilo yobuchopho kuyathandeka ikakhulukazi kulabo abakhetha indlela yemvelo, ephelele empilweni.
Enye yezindlela eziyinhloko zesenzo se-7,8-dihydroxyflavone yikhono layo lokwenza kusebenze indlela yokusayina ye-tropomyosin receptor kinase B (TrkB). I-TrkB iyisamukeli se-neurotrophic factor brain-derived neurotrophic factor (BDNF) futhi idlala indima ebalulekile ekukhuleni, ekusindeni, nasekusebenzeni kwama-neuron ohlelweni lwezinzwa olumaphakathi nese-peripheral. Ukwenziwa kusebenze kwe-TrkB receptor nge-7,8-dihydroxyflavone kuholela ku-phosphorylation yesizinda sayo se-intracellular, okubangela uchungechunge lwezenzakalo zesignali ezingezansi, ekugcineni zikhuthaze ukusinda kwe-neuronal, ukukhula nokuhlukaniswa.
Ucwaningo luye lwabonisa ukuthi i-7,8-dihydroxyflavone ibonisa imiphumela ye-neuroprotective kumamodeli ambalwa wezifo ze-neurodeergenerative, njenge-Alzheimer's disease nesifo sika-Parkinson. Ngokuvula indlela yokusayina ye-TrkB, i-7,8-dihydroxyflavone ithuthukisa ukusinda kwama-neurons, iwavikela ekucindezelekeni kwe-oxidative nokuvuvukala, futhi ikhuthaze ukwakheka kokuxhumana okusha kwe-synaptic, okungenzeka kubambezele noma kuhoxise lokhu kuncipha. ukuqhubeka kwesifo.
Ngaphezu kwemiphumela ye-neuroprotective, i-7,8-dihydroxyflavone itholakale inemiphumela ye-anxiolytic. Le miphumela kucatshangwa ukuthi ixoxisana ngokukwazi kwayo ukukhulisa imiphumela ye-BDNF ebuchosheni, ngaleyo ndlela ithuthukise ipulasitiki ye-neuronal nokuqina lapho ibhekene nokucindezeleka nokuphazamiseka kwemizwelo. Ukwengeza, ucwaningo lwe-preclinical lubonise ukuthi i-7,8-dihydroxyflavone ingathuthukisa izinqubo zokufunda nenkumbulo, ikhulise amathuba okusetshenziswa kwayo ekwelapheni ukukhubazeka kwengqondo okuhlobene nezimo ezifana nokuwohloka komqondo kanye nokulimala kobuchopho okubuhlungu.
Ubufakazi obusha bubonisa ukuthi ingase ibe nemiphumela enenzuzo kwezinye izicubu nezitho zomzimba. Isibonelo, i-7,8-dihydroxyflavone iboniswe ukuthi ine-anti-inflammatory, izakhiwo ze-antioxidant kumamodeli ahlukahlukene weselula nezilwane, okuphakamisa amandla ayo okwelapha izifo ezivuthayo ezingapheli.
Esinye sezitshalo ezine-7-8 dihydroxyflavonoids yi-Tridax procumbens, eyaziwa ngokuthi i-daisy noma i-Tridax daisy. Lesi sitshalo sitholakala ezindaweni ezishisayo futhi besisetshenziswa ngokwesiko emithini ye-Ayurvedic ngezindawo zaso eziningi zokwelapha. Abacwaningi bathola ukuthi i-Tridax procumbens iqukethe i-7 kuya ku-8 dihydroxyflavonoids, evusa isithakazelo ekuhloleni izinzuzo zayo zezempilo ezingaba khona.
Esinye isitshalo esiqukethe i-7-8 dihydroxyflavone isitshalo se-Godmania aesculifolia, esizalelwa eMexico. Lesi sitshalo sisetshenziswa emithini yendabuko yaseMexico ngenxa yezakhiwo zayo zokulwa nokuvuvukala kanye ne-analgesic. Ucwaningo lubonisa ukuthi i-Godmania aesculifolia iqukethe i-7-8 dihydroxyflavone, eye yaqala olunye ucwaningo mayelana nokusetshenziswa kwayo kokwelapha okungaba khona.
Ngaphezu kwe-Tridax procumbens kanye ne-Godmania aesculifolia, ezinye izitshalo ezimbalwa kucatshangwa ukuthi ziqukethe i-7-8 dihydroxyflavonoids, nakuba ucwaningo olwengeziwe ludingeka ukuze kuqinisekiswe ukuba khona kwazo kulezi zitshalo. Lezi zihlanganisa i-fisetin ne-acacia shrub.
1. Ukuthuthukiswa kwengqondo: Enye yezinzuzo ezaziwa kakhulu zezithasiselo ze-7,8-dihydroxyflavone yikhono layo lokuthuthukisa ukusebenza kwengqondo. Ucwaningo lubonisa ukuthi i-7,8-DHF isiza ukuthuthukisa inkumbulo, ukufunda, nokusebenza kobuchopho jikelele. Ngokugqugquzela ukukhula kwamangqamuzana obuchopho amasha kanye nokuqinisa ukuxhumana phakathi kwama-neurons akhona, izithasiselo ze-7,8-dihydroxyflavone zingasiza ukusekela impilo yobuchopho bakho kanye namakhono okuqonda.
I-2.Ukusekelwa Kwesimo Senhliziyo: Ngaphezu kwezinzuzo zomqondo, izithasiselo ze-7,8-dihydroxyflavone ziboniswe zinomthelela omuhle esimweni sengqondo. Ucwaningo lubonisa ukuthi i-7,8-DHF ingasiza ekulawuleni ama-neurotransmitters ahlobene nemizwelo ebuchosheni, njenge-dopamine ne-serotonin, edlala indima ebalulekile ekulawulweni kwemizwelo. Ngokusekela lawa ma-neurotransmitters, izithasiselo ze-7,8-dihydroxyflavone zingasiza ukuthuthukisa isimo sengqondo kanye nempilo yonke yemizwa.
3. Imiphumela ye-Neuroprotective: Izithako ze-7,8-dihydroxyflavone nazo zitholakale zinezakhiwo ze-neuroprotective. Lokhu kusho ukuthi zingasiza ukuvikela ubuchopho nesistimu yezinzwa emonakalweni obangelwa ukucindezeleka kwe-oxidative, ukuvuvukala nezinye izinqubo eziyingozi. Ngokusekela impilo nokusebenza kwamangqamuzana obuchopho, izithasiselo ze-7,8-dihydroxyflavone zingasiza ekuvimbeleni izifo ze-neurodegenerative kanye nokwehla kwengqondo okuhlobene neminyaka.
4. Ukusekelwa Kwe-Antioxidant: Enye inzuzo enkulu ye-7,8-dihydroxyflavone supplements yizindawo zayo zokulwa ne-antioxidant. Ama-Antioxidants ayizinhlanganisela ezisiza ukuvikela umzimba emonakalweni wama-radical wamahhala, okungama-molecule ayingozi angaba nomthelela ezinhlobonhlobo zezifo ezingapheli kanye nokuguga. Ngokukhipha ama-radicals mahhala kanye nokunciphisa ukucindezeleka okwenziwe nge-oxidative, i-7,8-DHF ingasiza ukusekela impilo yonke kanye nokuphila kahle.
5.Umphumela wokulwa nokuvuvukala: Ukuvuvukala kuyinqubo yemvelo esiza umzimba ukulwa nokutheleleka futhi uphulukise umonakalo. Nokho, ukuvuvukala okungamahlalakhona kungaholela ezinkingeni zempilo ezihlukahlukene, kuhlanganise nesifo senhliziyo, isifo sikashukela, nomdlavuza. I-7,8-Dihydroxyflavone supplements iboniswe ukuthi inemiphumela yokulwa nokuvuvukala, okusiza ukunciphisa ingozi yokuvuvukala okungapheli kanye nezingozi zempilo ezihambisana nazo.
Enye yezinto zokuqala okufanele uzicabangele lapho ukhetha isithasiselo se-7,8-dihydroxyflavone ikhwalithi yezithako. Bheka izithasiselo eziqukethe okumsulwa, ikhwalithi ephezulu engu-7,8-DHF engenazo izigcwalisi ezingeziwe noma izithako zokwenziwa. Kubalulekile futhi ukucabangela umthombo we-7,8-DHF yakho - bheka izithasiselo ezihlolelwe ubumsulwa namandla.
Ngaphezu kwekhwalithi yezithako, kubalulekile futhi ukucabangela umthamo kanye nohlobo lwesithasiselo. I-7,8-Dihydroxyflavone itholakala kumafomu e-capsule ne-powder, futhi umthamo ungahluka phakathi kwemikhiqizo. Sicela ucabangele okuncamelayo kanye nezidingo zakho lapho ukhetha ifomu nomthamo olungele wena. Kungase futhi kube usizo ukubonisana nochwepheshe bezokunakekelwa kwempilo ukuze uthole umthamo ovumelana kangcono nezidingo zakho zomuntu ngamunye.
Esinye isici esibalulekile okufanele sicatshangelwe lapho ukhetha isithasiselo se-7,8-dihydroxyflavone idumela lomkhiqizi. Bheka izithasiselo ezenziwe inkampani ehloniphekile enomlando wokukhiqiza imikhiqizo yekhwalithi ephezulu, ethembekile. Hlola izitifiketi ezifana ne-Good Manufacturing Practices (GMP) nokuhlola okuvela eceleni ukuze uqinisekise ukuthi izithako zakho ezithathiwe zihlangabezana nekhwalithi ephezulu kanye namazinga okuphepha.
Kungumqondo omuhle futhi ukufunda ukubuyekezwa nobufakazi obuvela kwabanye abasebenzisi ukuze uthole umbono wokusebenza kanye nekhwalithi yesithasiselo. Bheka impendulo evela kubantu abasebenzise lo mkhiqizo ukuze uthole ukwesekwa kwengqondo kanye nempilo yonke yobuchopho ukuze uqonde kangcono ukuthi lesi sengezo sikusebenzela kanjani.
Okokugcina, cabangela izindleko kanye nenani lezithasiselo zakho. Nakuba kubalulekile ukukhetha imikhiqizo esezingeni eliphezulu, kubalulekile futhi ukucabangela izindleko kanye nenani lezithasiselo zakho. Qhathanisa izintengo futhi ucabangele izindleko ngokuphakelwa ngakunye ukuze uqiniseke ukuthi uthola inani lemali yakho.
Inkampani engu-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lezithako zokudla okunomsoco kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, inkampani iphinde ibe ngumkhiqizi obhalisiwe we-FDA, oqinisekisa impilo yabantu ngekhwalithi ezinzile nokukhula okuqhubekayo. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye namathuluzi okuhlaziya kungokwesimanje futhi anemisebenzi eminingi, futhi ayakwazi ukukhiqiza amakhemikhali esikalini se-milligram kuya kuthani ngokuhambisana namazinga e-ISO 9001 kanye nezinqubo zokukhiqiza ze-GMP.
Q: Iyini i-7,8-Dihydroxyflavone?
A: I-7,8-Dihydroxyflavone iyi-flavonoid eyenzeka ngokwemvelo eye yafundelwa izinzuzo zayo ezingaba khona zezempilo, okuhlanganisa nomthelela wayo ekusebenzeni kwengqondo kanye nempilo yonke.
Q: Zisebenza kanjani izithasiselo ze-7,8-Dihydroxyflavone?
A: Izithako ze-7,8-Dihydroxyflavone kukholakala ukuthi zisebenza ngokusekela umsebenzi wephrotheni eyinhloko ebuchosheni ebizwa ngokuthi i-TrkB, ehilelekile ekukhuleni nasekuphileni kwama-neurons. Lokhu kusekelwa kungase kube nomthelela ekusebenzeni okuthuthukisiwe kwengqondo kanye nempilo yengqondo.
Q: Yiziphi izinzuzo ezingaba khona zokuthatha izithasiselo ze-7,8-Dihydroxyflavone?
A: Ezinye izinzuzo ezingaba khona zokuthatha izithasiselo ze-7,8-Dihydroxyflavone zingase zihlanganise inkumbulo ethuthukisiwe nokusebenza kwengqondo, ukusekelwa kwempilo yonke yobuchopho, kanye nemiphumela engase ibe khona yokuthuthukisa imizwa.
Q: Kufanele kuthathwe kanjani izithako ze-7,8-Dihydroxyflavone?
A: Umthamo ofanele wezithako ze-7,8-Dihydroxyflavone ungahluka kuye ngezici ngazinye, ngakho-ke kungcono ukulandela umthamo onconywayo kwilebula yomkhiqizo noma uthintane nochwepheshe bezempilo ukuze uthole isiqondiso.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Feb-20-2024
