Ingabe usohambweni lokuhlala kahle futhi ufuna izithasiselo zokuthuthukisa impilo yakho yomzimba neyengqondo? Ungabheki kude kunezithasiselo ze-7,8-dihydroxyflavone. I-7,8-Dihydroxyflavone iyi-flavonoid etholakala ezitshalweni ezithile futhi ihlolwe ngezinzuzo zayo ezingaba khona zempilo. Ucwaningo lubonisa ukuthi i-7,8-dihydroxyflavone inezakhiwo zokuvikela izinzwa, zokulwa nokuvuvukala, kanye ne-antioxidant, okwenza kube isithasiselo sempilo esithembisayo. Uma ufuna ukuthatha uhambo lwakho lwezempilo luye ezingeni elilandelayo, cabanga ngokufaka isithasiselo se-7,8-dihydroxyflavone ohlelweni lwakho lwansuku zonke.
Ngakho-ke kuyini ngempela7,8-dihydroxyflavoneI-7,8-DHF iyi-flavonoid etholakala kwezinye izitshalo nemifino. Yatholakala ngenkathi ifuna i-molecule elingisa umsebenzi we-neurotrophic factor (BDNF) etholakala ebuchosheni, i-molecule encane evuselela i-receptor ethile ebizwa ngokuthi i-tropomyosin-related kinase B (TrkB) ngoba i-peptide isebenza ku-Le receptor, ebizwa ngokuthi i-neurotrophic factor (BDNF) etholakala ebuchosheni, ayikwazi ukusetshenziswa ngenxa yokumuncwa kabi yingqondo.
I-7,8-DHF itholakale iyi-mimetic enamandla ye-BDNF, isebenza ngendlela efanayo ku-TrkB. Lokhu kusho ukuthi i-7,8-DHF ingaveza imiphumela efanayo ebuchosheni njenge-BDNF, futhi ingaba usizo kakhulu ngokwezokwelapha ngenxa yokumuncwa kwayo okungcono kanye nekhono lokuwela umgoqo wegazi nobuchopho.
Ngenxa yekhono layo lokuvuselela ama-receptor e-TrkB, ama-receptor e-TrkB adlala indima ebalulekile ekukhuleni nasekusindeni kwama-neurons ebuchosheni. Lapho ama-receptor e-TrkB esebenza, ama-neurons avame ukuzwa ukukhula nokuvikelwa. Lokhu kukhula kuvame ukuthinta ama-dendrite ama-neurons, anwebeka kuma-synapses ukuze axhumane nama-neurons alandelayo, kanti i-7,8-DHF iboniswe ukuthi ikhuthaza ukukhula kwala ma-dendrite abe ama-synapses, okusiza ukubuyisela izilwane Ukuxhumana phakathi kwama-neurons ngendlela yokuncipha kwengqondo.
Izifundo eziningi zisikisela ukuthi i-7,8-DHF ingaba namandla okuthuthukisa ukufunda kanye nenkumbulo, ukuvimbela izifo eziwohlokayo zemizwa, kanye nokusekela impilo yemizwa kanye neyemizwa. Lokhu okutholakele kubangele ukwanda kwesithakazelo ezithakazelweni ze-7,8-dihydroxyflavone njengezindlela zemvelo zokusekela impilo yobuchopho.
Abantu abaningi baphendukela ezithasiseleni ze-7,8-dihydroxyflavone ukuze basekele umsebenzi wabo wokuqonda, ikakhulukazi njengoba bekhula noma bebhekene nezinselele ezihlobene nenkumbulo nokugxila.Ukusebenzisa amakhemikhali emvelo ukusekela impilo yobuchopho kuyakhanga kakhulu labo abakhetha indlela yemvelo nephelele yempilo.
Enye yezindlela eziyinhloko zokusebenza kwe-7,8-dihydroxyflavone yikhono layo lokusebenzisa indlela yokubonisana ye-tropomyosin receptor kinase B (TrkB). I-TrkB iyi-receptor ye-neurotrophic factor ebuchosheni etholakala ku-neurotrophic factor (BDNF) futhi idlala indima ebalulekile ekukhuleni, ekusindeni, kanye nasekusebenzeni kwama-neurons ezinhlelweni zezinzwa eziphakathi nezingaphandle. Ukusebenza kwe-TrkB receptor yi-7,8-dihydroxyflavone kuholela ekufakweni kwe-phosphorylation kwesizinda sayo sangaphakathi kweseli, okubangela uchungechunge lwezehlakalo zokubonisana ezingezansi, ekugcineni kukhuthaza ukusinda kwe-neuronal, ukukhula kanye nokwehluka.
Izifundo zibonise ukuthi i-7,8-dihydroxyflavone ikhombisa imiphumela yokuvikela izinzwa kumamodeli amaningana ezifo eziwohloka yizinzwa, njengesifo i-Alzheimer's kanye nesifo i-Parkinson's. Ngokusebenzisa indlela yokubonisana ye-TrkB, i-7,8-dihydroxyflavone ithuthukisa ukusinda kwama-neurons, iwavikele ekucindezelekeni kwe-oxidative kanye nokuvuvukala, futhi ikhuthaza ukwakheka kokuxhumana okusha kwe-synaptic, okungenzeka kunciphise noma kubuyisele emuva ukuqhubeka kwalesi sifo.
Ngaphezu kwemiphumela yokuvikela izinzwa, i-7,8-dihydroxyflavone itholakale inemiphumela yokukhathazeka. Le miphumela kucatshangwa ukuthi ibangelwa ikhono layo lokukhulisa imiphumela ye-BDNF ebuchosheni, ngaleyo ndlela ithuthukise ukuqina kwemizwa kanye nokuqina lapho ubhekene nokucindezeleka kanye nokuphazamiseka kwemizwelo. Ngaphezu kwalokho, izifundo zangaphambi kokwelashwa zibonise ukuthi i-7,8-dihydroxyflavone ingathuthukisa izinqubo zokufunda kanye nenkumbulo, iphakamisa amathuba okusetshenziswa kwayo ekwelapheni ukukhubazeka kwengqondo okuhambisana nezimo ezifana nokuwohloka komqondo kanye nokulimala kobuchopho okubuhlungu.
Ubufakazi obusha busikisela ukuthi ingaba nemiphumela emihle nakwezinye izicubu nezitho zomzimba. Isibonelo, i-7,8-dihydroxyflavone iboniswe inezakhiwo zokulwa nokuvuvukala, i-antioxidant kumamodeli ahlukahlukene eseli nezilwane, okubonisa ukuthi inamandla okwelapha izifo zokuvuvukala ezingamahlalakhona.
Esinye sezitshalo ezine-dihydroxyflavonoids engu-7-8 yi-Tridax procumbens, eyaziwa kakhulu ngokuthi i-daisy noma i-Tridax daisy. Lesi sitshalo sivela ezindaweni ezishisayo futhi besisetshenziswa ngokwesiko kwezokwelapha ze-Ayurvedic ngenxa yezakhiwo zaso eziningi zokwelapha. Abacwaningi bathole ukuthi i-Tridax procumbens iqukethe i-dihydroxyflavonoids engu-7 kuya ku-8, okuvusa isithakazelo sokuhlola izinzuzo zayo zezempilo ezingaba khona.
Esinye isitshalo esiqukethe i-7-8 dihydroxyflavone yisitshalo i-Godmania aesculifolia, esidabuka eMexico. Lesi sitshalo sisetshenziswa emithini yendabuko yaseMexico ngenxa yezakhiwo zaso zokulwa nokuvuvukala kanye nezokudambisa ubuhlungu. Ucwaningo lubonisa ukuthi i-Godmania aesculifolia iqukethe i-7-8 dihydroxyflavone, okuye kwabangela ucwaningo olwengeziwe mayelana nokusetshenziswa kwayo okungenzeka kube ukwelapha.
Ngaphezu kwe-Tridax procumbens kanye ne-Godmania aesculifolia, kucatshangwa ukuthi ezinye izitshalo eziningana ziqukethe ama-dihydroxyflavonoid angu-7-8, yize kudingeka ucwaningo olwengeziwe ukuqinisekisa ukuba khona kwazo kulezi zitshalo. Lezi zitshalo zifaka phakathi i-fisetin kanye nesihlahla se-acacia.
1. Ukuthuthukiswa Kokuqonda: Enye yezinzuzo ezaziwa kakhulu zezithasiselo ze-7,8-dihydroxyflavone yikhono lazo lokuthuthukisa ukusebenza kokuqonda. Ucwaningo lubonisa ukuthi i-7,8-DHF isiza ukuthuthukisa inkumbulo, ukufunda, kanye nokusebenza kobuchopho jikelele. Ngokukhuthaza ukukhula kwamangqamuzana obuchopho amasha nokuqinisa ukuxhumana phakathi kwama-neurons akhona, izithasiselo ze-7,8-dihydroxyflavone zingasiza ekusekeleni impilo yobuchopho bakho kanye namakhono okuqonda.
2. Ukusekelwa Kwesimo Sengqondo: Ngaphezu kwezinzuzo zokuqonda, izithasiselo ezingu-7,8-dihydroxyflavone ziboniswe zinethonya elihle esimweni semizwa. Ucwaningo lubonisa ukuthi i-7,8-DHF ingasiza ekulawuleni ama-neurotransmitter ahlobene nesimo sengqondo ebuchosheni, njenge-dopamine ne-serotonin, ezidlala indima ebalulekile ekulawuleni isimo sengqondo. Ngokusekela la ma-neurotransmitter, izithasiselo ezingu-7,8-dihydroxyflavone zingasiza ekuthuthukiseni isimo sengqondo kanye nempilo yengqondo iyonke.
3. Imiphumela yokuvikela imizwa: Izithasiselo ze-7,8-dihydroxyflavone nazo zitholakale zinezakhiwo zokuvikela imizwa. Lokhu kusho ukuthi zingasiza ekuvikeleni ubuchopho kanye nesistimu yezinzwa ekulimaleni okubangelwa ukucindezeleka kwe-oxidative, ukuvuvukala kanye nezinye izinqubo eziyingozi. Ngokusekela impilo kanye nokusebenza kwamaseli obuchopho, izithasiselo ze-7,8-dihydroxyflavone zingasiza ekuvimbeleni izifo zemizwa kanye nokwehla kwengqondo okuhlobene nokuguga.
4. Ukusekelwa kwe-Antioxidant: Enye inzuzo enkulu yezithako ze-7,8-dihydroxyflavone yizakhiwo zayo ze-antioxidant. Ama-antioxidants ayizakhi ezisiza ukuvikela umzimba ekulimaleni kwama-free radical, okuyizinto eziyingozi ezingabangela izifo eziningi ezingamahlalakhona kanye nokuguga. Ngokususa ama-free radical kanye nokunciphisa ukucindezeleka kwe-oxidative, i-7,8-DHF ingasiza ekusekeleni impilo yonke kanye nenhlalakahle.
5.Umphumela wokulwa nokuvuvukala: Ukuvuvukala kuyinqubo yemvelo esiza umzimba ukulwa nokutheleleka nokwelapha umonakalo. Kodwa-ke, ukuvuvukala okungapheli kungaholela ezinkingeni ezahlukene zempilo, okuhlanganisa isifo senhliziyo, isifo sikashukela, nomdlavuza. Izithako ze-7,8-Dihydroxyflavone ziboniswe zinemiphumela yokulwa nokuvuvukala, zisiza ukunciphisa ingozi yokuvuvukala okungapheli kanye nezingozi zempilo ezihlobene nakho.
Enye yezinto zokuqala okufanele uzicabangele lapho ukhetha isithasiselo se-7,8-dihydroxyflavone ikhwalithi yezithako. Funa izithasiselo eziqukethe i-7,8-DHF emsulwa, esezingeni eliphezulu engenazo izithasiselo ezengeziwe noma izithako zokwenziwa. Kubalulekile futhi ukucabangela umthombo we-7,8-DHF yakho - funa izithasiselo ezihlolwe ubumsulwa namandla.
Ngaphezu kwekhwalithi yezithako, kubalulekile futhi ukucabangela umthamo kanye nohlobo lwesithako. I-7,8-Dihydroxyflavone itholakala ngezindlela ze-capsule kanye ne-powder, futhi umthamo ungahluka phakathi kwemikhiqizo. Sicela ucabangele izintandokazi zakho nezidingo zakho lapho ukhetha uhlobo kanye nomthamo ofanele wena. Kungasiza futhi ukubonisana nochwepheshe wezempilo ukuze uthole umthamo ofanelana kahle nezidingo zakho.
Esinye isici esibalulekile okufanele usicabangele lapho ukhetha isithasiselo se-7,8-dihydroxyflavone idumela lomkhiqizi. Funa izithasiselo ezenziwe yinkampani edumile enomlando wokukhiqiza imikhiqizo esezingeni eliphezulu nethembekile. Hlola izitifiketi ezifana ne-Good Manufacturing Practices (GMP) kanye nokuhlolwa komuntu wesithathu ukuqinisekisa ukuthi izithasiselo zakho zihlangabezana nezindinganiso zekhwalithi ephezulu kanye nokuphepha.
Kungumqondo omuhle futhi ukufunda ukubuyekezwa kanye nobufakazi obuvela kwabanye abasebenzisi ukuze uthole umbono wokusebenza kahle kanye nekhwalithi yesithasiselo. Funa impendulo kubantu abasebenzise lo mkhiqizo ukuze bathole ukwesekwa kwengqondo kanye nempilo yobuchopho iyonke ukuze baqonde kangcono ukuthi lesi sithasiselo sisebenza kanjani kuwe.
Okokugcina, cabanga ngezindleko kanye nenani lezithasiselo zakho. Nakuba kubalulekile ukukhetha imikhiqizo esezingeni eliphezulu, kubalulekile futhi ukucabangela izindleko kanye nenani lezithasiselo zakho. Qhathanisa amanani bese ucabangela izindleko ngokuphakelwa ngakunye ukuqinisekisa ukuthi uthola inani lemali yakho.
I-Suzhou Myland Pharm & Nutrition Inc. ibilokhu ibandakanyeka ebhizinisini lezithako zokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokuthengisa okukhishwe kwembewu yamagilebhisi.
Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye nesu le-R&D elithuthukisiwe kakhulu, inkampani ithuthukise imikhiqizo ehlukahlukene yokuncintisana futhi yaba yinkampani yezinsizakalo ezintsha zesayensi yokuphila, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.
Ngaphezu kwalokho, le nkampani iphinde ibe ngumkhiqizi obhalisiwe yi-FDA, eqinisekisa impilo yabantu ngekhwalithi ezinzile kanye nokukhula okusimeme. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi ziyakwazi ukukhiqiza amakhemikhali esikalini esingu-milligram kuya ku-ton ngokuhambisana nezindinganiso ze-ISO 9001 kanye nemikhuba yokukhiqiza ye-GMP.
Q: Kuyini i-7,8-Dihydroxyflavone?
A: I-7,8-Dihydroxyflavone iyi-flavonoid eyenzeka ngokwemvelo eye yacwaningwa ngezinzuzo zayo zempilo, okuhlanganisa nomthelela wayo ekusebenzeni kwengqondo kanye nenhlalakahle iyonke.
Q: Zisebenza kanjani izithasiselo ze-7,8-Dihydroxyflavone?
A: Izithasiselo ze-7,8-Dihydroxyflavone kukholakala ukuthi zisebenza ngokusekela umsebenzi weprotheyini ebalulekile ebuchosheni ebizwa ngokuthi i-TrkB, ehilelekile ekukhuleni nasekusindeni kwama-neurons. Lokhu kusekelwa kungasiza ekuthuthukiseni ukusebenza kwengqondo kanye nenhlalakahle yengqondo.
U: Yiziphi izinzuzo ezingaba khona zokuthatha izithasiselo ze-7,8-Dihydroxyflavone?
A: Ezinye izinzuzo ezingaba khona zokuthatha izithasiselo ze-7,8-Dihydroxyflavone zingafaka phakathi inkumbulo ethuthukisiwe kanye nokusebenza kwengqondo, ukwesekwa kwempilo yobuchopho iyonke, kanye nemiphumela engaba khona yokukhulisa imizwa.
Q: Kufanele zithathwe kanjani izithasiselo ze-7,8-Dihydroxyflavone?
A: Isilinganiso esifanele sezithasiselo ze-7,8-Dihydroxyflavone singahluka kuye ngezici ngazinye, ngakho-ke kungcono ukulandela isilinganiso esinconywayo esikulebula lomkhiqizo noma uthintane nochwepheshe wezempilo ukuze uthole isiqondiso.
Isixwayiso: Lesi sihloko senzelwe ulwazi olujwayelekile kuphela futhi akufanele sithathwe njenganoma yisiphi iseluleko sezokwelapha. Olunye ulwazi lweposi lebhulogi luvela kwi-inthanethi futhi alulona ochwepheshe. Le webhusayithi inesibopho sokuhlunga, ukufometha nokuhlela izihloko kuphela. Inhloso yokudlulisa ulwazi olwengeziwe akusho ukuthi uyavumelana nemibono yayo noma uqinisekisa ubuqiniso bokuqukethwe kwayo. Njalo xhumana nochwepheshe wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukwenza izinguquko ohlelweni lwakho lokunakekelwa kwempilo.
Isikhathi sokuthunyelwe: Feb-20-2024
