I-Mitochondria ibaluleke kakhulu njengesizinda samandla samaseli omzimba wethu, ihlinzeka ngamandla amakhulu ukugcina inhliziyo yethu ishaya, amaphaphu ethu ephefumula kanye nomzimba wethu usebenza ngokuvuselelwa kwansuku zonke. Kodwa-ke, ngokuhamba kwesikhathi, nangokukhula, izakhiwo zethu ezikhiqiza amandla, i-mitochondria, ziba sengozini yokulimala futhi zilahlekelwe amandla azo okusebenza ngempumelelo. I-mitochondria esebenza ngokugcwele ibalulekile empilweni yomuntu. Kodwa-ke, i-mitochondria nayo isengozini enkulu yokulimala okuvela emithonjeni ehlukahlukene, okuhlanganisa ukucindezeleka kwe-oxidative, ukuvuvukala, kanye nobuthi bemvelo. Lezi zici zingabangela ukulimala ku-DNA ye-mitochondrial, kuphazamise ikhono labo lokukhiqiza i-ATP nezinye izinhlanganisela ezibalulekile.
Ngenhlanhla, imizimba yethu ikhetha ngokukhetha ukususa i-mitochondria eyonakele nengasebenzi kahle emangqamuzaneni ethu ngokusebenzisa i-autophagy ye-mitochondrial ukuze sigcine impilo engcono futhi sigweme imiphumela engemihle yale mitochondria eyonakele, ngokusho kocwaningo olubonisa ukuthi inqubo ye-mitochondrial autophagy inendima ekulweni- ukuguga. Masiqonde ukuxhumana phakathi kwe-mitochondria nokulwa nokuguga!
Yiziphi izindima ze-mitochondria?
I-Mitochondria yi-organelles ebalulekile ekhiqiza amandla kumaseli ethu. Indima yabo eyinhloko iwukukhiqiza i-adenosine triphosphate (ATP), okuyimali yamandla amangqamuzana ethu. Uma sine-mitochondria eyengeziwe, singakhiqiza i-ATP eyengeziwe, okuholela ekwandiseni amandla nokuncipha kokukhathala. Phakathi kwezindima eziyinhloko eziyidlalayo yilezi:
(1)ukuhlinzeka amandla kanye nezinqubo ze-metabolic emzimbeni
(2)I-Mitochondrial autophagy ibona i-mitochondria eyonakele futhi iwasuse ngokukhetha, futhi ukususwa kwale mitochondria eyonakele kuthuthukisa i-biosynthesis ye-mitochondria entsha.
(3)Ingadlala indima ekuvimbeleni ukufa kwamangqamuzana ngokususa i-mitochondria
(4)Kuye kwaxhunyaniswa nokuthuthukiswa kohlu lwezinkinga zempilo, okuhlanganisa nesifo senhliziyo, izifo ze-neurodeergenerative ngisho nezinhlobo ezithile zomdlavuza.
Kuyini ukuxhumana phakathi kwe-mitochondria kanye ne-anti-aging?
Ucwaningo luye lwabonisa ukuthi njengoba sikhula, imvume nge-autophagy ye-mitochondrial i-dysregulated, okusho ukuthi amangqamuzana e-mitochondrial awakwazi ukusula imisebenzi yawo. Ngaphandle kwezinqubo zokulawula ikhwalithi ezithuthukisiwe ezifana ne-mitochondrial autophagy, ukulimala kwamaselula kungase kusheshiswe.
Ezifundweni zezilwane, isikhathi eside sokuphila siye sabonakala lapho izakhi zofuzo ezilawula i-autophagy ye-mitochondrial zivezwa, okuphakamisa ukuthi i-autophagy ye-mitochondrial nokuphila isikhathi eside kuhlobene. Ngaphezu kwalokho, i-autophagy ye-mitochondrial ekhubazekile ngokuvamile ibonakala ezifweni eziningana ezihlobene nobudala, kuhlanganise nesifo sika-Parkinson kanye ne-Alzheimer's, isifo senhliziyo, nomdlavuza, okuphakamisa ukuthi ukungenelela okuqondiswe kwe-mitochondrial autophagy kungase kube nendima ekuvimbeleni nasekulapheni izifo. Ekugcineni, isihluthulelo sokuguga ngomusa sisekuqondeni nasekusekeleni izinqubo eziyinkimbinkimbi kakhulu ezigcina umzimba usebenza. Ngokusebenzela ukukhuthaza i-autophagy ye-mitochondrial enempilo nokwenza ukukhetha kwendlela yokuphila ebeka kuqala inhlalakahle yethu, singavula izimfihlo zempilo ende nenempilo!
Indlela yokwandisa i-autophagy ye-mitochondrial
(1)Cabangela ukuzila ukudla okunezigaba kanye nomkhawulo wekhalori
Ucwaningo luye lwabonisa ukuthi i-autophagy ye-mitochondrial ingakhuthazwa ukungenelela okuhlukahlukene kwendlela yokuphila. Isibonelo, ukuvivinya umzimba kuye kwaboniswa ukwandisa i-autophagy ye-mitochondrial, ngaleyo ndlela kuthuthukisa umsebenzi we-mitochondrial. Ngaphezu kwalokho, ukungenelela kokudla okunjengokuzila ukudla okuphakathi noma ukuvinjelwa kwekhalori kungaphinde kukhuthaze i-mitochondrial autophagy, okuholela ekwandeni kwe-mitochondria enempilo.
(2)Ukuzivocavoca okungajwayelekile
Ukuzivocavoca kulula futhi kulula ukunamathela kukho. Kungakhuthaza impilo nokuphila isikhathi eside kanye nokuthuthukisa ukusebenza kwe-mitochondrial kanye nokufaka i-autophagy ye-mitochondrial, ngakho ukuzivocavoca kungase kuhlelwe ngokunengqondo ngamandla athile, ukuqeqeshwa kwe-aerobic nokukhuthazela ukuze kwandiswe i-autophagy ye-mitochondrial.
(3)I-Urolithin A iyi-molecule eyenza i-mitochondrial autophagy
I-Urolithin A iyinhlanganisela ye-metabolite ekhiqizwa ukuguqulwa kwe-ellagic tannins ngamagciwane amathumbu. Ama-precursors awo yi-ellagic acid ne-ellagitannin, engatholakala ezitshalweni eziningi ezidliwayo, njengegromegranate, ama-strawberries, ama-raspberries, ama-walnuts, njll., kodwa hhayi ukuthi ikhona ekudleni, ngoba amanye amagciwane angaguqula i-ellagitannin ku-urolithin. Futhi i-urolithin A, isakhi esiphilayo esakhiwe kusuka kuma-precursors okudla, into ekhonjiswe ukuthi icupha i-mitochondrial autophagy.
Ukubaluleka kwe-autophagy ye-mitochondrial
I-Mitochondrial autophagy iyinqubo engokwemvelo futhi ebalulekile esiza ukugcina i-mitochondria enempilo ngaphakathi kwamaseli ethu. Le nqubo ihilela ukuhlonza i-mitochondria eyonakele noma engasebenzi kahle futhi ngokukhetha ukuyikhipha kuseli ukuze kuvuleke i-mitochondria entsha, esebenzayo ukuze ithathelwe indawo yayo. Ngesikhathi esifanayo, inqubo ye-autophagy ye-mitochondrial isiza ukuqinisekisa ukuthi amazinga wamandla emizimba yethu ahlala ezinzile nokuthi amangqamuzana ethu nezicubu zihlala ziphilile futhi zisebenza.
Sengiphetha, ukulondoloza i-mitochondria enempilo kubalulekile empilweni nasenhlalakahleni yethu iyonke, futhi amangqamuzana ethu aguqule inqubo ebizwa ngokuthi i-mitochondrial autophagy ukuze aqinisekise ukuthi sinokunikezwa okuqhubekayo kwe-mitochondria enempilo. Kodwa-ke, ukungenelela kwendlela yokuphila (njengokuzivocavoca) kanye nokungenelela kokudla (njengokudla kwe-ketogenic) kanye nokusetshenziswa kwezithako zokudla kungasekela umsebenzi we-mitochondrial futhi kusize ukuvimbela izifo ezihlobene nobudala. Ngokunakekela i-mitochondria yethu, singaqinisekisa ukuthi sinamandla namandla esiwadingayo ukuze siphile impilo egcwele.
Ngaphezu kwalokho, singakwazi ngokucacile ukuxhumana phakathi kwe-mitochondria kanye nokulwa nokuguga, njengoba sikhula, inqubo ye-autophagy ye-mitochondrial ikhubazekile, okungukuthi, iholela ekuqoqweni kwe-mitochondria emangqamuzaneni, okuzila ukudla, ukuvinjelwa kwekhalori, i-urolithin A. , njll. kungabangela i-autophagy ye-mitochondrial futhi ingathuthukisa impilo kanye nokulwa nokuguga, lapho kokubili i-NAD+ ne-urolithin A zifaka isandla ekukhiqizweni kwe-mitochondria entsha ngenqubo ebizwa ngokuthi inqubo ye-biogenesis ebizwa ngokuthi i-biogenesis; Nokho, i-urolithin A inomunye umsebenzi obalulekile. Ilungiselela inqubo ebizwa nge-mitochondrial autophagy, lapho i-mitochondria eyonakele isuswa futhi igaywe kabusha ibe yi-mitochondria entsha, esebenza kahle kakhudlwana. Abantu abaningi ezimpilweni zethu bangase bangakwazi ukusekela ukuvivinya umzimba isikhathi eside, kodwa umkhiqizo ofakiwe esiwunikezayo, i-Urolithin A, unganikeza impilo ephelele.
Umbuzo: Ingabe kukhona ukudla okuthile empilweni yakho okungasiza ekuvimbeleni ukuguga ngaphambi kwesikhathi?
IMPENDULO: Yebo, okunye ukudla okunothe ngama-antioxidants, amavithamini namaminerali kungasiza ekukhuthazeni isikhumba esinempilo futhi kubambezele inqubo yokuguga. Izibonelo zihlanganisa izithelo, imifino, amaprotheni mafutha namafutha anempilo.
Isikhathi sokuthumela: Jun-01-2023
