Ekuphishekeleni indlela yokuphila enempilo, sivame ukufuna ukuthuthukisa inhlalakahle yethu ngezindlela ezihlukahlukene. Ukuvuvukala kuwukusabela kwemvelo komzimba ukuze uzivikele ekulimaleni futhi ukhuthaze ukuphulukiswa. Kodwa-ke, ukuvuvukala okungapheli kungaholela ezinkingeni zezempilo ezihlukahlukene, futhi izithako ezilwa nokuvuvukala ziye zaboniswa ukunciphisa ukuvuvukala emzimbeni. Zitholakala ekudleni, emakhambi, nakwezinye izithasiselo zokudla. Ukusuka ekwehliseni ukuvuvukala kuye ekusekeleni amasosha omzimba, izithasiselo ezilwa nokuvuvukala zidumile ngendima yazo engaba khona ekukhuthazeni impilo yonke. Nakuba izithako ezilwa nokuvuvukala zingaba isengezo esizuzisayo endleleni yokuphila enempilo, kubalulekile futhi ukugxila ekudleni ukudla okulinganiselayo nokuzivocavoca njalo.
Ukusabela kokuvuvukala kuyindlela yokuzivikela engokwemvelo yomzimba lapho ubhekene nezinto eziyingozi ezinjengamagciwane, amaseli alimele, noma izinto ezicasulayo. Le nqubo ebalulekile yokuphila isiza ukuvikela nokuphulukisa umzimba ekulimaleni noma ekuthelelekeni. Nakuba ukuvuvukala kuvame ukuhlotshaniswa nokubabomvu, ukushisa, ukuvuvukala, nobuhlungu, kuyingxenye ebalulekile yenqubo yokuphulukisa.
Uma kwenzeka ukulimala noma ukutheleleka, amasosha omzimba akhulula amakhemikhali ahlukahlukene namaseli asebenza ndawonye ukuze alwe nomhlaseli. Lawa makhemikhali abangela ukuba imithambo yegazi endaweni ethintekile ivuleke, ngaleyo ndlela andise ukugeleza kwegazi endaweni yokulimala noma ukutheleleka. Ukwanda kokugeleza kwegazi kubangela ububomvu nokufudumala endaweni.
Ngesikhathi esifanayo, imithambo yegazi ikwazi ukungena kalula, okwenza uketshezi, amaprotheni namangqamuzana amhlophe egazi avuzele ezicutshini ezizungezile. Lokhu kunqwabelana koketshezi kubangela ukuvuvukala, okusiza ukuhlukanisa indawo elimele futhi kuvimbele ukusakazeka kwezifo.
Ngaphezu kwalokho, amangqamuzana amhlophe egazi, ikakhulukazi ama-neutrophils nama-macrophages, akhangwa izindawo zokuvuvukala. La mangqamuzana agwinya futhi abhubhise abahlaseli bakwamanye amazwe, asuse amangqamuzana afile, futhi aqalise izinqubo zokulungisa izicubu. Izixhumi ezivuthayo ezifana ne-histamine nama-cytokines nazo ziyakhululwa phakathi nalokhu kusabela ukuze kuthuthukiswe amandla amasosha omzimba okulwa nezinto eziyingozi.
Nakuba ukuvuvukala kunendima ebalulekile ekuvikeleni umzimba, kungase futhi kube nemiphumela emibi uma kuba okungapheli noma okweqile. Ukuvuvukala okungapheli kwenzeka lapho amasosha omzimba esabela ngokweqile noma ehluleka ukuqeda imbangela yokuqala yokuvuvukala. Lokhu kusabela okuqhubekayo kokuzivikela komzimba kungaholela ekulimaleni kwezicubu kanye nokuthuthukiswa kwezifo ezihlukahlukene ezingapheli, okuhlanganisa i-rheumatoid arthritis, isifuba somoya, nesifo samathumbu esivuthayo.
Ngakho-ke ukuze ube nempilo engcono, ukulwa nokuvuvukala kubalulekile, ngakho-ke kuyini ukulwa nokuvuvukala? I-anti-inflammatory ibhekisela ezintweni noma izidakamizwa ezinciphisa ukuvuvukala futhi zidambise izimpawu zayo. Lezi zinto zisebenza ngokukhomba ama-molecule athile kanye nezindlela ezihilelekile ekuphenduleni kokuvuvukala. Zitholakala emithini, emithini yemvelo, kanye nokudla okuthile, futhi zingabuye zengezwe ekudleni okunezithako ezilwa nokuvuvukala.
Ngaphezu kokugcina ukudla okunempilo nokwenza izinguquko zokuphila, abantu abaningi baphendukela ezithasiselweni ezilwa nokuvuvukala ukuze balwe nokuvuvukala kangcono. Izithako ezilwa nokuvuvukala zinikeza indlela engokwemvelo nephelele yokulawula ukuvuvukala okungapheli. Ngokufaka lezi zithako ohlelweni lwakho lwansuku zonke, unganciphisa ukuvuvukala, ukhulule izinhlungu, uthuthukise ukusebenza kwamasosha omzimba, futhi uthuthukise impilo yonke.
Izithako ezilwa nokuvuvukala zihlanganisa imikhiqizo ehlukahlukene yemvelo kanye nezithako zokudla ezinezakhiwo ezinamandla zokulwa nokuvuvukala. Ziza ngezindlela eziningi, okuhlanganisa amaphilisi, amaphilisi, izimpushana, noketshezi. Ngokuqondisa izimbangela zokuvuvukala, lezi zithako zinikeza izinzuzo eziningi zezempilo, okuhlanganisa ukunciphisa ubuhlungu nokuvuvukala, ukuthuthukisa impilo ehlangene, ukulawula amazinga kashukela egazini, ukuthuthukisa ukusebenza kwengqondo, nokuthuthukisa ukusekelwa kwamasosha omzimba. Ukufaka lezi zithako ohlelweni lwakho lwansuku zonke kungasiza ekukhuthazeni impilo yonke futhi kunciphise ingozi yezifo ezingapheli ezihlobene nokuvuvukala.
Ukuvuvukala kuwukusabela okungokwemvelo okwenzeka emizimbeni yethu njengendlela yokuvimbela ukulimala, ukutheleleka, noma izifo. Nokho, lapho ukuvuvukala kuba okungapheli, kungaholela ezinkingeni ezinkulu zempilo. Ngenhlanhla, kukhona ama-anti-inflammatory agents angasiza ekunciphiseni ukuvuvukala nokuvimbela ukulimala kwesikhathi eside empilweni yethu.
●Yehlisa ukuvuvukala nobuhlungu: Ukuvuvukala okuningi, okufana nobuhlungu bamalunga kanye nobuhlungu bemisipha, kuhambisana nokungakhululeki. Izithako ezilwa nokuvuvukala zinganikeza ukukhululeka kobuhlungu bemvelo ngokuvimbela ama-molecule avuthayo nezindlela, ukunciphisa ukuvuvukala emthonjeni wawo. Kungasiza futhi ekunciphiseni izimpawu ezihlobene nezifo ezivuvukalayo, njenge-arthritis ne-asthma.
●Thuthukisa impilo yenhliziyo: Ukuvuvukala kuxhumene nezifo zenhliziyo nemithambo yegazi njengesifo senhliziyo nesifo sohlangothi. Ngokunciphisa ukuvuvukala, izinto ezilwa nokuvuvukala zingasiza ekunciphiseni ingozi yalezi zifo. Ucwaningo lubonisa ukuthi ukusetshenziswa njalo kwezidakamizwa ezilwa nokuvuvukala kunganciphisa amazinga e-C-reactive protein, uphawu lokuvuvukala emzimbeni. Lokhu, futhi, kunganciphisa ingozi yesifo senhliziyo futhi kuthuthukise impilo yonke yenhliziyo.
●Ukuthuthukisa impilo yengqondo nokusebenza kwengqondo: Ukuvuvukala okungapheli kuxhumene nezifo ze-neurodegenerative ezifana ne-Alzheimer's kanye ne-Parkinson. Ngokunciphisa ukuvuvukala ebuchosheni, ama-anti-inflammatory agents angase abambezele ukuqhubeka kwalezi zifo futhi akhuthaze impilo yobuchopho. Ukwengeza, izifundo zithole ukuhlobana phakathi kokuvuvukala nokuphazamiseka kwempilo yengqondo njengokucindezeleka nokukhathazeka. Ngokunciphisa ukuvuvukala, izinto ezilwa nokuvuvukala zingase zibe nomthelela omuhle empilweni yengqondo.
●Ukuthuthukisa umsebenzi wokuzivikela komzimba: Izidakamizwa ezilwa nokuvuvukala nazo zidlala indima ebalulekile ekwelapheni izifo ezizimele. Izifo ze-autoimmune zenzeka lapho amasosha omzimba ehlasela izicubu zawo ngephutha. Izifo eziningi ze-autoimmune, njenge-rheumatoid arthritis kanye ne-lupus, zibandakanya ukuvuvukala okungapheli. Ngokunciphisa ukuvuvukala, izinto ezilwa nokuvuvukala zingasiza ekudambiseni izimpawu futhi zithuthukise izinga lempilo yabantu abanalezi zimo.
1. I-Turmeric/Curcumin
Eyaziwa ngezakhiwo zayo ezinamandla zokulwa nokuvuvukala, i-turmeric, noma i-curcumin ehlanganisiwe esebenzayo, iyisengezo semvelo esinamandla. Ucwaningo oluningi luye lwabonisa ukuthi i-curcumin iyasebenza ekulweni nokuvuvukala okungapheli. Kuyasiza ekuvimbeleni ukukhiqizwa kwezimpawu zokuvuvukala emzimbeni futhi kunezakhiwo ze-antioxidant. Ukwengeza, i-curcumin iye yaxhunyaniswa nokugaya okuthuthukisiwe nokusebenza kobuchopho okuthuthukisiwe.
2. Green tea extract
Itiye elihlaza kudala laziwa ngezinzuzo zalo eziningi zezempilo, futhi okukhishwe kwalo sekudume kakhulu eminyakeni yamuva. Izinhlanganisela eziyinhloko ezisebenzayo ezibizwa ngokuthi ama-catechin zinemiphumela enamandla yokulwa nokuvuvukala. I-EGCG, i-catechin eningi kakhulu etiyeni eliluhlaza, icindezela ukuvuvukala futhi inciphisa ukucindezeleka okwenziwe nge-oxidative emzimbeni. Ukukhishwa kwetiye elihlaza nakho kungasiza ekulawuleni isisindo, ukusekela ukusebenza kobuchopho, futhi kusize ukunciphisa ingozi yesifo esingamahlalakhona.
I-OEA iyi-molecule ye-lipid eyenzeka ngokwemvelo eyingxenye yomndeni we-N-acylethanolamine (NAE). Ihlanganiswa ezicutshini ezihlukahlukene emzimbeni wethu, ikakhulukazi ekuphenduleni ukuvuvukala nobuhlungu. Ucwaningo lubonisa ukuthi i-OEA ingavimbela ukukhiqizwa kwama-molecule abangela ukuvuvukala adlala indima ebalulekile ekuqaleni nokuqhubeka kokuvuvukala.
Kutholwe ukuthi i-OEA iguqula ukusebenza kwamangqamuzana omzimba omzimba, okuhlanganisa ama-macrophage nama-lymphocyte anesibopho sokuphendula ukuvuvukala. Ngokunciphisa ukusebenza nokufuduka kwala mangqamuzana omzimba omzimba ezindaweni zokuvuvukala, i-OEA ingasiza ekunciphiseni ukukhiqizwa kwabalamuli abavuvukalayo, ngaleyo ndlela kunciphise izimpawu ezihambisana nokuvuvukala okungapheli.
Ngaphezu kwalokho, i-OEA isebenzisa imiphumela elwa nokuvuvukala ngokuvula ama-receptors athile, njenge-peroxisome proliferator-activated receptor-α (PPAR-α) kanye neziteshi ze-vanilloid ezingaba khona zesikhashana ze-vanilloid 1 (TRPV1). Lawa ma-receptors aziwa ngokulawula ukuvuvukala nezindlela zobuhlungu emizimbeni yethu. Ngokuvula lawa ma-receptors, i-OEA ivimbela ukukhiqizwa kwama-molecule e-pro-inflammatory futhi ivimbele ukudluliswa kwezimpawu zobuhlungu, inikeze izinzuzo ezimbili zokuvuvukala okungapheli okuhambisana nobuhlungu.
Kuyathakazelisa ukuthi i-OEA iphinde yabonakala inezindawo zokulwa nokuvuvukala kwesisu (GI). Ukuvuvukala okungapheli kwepheshana lesisu kuyinkinga evamile engaholela ezimweni ezifana nesifo sofuba (IBD). Ucwaningo lubonisa ukuthi i-OEA inganciphisa ukuvuvukala kwamathumbu ngokulungisa umsebenzi wamangqamuzana omzimba futhi ikhuthaze ukulungiswa kwezicubu zesisu.
Ukwengeza, i-OEA itholwe inomphumela wokuvimbela ekusebenzeni kwe-nuclear factor κB (NF-κB), i-molecule eyisihluthulelo yokusayina ehilelekile ekulawuleni ukuvuvukala. I-NF-κB yaziwa ngokukhuthaza ukuvezwa kwezakhi zofuzo ezifaka amakhodi we-pro-inflammatory factor. Ngokuvimbela ukusebenza kwe-NF-κB, i-OEA inganciphisa ukukhiqizwa nokukhululwa kwalezi zici ezivuthayo, ngaleyo ndlela ivimbele ukuvuvukala okungapheli.
Q: Yiziphi izithasiselo ezilwa nokuvuvukala?
A: Izithako ezilwa nokuvuvukala ziyizinto zemvelo ezisiza ukwehlisa ukuvuvukala emzimbeni. Zingahlanganisa amavithamini ahlukahlukene, amaminerali, kanye nezinhlanganisela ezisekelwe ezitshalweni eziye zaboniswa ukuthi zinezakhiwo zokulwa nokuvuvukala.
Q: Asebenza kanjani ama-anti-inflammatory supplements?
A: Izithako ezilwa nokuvuvukala zisebenza ngokunciphisa ukukhiqizwa kwezinhlanganisela ezivuvukalayo emzimbeni futhi zikhuthaze ukukhiqizwa kwezinhlanganisela ezilwa nokuvuvukala. Lokhu kusiza ukunciphisa ukuvuvukala futhi kungase kunikeze ukukhululeka ezimeni ezihlobene nokuvuvukala okungapheli.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Dec-06-2023
