I-Oleoylethanolamide (OEA) umkhiqizi we-powder CAS No.: 111-58-0 98%,85% ubumsulwa min.okwengeza izithako
Amapharamitha womkhiqizo
| Igama lomkhiqizo | I-Oleoyl ethanolamide |
| Elinye igama | I-N-oleoyl ethanolamine; N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide |
| Inombolo ye-CAS. | 111-58-0 |
| Ifomula yamangqamuzana | I-C20H39NO2 |
| Isisindo samangqamuzana | 325.53 |
| Ubumsulwa | 98.0%, 85.0% |
| Ukubukeka | I-crystal powder emhlophe |
| Ukupakisha | 1kg/isikhwama, 25kg/isigubhu |
| Isicelo | Ukunciphisa ubuhlungu, anti-inflammatory |
Isingeniso somkhiqizo
I-Bioactive lipid amide OEA ihlanganiswa emgudwini wesisu futhi ihlobene nezindawo ezimbalwa ezihlukile eziqinile, ezihlanganisa umsebenzi wokulwa nokuvuvukala, ukuphendula kwamasosha omzimba, ukugqugquzela ukubola kwamafutha kanye ne-fatty acid oxidation.I-OEA itholakala ku-omega-9 monounsaturated fatty acid oleic acid.Kubhekwa njenge-cannabinoid engapheli njenge-lipid, futhi iyisamukeli esicushwe yi-peroxisome proliferators α (PPAR- α) Izinqubo zokusebenzisana nokulamula ezilwa nokuvuvukala.Ngaphezu kwalokho, i-fatty acid ethanolamide ingumxhumanisi we-lipid olawula inani elikhulu lemisebenzi yomzimba.I-Oleoyl ethanolamide (OEA), njenge-lipid medium esebenzayo yezinto eziphilayo, iyi-peroxisome proliferator eyenziwe yasebenza- α (PPAR- α) I-agonist ephumelelayo elawula ukubonakaliswa okwandisiwe kwe-fatty acid transferase CD36, ngaleyo ndlela ilawula ukuziphatha kokudla.Ngaphezu kwalokho, i-OEA iyi-endogenous fatty acid ethanolamine ekhiqizwa ku-mucosa yamathumbu.Isignali ye-OEA ye-anorexia ingase ibe isici esiyisisekelo sohlelo lwe-physiological and metabolic olulawula ukudliwa kwamafutha okudla kanye nokukhuluphala.Ukuthathwa kwe-oleic acid kanye ne-OEA ewumphumela enikeza izici ze-anorexia kuncike ku-CD36, i-PPAR- α, i-adipose sensory receptors yamathumbu, i-histamine, i-oxytocin, ne-dopamine;Ukubangela ukwanda kwe-oxidation yamafutha kanye nezindleko zamandla ukuze kubangele ukusutha nokwandisa ukubambezeleka kokudla;Futhi noma yikuphi ukuphazamiseka kulezi zinhlelo kuzomisa noma kucindezela umuzwa wokugcwala okubangelwa amafutha.
Isici
(1) I-Oleoyl ethanolamide (OEA) iyi-molecule ekhiqizwa emzimbeni futhi evame ukuba khona emathunjini.
(2) I-Oleoyl ethanolamide (OEA) iyi-molecule elawula i-lipid metabolism kanye ne-homeostasis yamandla.Ngakho-ke, i-OEA ingaba nemiphumela ezuzisayo ye-metabolic ezigulini ze-NAFLD.
(3) I-Bioactive lipid amide oleoyl ethanolamide (OEA) inezici ezimbalwa ezihlukile eziqinile, ezihlanganisa umsebenzi wokulwa nokuvuvukala, ukulawulwa kokusabela kwamasosha omzimba, kanye nemiphumela yokulwa ne-antioxidant,
Izinhlelo zokusebenza
I-Oleoyl ethanolamide iyi-lipid yemvelo ye-ethanolamide engasetshenziswa njengohlelo lokudla kanye nokulawula isisindo sezilwane ezinomgogodla ezihlukahlukene.Kuyi-metabolite ye-oleic acid eyakhiwe emathunjini amancane omuntu.Inamathela ku-PPAR Alpha receptor futhi isiza ukulawula izici ezine: indlala, amafutha omzimba, i-cholesterol, nesisindo somzimba.I-PPAR Alpha imele i-alpha yokwamukela ecushwe ama-peroxide proliferators.
