Ukwembula Okuthrendayo Kwakamuva Kwezengezo ze-Alpha GPC zango-2024

I-Choline Alfoscerate,eyaziwa nangokuthi i-Alpha-GPC, iyinto ekhishwe ku-lecithin yesitshalo, kodwa akuyona i-phospholipid, kodwa i-phospholipid etholakala ku-Lipophilic fatty acids. I-Alpha-GPC isakhi esisebenzayo esitholakala kuwo wonke amaseli ezincelisayo. Ngenxa yokuthi i-hydrophilic kakhulu, imuncwa ngokushesha ngemva kokuphathwa ngomlomo. I-GPC iyisandulela se-acetylcholine (ACh) futhi inesithembiso esihle ekungasebenzini kahle kwe-choline.

I-GPC yeqa kalula umgoqo wegazi nobuchopho futhi inikeza umthombo we-choline we-biosynthesis ye-ACh ne-phosphatidylcholine. I-Phospholipids ne-acetylcholine, lapho ifinyelelwa emazingeni afanele, ikhuthaza ingqondo, ingqondo kanye nempilo ye-cerebrovascular. Ngaphezu kwalokho, ukuhlushwa okulinganiselwe kwe-Alpha-GPC ne-Ach kungakhuthaza izinqubo zomzimba futhi kuthuthukise ukusebenza komzimba. I-ACh ibamba iqhaza ekufinyezweni kwemisipha futhi iyi-neurotransmitter eyinhloko elawula izimpendulo zomzimba zokuzivocavoca.

Njengoba konke ukunyakaza kwemisipha kuhlobene nokufinyela, futhi ukufinyela kuhlobene nokugxila kwe-ACh yeselula etholakalayo, ukukhulisa amazinga e-ACh kuthuthukisa ukusebenza kwemisipha. Uma kuqhathaniswa namanye ama-precursors e-choline avamile, i-Alpha-GPC ngokuphepha nangempumelelo yandisa amazinga e-choline egazini nasengqondweni. Ucwaningo oluningi luye lwaqinisekisa izinzuzo ezihlukahlukene ze-Alpha-GPC futhi lwaphakamisa ukuthi ukwesekwa ngomlomo kungase kudlale indima ebalulekile ekuthuthukiseni ukusebenza kwezinzwa, ukusebenza ngokomzimba, kanye nokuthuthukisa inkumbulo.

Ukusebenza kwe-Alpha-GPC

Thuthukisa amandla obuchopho

Lapho landa inani lamangqamuzana ezinzwa ebuchosheni, amandla awo aqina, athumela ngokushesha izimpawu zezinzwa, namandla okusebenza obuchopho aqina. I-Alpha-GPC ingathuthukisa ngokugcwele ukusebenza kobuchopho ngokuthuthukisa ubungqabavu bamaseli ezinzwa kanye nekhono lokudlulisela lamasignali ezinzwa. Mayelana nokuthuthukisa i-cholinergic neurotransmission, ukudluliselwa kwesignali phakathi kwamangqamuzana ezinzwa kuncike ekudluliseleni ama-neurotransmitters, futhi i-acetylcholine iyisithunywa esibalulekile samakhemikhali kanye ne-neurotransmitter eqinisekisa ukucabanga okusebenzayo futhi igcina ukusebenzisana phakathi kobuchopho nomzimba wonke. I-Alpha-GPC ingabola ibe yi-3-glycerol phosphate ne-choline ebuchosheni futhi iyisiphakeli esisebenza kahle kakhulu se-acetylcholine. Ingathuthukisa inkumbulo futhi ithuthukise ukucabanga ngokukhuthaza ukuhlanganiswa nokukhululwa kwe-acetylcholine ebuchosheni. Mayelana nokuthuthukisa ukuzinza noketshezi lwamangqamuzana olwelwesi lwamangqamuzana, i-Alpha-GPC ingakhuthaza ukuhlanganiswa kwe-phosphoinositide, ngaleyo ndlela ithuthukise ukuzinza noketshezi lwamangqamuzana eseli. Ama-Neurons anesakhiwo esiphelele angadlulisela kangcono ulwazi futhi athuthukise ukukhalipha kokucabanga komzimba. Sebenzisa.

Vikela izinzwa

Izici zokukhula zezicubu zezinzwa, okuyizici ze-neurotrophic, zingalawula ukuhlukaniswa kwe-stem cell futhi zikhuthaze ukwakheka kokuxhumana okusha kwe-neural. I-Alpha-GPC ingakhuthaza ukugcinwa kwezinto ezihlukahlukene ze-neurotrophic futhi ivule izindlela zokubonisa ezihlobene nokusinda kweseli, ngaleyo ndlela ibe nomphumela we-neuroprotective. Thuthukisa izinga lomqondo lomzimba. Ngesikhathi esifanayo, i-Alpha-GPC ingaphinde ikhuthaze ukugcinwa kwe-hormone yokukhula futhi igcine impilo yomzimba ngokwandisa amazinga e-hormone okukhula komzimba.

I-Antioxidant

I-oxidation nokuvuvukala yizimbangela eziyinhloko zokuguga nokufa kwamangqamuzana obuchopho. I-Alpha-GPC ingasusa ama-radicals mahhala emzimbeni, ilwe nokucindezeleka kwe-oxidative, futhi inganciphisa ukuvuvukala okufana ne-nuclear factor NF-κB, i-tumor necrosis factor TNF-α, ne-interleukin IL-6. Ukukhululwa kwezici kumelana nokuvuvukala kobuchopho, ngaleyo ndlela kubuyisela kakhulu ukwehla kokusebenza kwengqondo nokuvimbela ukuvela nokuthuthukiswa kwezifo ze-neurodegenerative. Imiphumela efanele iye yasekelwa imiphumela yomtholampilo.

Ocwaningweni oluthi "Umphumela we-Alpha-GPC Ekukhubazekeni Kwenkumbulo Ehlobene Neminyaka", izifundo ze-4 zanikezwa i-placebo, kanti ezinye izifundo ze-5 zanikezwa i-Alpha-GPC (1200 mg / ngosuku), ngemva kokuphathwa komlomo okuqhubekayo kwezinyanga ze-3, i-16 ama-electrode asetshenziselwa ukurekhoda amaza obuchopho imizuzu engu-5 ngenkathi izifundo ziphapheme futhi ziphumule. Imiphumela yabonisa ukuthi uma iqhathaniswa ne-placebo, i-Alpha-GPC ikwazile ukukhulisa kakhulu ingxenye yamaza obuchopho ashesha kakhulu, kuyilapho inomkhuba wokunciphisa amaza ahamba kancane. Okusho ukuthi, kungathuthukisa ubungqabavu bobuchopho babantu abaneminyaka ephakathi futhi kubambezele ukuguga komzimba.

Lawula imizwa

I-Dopamine ingenza abantu bazizwe bejabule, futhi i-serotonin ne-gamma-aminobutyric acid ingalawula isimo somzimba. I-Alpha-GPC ingakhuthaza ukukhululwa kwe-dopamine, ilawule ukuvezwa kwabathumeli be-dopamine, ithuthukise i-dopamine neurotransmission ebuchosheni, futhi ikhulise amazinga e-serotonin ku-striatum kanye ne-prefrontal cortex; kungase futhi kukhuthaze ngokuphawulekayo γ- Ukukhululwa kwe-aminobutyric acid kukhulula ukuqwasha, ngaleyo ndlela kusebenzisa imiphumela yayo elwa nokucindezeleka, edambisa ukukhathazeka neyokuzinza kwemizwelo.

Ukwengeza, i-Alpha-GPC ibonakala ikwazi ukuthuthukisa ukumuncwa kwe-iron non-heme ekudleni, okufana nomphumela we-vitamin C ngesilinganiso se-2: 1 ngensimbi, ngakho-ke i-Alpha-GPC ibhekwa njenge, noma okungenani ukufaka isandla, ekuthuthukisweni kwemikhiqizo yenyama. I-Phenomenon yokumuncwa kwensimbi okungeyona i-nonheme. Ukwengeza, ukugcwalisa nge-Alpha-GPC nakho kungasiza inqubo yokushiswa kwamafutha futhi kusekele i-lipid metabolism. Lokhu kungenxa yendima ye-choline njengesakhi se-lipophilic. Amazinga anempilo alesi sakhi somsoco aqinisekisa ukuthi ama-fatty acids ayatholakala ku-cell mitochondria, engaguqula lawa mafutha abe yi-ATP noma amandla.

Izibuyekezo zokulawula

I-Alpha GPC isineminyaka engaphezu kwengu-10 isetshenziswa. Njengamanje, i-Alpha GPC iwukudla okusha okuluhlaza eJapan futhi ivame ukusetshenziswa ekuthuthukisweni kokudla okusebenzayo. Ngaphezu kwalokho, i-United States, i-Canada, i-Switzerland namanye amazwe agunyaze ngokulandelana noma avumela i-Alpha GPC ukuthi yengezwe ekudleni ngemva kwe-Japan. E-United States, i-Alpha GPC ilawulwa Njengento Evame Ukubonwa Njengephephile (GRAS). E-Canada, i-Alpha GPC ivunyelwe njengomkhiqizo wezempilo wemvelo.

Izinhlelo zokusebenza zemakethe kanye nezitayela zemikhiqizo

Ngenxa yedatha enganele yokuphepha kwe-Alpha GPC ezinsaneni, kwabesifazane abakhulelwe, nakwabesifazane abancelisa, ngokusekelwe esimisweni sokuvimbela ubungozi, la maqembu angenhla akufanele ayidle, futhi ilebula nemiyalelo kufanele kubonise iqembu elingafaneleki. E-United States, Japan, Canada nakwamanye amazwe, i-Alpha GPC isetshenziswe kabanzi ekudleni. Imikhiqizo ehlobene ihlanganisa izithasiselo zokudla, iziphuzo, ama-gummies nezinye izigaba, futhi umkhiqizo ngamunye unomsebenzi ocacile nokusetshenziswa okunconyiwe.

Inani namaqembu anconyiwe. Isibonelo, e-United States, kunezithako zokudla ezingaphezu kuka-300 ze-Alpha GPC kuphela, ezinemiphumela efunwayo ehlanganisa ukuthuthukisa inkumbulo nokusebenza kwengqondo, ukuthuthukisa ukusebenza kwemoto, njll. Umthamo wansuku zonke ngu-300-1200 mg.
Isimo samanje sobuchwepheshe bokukhiqiza

Ucwaningo lubonisa ukuthi ukuhlanganiswa kwamakhemikhali kungenye yezindlela eziyinhloko zokukhiqiza ze-Alpha GPC. Ukusebenzisa i-polyphosphoric acid, i-choline chloride, i-R-3-chloro-1,2-propanediol, i-sodium hydroxide namanzi njengezinto zokusetshenziswa, ngemva kokusabela kwe-condensation kanye ne-esterification, i-decolorized, ukungcola kususiwe, kugxilwe, kucwengisiswe futhi omisiwe. ingatholwa ngezinye izinqubo. Kodwa-ke, ukuhlanganiswa kwamakhemikhali endabuko, i-hydrolysis yamakhemikhali, i-alcoholsis yamakhemikhali nezinye izindlela zonke zibhekana nezinkinga ezifana nokungcoliswa kwemvelo, izindleko eziphezulu, nezinqubo eziyinkimbinkimbi zokulungiselela.

Eminyakeni yamuva nje, ukulungiswa kwe-Alpha GPC ngezindlela ze-bioenzymatic sekuthole ukunakwa okwengeziwe. Izindlela ze-enzymatic ze-aqueous-phase, izindlela ze-enzymatic ze-non-aqueous-phase, njll. ziye zavela ngokulandelana. Uma kuqhathaniswa nezindlela zamakhemikhali, ukulungiswa kwe-Alpha GPC ngezindlela ze-bioenzymatic kunezimo zokusabela ezithambile kanye nezinqubo ezilula. , ukusebenza kahle okuphezulu kwe-catalytic futhi kulungele ukukhiqizwa kwezentengiselwano ezinkulu.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngempushana ye-Alpha GPC Supplement yekhwalithi ephezulu kanye nobumsulwa.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani angcono kakhulu. Impushana yethu ye-Alpha GPC Supplement ihlolelwa ngokuqinile ubumsulwa namandla, iqinisekisa ukuthi uthola isengezo sekhwalithi ephezulu ongasethemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yeselula, uthuthukise amasosha akho omzimba noma uthuthukise impilo yakho yonke, i-Alpha GPC Supplement powder yethu iyisinqumo esihle kakhulu.

Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, i-Suzhou Myland Pharm isungule uhide lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ihambisane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.

I-Alpha GPC yaziwa njenge-hygroscopic, okusho ukuthi imunca umswakama emoyeni ozungezile. Ngalesi sizathu, izithasiselo kufanele zigcinwe ezitsheni ezingangeni moya futhi akufanele zivezwe emoyeni isikhathi eside.

Imicabango yokugcina

I-Alpha GPC isetshenziselwa ukuletha i-choline ebuchosheni kuwo wonke umgoqo wegazi nobuchopho. Kuyisandulela se-acetylcholine, i-neurotransmitter ekhuthaza impilo yengqondo. Izithasiselo ze-Alpha GPC zingasetshenziswa ukuze kuzuze impilo yakho yokuqonda ngokuthuthukisa inkumbulo, ukufunda, nokugxilisa ingqondo. Ucwaningo luphinde lubonise ukuthi i-Alpha GPC isiza ukukhulisa amandla omzimba namandla emisipha.