Kwembulwa Amathrendi Akamuva Ezithasiselo ze-Alpha GPC zika-2024

I-Choline Alfoscerate,eyaziwa nangokuthi i-Alpha-GPC, iyisithako esikhishwe ku-lecithin yezitshalo, kodwa akuyona i-phospholipid, kodwa i-phospholipid etholakala ezintweni ze-Lipophilic fatty acid. I-Alpha-GPC iyisakhi esisebenza ngezindlela eziningi esitholakala kuwo wonke amaseli ezilwane ezincelisayo. Ngenxa yokuthi ithanda kakhulu amanzi, imuncwa ngokushesha ngemva kokuphathwa ngomlomo. I-GPC iyisandulela se-acetylcholine (ACh) futhi inesithembiso esikhulu ekusebenzeni kabi kwe-choline.

I-GPC idlula kalula isithiyo segazi nobuchopho futhi ihlinzeka ngomthombo we-choline wokwenziwa kwe-ACh kanye ne-phosphatidylcholine. Ama-Phospholipid kanye ne-acetylcholine, uma efinyelelwa emazingeni afanele, akhuthaza impilo yengqondo, yengqondo kanye ne-cerebrovascular. Ngaphezu kwalokho, ukuhlushwa okulinganiselayo kwe-Alpha-GPC kanye ne-Ach kungakhuthaza izinqubo zomzimba futhi kuthuthukise ukusebenza ngokomzimba. I-ACh ihlanganyela ekucindezelweni kwemisipha futhi iyi-neurotransmitter eyinhloko elawula izimpendulo zomzimba zokuzivocavoca.

Njengoba yonke imisipha ihambisana nokufinyela, kanti ukufinyela kuhlobene nokuhlushwa kwe-ACh yeselula okutholakalayo, ukwandisa amazinga e-ACh kuthuthukisa ukusebenza kwemisipha. Uma kuqhathaniswa nezinye izandulela ze-choline ezivamile, i-Alpha-GPC inyusa amazinga e-choline ngokuphepha nangendlela ephumelelayo egazini nasebuchosheni. Izifundo eziningi ziqinisekisile izinzuzo ezahlukahlukene ze-Alpha-GPC futhi zaphakamisa ukuthi ukwengeza ngomlomo kungadlala indima ebalulekile ekuthuthukiseni ukusebenza kwezinzwa, ukusebenza ngokomzimba, kanye nokuthuthukisa inkumbulo.

Ukusebenza kahle kwe-Alpha-GPC

Thuthukisa amandla obuchopho

Uma inani elikhulu lamaseli ezinzwa ebuchosheni, amandla awo aqina, adlulisela ngokushesha izimpawu zezinzwa, futhi amandla okucubungula ubuchopho aqina. I-Alpha-GPC ingathuthukisa ngokuphelele ukusebenza kobuchopho ngokuthuthukisa amandla amaseli ezinzwa kanye nekhono lokudlulisa izimpawu zezinzwa. Ngokuphathelene nokuthuthukisa ukudluliselwa kwe-cholinergic neurotransmission, ukudluliselwa kwesignali phakathi kwamaseli ezinzwa kuncike ekudluliselweni kwama-neurotransmitter, kanti i-acetylcholine iyisithunywa samakhemikhali esiyinhloko kanye ne-neurotransmitter eqinisekisa ukucabanga okusebenzayo futhi igcina ukuhambisana phakathi kobuchopho nomzimba wonke. I-Alpha-GPC ingahlukaniswa ibe yi-3-glycerol phosphate kanye ne-choline ebuchosheni futhi ingumhlinzeki osebenza kahle kakhulu we-acetylcholine. Ingathuthukisa inkumbulo futhi ithuthukise ukucabanga ngokukhuthaza ukwakheka nokukhululwa kwe-acetylcholine ebuchosheni. Ngokuphathelene nokuthuthukisa ukuzinza nokugeleza kwamaseli, i-Alpha-GPC ingakhuthaza ukwakheka kwe-phosphoinositide, ngaleyo ndlela ithuthukise ukuzinza nokugeleza kwamaseli. Ama-neurons anesakhiwo esiphelele angadlulisela kangcono ulwazi futhi athuthukise ukuqina kokucabanga komzimba. Sebenzisa.

Vikela izinzwa

Izici zokukhula kwezicubu zezinzwa, okungukuthi izici ze-neurotrophic, zingalawula ukuhlukaniswa kwamaseli e-stem futhi zikhuthaze ukwakheka kokuxhumana okusha kwe-neural. I-Alpha-GPC ingakhuthaza ukukhishwa kwezinhlobo ezahlukene ze-neurotrophic futhi isebenze izindlela zokubonisana ezihlobene nokusinda kwamaseli, ngaleyo ndlela ibe nomphumela wokuvikela imizwa. Thuthukisa izinga lokuqonda lomzimba. Ngesikhathi esifanayo, i-Alpha-GPC ingakhuthaza futhi ukukhishwa kwe-hormone yokukhula futhi ilondoloze impilo yomzimba ngokwandisa amazinga e-hormone yokukhula yomzimba.

I-Antioxidant

Ukubola kanye nokuvuvukala yizimbangela eziyinhloko zokuguga nokufa kwamangqamuzana obuchopho. I-Alpha-GPC ingasusa ama-free radical emzimbeni, ilwe nokucindezeleka kwe-oxidative, futhi inganciphisa nokuvuvukala okufana ne-nuclear factor NF-κB, i-tumor necrosis factor TNF-α, kanye ne-interleukin IL-6. Ukukhishwa kwezinto kuvimbela ukuvuvukala kobuchopho, ngaleyo ndlela kuguqula kakhulu ukwehla komsebenzi wokuqonda futhi kuvimbele ukwenzeka kanye nokuthuthukiswa kwezifo eziwohlokayo zemizwa. Imiphumela efanele isekelwe yimiphumela yezokwelapha.

Esifundweni esithi "Umphumela we-Alpha-GPC Ekukhubazekeni Kwenkumbulo Okuhlobene Nobudala", abantu abane banikezwa i-placebo, kanti abanye abantu abahlanu banikezwa i-Alpha-GPC (1200 mg/ngosuku), ngemva kokuphathwa ngomlomo njalo izinyanga ezi-3, kwasetshenziswa ama-electrode ayi-16 ukuqopha amaza obuchopho imizuzu emi-5 ngenkathi abantu bephapheme futhi bephumule. Imiphumela ibonise ukuthi uma kuqhathaniswa ne-placebo, i-Alpha-GPC ikwazile ukwandisa kakhulu isilinganiso samaza obuchopho ashesha kakhulu, kuyilapho inomkhuba wokunciphisa amaza ahamba kancane. Okusho ukuthi, ingathuthukisa amandla obuchopho babantu abaseminyakeni ephakathi futhi ibambezele ukuguga komzimba.

Lawula imizwa

I-Dopamine ingenza abantu bazizwe bejabule, kanti i-serotonin kanye ne-gamma-aminobutyric acid kungalawula isimo sengqondo somzimba. I-Alpha-GPC ingakhuthaza ukukhishwa kwe-dopamine, ithuthukise ukuvezwa kwezithuthi ze-dopamine, ithuthukise ukudluliselwa kwe-dopamine ebuchosheni, futhi inyuse amazinga e-serotonin ku-striatum kanye ne-prefrontal cortex; ingakhuthaza kakhulu i-γ- Ukukhishwa kwe-aminobutyric acid kunciphisa ukungakwazi ukulala, ngaleyo ndlela kusebenzise imiphumela yayo yokulwa nokudangala, ukuqeda ukukhathazeka kanye nokuzinzisa isimo sengqondo.

Ngaphezu kwalokho, i-Alpha-GPC ibonakala ikwazi nokuthuthukisa ukumuncwa kwe-non-heme iron ekudleni, okufana nomphumela we-vitamin C ngesilinganiso esingu-2:1 ne-iron, ngakho-ke i-Alpha-GPC ibhekwa njenge, noma okungenani inegalelo, ekuthuthukisweni kwemikhiqizo yenyama. Isici sokumuncwa kwe-non-heme iron. Ngaphezu kwalokho, ukwengeza nge-Alpha-GPC kungasiza futhi inqubo yokushisa amafutha futhi kusekele i-lipid metabolism. Lokhu kungenxa yendima ye-choline njengesakhi se-lipophilic. Amazinga anempilo alesi sakhi aqinisekisa ukuthi ama-fatty acid ayatholakala kumaseli e-mitochondria, angaguqula lawa mafutha abe yi-ATP noma amandla.

Izibuyekezo zomthetho

I-Alpha GPC ibilokhu isetshenziswa iminyaka engaphezu kwe-10. Njengamanje, i-Alpha GPC iyinto entsha yokudla eluhlaza eJapane futhi ivame ukusetshenziswa ekuthuthukiseni ukudla okusebenzayo. Ngaphezu kwalokho, i-United States, i-Canada, i-Switzerland kanye namanye amazwe avumile noma avumela i-Alpha GPC ukuthi ifakwe ekudleni ngemva kweJapane ngokulandelana. E-United States, i-Alpha GPC ilawulwa njengeSinto Esivame Ukuqashelwa Njengesiphephile (GRAS). E-Canada, i-Alpha GPC ivunyelwe njengomkhiqizo wezempilo wemvelo.

Izinhlelo zokusebenza zemakethe kanye nezitayela zomkhiqizo

Ngenxa yokuntuleka kwedatha eyanele ngokuphepha kwe-Alpha GPC ezinganeni, kwabesifazane abakhulelwe, nakwabesifazane abancelisayo, ngokusekelwe esimisweni sokuvimbela ingozi, amaqembu angenhla akufanele ayidle, futhi ilebula nemiyalelo kufanele ibonise iqembu elingafanele. E-United States, eJapane, eCanada nakwamanye amazwe, i-Alpha GPC isetshenziswe kabanzi ekudleni. Imikhiqizo ehlobene ihlanganisa izithako zokudla, iziphuzo, ama-gummies nezinye izigaba, futhi umkhiqizo ngamunye unomsebenzi ocacile kanye nokusetshenziswa okunconywayo.

Ubuningi namaqembu anconyiwe. Isibonelo, e-United States, kunezithasiselo zokudla ezingaphezu kuka-300 ze-Alpha GPC kuphela, nemiphumela eshiwoyo ehlanganisa ukuthuthukisa inkumbulo nokusebenza kwengqondo, ukuthuthukisa ukusebenza kwemisipha, njll. Umthamo wansuku zonke u-300-1200 mg.
Isimo samanje sobuchwepheshe bokukhiqiza

Ucwaningo lubonisa ukuthi ukwenziwa kwamakhemikhali kungenye yezindlela eziyinhloko zokukhiqiza ze-Alpha GPC. Ukusebenzisa i-polyphosphoric acid, i-choline chloride, i-R-3-chloro-1,2-propanediol, i-sodium hydroxide namanzi njengezinto zokusetshenziswa, ngemva kokusabela kokujiya kanye ne-esterification, kuyasuswa umbala, ukungcola kususwe, kugxilwe, kuhlungwe futhi komiswe. kungatholakala ngezinye izinqubo. Kodwa-ke, ukwenziwa kwamakhemikhali kwendabuko, i-hydrolysis yamakhemikhali, i-alcoholsis yamakhemikhali nezinye izindlela zonke zibhekene nezinkinga ezifana nokungcola kwemvelo, izindleko eziphezulu, kanye nezinqubo zokulungiselela eziyinkimbinkimbi.

Eminyakeni yamuva nje, ukulungiswa kwe-Alpha GPC ngezindlela ze-bioenzymatic kuye kwathola ukunakwa okwengeziwe. Izindlela ze-enzymatic ze-Aqueous-phase, izindlela ze-enzymatic ezingezona eze-aqueous-phase, njll. ziye zavela ngokulandelana. Uma kuqhathaniswa nezindlela zamakhemikhali, ukulungiswa kwe-Alpha GPC ngezindlela ze-bioenzymatic kunezimo zokusabela ezithambile kanye nezinqubo ezilula. , ukusebenza kahle okuphezulu kwe-catalytic futhi kufanelekile ekukhiqizweni okukhulu kwezentengiselwano.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe yi-FDA ohlinzeka ngempuphu ye-Alpha GPC Supplement esezingeni eliphezulu nehlanzekile.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani amahle kakhulu. Impuphu yethu ye-Alpha GPC Supplement ihlolwe ngokucophelela ukuhlanzeka kanye namandla, okuqinisekisa ukuthi uthola isithasiselo sekhwalithi ephezulu ongasithemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yamaseli, ukukhulisa amasosha omzimba wakho noma ukuthuthukisa impilo iyonke, impuphu yethu ye-Alpha GPC Supplement iyisinqumo esifanele.

Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukisiwe kakhulu, i-Suzhou Myland Pharm ithuthukise imikhiqizo ehlukahlukene encintisanayo futhi yaba yinkampani yezinsizakalo zesayensi yokuphila entsha, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.

I-Alpha GPC yaziwa ngokuba yi-hygroscopic, okusho ukuthi imunca umswakama ovela emoyeni ozungezile. Ngenxa yalesi sizathu, izithako kufanele zigcinwe ezitsheni ezingangeni moya futhi akufanele zivezwe emoyeni isikhathi eside.

Imicabango yokugcina

I-Alpha GPC isetshenziselwa ukuletha i-choline ebuchosheni ngaphesheya kwesithiyo segazi nobuchopho. Iyisandulela se-acetylcholine, i-neurotransmitter ekhuthaza impilo yobuchopho. Izithasiselo ze-Alpha GPC zingasetshenziswa ukuzuzisa impilo yakho yobuchopho ngokuthuthukisa inkumbulo, ukufunda, kanye nokugxila. Ucwaningo luphinde lubonise ukuthi i-Alpha GPC isiza ekwandiseni amandla omzimba kanye namandla emisipha.