I-Urolithin A iyi-metabolite yemvelo ekhiqizwa lapho umzimba ugaya izinhlanganisela ezithile zezithelo ezinjengamahalananda, ama-strawberries, nama-raspberries. Le metabolite iboniswe ukuthi inohlu lwezinzuzo zezempilo futhi iyinhlanganisela ethembisayo yokulwa nokuguga enamandla okuguqula indlela esibhekana ngayo nokuguga. Ikhono layo lokusekela ukusebenza kwe-mitochondrial, impilo yemisipha, nokusebenza kwengqondo kuyenza ibe isengezo esiphoqayo kulabo abafuna ukugcina ubusha nobungqabavu. Njengoba ucwaningo lwe-urolithin A luqhubeka nokuvela, kungenzeka lube yisisekelo sokungenelela okuzayo okulwa nokuguga. Qaphela le nhlanganisela enamandla—ingase ibe isihluthulelo sokuvula umthombo wobusha.
Urolithin A i-metabolite ekhiqizwa emathunjini ngemva kokudla ukudla okuthile, njengamahalananda, izithelo eziqukethe i-ellagitannin, namantongomane. Ucwaningo lubonisa ukuthi i-urolithin A inezici ezinamandla zokulwa nokuguga futhi ingase idlale indima ebalulekile ekukhuthazeni impilo yeselula nokuphila isikhathi eside.
I-Urolithin A yenza kusebenze inqubo ebizwa ngokuthi i-mitophagy. I-Mitophagy yindlela yemvelo yomzimba yokususa i-mitochondria eyonakele noma engasebenzi, izikhungo zamandla zamaseli. Njengoba sikhula, i-mitochondria yethu ayisebenzi kahle futhi iqongelela umonakalo, okuholela ekwehleni kokusebenza kwamaseli kanye nempilo iyonke. Ngokukhuthaza i-mitophagy, i-urolithin A isiza ukubuyisela futhi igcwalise izimboni zethu zamandla amaselula, okungenzeka kubambezele inqubo yokuguga.
Ngaphezu kokuthuthukisa impilo ye-mitochondrial, i-urolithin A nayo inezindawo zokulwa nokuvuvukala kanye ne-anti-inflammatory. Ukucindezeleka kwe-oxidative nokuvuvukala okungapheli yizici ezimbili ezibalulekile zokuguga kanye nezifo ezihlobene neminyaka. I-Urolithin A isiza ukulwa nalezi zinqubo, ivikela amangqamuzana ethu nezicubu ekugugeni nasekugugeni.
Ngaphezu kwalokho, i-urolithin A iye yaboniswa ukuthuthukisa ukusebenza kwemisipha futhi ikhuthaze impilo yemisipha, eba ebaluleke kakhulu njengoba sikhula. I-Sarcopenia, noma ukulahlekelwa kwemisipha okuhlobene neminyaka yobudala, kuyinkinga evamile kubantu abadala asebekhulile futhi ingaholela ebuthakathakeni nokuncipha kwekhwalithi yokuphila jikelele. Ngokusekela ukusebenza kwemisipha, i-urolithin A ingasiza ukugcina amandla nokuhamba njengoba sikhula.
Okokuqala, ake sihlolisise ukuthi iyini i-urolithin nokuthi isebenza kanjani emzimbeni. Ama-Urolithin ama-metabolites akhiqizwa lapho amagciwane amathumbu ephula ama-ellagitannins, atholakala ezithelweni ezinjengamahalananda namajikijolo. Le nqubo ibalulekile ngoba i-urolithin ayikwazi ukutholwa ngokuqondile ngokudla lezi zithelo. Uma sekukhiqizwe, ama-urolithin kucatshangwa ukuthi anezinzuzo ezihlukahlukene zezempilo, okuhlanganisa ukuthuthukisa umsebenzi we-mitochondrial (okubalulekile ekukhiqizeni amandla eselula) nokukhuthaza impilo yemisipha nokuphila isikhathi eside.
Ucwaningo olushicilelwe kumagazini i-Nature Metabolism lwathola ukuthi i-urolithin A, enye yezinhlobo ezifundwe kakhulu ze-urolithin, ithuthukise ukusebenza kwemisipha nokukhuthazela kumagundane asebekhulile. Lokhu kutholakala kuyathembisa ngoba kuphakamisa ukuthi i-urolithin ingase ibe nezinzuzo ezingaba khona ekwehleni kwemisipha okuhambisana nokuguga.
Ngaphezu kwezinzuzo ezingaba khona zempilo yemisipha, i-urolithin nayo iye yafundelwa izakhiwo zayo zokulwa nokuguga. Olunye ucwaningo olwanyatheliswa kumagazini i-Nature Medicine ngo-2016 lwabonisa ukuthi i-urolithin A ingavuselela i-mitochondria kumaseli asebekhulile, ngaleyo ndlela ithuthukise ukusebenza kwamangqamuzana futhi ibambezele inqubo yokuguga.
Enye yezinhlobo ezivame kakhulu ze-urolithin A injengesengezo sokudla. Lezi zithako zivame ukutholakala ku-pomegranate extract noma i-ellagic acid futhi zithathwa ngendlela ye-capsule. Kodwa-ke, i-bioavailability ye-urolithin A efomini le-supplement ingase ihluke, futhi ezinye izifundo ziphakamisa ukuthi ingase ingasebenzi kahle kunezinye izinhlobo.
Olunye uhlobo lwe-urolithin A luyisithako esisebenzayo sokudla. Ezinye izinkampani seziqalile ukwengeza i-urolithin A emikhiqizweni ehlukahlukene yokudla neziphuzo, njengamabha amaprotheni, iziphuzo nezimpushana. Le mikhiqizo ihlinzeka ngendlela elula nemnandi yokusebenzisa i-urolithin A.
Enye yezindlela ezithembisayo kakhulu ze-urolithin A njengesengezo sezinga lemithi. Le mikhiqizo ihlolwa ngokuqinile futhi ilawulwe ikhwalithi ukuze kuqinisekiswe ubumsulwa namandla. I-urolithin A yezinga lezemithi inikeza i-bioavailability ephezulu kakhulu nokusebenza ngempumelelo, okuyenza ibe yifomu elingcono kakhulu lokuthola izinzuzo zezempilo ezingaba khona zalesi sithako.
Ngaphezu kwalawa mafomu, ucwaningo lusaqhubeka futhi ekuthuthukisweni kwama-analogue e-urolithin A, okuyizinhlanganisela zokwenziwa eziklanyelwe ukulingisa imiphumela ye-urolithin A yemvelo. Lezi zifaniso zingase zinikeze izinzuzo eziyingqayizivele ngokuya nge-bioavailability, ukuzinza, namandla.
1. Izakhiwo zokulwa nokuguga
I-Mitochondria yimithombo yamandla yamaseli ethu, anesibopho sokukhiqiza amandla nokulawula izinqubo zamaselula. Njengoba sikhula, i-mitochondria yethu iyancipha ukusebenza kahle, okwenza umsebenzi weselula uwoke wehle. I-Urolithin A ikhonjiswe ukuthi ivuselela i-mitochondria yokuguga, ngaleyo ndlela ithuthukise ukukhiqizwa kwamandla kanye nempilo yonke yamaselula. Ngaphezu kwezinzuzo zayo ku-mitochondria, i-urolithin A itholakale yenza kusebenze inqubo ebizwa ngokuthi i-autophagy. I-Autophagy iyindlela engokwemvelo yomzimba yokususa amangqamuzana alimele noma angasebenzi, ngaleyo ndlela ikhuthaze ukuvuselelwa kwamaseli kanye nempilo iyonke. Ngokuthuthukisa i-autophagy, i-Urolithin A isiza ukususa amangqamuzana amadala, agugile emzimbeni futhi esikhundleni sawo ngamaseli amasha, anempilo, ngaleyo ndlela ithuthukise ukusebenza kwezicubu kanye namandla ayo wonke.
2. Izakhiwo zokulwa nokuvuvukala
Ukuvuvukala okungapheli nokucindezeleka okwenziwe nge-oxidative yizimbangela eziyinhloko zenqubo yokuguga, okuholela ochungechungeni lwezifo ezihlobene nobudala. Ngokunciphisa ukuvuvukala nokucindezeleka okwenziwe nge-oxidative, i-urolithin A ingase ivimbele ukukhiqizwa kwama-molecule avuthayo futhi isize ukuvimbela lezi zifo ezihlobene nobudala. isifo, futhi ikhuthaza impilo yonke nokuphila isikhathi eside.
3. Impilo yemisipha
I-Urolithin A nayo itholakale ikhuthaza impilo yemisipha nokusebenza. Njengoba sikhula, isisindo semisipha namandla ethu ayancipha ngokwemvelo. Kodwa-ke, i-urolithin A ingathuthukisa ukuguquguquka kwamangqamuzana emisipha futhi ithuthukise ukusebenza kwemisipha, engasiza ukuwohloka kwemisipha okuhlobene nokukhula kancane.
4. Impilo Yamathumbu
Ucwaningo olusha luphakamisa ukuthi i-urolithin A ingase ibambe iqhaza ekukhuthazeni impilo yamathumbu. Kutholakale ukuthi kunemiphumela ye-prebiotic, okusho ukuthi isekela ukukhula kwamagciwane amahle emathunjini. I-gut microbiome enempilo ibalulekile empilweni yonke, njengoba ingaba nomthelela kuyo yonke into kusukela ekugayweni kokudla kuya ekusebenzeni komzimba.
5. Impilo yengqondo
Kukhona nobufakazi bokuthi i-urolithin A ingase ibe nomthelela omuhle empilweni yengqondo. Ucwaningo lukhombisa ukuthi lungasiza ukuvikela izifo ze-neurodeergenerative njenge-Alzheimer's ngokunciphisa ukunqwabelana kwamaprotheni ayingozi ebuchosheni. Lokhu kuphakamisa izinzuzo ezingaba khona zempilo yobuchopho nokusebenza kwengqondo.
Ngezinhlamvu zawo ezibomvu ze-ruby kanye ne-tart flavour, amahalananda aziswa ngezinzuzo zawo eziningi zezempilo. Kusukela kokuqukethwe kwaso kwe-antioxidant ephezulu kuya ezicini ezingaba khona zokulwa nokuvuvukala, lesi sithelo sekuyisikhathi eside sithathwa njengesinamandla emhlabeni wokudla okunomsoco. Enye yezinhlanganisela ezithakazelisa kakhulu ezitholakala kumapomegranati i-urolithin, i-metabolite ebilokhu iyisihloko sezifundo eziningi ngemiphumela yayo engaba khona yokuthuthukisa impilo.
Ukuze uqonde impendulo yalo mbuzo, kubalulekile ukujula kwisayensi ngemuva kwe-urolithin nokuthi akhiwa kanjani. Uma sidla ukudla okunothe ngama-ellagitannins, njengamahalananda, lezi zinhlanganisela zihlukaniswa zibe urolithin nge-gut microbiota yethu. Kodwa-ke, akuwona wonke umuntu onokwakheka okufanayo kwe-gut microbiota, okuholela ekuhlukeni kokukhiqizwa kwe-urolithin phakathi kwabantu.
Nakuba amapomegranati angumthombo ocebile we-ellagitannins, inani le-urolithin elakhiwe emzimbeni lingahluka. Lokhu kuhlukahluka kuholele ekuthuthukisweni kwezithako ze-urolithin ezitholakala ku-pomegranate extract, okuqinisekisa ukutholakala okuqhubekayo kwale metabolite enenzuzo. Lezi zithako zithola ukunakwa kwamandla azo okusekela impilo yemisipha, ukuthuthukisa ukusebenza kwe-mitochondrial, nokuthuthukisa impilo yonke.
Ukuvela kwezithako ze-urolithin kuye kwavusa isithakazelo emandleni azo okusebenzisa izinzuzo zezempilo zamahalananda ngaphandle kokuthembela ekwehlukeni komuntu ngamunye ekukhiqizeni i-urolithin. Kulabo abangase bangawadli amahalananda njalo noma abangazuzi ngokugcwele kokuqukethwe kwawo kwe-urolithin ngenxa yokwakheka kwe-gut microbiota yabo.
Umbuzo wokuthi i-pomegranate ekhishwe iqukethe i-urolithin ingaphendulwa ngokuvumayo. Nakuba i-urolithin iwumkhiqizo wemvelo wokusebenzisa amapomegranati, ukuhlukahluka ekukhiqizeni kwawo emzimbeni kubangele ukuthuthukiswa kwezithako ze-urolithin ukuze kuqinisekiswe ukudliwa okuqhubekayo kwale metabolite enenzuzo.
Njengoba ucwaningo luqhubeka nokuveza imiphumela ekhuthaza impilo ye-urolithin, ukusebenzisa i-pomegranate ekhishwe njengomthombo wale nhlanganisela kunamandla amakhulu. Kungakhathaliseki ukuthi ngokudla amapomegranati ngokwawo noma ngokusebenzisa izithasiselo ze-urolithin, ukusebenzisa amandla e-urolithin kuyindlela ethembisayo yokweseka impilo yonke kanye nokuphila kahle.
Lapho ukhetha isengezo se-urolithin A, kunezici ezimbalwa ezibalulekile okufanele uzicabangele. Okokuqala nokubalulekile, kubalulekile ukuthola umkhiqizi ohloniphekile osebenzisa izithako zekhwalithi ephezulu futhi olandela izindinganiso eziqinile zokulawula ikhwalithi. Bheka izithasiselo ezihlolelwe ubumsulwa namandla ukuze uqinisekise ukuthi uthola umkhiqizo ophephile futhi osebenzayo.
Ukwengeza, cabangela uhlobo lwe-urolithin A olusetshenziswa ekwengezeni. I-Urolithin A ivame ukuhlanganiswa nezinye izinhlanganisela, njenge-urolithin B noma i-ellagic acid, engase ithuthukise imiphumela yayo. Bheka izithasiselo ezisebenzisa uhlobo olutholakala nge-bioavailable lwe-urolithin A ukukhulisa ukumuncwa nokusebenza kwayo emzimbeni.
Okokugcina, cabangela izidingo zakho zezempilo kanye nemigomo yakho ethile yokuthatha izithasiselo ze-urolithin A. Isibonelo, uma ungumdlali ofuna ukuthuthukisa ukusebenza kwemisipha, ungase ukhethe isengezo esakhelwe ngokukhethekile impilo yemisipha nokululama.
I-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lesengezo sokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, inkampani iphinde ibe ngumkhiqizi obhalisiwe we-FDA, oqinisekisa impilo yabantu ngekhwalithi ezinzile nokukhula okuqhubekayo. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye namathuluzi okuhlaziya kungokwesimanje futhi anemisebenzi eminingi, futhi ayakwazi ukukhiqiza amakhemikhali esikalini se-milligram kuya kuthani ngokuhambisana namazinga e-ISO 9001 kanye nezinqubo zokukhiqiza ze-GMP.
Umbuzo: Iyini i-ketone ester futhi isebenza kanjani?
A: I-Ketone ester iyisengezo esinikeza umzimba ngama-ketones, akhiqizwa ngokwemvelo yisibindi ngesikhathi sokuzila ukudla noma ukudla okuphansi kwe-carbohydrate. Lapho idliwe, i-ketone ester ingakhuphula ngokushesha amazinga e-ketone egazini, inikeze umzimba omunye umthombo wamafutha ku-glucose.
Q: Ngingayifaka kanjani i-ketone ester esimisweni sami sansuku zonke?
A: I-Ketone ester ingafakwa esimisweni sakho sansuku zonke ngokuyithatha ekuseni njengesengezo sangaphambi kokuzivocavoca, ukuyisebenzisela ukuthuthukisa ukusebenza kwengqondo nokugxila ngesikhathi somsebenzi noma izikhathi zokufunda, noma ukuyidla njengosizo lokubuyisela ngemva kokuzivocavoca. Ingasetshenziswa futhi njengethuluzi lokushintshela ekudleni kwe-ketogenic noma ukuzila ukudla okuphakathi.
Q: Ingabe ikhona imiphumela emibi noma izinyathelo okufanele uzicabangele lapho usebenzisa i-ketone ester?
A: Nakuba i-ketone ester ngokuvamile ibhekwa njengephephile kubantu abaningi, abanye abantu bangase babhekane nokungakhululeki okuncane kwesisu lapho beqala ukuyisebenzisa. Kubalulekile futhi ukubonisana nochwepheshe bezempilo ngaphambi kokufaka i-ketone ester esimisweni sakho, ikakhulukazi uma unezimo zempilo ezicashile noma uthatha imithi.
Q: Ngingayandisa kanjani imiphumela yokusebenzisa i-ketone ester?
A: Ukwandisa imiphumela yokusebenzisa i-ketone ester, kubalulekile ukubhanqa ukusetshenziswa kwayo nendlela yokuphila enempilo ehlanganisa ukuvivinya umzimba okuvamile, ukufakwa kwamanzi okwanele, nokudla okulinganiselayo. Ukwengeza, ukunaka isikhathi sokusetshenziswa kwe-ketone ester ngokuhlobene nemisebenzi yakho nemigomo kungasiza ukwandisa imiphumela yayo.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Jan-15-2024
