I-Urolithin A iyi-metabolite yemvelo ekhiqizwa lapho umzimba ugaya amakhemikhali athile ezithelweni ezifana namapomegranate, ama-strawberry, nama-raspberry. Le metabolite iboniswe inezinzuzo eziningi zezempilo futhi iyinhlanganisela ethembisayo yokulwa nokuguga enamandla okuguqula indlela esibhekana ngayo nokuguga. Amandla ayo okusekela ukusebenza kwe-mitochondrial, impilo yemisipha, kanye nokusebenza kwengqondo kwenza kube yisengezo esithakazelisayo kulabo abafuna ukugcina ubusha kanye namandla. Njengoba ucwaningo nge-urolithin A luqhubeka nokukhula, cishe luzoba yitshe lesisekelo lezindlela zokulwa nokuguga zesikhathi esizayo. Hlala uqaphile le nhlanganisela enamandla—ingaba yisihluthulelo sokuvula umthombo wobusha.
I-Urolithin A iyi-metabolite ekhiqizwa emathunjini ngemva kokudla ukudla okuthile, njenge-pomegranate, izithelo eziqukethe i-ellagitannin, kanye namantongomane. Ucwaningo lubonisa ukuthi i-urolithin A inezakhiwo ezinamandla zokulwa nokuguga futhi ingadlala indima ebalulekile ekukhuthazeni impilo yamaseli kanye nokuphila isikhathi eside.
I-Urolithin A ivuselela inqubo ebizwa ngokuthi i-mitophagy. I-Mitophagy iyindlela yemvelo yomzimba yokususa i-mitochondria eyonakele noma engasebenzi kahle, izindawo zamandla zamaseli. Njengoba siguga, i-mitochondria yethu ayisebenzi kahle futhi iqoqa umonakalo, okuholela ekusebenzeni kweseli okunciphile kanye nempilo iyonke. Ngokukhuthaza i-mitophagy, i-urolithin A isiza ekubuyiseleni nasekugcwaliseni amafektri ethu amandla amaseli, okungenzeka ukuthi inciphise inqubo yokuguga.
Ngaphezu kokukhuthaza impilo ye-mitochondrial, i-urolithin A futhi inezakhiwo zokulwa ne-antioxidant kanye nokulwa nokuvuvukala. Ukucindezeleka kwe-oxidative kanye nokuvuvukala okungapheli kuyizinto ezimbili ezibalulekile ezibangela ukuguga kanye nezifo ezihlobene nokuguga. I-Urolithin A iyasiza ekulweni nalezi zinqubo, ivikela amangqamuzana ethu nezicubu ekugugeni nasekudabukeni kokuguga.
Ngaphezu kwalokho, i-urolithin A iboniswe ukuthi ithuthukisa ukusebenza kwemisipha futhi ikhuthaze impilo yemisipha, okuba yinto ebaluleke kakhulu njengoba siguga. I-Sarcopenia, noma ukulahlekelwa kwemisipha okuhlobene nokuguga, kuyinkinga evamile kubantu abadala futhi ingaholela ebuthakathakeni kanye nokwehla kwekhwalithi yokuphila iyonke. Ngokusekela ukusebenza kwemisipha, i-urolithin A ingasiza ekugcineni amandla nokuhamba njengoba siguga.
Okokuqala, ake sibheke kabanzi ukuthi iyini i-urolithin nokuthi isebenza kanjani emzimbeni. Ama-Urolithin angama-metabolites akhiqizwa lapho amagciwane amathumbu ephula ama-ellagitannins, atholakala ezithelweni ezifana namapomegranati namajikijolo. Le nqubo ibalulekile ngoba i-urolithin ayikwazi ukutholakala ngqo ngokudla lezi zithelo. Uma sezikhiqizwe, ama-urolithin kucatshangwa ukuthi anezinzuzo eziningi zezempilo, okuhlanganisa ukuthuthukisa ukusebenza kwe-mitochondrial (okubalulekile ekukhiqizweni kwamandla eseli) kanye nokukhuthaza impilo yemisipha nokuphila isikhathi eside.
Ucwaningo olushicilelwe kumagazini i-Nature Metabolism luthole ukuthi i-urolithin A, enye yezinhlobo ze-urolithin ezifundwe kakhulu, ithuthukisa ukusebenza kwemisipha kanye nokukhuthazela emagundwini asebekhulile. Lokhu okutholakele kuyathembisa ngoba kusikisela ukuthi ama-urolithin angaba nezinzuzo ezingaba khona ekuwohlokeni kwemisipha okuhlobene nokuguga.
Ngaphezu kwezinzuzo ezingaba khona empilweni yemisipha, i-urolithin nayo ifundwe ngezakhiwo zayo zokulwa nokuguga. Olunye ucwaningo olwanyatheliswa kuyi-Nature Medicine ngo-2016 lubonise ukuthi i-urolithin A ingavuselela i-mitochondria kumaseli agugayo, ngaleyo ndlela ithuthukise ukusebenza kwamaseli futhi inciphise inqubo yokuguga.
Enye yezinhlobo ezivame kakhulu ze-urolithin A iwukuba yisithasiselo sokudla. Lezi zithasiselo zivame ukutholakala ku-pomegranate extract noma i-ellagic acid futhi zithathwa ngesimo se-capsule. Kodwa-ke, ukutholakala kwe-urolithin A ngendlela yesithasiselo kungahluka, futhi ezinye izifundo ziphakamisa ukuthi ingase ingasebenzi kahle kunezinye izinhlobo.
Olunye uhlobo lwe-urolithin A luyisithako sokudla esisebenzayo. Ezinye izinkampani seziqalile ukwengeza i-urolithin A emikhiqizweni eyahlukahlukene yokudla neziphuzo, njenge-protein bar, iziphuzo kanye nophuphu. Le mikhiqizo inikeza indlela elula nemnandi yokusebenzisa i-urolithin A.
Enye yezinhlobo ezithembisayo kakhulu ze-urolithin A iwukuba yisengezo sezinga lemithi. Le mikhiqizo ihlolwa ngokuqinile futhi ilawulwa ikhwalithi ukuqinisekisa ubumsulwa kanye namandla. I-urolithin A yezinga lemithi inikeza ukutholakala okuphezulu kakhulu kwe-bioavailability kanye nokusebenza kahle, okwenza kube yindlela engcono kakhulu yokuthola izinzuzo zezempilo ezingaba khona zale nhlanganisela.
Ngaphezu kwalezi zinhlobo, ucwaningo luyaqhubeka nokuthuthukiswa kwama-analogue e-urolithin A, okuyizinto zokwenziwa ezenzelwe ukulingisa imiphumela ye-urolithin A yemvelo. Lezi analogue zingase zinikeze izinzuzo eziyingqayizivele ngokuya ngokutholakala kwezinto eziphilayo, ukuzinza, kanye namandla.
1. Izakhiwo zokulwa nokuguga
Ama-Mitochondria ayizikhumulo zamandla zamaseli ethu, anesibopho sokukhiqiza amandla nokulawula izinqubo zamaseli. Njengoba siguga, i-mitochondria yethu ayisebenzi kahle, okubangela ukuthi ukusebenza kwamaseli wonke kwehle. I-Urolithin A iboniswe ukuthi ivuselela i-mitochondria yokuguga, ngaleyo ndlela ithuthukise ukukhiqizwa kwamandla kanye nempilo yamaseli iyonke. Ngaphezu kwezinzuzo zayo ku-mitochondria, i-urolithin A itholakale ukuthi isebenzisa inqubo ebizwa ngokuthi i-autophagy. I-Autophagy iyindlela yemvelo yomzimba yokususa amaseli alimele noma angasebenzi kahle, ngaleyo ndlela ikhuthaze ukuvuselelwa kwamaseli kanye nempilo iyonke. Ngokuthuthukisa i-autophagy, i-Urolithin A isiza ukususa amaseli amadala, agugile emzimbeni futhi iwashintshe ngamaseli amasha, anempilo, ngaleyo ndlela ithuthukise ukusebenza kwezicubu kanye namandla onke.
2. Izakhiwo zokulwa nokuvuvukala
Ukuvuvukala okungapheli kanye nokucindezeleka kwe-oxidative kuyizimbangela eziyinhloko zenqubo yokuguga, okuholela ochungechungeni lwezifo ezihlobene nokuguga. Ngokunciphisa ukuvuvukala kanye nokucindezeleka kwe-oxidative, i-urolithin A ingavimbela ukukhiqizwa kwama-molecule okuvuvukala futhi isize ekuvimbeleni lezi zifo ezihlobene nokuguga. futhi ikhuthaze impilo yonke kanye nokuphila isikhathi eside.
3. Impilo yemisipha
I-Urolithin A nayo itholakale ikhuthaza impilo nokusebenza kwemisipha. Njengoba siguga, ubukhulu bemisipha yethu namandla ayo kwehla ngokwemvelo. Kodwa-ke, i-urolithin A ingathuthukisa ukuguquka kwamaseli emisipha futhi ithuthukise ukusebenza kwemisipha, okungasiza ekunciphiseni ukuwohloka kwemisipha okuhlobene nokuguga.
4. Impilo Yamathumbu
Ucwaningo olusha lusikisela ukuthi i-urolithin A ingadlala indima ekukhuthazeni impilo yamathumbu. Kutholakale ukuthi inemiphumela ye-prebiotic, okusho ukuthi isekela ukukhula kwamagciwane amahle emathunjini. I-microbiome yamathumbu enempilo ibalulekile empilweni iyonke, njengoba ingathonya konke kusukela ekugayweni kokudla kuya ekusebenzeni komzimba.
5. Impilo yokuqonda
Kukhona nobufakazi bokuthi i-urolithin A ingaba nomthelela omuhle empilweni yobuchopho. Ucwaningo lubonisa ukuthi ingasiza ekuvimbeleni izifo eziwohlokayo zemizwa njenge-Alzheimer's ngokunciphisa ukunqwabelana kwamaprotheni ayingozi ebuchosheni. Lokhu kusikisela izinzuzo ezingaba khona empilweni yobuchopho kanye nokusebenza kobuchopho.
Ngembewu yayo ebomvu njenge-ruby kanye nokunambitheka kwayo okumnandi, amapomegranate ayaziswa ngezinzuzo zawo eziningi zezempilo. Kusukela kokuqukethwe kwawo okuphezulu kwe-antioxidant kuya kwezakhiwo zawo ezingaba khona zokulwa nokuvuvukala, lesi sithelo sesibhekwa njengesinamandla emhlabeni wezondlo. Enye yezinto ezithakazelisa kakhulu ezitholakala kumapomegranate yi-urolithin, i-metabolite ebilokhu ifundwa ngezifundo eziningi ngemiphumela yayo engaba khona yokukhuthaza impilo.
Ukuze siqonde impendulo yalo mbuzo, kubalulekile ukuhlolisisa ngokujulile isayensi ngemuva kwama-urolithin nokuthi akhiwa kanjani. Uma sidla ukudla okucebile ngama-ellagitannins, njengepomegranate, lawa ma-compound ahlukaniswa abe ama-urolithin yi-gut microbiota yethu. Kodwa-ke, akuwona wonke umuntu onesakhiwo esifanayo se-gut microbiota, okuholela ekwehlukeni kokukhiqizwa kwe-urolithin phakathi kwabantu ngabanye.
Nakuba amapomegranate angumthombo ocebile wama-ellagitannins, inani le-urolithin elakhiwe emzimbeni lingahluka. Lokhu kuhlukahluka kwaholela ekuthuthukisweni kwezithasiselo ze-urolithin ezithathwe ku-pomegranate extract, okuqinisekisa ukuthi le metabolite enenzuzo iyaqhubeka nokudla. Lezi zithasiselo zithola ukunakwa ngenxa yamandla azo okusekela impilo yemisipha, ukuthuthukisa ukusebenza kwe-mitochondrial, nokuthuthukisa impilo iyonke.
Ukuvela kwezithasiselo ze-urolithin kuye kwavusa isithakazelo emandleni azo okusebenzisa izinzuzo zezempilo zamapomegranati ngaphandle kokuthembela ekuhlukeni komuntu ngamunye ekukhiqizweni kwe-urolithin. Kulabo abangase bangadli amapomegranati njalo noma abangase bangazuzi ngokugcwele okuqukethwe kwawo kwe-urolithin ngenxa yokwakheka kwe-microbiota yawo esiswini.
Umbuzo wokuthi ngabe i-pomegranate extract iqukethe i-urolithins ungaphendulwa ngo-affirmative. Nakuba i-urolithin ingumkhiqizo wemvelo wokudla amapomegranate, ukuguquguquka kokukhiqizwa kwawo emzimbeni kwabangela ukuthuthukiswa kwezithasiselo ze-urolithin ukuqinisekisa ukuthi le metabolite enenzuzo iyaqhubeka nokudla.
Njengoba ucwaningo luqhubeka nokwembula imiphumela yokuthuthukisa impilo yama-urolithin, ukusebenzisa i-pomegranate extract njengomthombo walesi sakhi kunamandla amakhulu. Kungakhathaliseki ukuthi ngokusebenzisa amapomegranate ngokwawo noma ukusebenzisa izithasiselo ze-urolithin, ukusebenzisa amandla ama-urolithin kuyindlela ethembisayo yokusekela impilo yonke kanye nenhlalakahle.
Uma ukhetha isithasiselo se-urolithin A, kunezici eziningana ezibalulekile okufanele uzicabangele. Okokuqala nokubaluleke kakhulu, kubalulekile ukuthola umenzi odumile osebenzisa izithako ezisezingeni eliphezulu futhi olandela amazinga okulawula ikhwalithi aqinile. Funa izithasiselo ezihlolwe ngumuntu wesithathu ukuze zibonakale zihlanzekile futhi zinamandla ukuqinisekisa ukuthi uthola umkhiqizo ophephile futhi osebenzayo.
Ngaphezu kwalokho, cabanga ngohlobo lwe-urolithin A olusetshenziswa kulesi sithasiselo. I-Urolithin A ivame ukuhlanganiswa nezinye izinto ezisetshenziswayo, njenge-urolithin B noma i-ellagic acid, okungase kuthuthukise imiphumela yayo. Funa izithasiselo ezisebenzisa uhlobo olutholakala kalula lwe-urolithin A ukuze kwandiswe ukumuncwa kwayo nokusebenza kwayo emzimbeni.
Okokugcina, cabanga ngezidingo zakho zempilo kanye nemigomo yakho ethile yokusebenzisa izithasiselo ze-urolithin A. Isibonelo, uma ungumdlali ofuna ukuthuthukisa ukusebenza kwemisipha, ungakhetha isithasiselo esenzelwe ngqo impilo yemisipha nokululama.
I-Suzhou Myland Pharm & Nutrition Inc. ibilokhu ibandakanyeka ebhizinisini lezithako zokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokuthengisa okukhishwe kwembewu yamagilebhisi.
Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye nesu le-R&D elithuthukisiwe kakhulu, inkampani ithuthukise imikhiqizo ehlukahlukene yokuncintisana futhi yaba yinkampani yezinsizakalo ezintsha zesayensi yokuphila, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.
Ngaphezu kwalokho, le nkampani iphinde ibe ngumkhiqizi obhalisiwe yi-FDA, eqinisekisa impilo yabantu ngekhwalithi ezinzile kanye nokukhula okusimeme. Izinsiza ze-R&D zenkampani kanye nezindawo zokukhiqiza kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi ziyakwazi ukukhiqiza amakhemikhali esikalini esingu-milligram kuya ku-ton ngokuhambisana nezindinganiso ze-ISO 9001 kanye nemikhuba yokukhiqiza ye-GMP.
Q: Iyini i-ketone ester futhi isebenza kanjani?
A: I-ketone ester iyisengezo esinikeza umzimba ama-ketone, akhiqizwa ngokwemvelo yisibindi ngezikhathi zokuzila ukudla noma ukudla ama-carbohydrate aphansi. Uma igwinywa, i-ketone ester ingakhuphula amazinga e-ketone egazini ngokushesha, inikeze umzimba umthombo wamandla ohlukile esikhundleni se-glucose.
U: Ngingayifaka kanjani i-ketone ester ohlelweni lwami lwansuku zonke?
A: I-ketone ester ingafakwa ohlelweni lwakho lwansuku zonke ngokuyithatha ekuseni njengesengezo sangaphambi kokuzivocavoca, ukuyisebenzisela ukuthuthukisa ukusebenza kwengqondo nokugxila ngesikhathi somsebenzi noma sezifundo, noma ukuyisebenzisa njengosizo lokululama ngemva kokuzivocavoca. Ingasetshenziswa futhi njengethuluzi lokushintshela ekudleni kwe-ketogenic noma ukuzila ukudla ngezikhathi ezithile.
U: Ingabe kukhona imiphumela emibi noma izinyathelo zokuphepha okufanele uzicabangele lapho usebenzisa i-ketone ester?
A: Nakuba i-ketone ester ngokuvamile ibhekwa njengephephile kubantu abaningi, abanye abantu bangase babe nokungakhululeki okuncane kwesisu lapho beqala ukuyisebenzisa. Kubalulekile futhi ukubonisana nochwepheshe wezempilo ngaphambi kokufaka i-ketone ester ohlelweni lwakho, ikakhulukazi uma unezinkinga zempilo eziyisisekelo noma uthatha imithi.
U: Ngingayandisa kanjani imiphumela yokusebenzisa i-ketone ester?
A: Ukuze kukhuliswe imiphumela yokusebenzisa i-ketone ester, kubalulekile ukuhlanganisa ukusetshenziswa kwayo nendlela yokuphila enempilo ehlanganisa ukuzivocavoca njalo, ukuphuza amanzi anele, kanye nokudla okulinganiselayo. Ngaphezu kwalokho, ukunaka isikhathi sokusetshenziswa kwe-ketone ester maqondana nemisebenzi yakho kanye nemigomo kungasiza ekwenzeni ngcono imiphumela yayo.
Isixwayiso: Lesi sihloko senzelwe ulwazi olujwayelekile kuphela futhi akufanele sithathwe njenganoma yisiphi iseluleko sezokwelapha. Olunye ulwazi lweposi lebhulogi luvela kwi-inthanethi futhi alulona ochwepheshe. Le webhusayithi inesibopho sokuhlunga, ukufometha nokuhlela izihloko kuphela. Inhloso yokudlulisa ulwazi olwengeziwe akusho ukuthi uyavumelana nemibono yayo noma uqinisekisa ubuqiniso bokuqukethwe kwayo. Njalo xhumana nochwepheshe wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukwenza izinguquko ohlelweni lwakho lokunakekelwa kwempilo.
Isikhathi sokuthunyelwe: Jan-15-2024
