Yini okudingeka ukwazi ngepalmitoylethanolamide (PEA)?

I-Palmitoylethanolamide (PEA) iyi-amide ye-fatty acid eyenzeka ngokwemvelo eye yaheha ukunakwa ngezinzuzo zayo zezempilo ezingaba khona. Le nhlanganisela itholakala ezicutshini ezihlukahlukene emzimbeni wonke, futhi ucwaningo lusikisela ukuthi i-palmitamideethanol (PEA) ingadambisa ukuvuvukala, inciphise ubuhlungu, futhi ingase ikhuthaze impilo yamathumbu futhi ibambezele ukuguga. Ingase ibe nezinhlobonhlobo zezinzuzo zezempilo. Okuqukethwe okulandelayo kuzohlola izinzuzo zezempilo ze-palmitoylethanolamide (PEA), ukuthi isebenza kanjani emzimbeni womuntu, nokuthi ungayithola kanjani i-palmitoylethanolamide (PEA) yekhwalithi ephezulu.

Iyini i-palmitoylethanolamide (PEA)?

I-Palmitoylethanolamide (PEA) iyinhlanganisela eyenzeka ngokwemvelo efana ne-endocannabinoid eyaziwa ngezici zayo ezingapheli zokudambisa ubuhlungu kanye nezokulwa nokuvuvukala. Ngaphezu kokwenziwa ngumzimba, i-PEA itholakala ekudleni okuhlukahlukene okuhlanganisa: ushizi, izikhupha zamaqanda, inyama, ubisi, amantongomane, i-soy lecithin.

uthi bewazi? Lapho umzimba uhlangabezana nezinto ezicindezelayo, ezinjengokulimala noma ukuvuvukala, amazinga e-PEA ayalungisa ukuze kugcinwe i-homeostasis yeselula.

I-palmitoylethanolamide iwuthinta kanjani umzimba womuntu?

Ososayensi abakaqondi ngokugcwele indlela yokusebenza kwe-palmitoylethanolamide. Noma kunjalo, sihambe ibanga elide, sibonga uProfesa uRita Levi-Montalcini, owathi ku-1992-1996 wachaza indlela evamile yokusebenza kwe-palmitoylethanolamide. Kusukela ngaleso sikhathi, uye waqhubeka nokutadisha imiphumela ye-palmitoylethanolamide ebuhlungu be-neuropathic kanye ne-allergies.

I-Palmitoylethanolamide ingaletha izinzuzo ezinkulu zezempilo ezine kubantu:

●Yehlisa ukusabela kokuvuvukala.

●Yehlisa ukusebenza kwe-mast cell (ukungezwani komzimba nezinto).

●Qinisa umsebenzi wesistimu ye-hemp engapheli.

●Yenza ama-receptors athile asebenze emzimbeni.

I-PEA iyisebenzisa kanjani imiphumela yayo yokulwa nokuvuvukala kanye ne-analgesic?

Izinzuzo zezempilo ze-PEA zihlanganisa imiphumela kumaseli omzimba alawula ukuvuvukala, ikakhulukazi ebuchosheni. I-PEA ingasiza ekunciphiseni ukukhiqizwa kwezinto ezivuvukalayo. Kodwa-ke, i-PEA isebenza ngokuyinhloko kuma-receptors kumaseli, alawula izici ezihlukahlukene zokusebenza kwamaseli. Lawa ma-receptors abizwa ngokuthi ama-PPAR. I-PEA nezinye izinhlanganisela ezisiza ukwenza kusebenze i-PPAR zinganciphisa ubuhlungu futhi zingandisa futhi umzimba ngokushisa amafutha, i-serum triglycerides ephansi, ikhulise i-serum HDL cholesterol, ithuthukise ukulawula ushukela wegazi, futhi isize ukuncipha kwesisindo.

Palmitoylethanolamide Izinzuzo

Ngenxa yemiphumela ye-analgesic ne-anti-inflammatory, ucwaningo lubonisa ukuthi i-PEA ingasiza ngezimo ezihlukahlukene ezihlobene nobuhlungu, njenge-fibromyalgia, i-sciatica, ne-osteoarthritis.

1. Ukudambisa ubuhlungu kanye nempendulo yokuvuvukala

Ubuhlungu obungapheli buyinkinga engathi sína ehlupha iziguli emhlabeni wonke, futhi njengoba inani labantu likhula, le nkinga izobaluleka kakhulu. Omunye wemisebenzi ye-palmitoylethanolamide ukuthi ingasiza ukukhulula ubuhlungu nokuvuvukala. I-palmitoylethanolamide isebenzisana ne-CB1 kanye ne-CB2 receptors, okuyizingxenye ezibalulekile zesistimu ye-hemp engapheli. Lolu hlelo lunesibopho sokugcina i-homeostasis noma ibhalansi emzimbeni.

Lapho ukulimala noma impendulo yokuvuvukala kwenzeka, umzimba ukhulula izinhlanganisela ze-hemp ezingapheli ukusiza ukulawula impendulo yokuzivikela komzimba. I-palmitoylethanolamide ingasiza ekwandiseni amazinga e-hemp angapheli emzimbeni, ngaleyo ndlela ikhulule ubuhlungu nokuvuvukala.

Ukwengeza, i-palmitoylethanolamide inganciphisa ukukhululwa kwamakhemikhali avuthayo futhi inciphise izimpendulo zokuvuvukala kwezinzwa jikelele. Le miphumela yenza i-palmitoylethanolamide ibe yithuluzi elinamandla lokusiza ukulawula ubuhlungu nezimpendulo zokuvuvukala. Ucwaningo lubonisa ukuthi i-palmitoylethanolamide ingase futhi iphumelele ebuhlungu be-sciatica kanye ne-carpal tunnel syndrome.

2. I-Fibromyalgia

Ucwaningo oluningi lubonisa ukuthi i-PEA ingasiza ekunciphiseni izimpawu ze-fibromyalgia, isifo esingelapheki sezinzwa esibangela ubuhlungu obusakazekile. Uma isetshenziswa njengesengezo ekwelashweni kwendabuko, ukungeniswa kwe-PEA kunciphisa ukushuba kobuhlungu futhi kuthuthukisa ikhwalithi yokuphila ngokuhamba kwesikhathi. Ngokocwaningo oluthile, ukuthatha i-PEA izinyanga ezintathu kunciphisa kakhulu ubuhlungu kubantu abane-fibromyalgia.

3. Ubuhlungu beqolo

Ucwaningo lokuqala lukhomba ekusebenzeni okungaba khona kwe-PEA yobuhlungu beqolo. Ucwaningo lokubheka lwe-2017 lubonise ukuthi i-PEA iphinde yanciphisa ubuhlungu obukhulu ezigulini ezine-syndrome yokuhlinzwa emuva ehlulekile.

Abantu abahlukunyezwa yi-sciatica, ubuhlungu obusuka emhlane ophansi phansi kowodwa noma emilenzeni yomibili, bangase bathole ukukhululeka ngemva kokuthatha i-PEA. Uhlolo olungahleliwe, olungaboni kabili, olulawulwa yi-placebo lufunde imiphumela yedosi ephezulu nephansi ye-PEA ngokumelene ne-placebo. Ubuhlungu buncishiswe ngaphezu kwe-50% eqenjini le-high-dose. Nakuba i-PEA yedosi ephansi ayizange ifinyelele izinga elifanayo lokukhululeka kobuhlungu njengomthamo ophezulu, yomibili imithamo yayisebenza kakhulu kune-placebo.

4. I-Osteoarthritis

I-PEA ingase ibe yinzuzo kubantu abane-osteoarthritis, isifo esibonakala ngokuwohloka koqwanga oluhlangene nethambo. Ababambiqhaza ocwaningweni olulodwa abathole i-PEA bathole ukuthuthuka okubalulekile kumaphuzu we-Western Ontario kanye ne-McMaster Universities Osteoarthritis Index (WOMAC) uma kuqhathaniswa neqembu le-placebo. I-WOMAC iwuhlu lwemibuzo oluklanyelwe ukuhlola isimo nezimpawu (isb, ubuhlungu, ukuqina, ukusebenza komzimba) ezigulini ezine-osteoarthritis yamadolo ne-hip.

Olunye ucwaningo oluhilela iziguli ezinobuhlungu be-temporomandibular arthritic (TMJ) obuhambisana ne-osteoarthritis lubonise ukuthi ukuxhaswa kwe-PEA kwathuthukisa kakhulu ubuhlungu obunamandla ngemva kwezinsuku ezingu-14 uma kuqhathaniswa ne-ibuprofen. Iqembu elinikezwe i-PEA izinsuku ezingu-14 libonise ukuthuthuka okukhulu kakhulu ekuvulekeni komlomo okukhulu (isilinganiso sokukhulula ubuhlungu) kuneqembu le-ibuprofen.

5. Ubuhlungu be-Neuropathic

Ucwaningo lokuqala nokuhlolwa kwezilwane lusikisela ukuthi i-PEA ingasiza ngobuhlungu be-neuropathic (okubangelwa ukulimala kwemizwa ethwala imilayezo phakathi kobuchopho nomgogodla), ikakhulukazi kubantu abane-carpal tunnel syndrome, i-diabetesic neuropathy, i-chemotherapy Abantu abane-peripheral neuropathy, chronic. ubuhlungu be-pelvic, nobuhlungu obuhambisana nesifo sohlangothi kanye ne-multiple sclerosis. Ukuhlolwa okwengeziwe kwemitholampilo kuyadingeka ukuze kunqunywe ukusebenza kwe-PEA ekuxazululeni ubuhlungu be-neuropathic.

6. Ukuguga Okunempilo

Ukwephuza inqubo yokuguga kuwumgomo owusizo ophishekelwa ososayensi abaningi emhlabeni wonke. I-Palmitoylethanolamide ibhekwa njengesengezo sokulwa nokuguga esingasiza ukuvikela amangqamuzana emonakalweni we-oxidative, okuyimbangela enkulu yokuguga.

Uma amangqamuzana evezwa ekusebenzeni ngokweqile kwama-radical wamahhala, ukusabela kwe-oxidative kungenzeka, okuholela ekufeni kweseli ngaphambi kwesikhathi. Ukungena kokudla okungenampilo, ukubhema, nokunye ukuvezwa kwemvelo okunjengokungcola komoya nakho kwandisa umonakalo we-oxidative.I-Palmitoylethanolamide ingase ivimbele lo monakalo ngokususa ama-radicals mahhala futhi inciphise impendulo yokuvuvukala jikelele emzimbeni.

Ukwengeza, i-palmitoylethanolamide ethanol ikhonjiswe ukuthi ingase ikhuthaze ukukhiqizwa kwe-collagen namanye amaprotheni esikhumba abalulekile. Ngakho-ke, kungase kunciphise ukubukeka kwemibimbi nemigqa emihle, esebenza njengomvikeli ovela ngaphakathi kwamaseli.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngempushana ye-Palmitoylethanolamide (PEA) yekhwalithi ephezulu nephezulu.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani angcono kakhulu. I-Palmitoylethanolamide (PEA) yethu powder ihlolwe ngokuqinile ukuhlanzeka namandla, iqinisekisa ukuthi uthola isengezo sekhwalithi ephezulu ongayethemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yeselula, ukuqinisa amasosha akho omzimba, noma uthuthukise impilo yonke, i-Palmitoylethanolamide (PEA) powder yethu iyisinqumo esihle kakhulu.

Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, i-Suzhou Myland Pharm isungule uhide lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izindawo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kuma-milligrams kuye kumathani esikalini, futhi ithobelane namazinga e-ISO 9001 kanye nokucaciswa kokukhiqiza kwe-GMP.