Yini okudingeka uyazi nge-palmitoylethanolamide (PEA)?

I-Palmitoylethanolamide (PEA) iyi-amide ye-fatty acid eyenzeka ngokwemvelo eye yadonsela ukunaka ngezinzuzo zayo ezingaba khona kwezempilo. Le nhlanganisela itholakala ezicutshini ezahlukahlukene emzimbeni wonke, futhi ucwaningo luphakamisa ukuthi i-palmitamideethanol (PEA) inganciphisa ukuvuvukala, inciphise ubuhlungu, futhi ingakhuthaza impilo yamathumbu futhi ilibazise ukuguga. Ingase ibe nezinzuzo ezahlukene zezempilo. Okuqukethwe okulandelayo kuzohlola izinzuzo zezempilo ze-palmitoylethanolamide (PEA), ukuthi isebenza kanjani emzimbeni womuntu, nokuthi ungayithola kanjani i-palmitoylethanolamide (PEA) esezingeni eliphezulu.

Kuyini i-palmitoylethanolamide (PEA)?

I-Palmitoylethanolamide (i-PEA) iyinhlanganisela efana ne-endocannabinoid eyenzeka ngokwemvelo eyaziwa ngezakhiwo zayo ezingapheli zokunciphisa ubuhlungu kanye nokulwa nokuvuvukala. Ngaphezu kokwenziwa ngumzimba, i-PEA itholakala ekudleni okuhlukahlukene okuhlanganisa: ushizi, amaqanda oqanda, inyama, ubisi, amakinati, i-soy lecithin.

Ubuwazi? Lapho umzimba uhlangabezana nezinto ezibangela ukucindezeleka, njengokulimala noma ukuvuvukala, amazinga e-PEA ayajwayela ukugcina i-homeostasis yamaseli.

I-palmitoylethanolamide iwuthinta kanjani umzimba womuntu?

Ososayensi abakayiqondi ngokugcwele indlela esebenza ngayo i-palmitoylethanolamide. Noma kunjalo, sesihambe ibanga elide, sibonga uSolwazi uRita Levi-Montalcini, owachaza indlela esebenza ngayo i-palmitoylethanolamide ngo-1992-1996. Kusukela ngaleso sikhathi, uqhubeke nokufunda ngemiphumela ye-palmitoylethanolamide ebuhlungwini be-neuropathic kanye nokungezwani komzimba.

I-Palmitoylethanolamide ingaletha izinzuzo ezine ezinkulu zempilo kubantu:

● Yehlisa ukusabela kokuvuvukala.

●Nciphisa ukusebenza kweseli le-mast (ukungezwani komzimba).

●Qinisa umsebenzi wohlelo lwe-hemp oluvela emvelweni.

●Vuselela ama-receptor athile emzimbeni.

I-PEA isebenzisa kanjani imiphumela yayo yokulwa nokuvuvukala kanye neyokulwa nobuhlungu?

Izinzuzo zezempilo ze-PEA zifaka phakathi imiphumela kumaseli omzimba alawula ukuvuvukala, ikakhulukazi ebuchosheni. I-PEA ingasiza ekunciphiseni ukukhiqizwa kwezinto ezivuvukalayo. Kodwa-ke, i-PEA isebenza kakhulu kuma-receptor kumaseli, alawula izici ezahlukahlukene zomsebenzi wamaseli. Lawa ma-receptor abizwa ngokuthi ama-PPAR. I-PEA kanye nezinye izinto ezisiza ekusebenzeni kwe-PPAR zinganciphisa ubuhlungu futhi zingakhulisa nokusetshenziswa kwe-metabolism ngokushisa amafutha, ukwehlisa ama-triglycerides egazini, kwandise i-cholesterol ye-HDL egazini, kuthuthukise ukulawulwa koshukela egazini, futhi kusize ekunciphiseni isisindo.

Izinzuzo zePalmitoylethanolamide

Ngenxa yemiphumela yayo yokudambisa ubuhlungu kanye nokulwa nokuvuvukala, ucwaningo luphakamisa ukuthi i-PEA ingasiza ezimweni ezahlukahlukene ezihlobene nobuhlungu, njenge-fibromyalgia, i-sciatica, kanye ne-osteoarthritis.

1. Ukuqeda ubuhlungu kanye nokusabela kokuvuvukala

Ubuhlungu obungapheli buyinkinga enkulu ehlupha iziguli emhlabeni wonke, futhi njengoba inani labantu likhula, le nkinga izobe ibaluleke kakhulu. Omunye wemisebenzi ye-palmitoylethanolamide ukuthi ingasiza ekunciphiseni ubuhlungu nokuvuvukala. I-palmitoylethanolamide ixhumana nama-receptor e-CB1 kanye ne-CB2, okuyizinto ezibalulekile zesistimu ye-hemp yangaphakathi. Lolu hlelo lunesibopho sokugcina i-homeostasis noma ibhalansi emzimbeni.

Uma kwenzeka ukulimala noma ukusabela kokuvuvukala, umzimba ukhipha ama-compounds e-hemp angaphandle ukusiza ukulawula impendulo yokuzivikela komzimba. I-palmitoylethanolamide ingasiza ekwandiseni amazinga e-hemp angaphandle emzimbeni, ngaleyo ndlela inciphise ubuhlungu nokuvuvukala.

Ngaphezu kwalokho, i-palmitoylethanolamide inganciphisa ukukhishwa kwamakhemikhali okuvuvukala futhi inciphise izimpendulo zokuvuvukala kwezinzwa. Le miphumela yenza i-palmitoylethanolamide ibe ithuluzi elingasiza ekulawuleni ubuhlungu kanye nezimpendulo zokuvuvukala. Izifundo zibonisa ukuthi i-palmitoylethanolamide ingase isebenze kahle nasebuhlungu be-sciatica kanye ne-carpal tunnel syndrome.

2. I-Fibromyalgia

Izifundo eziningana zisikisela ukuthi i-PEA ingasiza ekunciphiseni izimpawu ze-fibromyalgia, isifo esingapheli sezinzwa esibangela ubuhlungu obusabalele. Uma isetshenziswa njengesithasiselo ekwelashweni kwendabuko, ukuphuza i-PEA kunciphisa ubuhlungu obukhulu futhi kuthuthukisa ikhwalithi yokuphila ngokuhamba kwesikhathi. Ngokusho kocwaningo olulodwa, ukuthatha i-PEA izinyanga ezintathu kunciphisa kakhulu ubuhlungu kubantu abane-fibromyalgia.

3. Ubuhlungu bomhlane

Ucwaningo lokuqala lukhomba ukusebenza kahle kwe-PEA ezinhlungwini zomhlane. Ucwaningo lokubuka lwango-2017 lubonise ukuthi i-PEA yehlisa kakhulu ubukhali bobuhlungu ezigulini ezine-syndrome yokuhlinzwa komhlane ehlulekile.

Abantu abahlushwa yi-sciatica, ubuhlungu obuqala emhlane ongezansi phansi komunye noma emilenzeni yomibili, bangathola impumuzo ngemuva kokuthatha i-PEA. Ukuhlolwa okungahleliwe, okungaboni kabili, okulawulwa yi-placebo kufunde imiphumela ye-PEA yomthamo ophezulu nophansi uma kuqhathaniswa ne-placebo. Ubuhlungu buncishiswe ngaphezu kuka-50% eqenjini lomthamo ophezulu. Nakuba i-PEA yomthamo ophansi ingazange ifinyelele izinga elifanayo lokunciphisa ubuhlungu njengomthamo ophezulu, womabili amanani ayesebenza kahle kakhulu kune-placebo.

4. I-Osteoarthritis

I-PEA ingaba wusizo kubantu abane-osteoarthritis, isifo esibonakala ngokuwohloka kwe-cartilage kanye namathambo amalunga. Abahlanganyeli ocwaningweni olulodwa abathole i-PEA bahlangabezane nokuthuthuka okukhulu eWestern Ontario naseMcMaster Universities Osteoarthritis Index (WOMAC) scores uma kuqhathaniswa neqembu le-placebo. I-WOMAC iyi-questionnaire eyenzelwe ukuhlola isimo kanye nezimpawu (isb., ubuhlungu, ukuqina, ukusebenza komzimba) ezigulini ezine-osteoarthritis yamadolo kanye neyesinqe.

Olunye ucwaningo oluhilela iziguli ezinobuhlungu be-temporomandibular arthritic (TMJ) obuhambisana ne-osteoarthritis lubonise ukuthi ukwengezwa kwe-PEA kuthuthukise kakhulu ubukhulu bobuhlungu ngemva kwezinsuku ezingu-14 uma kuqhathaniswa ne-ibuprofen. Iqembu elinikezwe i-PEA izinsuku ezingu-14 libonise ukuthuthuka okukhulu kakhulu ekuvulekeni komlomo okuphezulu (isilinganiso sokuqeda ubuhlungu) kuneqembu le-ibuprofen.

5. Ubuhlungu be-neuropathic

Izifundo zamacala okuqala kanye nokuhlolwa kwezilwane kusikisela ukuthi i-PEA ingasiza ngobuhlungu be-neuropathic (obubangelwa ukulimala kwemizwa ethwala imiyalezo phakathi kobuchopho nomgogodla), ikakhulukazi kubantu abane-carpal tunnel syndrome, i-diabetesic neuropathy, i-chemotherapy Abantu abane-peripheral neuropathy, ubuhlungu obungapheli be-pelvic, kanye nobuhlungu obuhambisana nesifo sohlangothi kanye ne-multiple sclerosis. Kudingeka ezinye izivivinyo zemitholampilo ukuze kutholakale ukusebenza kahle kwe-PEA ekuxazululeni ubuhlungu be-neuropathic.

6. Ukuguga Okunempilo

Ukuhlehlisa inqubo yokuguga kuwumgomo owusizo ophishekelwa ososayensi abaningi emhlabeni jikelele. I-Palmitoylethanolamide ibhekwa njengesithasiselo sokulwa nokuguga esingasiza ekuvikeleni amaseli ekulimaleni kwe-oxidative, okuyimbangela eyinhloko yokuguga.

Uma amangqamuzana evezwa umsebenzi omkhulu wama-free radical, ukusabela kwe-oxidative kungenzeka, okuholela ekufeni kwamangqamuzana ngaphambi kwesikhathi. Ukudla ukudla okungenampilo, ukubhema, nokunye ukuchayeka kwemvelo njengokungcola komoya nakho kwandisa umonakalo we-oxidative. I-Palmitoylethanolamide ingavimbela lo monakalo ngokususa ama-free radical nokunciphisa impendulo yokuvuvukala emzimbeni.

Ngaphezu kwalokho, i-palmitoylethanolamide ethanol iboniswe ukuthi ingakhuthaza ukukhiqizwa kwe-collagen namanye amaprotheni esikhumba abalulekile. Ngakho-ke, inganciphisa ukubonakala kwemibimbi kanye nemigqa emincane, isebenze njengesivikelo esivela ngaphakathi kwamaseli.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe yi-FDA ohlinzeka ngempuphu ye-Palmitoylethanolamide (PEA) esezingeni eliphezulu nehlanzekile.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani amahle kakhulu. Impuphu yethu yePalmitoylethanolamide (PEA) ihlolwe ngokucophelela ukuze ibonakale ihlanzekile futhi inamandla, okuqinisekisa ukuthi uthola isithasiselo sekhwalithi ephezulu ongasithemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yamaseli, ukukhulisa amasosha omzimba wakho, noma ukuthuthukisa impilo iyonke, impuphu yethu yePalmitoylethanolamide (PEA) iyisinqumo esifanele.

Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukisiwe kakhulu, i-Suzhou Myland Pharm ithuthukise imikhiqizo ehlukahlukene encintisanayo futhi yaba yinkampani yezinsizakalo zesayensi yokuphila entsha, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.