Iyini i-Choline Alfoscerate futhi Ingasiza Kanjani Ubuchopho Bakho?

Njengengxenye ye-endogenous emzimbeni womuntu, I-L-α-glycerophosphocholine ingangena kumgoqo wegazi nobuchopho futhi ibe ne-bioavailability ephezulu kakhulu. Kuwumsoco osezingeni eliphezulu obalulekile emzimbeni womuntu. "Isithiyo sobuchopho begazi siyisakhiwo esiminyene, 'esifana nodonga' phakathi kwe-capillary plexuses yobuchopho. I-L-α-glycerophosphocholine ingangena kalula emgodleni wegazi nobuchopho futhi ibambe iqhaza ekuthuthukiseni inkumbulo, ukuthuthukisa ukucabanga, kanye inezinzuzo ezingaba khona ekudambiseni ukukhathazeka, ukuzinza kwemizwa, nokwandisa amandla emisipha nokukhuthazela "Imiphumela yokudla okunomsoco ye-L-α-glycerophosphocholine ibonakala ngokuyinhloko ezicini ze-5.

Enye iwukuthuthukisa ukusebenza kobuchopho. Lapho landa inani lamangqamuzana ezinzwa ebuchosheni, amandla awo aqina, athumela ngokushesha izimpawu zezinzwa, namandla okusebenza obuchopho aqina. I-L-α-glycerophosphocholine ingathuthukisa ngokugcwele ukusebenza kobuchopho ngokuthuthukisa ubungqabavu bamangqamuzana ezinzwa kanye nekhono lokudlulisela lamasignali ezinzwa. Mayelana nokuthuthukisa i-cholinergic neurotransmission, ukudluliselwa kwesignali phakathi kwamangqamuzana ezinzwa kuncike ekudluliseleni ama-neurotransmitters, futhi i-acetylcholine iyisithunywa esibalulekile samakhemikhali kanye ne-neurotransmitter eqinisekisa ukucabanga okusebenzayo futhi igcina ukusebenzisana phakathi kobuchopho nomzimba wonke.

I-L-α-glycerophosphocholine ingadilizwa ibe yi-3-glycerol phosphate ne-choline ebuchosheni futhi iyisiphakeli esisebenza kahle kakhulu se-acetylcholine. Ingathuthukisa inkumbulo futhi ithuthukise ukucabanga ngokukhuthaza ukuhlanganiswa nokukhululwa kwe-acetylcholine ebuchosheni. Mayelana nokuthuthukisa ukuzinza noketshezi lwamangqamuzana olwelwesi lwamangqamuzana, i-L-α-glycerophosphocholine ingakhuthaza ukuhlanganiswa kwe-phosphoinositide, ngaleyo ndlela ithuthukise ukuzinza noketshezi lwamangqamuzana eseli. Ama-Neurons anezakhiwo ezingaguquki angadlulisela kangcono ulwazi. Thuthukisa ikhono lokucabanga lomzimba.

Okwesibili ukudla okunomsoco kanye nokuvikelwa kwezinzwa. Izici ze-Neurotrophic, izici zokukhula kwezicubu zezinzwa, zingalawula ukuhlukaniswa kwe-stem cell futhi zikhuthaze ukwakheka kokuxhumana okusha kwe-neural. I-L-α-glycerophosphocholine ingakhuthaza ukugcinwa kwezici ezihlukahlukene ze-neurotrophic futhi isebenze izindlela zokusayina ezihlobene nokusinda kweseli, ngaleyo ndlela Iba nomphumela we-neuroprotective futhi ithuthukise izinga lokuqonda komzimba. Ngesikhathi esifanayo, i-L-α-glycerophosphocholine ingaphinde ikhuthaze ukukhiqizwa kwe-hormone yokukhula futhi igcine impilo yomzimba ngokwandisa amazinga e-hormone okukhula komzimba.

Eyesithathu i-antioxidant. I-oxidation nokuvuvukala yizimbangela eziyinhloko zokuguga nokufa kwamangqamuzana obuchopho. I-L-α-glycerophosphocholine ingasusa ama-radicals mahhala emzimbeni, ilwe nokucindezeleka kwe-oxidative, futhi inganciphisa isici se-nuclear NF-κB, i-tumor necrosis factor TNF-α, ne-interleukins. Ukukhululwa kwezinto ezivuvukalayo ezifana ne-IL-6 kumelana nokuvuvukala kobuchopho, ngaleyo ndlela kubuyisela kakhulu ukwehla kokusebenza kwengqondo nokuvimbela ukuvela nokuthuthukiswa kwezifo ze-neurodeergenerative.

Imiphumela efanele iye yasekelwa imiphumela yomtholampilo. Esicwaningweni esithi "Umphumela we-L-α-glycerophosphocholine ekukhubazekeni kwenkumbulo ehlobene neminyaka", izifundo ze-4 zanikezwa i-placebo, kanti ezinye izifundo ze-5 zanikezwa Ngemva kokuthatha i-L-α-glycerophosphocholine (1200 mg / ngosuku) ngomlomo izinyanga ze-3 , ama-electrode angu-16 asetshenziselwa ukurekhoda amaza obuchopho imizuzu engu-5 ngenkathi izifundo ziphapheme futhi ziphumule. Imiphumela yabonisa ukuthi uma kuqhathaniswa ne-placebo, i-L-alpha-glycerophosphocholine yandisa kakhulu ingxenye yamaza obuchopho ashesha kakhulu kuyilapho inomkhuba wokunciphisa amaza anensa. Okusho ukuthi, kungathuthukisa ubungqabavu bobuchopho babantu abaneminyaka ephakathi futhi kubambezele ukuguga komzimba.

Okwesine ukulawula imizwa. I-Dopamine ingenza abantu bazizwe bejabule, futhi i-serotonin ne-gamma-aminobutyric acid ingalawula isimo somzimba. I-L-α-glycerophosphocholine ingakhuthaza ukukhululwa kwe-dopamine, ikhulise-ilawula inkulumo yabathuthi be-dopamine, ithuthukise i-dopamine neurotransmission ebuchosheni, futhi ikhulise amazinga e-serotonin ku-striatum kanye ne-prefrontal cortex; kungase futhi kukhuthaze ngokuphawulekayo i-endogenous Ukukhululwa kwe-γ-aminobutyric acid ku-tissue ye-cortical yocansi kukhulula ukuqwasha, ngaleyo ndlela kusebenzisa imiphumela yayo yokulwa nokucindezeleka, ukudambisa ukukhathazeka kanye nokuzinza kwemizwelo.

Okwesihlanu ukuthuthukisa ukusebenza kwezemidlalo. Ngesikhathi sokuzivocavoca, i-L-alpha-glycerophosphocholine iphinde ithuthukise ukwakheka komzimba ngokwandisa imisipha kanye nokwenza ngcono umsebenzi we-metabolic jikelele ngokwandisa ukukhiqizwa kwe-hormone yokukhula okunamandla kanye nokukhishwa kwamandla. Ngaphezu kwalokho, i-L-α-glycerophosphocholine ingasheshisa futhi ukudluliswa kwe-neurotransmitter, ithuthukise ukusebenza kahle koxhumo lwe-neuromuscular, ikhulise ukuqina nokukhuthazela kwemisipha yamathambo, ngaleyo ndlela ithuthukise ukuqina komzimba, ukulwa nokukhathala, futhi ibe nethonya elihle ekukhuleni kwemisipha. . ithonya.

Ngakho abantu bangawutholaphi lo msoco onezinzuzo eziningi kangaka ezingaba khona? Eqinisweni, i-L-α-glycerophosphocholine iqukethwe ekudleni okuningi okufana namaqanda, inkukhu, ne-rainbow trout, kodwa okuqukethwe ngokuvamile kuncane. Ngokusho "kwe-Second Edition ye-US General Food Choline Content Database" eshicilelwe uMnyango Wezolimo wase-United States, okuqukethwe kwe-L-α-glycerophosphocholine enanini lokudla okungu-630 ezigabeni ezingu-22 kubonise ukuthi i-L-α-glycerophosphocholine ngayinye eyi-100. amagremu okudla Okuqukethwe kwe-glycerophosphocholine kusuka ku-0 kuya ku-190 mg. Ngakho-ke, ukuze kuhlangatshezwane nezidingo zokukhula komzimba womuntu, ukuthuthukiswa kanye ne-metabolism, izithako ezengeziwe zingenziwa ngendlela efanele.

I-Chemical synthesis ingenye yezindlela eziyinhloko zokukhiqiza i-L-α-glycerophosphocholine. Ukusebenzisa i-polyphosphoric acid, i-choline chloride, i-R-3-chloro-1,2-propanediol, i-sodium hydroxide namanzi njengezinto zokusetshenziswa, ngemva kokusabela kwe-condensation kanye ne-esterification, i-decolorized, ukungcola kususiwe, kugxilwe, kucwengisiswe futhi omisiwe. I-L-α-glycerophosphocholine eyenziwe ngezinye izinqubo ingangezwa eziphuzweni ezithambile, iziphuzo zezemidlalo, ikhofi, ama-gummies, ama-oatmeal energy bar, njll., futhi ingasebenzisa imiphumela yayo yokudla okunomsoco ngendlela ehlosiwe ukuze kuhlangatshezwane nempilo yokudla okunomsoco yabathengi. isidingo.

E-United States, eJapane, eCanada nakwamanye amazwe, i-L-α-glycerophosphocholine isetshenziswe kabanzi ekudleni. Imikhiqizo ehlobene ihlanganisa izithasiselo zokudla, iziphuzo, ama-gummies nezinye izigaba, futhi umkhiqizo ngamunye uneMisebenzi ecacile, umthamo onconywayo kanye namaqembu anconyiwe.

I-Suzhou Myland Pharm & Nutrition Inc.ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngempushana ye-Alpha GPC yekhwalithi ephezulu kanye nobumsulwa.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani angcono kakhulu. I-Alpha GPC yethu powder ihlolelwa ngokuqinile ubumsulwa namandla, iqinisekisa ukuthi uthola isengezo sekhwalithi ephezulu ongasethemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yeselula, ukuqinisa amasosha akho omzimba noma uthuthukise impilo yonke, i-Alpha GPC yethu powder iyisinqumo esihle kakhulu.

Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, i-Suzhou Myland Pharm isungule uhide lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ihambisane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.