Kuyini i-Choline Alfoscerate futhi ingasiza kanjani ubuchopho bakho?

Njengento engokwemvelo emzimbeni womuntu, I-L-α-glycerophosphocholine ingangena phakathi kwesithiyo segazi nobuchopho futhi inokutholakala okuphezulu kakhulu kwe-bioavailability. Kuyisakhamzimba sekhwalithi ephezulu esibalulekile emzimbeni womuntu. "Isithiyo segazi nobuchopho siyisakhiwo esiminyene, 'esifana nodonga' phakathi kwe-capillary plexuses yobuchopho. I-L-α-glycerophosphocholine ingangena kalula phakathi kwesithiyo segazi nobuchopho futhi idlale indima ekuthuthukiseni inkumbulo, ekuthuthukiseni ukucabanga, futhi Inezinzuzo ezingaba khona ekunciphiseni ukukhathazeka, ekuzinziseni isimo sengqondo, nasekukhuliseni amandla emisipha nokukhuthazela. "Imiphumela yokudla okunempilo ye-L-α-glycerophosphocholine ibonakala kakhulu ezicini ezi-5.

Enye iwukuthuthukisa ukusebenza kobuchopho. Uma inani lamaseli ezinzwa ebuchosheni likhula, amandla awo aqina, adlulisela ngokushesha izimpawu zezinzwa, futhi amandla okucubungula ubuchopho aqina. I-L-α-glycerophosphocholine ingathuthukisa ngokuphelele ukusebenza kobuchopho ngokuthuthukisa amandla amaseli ezinzwa kanye nekhono lokudlulisa izimpawu zezinzwa. Ngokuphathelene nokuthuthukisa ukudluliselwa kwe-cholinergic neurotransmission, ukudluliselwa kwesignali phakathi kwamaseli ezinzwa kuncike ekudluliselweni kwama-neurotransmitter, kanti i-acetylcholine iyisithunywa samakhemikhali esibalulekile kanye ne-neurotransmitter eqinisekisa ukucabanga okusebenzayo futhi igcina ukubambisana phakathi kobuchopho nomzimba wonke.

I-L-α-glycerophosphocholine ingahlukaniswa ibe yi-3-glycerol phosphate kanye ne-choline ebuchosheni futhi iwumthombo osebenza kahle kakhulu we-acetylcholine. Ingathuthukisa inkumbulo futhi ithuthukise ukucabanga ngokukhuthaza ukwakheka nokukhululwa kwe-acetylcholine ebuchosheni. Ngokuphathelene nokuthuthukisa ukuzinza nokugeleza kwama-membrane eseli, i-L-α-glycerophosphocholine ingakhuthaza ukwakheka kwe-phosphoinositide, ngaleyo ndlela ithuthukise ukuzinza nokugeleza kwama-membrane eseli. Ama-neuron anezakhiwo eziphelele angadlulisela kangcono ulwazi. Thuthukisa ukuqina kokucabanga komzimba.

Okwesibili ukudla okunempilo kanye nokuvikelwa kwemizwa. Izici ze-neurotrophic, izici zokukhula kwezicubu zemizwa, zingalawula ukuhlukaniswa kwamaseli e-stem futhi zikhuthaze ukwakheka kokuxhumana okusha kwemizwa. I-L-α-glycerophosphocholine ingakhuthaza ukukhiqizwa kwezinto ezahlukahlukene ze-neurotrophic futhi isebenze izindlela zokubonisana ezihlobene nokusinda kwamaseli, ngaleyo ndlela inomthelela wokuvikela imizwa futhi ithuthukise izinga lokuqonda lomzimba. Ngesikhathi esifanayo, i-L-α-glycerophosphocholine ingakhuthaza nokukhiqizwa kwe-hormone yokukhula futhi ilondoloze impilo yomzimba ngokwandisa amazinga e-hormone yokukhula yomzimba.

Okwesithathu yi-antioxidant. Ukubola kanye nokuvuvukala yizimbangela eziyinhloko zokuguga nokufa kwamangqamuzana obuchopho. I-L-α-glycerophosphocholine ingasusa ama-free radicals emzimbeni, ilwe nokucindezeleka kwe-oxidative, futhi inganciphisa ne-nuclear factor NF-κB, i-tumor necrosis factor TNF-α, kanye nama-interleukins. Ukukhishwa kwezinto ezivuvukalayo njenge-IL-6 kuvimbela ukuvuvukala kobuchopho, ngaleyo ndlela kuguqula kakhulu ukwehla komsebenzi wokuqonda futhi kuvimbele ukwenzeka kanye nokuthuthukiswa kwezifo eziwohlokayo.

Imiphumela efanele isekelwe yimiphumela yezokwelapha. Esifundweni esithi "Umphumela we-L-α-glycerophosphocholine ekukhubazekeni kwenkumbulo okuhlobene nokuguga", abantu abane banikezwa i-placebo, kanti abanye abantu abahlanu banikezwa. Ngemva kokuthatha i-L-α-glycerophosphocholine (1200 mg/ngosuku) ngomlomo izinyanga ezi-3, kwasetshenziswa ama-electrode ayi-16 ukuqopha amaza obuchopho imizuzu emi-5 ngenkathi abantu bephapheme futhi bephumula. Imiphumela ibonise ukuthi uma kuqhathaniswa ne-placebo, i-L-alpha-glycerophosphocholine yandise kakhulu isilinganiso samaza obuchopho asheshayo ngenkathi inomkhuba wokunciphisa amaza ahamba kancane. Okusho ukuthi, ingathuthukisa amandla obuchopho babantu abaseminyakeni ephakathi futhi ibambezele ukuguga komzimba.

Okwesine ukulawula imizwa. I-Dopamine ingenza abantu bazizwe bejabule, kanti i-serotonin kanye ne-gamma-aminobutyric acid kungalawula isimo sengqondo somzimba. I-L-α-glycerophosphocholine ingakhuthaza ukukhululwa kwe-dopamine, ithuthukise ukuvezwa kwabathuthi be-dopamine, ithuthukise ukudluliselwa kwe-dopamine ebuchosheni, futhi inyuse amazinga e-serotonin ku-striatum kanye ne-prefrontal cortex; ingakhuthaza kakhulu futhi i-endogenous. Ukukhululwa kwe-γ-aminobutyric acid ezicutshini ze-cortical zocansi kunciphisa ukungakwazi ukulala, ngaleyo ndlela kusebenzise imiphumela yayo yokulwa nokudangala, ukuqeda ukukhathazeka kanye nokuzinzisa isimo sengqondo.

Okwesihlanu ukuthuthukisa ukusebenza kwezemidlalo. Ngesikhathi sokuzivocavoca, i-L-alpha-glycerophosphocholine iphinde ithuthukise ukwakheka komzimba ngokwandisa isisindo semisipha nokuthuthukisa umsebenzi we-metabolic ngokwandisa ukukhiqizwa kwe-hormone yokukhula okunamandla kanye nokukhishwa kwamandla. Ngaphezu kwalokho, i-L-α-glycerophosphocholine ingasheshisa nokudluliselwa kwe-neurotransmitter, ithuthukise ukusebenza kahle kokuxhumana kwemisipha, yandise ukugoba kanye nokukhuthazela kwemisipha yamathambo, ngaleyo ndlela ithuthukise amandla okuzivocavoca komzimba, ukulwa nokukhathala, futhi ibe nethonya elihle ekukhuleni kwemisipha.

Ngakho-ke abantu bangasitholaphi lesi sakhi esinenzuzo eziningi kangaka? Eqinisweni, i-L-α-glycerophosphocholine itholakala ekudleni okuningi okufana namaqanda, inkukhu, kanye ne-rainbow trout, kodwa okuqukethwe ngokuvamile kuncane. Ngokusho kwe-"Second Edition of the US General Food Choline Content Database" enyatheliswa yi-United States Department of Agriculture, okuqukethwe kwe-L-α-glycerophosphocholine ekudleni okungu-630 okuphelele ezigabeni ezingu-22 kubonise ukuthi i-L-α-glycerophosphocholine ngamagremu ayi-100 okudla. Okuqukethwe kwe-glycerophosphocholine kusuka ku-0 kuya ku-190 mg. Ngakho-ke, ukuze kuhlangatshezwane nezidingo zokukhula komzimba womuntu, intuthuko kanye ne-metabolism, kungenziwa izithasiselo ezengeziwe ngendlela efanele.

Ukwenziwa kwamakhemikhali kungenye yezindlela eziyinhloko zokukhiqiza i-L-α-glycerophosphocholine. Kusetshenziswa i-polyphosphoric acid, i-choline chloride, i-R-3-chloro-1,2-propanediol, i-sodium hydroxide namanzi njengezinto zokusetshenziswa, ngemva kokusabela kokujiya kanye ne-esterification, iyasuswa umbala, ukungcola kususwe, kugxilwe, kuhlungwe futhi komiswe. I-L-α-glycerophosphocholine eyenziwe ngezinye izinqubo ingafakwa eziphuzweni ezibandayo, eziphuzweni zezemidlalo, ekhofi, kuma-gummies, kuma-oatmeal energy bar, njll., futhi ingasebenzisa imiphumela yayo yokudla ngendlela eqondiwe ukuze ihlangabezane nempilo yokudla ehlukahlukene yabathengi.

E-United States, eJapane, eCanada nakwamanye amazwe, i-L-α-glycerophosphocholine isetshenziswe kabanzi ekudleni. Imikhiqizo ehlobene ihlanganisa izithako zokudla, iziphuzo, ama-gummies nezinye izigaba, futhi umkhiqizo ngamunye uneMisebenzi ecacile, umthamo onconywayo kanye namaqembu anconywayo.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe yi-FDA ohlinzeka ngempuphu ye-Alpha GPC esezingeni eliphezulu futhi emsulwa.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani amahle kakhulu. Impuphu yethu ye-Alpha GPC ihlolwe ngokucophelela ukuhlanzeka kanye namandla, okuqinisekisa ukuthi uthola isithasiselo sekhwalithi ephezulu ongasithemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yamaseli, ukukhulisa amasosha omzimba wakho noma ukuthuthukisa impilo iyonke, impuphu yethu ye-Alpha GPC iyisinqumo esifanele.

Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukisiwe kakhulu, i-Suzhou Myland Pharm ithuthukise imikhiqizo ehlukahlukene encintisanayo futhi yaba yinkampani yezinsizakalo zesayensi yokuphila entsha, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.