Iyini i-Salidroside futhi ingakusiza kanjani?

I-Salidroside yaziwa nangokuthi (4-hydroxy-phenyl)-β-D-glucopyranoside, eyaziwa nangokuthi i-salidroside kanye ne-rhodiola extract. Ingakhishwa ku-Rhodiola rosea noma yenziwe ngokwenziwa. I-Salidroside iyi-antioxidant yemvelo evikela amangqamuzana ezinzwa ngokususa i-ROS futhi ivimbele i-apoptosis yamaseli.

I-Rhodiola rosea iyisitshalo esihlala isikhathi eside esikhula ezindaweni ezinobanda obuphezulu, ukoma, i-anoxia, imisebe enamandla ye-ultraviolet, kanye nomehluko omkhulu wokushisa phakathi kwemini nobusuku endaweni ephakeme ngamamitha ayi-1,600 kuya ku-4,000. Iyakwazi ukuzivumelanisa nezimo zemvelo kanye namandla ayo amakhulu kakhulu.

I-Salidroside--I-Antioxidant

I-Salidroside iyi-antioxidant yemvelo engasusa izinhlobo ze-oxygen ezisabelayo (i-ROS), ivimbele i-apoptosis, futhi ivikele amaseli ezinzwa. Ingathuthukisa amakhono okuvikela i-antioxidant esikhumba ngokusebenzisa izinhlelo ze-enzyme ze-antioxidant zangaphakathi kweseli, njenge-superoxide dismutase (SOD), i-glutathione peroxidase (GSH-Px), njll.

Ukwanda ngokweqile kwe-calcium ngaphakathi kweseli kungenye yezimbangela eziyinhloko ze-neuronal apoptosis. I-Rhodiola rosea extract kanye ne-salidroside kunganciphisa ukwanda kwamazinga e-calcium yamahhala ngaphakathi kweseli okubangelwa ukucindezeleka kwe-oxidative futhi kuvikele amaseli e-cortical womuntu ku-glutamate. kanye ne-hydrogen peroxide-induced apoptosis. I-Salidroside ingavimbela ukusebenza kwe-microglial ebangelwa yi-lipopolysaccharide, ivimbele ukukhiqizwa kwe-NO, ivimbele umsebenzi we-nitric oxide synthase (iNOS) ongasebenzi kahle, futhi inciphise amazinga e-TNF-α kanye ne-IL-1β. , IL-6.

I-Salidroside ivimbela i-NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) kanye nomlawuli wempendulo yentuthuko kanye nomonakalo we-DNA 1 (REDD1)/ithagethi ye-rapamycin (mTOR)/p70 ribosome. Indlela yokusayina ye-protein S6 kinase isebenzisa umlawuli wolwazi oluthule we-protein kinase/AMP oxhomeke ku-AMP, i-RAS homologous gene member A/MAPK kanye ne-PI3K/Akt signaling pathways.

Izinzuzo ze-Salidroside

1. Umphumela wokulawula ngezindlela ezimbili: I-Rhodiola rosea ihlanganisa zonke izici ezinhle emzimbeni futhi inomphumela wokulawula ngezindlela ezimbili wokulungisa ukuntuleka nokunciphisa okweqile. Ngokulawula imisebenzi yesimiso sezinzwa, uhlelo lwe-endocrine kanye nohlelo lwe-metabolic, ushukela wegazi, amafutha egazini, umfutho wegazi kanye nemisebenzi yenhliziyo nemithambo yegazi ingabuyiselwa emazingeni ajwayelekile.

2. Ukulawulwa okuphumelelayo kwesimiso sezinzwa: kuqeda ngempumelelo ukucindezeleka kwabantu, kulinganisela isimiso sezinzwa esiyinhloko, kuthuthukisa ukulala nokucasuka, injabulo noma ukucindezeleka; kuthuthukisa ukunaka nokuthuthukisa inkumbulo. Vuselela ubuchopho, nciphisa amazinga amaphutha, thuthukisa ukusebenza kahle komsebenzi nokutadisha, futhi uvimbele isifo i-Alzheimer's.

3. Ukulwa nokukhathala: I-Rhodiola rosea inomphumela we-cardiotonic, ongandisa isikhathi semisebenzi evamile yobuchopho nomzimba futhi wandise umthamo womthwalo wezinzwa zobuchopho nemisipha yomzimba. Inomthelela omkhulu ekuvimbeleni nasekwelapheni i-fatigue syndrome kanye nokugcina amandla aqinile kanye namandla isikhathi eside.

4. Ukulwa nemisebe kanye nokulwa nesimila: I-Salidroside ingakhuphula ngempumelelo izinga lokuguqulwa kwama-T lymphocyte kanye nomsebenzi wama-phagocyte, ithuthukise amasosha omzimba, ivimbele ukukhula kwesimila, ikhulise amaseli amhlophe egazi, imelane nemisebe ye-microwave, futhi yelaphe iziguli ezinomdlavuza ngemva kokwelashwa ngemisebe kanye nezinye. Inomphumela omuhle kakhulu wokuvuselela kulabo ababuthakathaka ngokomzimba ngemva kokugula.

5. I-Anti-hypoxia: I-Rhodiola rosea inganciphisa izinga lokusetshenziswa komoya-mpilo emzimbeni, ithuthukise ukubekezelela kobuchopho i-hypoxia, futhi ngesikhathi esifanayo yandise amandla okuthwala umoya-mpilo egazini, yandise ukumelana nezifo zomzimba, futhi ilulame ngokushesha izicubu ezigulayo.

6. Umphumela emisipheni ebushelelezi yomuntu: I-asthma ibangelwa ukuqaqamba kwemisipha ebushelelezi. I-Rhodiola rosea ingaqeda ngempumelelo ukuqaqamba kwemisipha ebushelelezi futhi ilawule ukunyakaza kwemisipha ebushelelezi yamathumbu. Inemiphumela esobala ku-asthma, i-bronchitis, i-phlegm, ukuqunjelwa, njll.

7. Umphumela ku-rheumatoid arthritis: I-arthritis ibangelwa ububi obuthathu bomoya, umkhuhlane, kanye nomswakama. Inani elikhulu lezilingo zezokwelapha liye lafakazela ukuthi i-Rhodiola rosea ingaxosha umoya, imelane nomkhuhlane, futhi iqede ubuhlungu. Ikakhulukazi inemiphumela esobala ekuvuvukeni kwamalunga. Ukuvuvukala kanye nomphumela wokuvimbela.

8. Ukulwa nokuguga: I-Rhodiola rosea ingalibazisa ukuguga kwamaseli, yandise umsebenzi we-SOD emzimbeni, futhi ivimbele ukwakheka kwe-lipofuscin yangaphakathi kweseli kanye nezinhlobo ze-oxygen ezisabelayo. Ithuthukisa imetabolism yamaseli kanye nokwakheka kwawo futhi ithuthukise amandla amaseli. Ngaphezu kwalokho, inemiphumela emihle kanye nokunakekelwa kwesikhumba.

Insimu Yokunakekelwa Kwesikhumba Ne-Salidroside

Emkhakheni wokunakekelwa kwesikhumba, i-salidroside ingamelana nomonakalo we-ultraviolet futhi isuse ama-free radical akhiqizwa yi-mitochondria. Imiphumela yayo yokulwa ne-antioxidant kanye nokulwa nokuvuvukala ingathuthukisa isimo sesikhumba, inciphise imibimbi, futhi yenze isikhumba sibukeke sisisha.

I-Rhodiola rosea inganciphisa umsebenzi we-acid phosphatase kanye nemikhiqizo yokugcina yokubola kwe-lipid peroxide (LPO) ngokwandisa umsebenzi wama-enzyme ahlobene ne-antioxidant (i-SOD superoxide dismutase, i-GSH-Px glutathione peroxidase kanye ne-CAT) kanye nokuqukethwe kwe-MDA, ngaleyo ndlela ithuthukise ikhono lomzimba lokuqongelela ama-free radicals, inciphise izinga lokubola kwama-biofilms, futhi ivikele amangqamuzana nezicubu zomzimba ekulimaleni kwama-free radicals.

Vimbela ukuthwebula izithombe zesikhumba

I-Salidroside inganciphisa ukuwohloka kwe-extracellular matrix njenge-collagen futhi ikhuthaze ukukhula kwama-fibroblast, ngaleyo ndlela ithuthukise ukuqina kwesikhumba, ibambezele ukwenzeka kwemibimbi yesikhumba, futhi ifeze injongo yokumelana nokuguga kwesikhumba.

Ukumhlophe

I-Salidroside inganciphisa ukwakheka kwe-melanin ngokuvimbela umsebenzi we-tyrosinase. I-Tyrosinase iyi-enzyme eyinhloko yokwakheka kwe-melanin. I-Salidroside ingabopha i-tyrosinase futhi inciphise umsebenzi wayo, ngaleyo ndlela inciphise ukukhiqizwa kwe-melanin.

I-Salidroside ingavimbela futhi ukwakheka kwe-melanin ngokulawula izindlela zokubonisa izimpawu kuma-melanocyte, njengendlela yokubonisa izimpawu ye-MITF. I-MITF iyisici esibalulekile sokubhala izimpawu kuma-melanocyte, esilawula ukuvezwa kwama-enzyme ahlobene nokwakheka kwe-melanin njenge-tyrosinase. I-Salidroside inganciphisa ukuvezwa kwe-MITF, ngaleyo ndlela inciphise ukwakheka kwe-melanin.

Ukulwa nokuvuvukala

I-Salidroside inganciphisa impendulo yokuvuvukala okubangelwa imisebe ye-ultraviolet, ilungise amangqamuzana esikhumba alimele, futhi ikhuthaze ukuvuselelwa nokulungiswa kwesikhumba.

Isimo samanje sokukhiqizwa kwe-salidroside

1) Ngokuyinhloko ngithembele ekukhishweni kwezitshalo

I-Rhodiola rosea iwuhlobo lwesitshalo esiluhlaza esihlala isikhathi eside, i-Rhodiola rosea ikhula kakhulu ezindaweni ezinomkhuhlane omkhulu, i-anoxia, ukoma kanye nomehluko omkhulu wokushisa phakathi kwemini nobusuku endaweni ephakeme ngamamitha ayi-1600-4000. Ingenye yezitshalo zasendle ezisemaphethelweni. I-China ingenye yezindawo ezikhiqiza kakhulu i-Rhodiola rosea emhlabeni, kodwa imikhuba yokuphila ye-Rhodiola rosea ikhethekile impela. Akukhona nje kuphela ukuthi kunzima ukuyilima ngendlela yokwenziwa, kodwa isivuno sezinhlobo zasendle siphansi kakhulu. Njengamanje, igebe lesidingo saminyaka yonke se-Rhodiola rosea liphezulu ngamathani angu-2,200.

2) Ukwenziwa kwamakhemikhali kanye nokubiliswa kwezinto eziphilayo

Ngenxa yokuqukethwe okuphansi kanye nezindleko eziphezulu zokukhiqiza ezitshalweni, ngaphezu kwezindlela zokukhipha zemvelo, izindlela zokukhiqiza i-salidroside zifaka phakathi nezindlela zokwenziwa kwamakhemikhali, izindlela zokuvubela izinto eziphilayo, njll. Phakathi kwazo, njengoba ubuchwepheshe buqhubeka nokuvuthwa, ukuvubela izinto eziphilayo sekuyindlela yobuchwepheshe eyinhloko yocwaningo kanye nentuthuko kanye nokukhiqizwa kwe-salidroside. Njengamanje, iSuzhou Mailun ithole imiphumela yocwaningo kanye nentuthuko futhi ifinyelele ekwakhiweni kwezimboni.

Ukukhishwa kwemisebe kuyingxenye engenakugwenywa yempilo yethu yansuku zonke futhi kuvame ukusetshenziswa ekuxilongweni nasekwelashweni kwezokwelapha. Kodwa-ke, umonakalo obangelwa ukushiswa kwemisebe ezicutshini nasemaseli abantu awunakunakwa. Ngakho-ke, ukuthola izinto ezivikela imisebe ezisebenzayo, ezinobuthi obuphansi noma ezingenabo ubuthi bekulokhu kuyindaba yocwaningo.

I-Suzhou Myland Nutraceuticals Inc. ingumkhiqizi obhalisiwe yi-FDA ohlinzeka ngempuphu ye-Salidroside esezingeni eliphezulu futhi emsulwa.

KwaSuzhou Myland sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani amahle kakhulu. Impuphu yethu ye-Salidroside ihlolwe ngokucophelela ukuhlanzeka kanye namandla, okuqinisekisa ukuthi uthola isithasiselo sekhwalithi ephezulu ongasithemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yamaseli, ukukhulisa amasosha omzimba wakho noma ukuthuthukisa impilo iyonke, impuphu yethu ye-Salidroside iyisinqumo esifanele.

Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukisiwe kakhulu, iSuzhou Myland ithuthukise imikhiqizo ehlukahlukene yokuncintisana futhi yaba yinkampani yezinsizakalo zesayensi yokuphila entsha, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland iphinde ibe ngumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.