Iyini i-spermidine? Umhlahlandlela olula we-spermidine

I-Spermidineluhlobo lwe-polyamine. Ama-Polyamines amancane, anamafutha, ama-polycationic (-NH3+) ama-biomolecules. Kunezinhlobo ezine ze-polyamine eziyinhloko ezilwaneni ezincelisayo: i-spermine, i-spermidine, i-purescine ne-cadaverine. I-Spermine ingeye-tetramines, i-spermidine ingeye-triamines, i-purescine ne-cadaverine ingeye-diamines. Izinombolo ezihlukene zamaqembu e-amino ziwanikeza izici ezihlukahlukene zomzimba.

I-Spermidine kubantu

I-Spermidine ayitholakali kuphela esidodeni, kodwa futhi isakazwa kabanzi kwezinye izicubu namaseli omzimba womuntu. Ukugxila kwe-intracellular spermidine ikakhulukazi kuncike ezintweni ezine:

①I-Intracellular synthesis:

I-Arginine → putrescine → i-spermidine ← isidoda. I-Arginine iyinhloko yokusetshenziswa kwe-spermidine kumaseli. Ikhiqizwa yi-arginase ukuze ikhiqize i-ornithine ne-urea. I-Ornithine bese isetshenziselwa ukukhiqiza i-purescine ngaphansi kwesenzo se-ornithine decarboxylase (ODC1). Lesi yisinyathelo sokunciphisa izinga), i-purescine ikhiqiza i-spermidine ngaphansi kwesenzo se-spermidine synthase (SPDS). I-spermidine nayo ingakhiqizwa ngokuwohloka kwe-spermine.

②Ukuthathwa kwe-extracellular:

Ihlukaniswe yaba ukudla kanye ne-intestinal microbial synthesis. Ukudla okucebile nge-spermidine kuhlanganisa igciwane likakolweni, i-natto, ubhontshisi wesoya, amakhowe, njll. I-Spermine ne-spermidine efakwe ekudleni imuncwa ngokushesha emathunjini futhi isatshalaliswe ngaphandle kokuwohloka, ngakho ukuhlushwa kwe-spermidine egazini ku-Concentrations kuhluke kakhulu. Amabhaktheriya angama-Probiotic ku-microbiota yamathumbu afana ne-Bifidobacterium nawo angahlanganisa i-spermidine.

③I-Catabolism:

I-Spermine emzimbeni iyabola kancane kancane ibe yi-spermidine kanye ne-purescine nge-N1-acetyltransferase (SSAT), i-polyamine oxidase (PAO) namanye ama-amine oxidase, kuyilapho i-purescine iguqulwa ibe yi-aminobutyric acid ngama-oxidase. Ekugcineni, ama-amine ions kanye ne-carbon dioxide akhiqizwa futhi akhishwe emzimbeni.

④Iminyaka yobudala:

Ukuhlushwa kwe-spermidine kuyashintsha ngokuya ngeminyaka. Abacwaningi balinganisa ukuhlushwa kwe-polyamines ezicutshini ezihlukahlukene kanye nezitho ze-3-isonto ubudala, i-10-isonto ubudala kanye ne-26-isonto ubudala amagundane futhi bathola ukuthi ngokuyisisekelo igcinwe ku-pancreas, ubuchopho kanye nesibeletho. Izinguquko emathunjini ziyancipha kancane ngokukhula, futhi zehla kakhulu ku-thymus, i-spleen, i-ovary, isibindi, isisu, amaphaphu, izinso, inhliziyo kanye nemisipha. Akunzima ngathi ukucabangela ukuthi izizathu zalolu shintsho zihlanganisa izinguquko zokudla, izinguquko ekwakhekeni kwezitshalo zamathumbu emathunjini, umsebenzi oncishisiwe we-polyamine synthase, njll.

Inhloso yemvelo ye-spermidine

Kungani i-molecule encane kangaka iyinto ebalulekile emzimbeni womuntu? Imfihlo empeleni ilele esakhiweni sayo: I-Spermidine i-polycationic (-NH3+) i-amine enamafutha e-amine molecule encane ekhona efomini le-multi-protonated ngaphansi kwezimo ze-pH ye-physiological, nama-ion amahle asakazwa kulo lonke i-carbon chain. Ishaja kagesi, inomsebenzi oqinile wokuphila komzimba.

Ngakho-ke, kungakhathaliseki ukuthi ama-nucleic acids, ama-phospholipids, amaprotheni ane-acidic aqukethe izinsalela ze-acidic, i-pectic polysaccharides equkethe amaqembu e-carboxyl nama-sulfate, noma ama-neurotransmitters nama-hormone (i-dopamine, i-epinephrine, i-serotonin, i-hormone yegilo, njll.) enezakhiwo ezifanayo, Okungenzeka kube okuhlosiwe kwe-spermidine. ukubopha. Ezibucayi kakhulu yilezi:

① I-Nucleic acid:

Ucwaningo luye lwathola ukuthi ama-polyamine amaningi akhona ngesimo se-polyamine-RNA complexes ngaphakathi kwamaseli, anezilinganiso ezingu-1-4 ze-polyamine eziboshwe ngezilinganiso eziyi-100 ze-phosphate compounds. Ngakho-ke, indima eyinhloko ye-spermidine ihlobene nezinguquko zesakhiwo kanye nokuhunyushwa kwe-RNA, njengokuthinta izigaba ezihlukahlukene ze-protein synthesis ngokuthinta isakhiwo sesibili se-mRNA, i-tRNA ne-rRNA. I-Spermidine ingase futhi yakhe "amabhuloho" azinzile phakathi kwemicu ye-DNA ene-helical ephindwe kabili, inciphisa ukufinyeleleka kwama-radicals mahhala noma amanye ama-ejenti alimaza i-DNA, nokuvikela i-DNA ekukhanyeni okushisayo kanye nemisebe ye-X-ray.

②Amaprotheni:

I-Spermidine ingabophezela kumaprotheni aphethe amacala amakhulu amabi futhi iguqule ukwakheka kwendawo kwamaprotheni, ngaleyo ndlela kuthinte umsebenzi wayo wokuphila. Izibonelo zifaka ama-protein kinases/phosphatases (isixhumanisi esibalulekile ezindleleni eziningi zokudlulisela isignali), ama-enzyme ahilelekile ku-histone methylation kanye ne-acetylation (ethinta ukubonakaliswa kofuzo ngokushintsha i-epigenetics), i-acetylcholinesterase (ingxenye ebalulekile yezifo ze-neurodegenerative). omunye wemithi yokwelapha), i-ion channel receptors (njenge-AMPA, i-AMDA receptors), njll.

I-Suzhou Myland ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngekhwalithi ephezulu nokuhlanzeka okuphezulu kwe-Spermidine powder.

E-Suzhou Myland, sizibophezele ekunikezeni imikhiqizo yekhwalithi engcono kakhulu ngamanani angcono kakhulu. I-Spermidine powder yethu ihlolwe ngokuqinile ukuhlanzeka namandla, iqinisekisa ukuthi uthola isengezo sekhwalithi ephezulu ongayethemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yeselula, ukuqinisa amasosha akho omzimba noma uthuthukise impilo yonke, i-Spermidine powder yethu iyisinqumo esiphelele.

Njengoba ineminyaka engu-30 yokuhlangenwe nakho futhi iqhutshwa ubuchwepheshe obuphezulu kanye nesu le-R&D elilungiselelwe kakhulu, i-Spermidine ithuthukise uhla lwemikhiqizo yokuncintisana ukuze ibe isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinsizakalo zokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izinsiza zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ayakwazi ukukhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi athobelane namazinga e-ISO 9001 kanye nokucaciswa kokukhiqiza kwe-GMP.