Iyini i-spermidine? Umhlahlandlela olula we-spermidine

I-Spermidineuhlobo lwe-polyamine. Ama-polyamine amancane, anamafutha, ama-polycationic biomolecule (-NH3+). Kunezinhlobo ezine eziyinhloko zama-polyamine ezincelisayo: i-spermine, i-spermidine, i-putrescine kanye ne-cadaverine. I-spermine ingeye-tetramine, i-spermidine ingeye-triamines, i-putrescine kanye ne-cadaverine ingeye-diamines. Inani elihlukene lamaqembu ama-amino liwanikeza izakhiwo ezahlukene zomzimba.

I-Spermidine kubantu

I-Spermidine ayitholakali nje kuphela esidodeni, kodwa futhi isakazeka kabanzi kwezinye izicubu namaseli omzimba womuntu. Ukuhlushwa kwe-spermidine ngaphakathi kweseli kuncike kakhulu ezintweni ezine:

①Ukwenziwa kwangaphakathi kwamangqamuzana:

I-Arginine → i-putrescine → i-spermidine ← i-spermine. I-Arginine iyinto eyinhloko yokwenziwa kwe-spermidine emaseli. Iqhutshwa yi-arginase ukukhiqiza i-ornithine ne-urea. I-Ornithine isetshenziswa ukukhiqiza i-putrescine ngaphansi kwesenzo se-ornithine decarboxylase (ODC1). Lesi yisinyathelo esikhawulela izinga), i-putrescine ikhiqiza i-spermidine ngaphansi kwesenzo se-spermidine synthase (SPDS). I-Spermidine ingakhiqizwa futhi ngokuwohloka kwe-spermine.

②Ukumuncwa kwangaphandle kwamangqamuzana:

Kuhlukaniswe ngokudla kanye nokwakheka kwamagciwane amathumbu. Ukudla okucebile nge-spermidine kufaka phakathi i-wheat germ, i-natto, ubhontshisi, amakhowe, njll. I-spermine kanye ne-spermidine ezidliwayo ekudleni zimuncwa ngokushesha emathunjini futhi zisakazwe ngaphandle kokuwohloka, ngakho-ke ukugcwala kwe-spermidine egazini kuhlukile kakhulu. Ama-probiotic bacteria kuma-intestinal microbiota njenge-Bifidobacterium nawo angakhiqiza i-spermidine.

③Ukuguqulwa kwe-Catabolism:

Isidoda emzimbeni sihlukaniswa kancane kancane sibe yi-spermidine kanye ne-putrescine yi-N1-acetyltransferase (SSAT), i-polyamine oxidase (PAO) kanye namanye ama-amine oxidases, kuyilapho i-putrescine iguqulwa ibe yi-aminobutyric acid yi-oxidases. Ekugcineni, ama-amine ion kanye ne-carbon dioxide kukhiqizwa futhi kukhishwe emzimbeni.

④Ubudala:

Ukuhlushwa kwe-spermidine kuyashintsha ngokuguga. Abacwaningi balinganise ukuhlushwa kwe-polyamine ezicutshini nasezithweni ezahlukahlukene zamagundane anamaviki amathathu, amasonto ayi-10 kanye namasonto angama-26 ubudala futhi bathola ukuthi empeleni kugcinwe ku-pancreas, ebuchosheni nasesibelethweni. Izinguquko emathunjini ziyancipha kancane ngokuguga, futhi zehla kakhulu ku-thymus, spleen, ovary, isibindi, isisu, amaphaphu, izinso, inhliziyo kanye nemisipha. Akunzima ngathi ukuqagela ukuthi izizathu zalolu shintsho zifaka phakathi izinguquko zokudla, izinguquko esakhiweni sezitshalo zamathumbu, umsebenzi onciphile we-polyamine synthase, njll.

Inhloso yemvelo ye-spermidine

Kungani i-molecule encane elula kangaka iyinto ebalulekile emzimbeni womuntu? Imfihlo empeleni isesimeni sayo: I-Spermidine iyi-molecule encane ye-polycationic (-NH3+) fatty amine ekhona ngesimo esine-protonated ngaphansi kwezimo ze-pH physiological, enama-ion amahle asakazwa kulo lonke uchungechunge lwekhabhoni. Ishaja kagesi, inomsebenzi oqinile physiological.

Ngakho-ke, kungakhathaliseki ukuthi yi-nucleic acid, ama-phospholipid, amaprotheni ane-acid aqukethe izinsalela ze-acid, ama-polysaccharides e-pectic aqukethe amaqembu e-carboxyl nama-sulfate, noma ama-neurotransmitters nama-hormone (i-dopamine, i-epinephrine, i-serotonin, i-thyroid hormone, njll.) anezakhiwo ezifanayo, Kungenzeka kube yinhloso yokubopha i-spermidine. Ezibaluleke kakhulu yilezi:

① I-asidi ye-nucleic:

Izifundo zithole ukuthi iningi lama-polyamine likhona ngesimo sama-polyamine-RNA complexes ngaphakathi kwamaseli, kanye nama-equivalents angu-1-4 e-polyamine aboshwe ngama-equivalents ayi-100 e-phosphate compounds. Ngakho-ke, indima eyinhloko ye-spermidine ihlobene nezinguquko zesakhiwo kanye nokuhumusha kwe-RNA, njengokuthinta izigaba ezahlukene zokwenziwa kwamaprotheni ngokuthinta isakhiwo sesibili se-mRNA, i-tRNA kanye ne-rRNA. I-Spermidine ingakha futhi "amabhuloho" azinzile phakathi kwezintambo ze-DNA ezine-helical ezimbili, ukunciphisa ukufinyeleleka kwama-free radical noma amanye ama-ejenti alimaza i-DNA, kanye nokuvikela i-DNA ekushintsheni kokushisa kanye nemisebe ye-X-ray.

②Amaprotheni:

I-Spermidine ingabopha amaprotheni athwala amacala amakhulu amabi futhi ishintshe ukwakheka kwendawo kweprotheyini, ngaleyo ndlela ithinte umsebenzi wayo womzimba. Izibonelo zifaka phakathi ama-protein kinase/phosphatases (isixhumanisi esibalulekile ezindleleni eziningi zokudluliselwa kwesignali), ama-enzyme ahilelekile ku-methylation ye-histone kanye ne-acetylation (okuthinta ukubonakaliswa kwezakhi zofuzo ngokushintsha i-epigenetics), i-acetylcholinesterase (ingxenye ebalulekile yezifo eziwohlokayo zemizwa). omunye wemithi yokwelapha), ama-receptor esiteshi se-ion (njenge-AMPA, ama-receptor e-AMDA), njll.

I-Suzhou Myland ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngempuphu ye-Spermidine esezingeni eliphezulu futhi emsulwa kakhulu.

KwaSuzhou Myland, sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani amahle kakhulu. Impuphu yethu yeSpermidine ihlolwe ngokucophelela ukuhlanzeka kanye namandla, okuqinisekisa ukuthi uthola isithasiselo sekhwalithi ephezulu ongasithemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yamaseli, ukukhulisa amasosha omzimba wakho noma ukuthuthukisa impilo iyonke, impuphu yethu yeSpermidine iyisinqumo esifanele.

Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye nesu le-R&D elithuthukisiwe kakhulu, i-Spermidine ithuthukise imikhiqizo eminingi encintisanayo ukuze ibe yinkampani yezinsizakalo zesayensi yokuphila entsha, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland iphinde ibe ngumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi ziyakwazi ukukhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.