Iyini i-telomerase activator-cycloastraganol etholwe njengamanje?

Ngo-1985, uGreider et al. okokuqala kwatholwa i-telomerase, futhi le enzyme esanda kutholwa ingangeza ukuphindaphinda kwe-DNA ekugcineni kwama-chromosome ukuze kugcinwe ubude be-telomere. I-Telomerase iyinkimbinkimbi ye-ribonucleoprotein ewumgogodla wayo ohlanganisa i-TERT ne-TERC, okuyi-TERT ewukhiye wokulawula umsebenzi we-telomerase. Ubude be-telomere buyaqhubeka bufinyeza njengoba amaseli ehlukana. Uma ifinyelela inani elibalulekile, idala izimpawu zokulimala kwe-DNA, okuholela ekunciphiseni umjikelezo weseli kanye nochungechunge lwezifo zokuhluleka kwezicubu ezibonakala ngama-telomere amafushane.

Ngo-2010, inkampani yaseMelika i-Geron yasebenzisana ne-Hong Kong University of Science and Technology kuphrojekthi yocwaningo yokuhlola izishoshovu ze-telomerase. Kwatholakala ukuthii-cycloastraganolingenza kusebenze umsebenzi we-telomerase futhi yenze isandiso se-telomere. Lokhu kutholakala kukhuthaze ngenkuthalo ukuthuthukiswa kwezicupha ze-telomerase. Inqubekelaphambili yocwaningo kanye nokuthuthukiswa komkhiqizo ohlobene we-astragalus alcohol. I-Cycloastragenol (CAG) okwamanje ukuphela kwe-telomerase activator phakathi kwemikhiqizo yemvelo. Ingakwazi ukulwa ngokuphumelelayo nokunciphisa i-telomere futhi ine-anti-aging, anti-apoptosis, anti-fibrosis, i-immune regulation, ukukhuthazwa kokwanda kwamangqamuzana nokuphulukiswa kwesilonda, njll.

Cycloastragenol nokuguga

ama-telomeres
Ama-telomere ayizakhiwo ezikhethekile ekugcineni kwama-chromosome avikela ama-chromosome futhi afinyeze ngokuphindaphinda kwe-chromosome nokuhlukaniswa kwamaseli. Amaseli nawo ayaguga njengoba ama-telomere eba mfishane.

i-telomerase
I-telomerase ingahlanganisa ama-telomere ukuze izinze ubude nokwakheka kwama-telomere, ngaleyo ndlela ivikele ama-chromosome futhi ibambezele ukuguga kwamaselula.

I-Anti-Aging: I-activator ye-telomerase, edlala umphumela wokulwa nokuguga ngokwandisa i-telomerase futhi ngaleyo ndlela ibambezele ukufinyezwa kwama-telomere.

Ama-telomeres ama-caps atholakala ekugcineni kwama-chromosome eseli awavikela emonakalweni phakathi nokuhlukaniswa kwamaseli. Njengoba amangqamuzana eqhubeka ehlukana, ama-telomere ayaqhubeka efinyeza, afinyelele iphuzu elibucayi lapho amangqamuzana azoguga noma afe. I-telomerase inganweba ubude bama-telomere, futhi isikhathi sokuphila samangqamuzana ngokwemvelo sizokhula ngokufanele.

Ukuguga kuyingxenye yokuphila engenakugwenywa; kodwa-ke, abacwaningi bacwaninga izindlela zokwelapha ezihlukahlukene ukuze bazame ukugwema eminye yemiphumela yokuguga, kuhlanganise nokufunda ama-senolytics. I-Senolytics yizinhlanganisela eziqeda amaseli e-senescent (ukuguga) futhi aboniswe ukunciphisa imiphumela yokuguga. Ucwaningo olusha luphakamisa ukuthi i-cycloastraganol inemiphumela yokulwa nokuguga.

Lolu cwaningo, oluvela e-China futhi lwashicilelwa ku-International Journal of Molecular Sciences, lugxile kumangqamuzana abantu abasafufusa kanye namagundane ane-radiation-indued senescence. I-Cycloastragenol inciphisa amaseli e-senescent ngaphandle kokuthinta amaseli angenayo i-senescent. Ukwelashwa kwe-Cycloastragenol futhi kunciphisa amaprotheni kumaseli e-senescent adingekayo ekukhuleni kwamangqamuzana nokuphila. Ukwengeza, ivimbela ukunyakaza kwamaseli okuhlotshaniswa namaseli okuvuvukala ahlobene nobudala nezinqubo. Amagundane asebekhulile aphathwe nge-cycloastraganol atholwe enamaseli e-senescent ambalwa kanye nokungasebenzi kahle komzimba okuhlobene nobudala.

I-Cycloastragenol inciphisa amaseli e-senescent

I-Senescence iwuphawu olwaziwayo lokuguga, kodwa abacwaningi bathole ukuthi ukususa amangqamuzana ezinzwa kanye nama-molecule awo abonisa ukuvuvukala angasiza ekuvimbeleni izifo ezihlobene nobudala futhi ngisho nokuzibuyisela emuva kwezinye izimo. Lapha, abacwaningi baphatha amangqamuzana omuntu nge-cycloastraganol futhi bathola ukuthi iwaqeda ngempumelelo amaseli enzwa ngaphandle kokuthinta amaseli angewona amaseli. Ngaphezu kwalokho, izimpawu zamaselula zamaseli e-senescent zehliswa kakhulu ngemuva kokwelashwa kwe-cycloastraganol.

Ucwaningo lwangaphambilini lubonise ukuthi indlela ye-PI3K/AKT/mTOR—indlela yokubonisa ehilelekile ekukhuleni kwamangqamuzana nasekusindeni—ihilelekile ezinqubweni zokuvuvukala eziqalwa amangqamuzana e-senescent, okusiza ukukhuthaza ukuzwela kwamangqamuzana azungezile. Abacwaningi bathola ukuthi i-cycloastragenol isize ukunciphisa amaprotheni kule ndlela, iphakamisa ukuthi i-compound ingasebenza ngokuvimba indlela ye-PI3K/AKT/mTOR ukusiza ukuvimbela ukuguga. Ngaphezu kwalokho, i-cycloastragenol ikhonjisiwe ukunciphisa amandla amaseli e-senescent ukukhuthaza ukuzwela ngokukhululwa kwama-molecule avuvukalayo, izici zokukhula, nama-immunomodulators, okuhambisana neziphakamiso zokunciphisa ukusayinda kwe-PI3K, AKT, kanye ne-mTOR kunganciphisa imiphumela ekhuthaza ukuzwela phakathi kwamaseli azungezile. .

I-Cycloastragenol ingeye-triterpene saponins futhi itholakala ikakhulukazi ku-hydrolysis ye-astragaloside IV. Inesisindo esincane samangqamuzana kanye ne-lipophilicity eqinile, enenzuzo ekungeneni kwe-biofilm kanye nokumunca emathunjini ukuze kuzuzwe i-bioavailability engcono. Ukusebenza kwe-cycloastragalinol
1. Ukwelashwa kokulimala kobuchopho
2. Thuthukisa i-fibrosis yesibindi
3. Ukwelashwa kwe-osteoporosis
4. Umphumela wokuguga
5. Libazisa ukuguga kwamangqamuzana

Kungani kudingekile ukwenza i-cycloastraganol?

① I-Cycloastraganol inemiphumela ehlukahlukene yezemithi efana nokuvimbela i-apoptosis yeseli yobuchopho kanye ne-neuroinflammation ngesikhathi se-cerebral ischemia nokugcina umgoqo wegazi nobuchopho.
② I-Cycloastragenol ukuphela kwenhlanganisela ye-molecule encane ye-terpenoid enomsebenzi we-telomerase otholakele kuze kube manje futhi ingalapha izifo ze-neurodegenerative.
③ Inemiphumela yokuvimbela i-myocardial fibrosis futhi ithuthukise ukuvikeleka kwe-anti-tumor. Kuyi-molecule ethandwayo ocwaningweni nasekuthuthukisweni kwezidakamizwa ezilwa nokuguga.

Izinkinga ezikhona

Okuqukethwe kwe-cycloastraganol ku-Astragalus membranaceus kuphansi kakhulu futhi kunzima ukukuthola ngokuqondile. Isu elikhona lokukhiqiza i-cycloastraganol lincike ekukhishweni komuthi wendabuko waseShayina, otholwa kakhulu ngokuguqula i-astragaloside IV ku-Astragalus membranaceus. Okusho ukuthi, i-astragaloside IV itholakala ngokutshala kwe-astragalus kanye nobuchwepheshe besiko lwezicubu, bese i-astragaloside IV iguqulwa ibe yi-cycloastragaloside kusetshenziswa i-acidolysis, i-Smith degradation, i-enzyme kanye ne-microbial hydrolysis. Kodwa-ke, lezi zindlela zokulungiselela zibiza kakhulu, kulula ukubangela ukungcoliswa kwemvelo, kunzima ukuhlukanisa nokuhlanza, futhi azihambisani nokusetshenziswa nokukhuthazwa. Ngakho-ke, abantu baphendule ukunaka kwabo ku-synthesis yokwenziwa ye-cycloastraganol.

Ungayisebenzisa kanjani i-synthetic biology ukuze uhlanganise? ---Synthetic Biology

I-Synthetic Biology ibhekisela ekwakhiweni okuhlosiwe, ukuguqulwa, ngisho nokudalwa "kwempilo yokwenziwa" ngemisebenzi engeyona eyemvelo ngaphansi kokuqondisa kwemibono yobunjiniyela, okungukuthi, ubunjiniyela bebhayoloji. Ngokuvamile, ikhiqizwa kusetshenziswa izindlela zebhayoloji.