Iyini i-telomerase activator-cycloastraganol etholakale njengamanje?

Ngo-1985, uGreider nabanye bathola i-telomerase okokuqala, futhi le enzyme esanda kutholakala ingangeza ukuphindaphinda kwe-DNA emaphethelweni ama-chromosome ukuze kugcinwe ubude be-telomere. I-Telomerase iyinhlanganisela ye-ribonucleoprotein enomnyombo wayo we-catalytic ohlanganisa i-TERT ne-TERC, lapho i-TERT iyisihluthulelo sokulawula umsebenzi we-telomerase. Ubude be-telomere buyaqhubeka bufinyela njengoba amaseli ehlukana. Uma ifinyelela inani elibalulekile, ibangela izimpawu zokulimala kwe-DNA, okuholela emjikelezweni weseli ofinyeziwe kanye nochungechunge lwezifo zokwehluleka kwezicubu ezibonakala ngama-telomere amafushane.

Ngo-2010, inkampani yaseMelika iGeron yabambisana neHong Kong University of Science and Technology kuphrojekthi yocwaningo yokuhlola ama-activator e-telomerase. Kwatholakala ukuthii-cycloastraganolingavuselela umsebenzi we-telomerase futhi ibangele ukwanda kwe-telomere. Lokhu kutholwa kukhuthaze ngenkuthalo ukuthuthukiswa kweziqalisi ze-telomerase. Inqubekela phambili yocwaningo kanye nokuthuthukiswa komkhiqizo ohlobene we-astragalus alcohol. I-Cycloastragenol (CAG) okwamanje iyona kuphela isiqalisi se-telomerase esibikiwe phakathi kwemikhiqizo yemvelo. Ingalwa ngempumelelo nokufinyezwa kwe-telomere futhi ine-anti-aging, anti-apoptosis, anti-fibrosis, i-immune regulation, ikhuthaza ukwanda kwamaseli kanye nokuphulukiswa kwamanxeba, njll. Imiphumela yezokwelapha, ngaleyo ndlela ibe nemiphumela engaba khona yokwelapha ezifweni ezihlobene nokungasebenzi kahle kwe-telomere.

I-cycloastragenol kanye nokuguga

ama-telomere
Ama-Telomere ayizakhiwo ezikhethekile ekugcineni kwama-chromosome ezivikela ama-chromosome futhi zifinyeze ngokuphindaphinda kwama-chromosome kanye nokuhlukaniswa kwamaseli. Amaseli nawo ayaguga njengoba ama-telomere efinyeza.

i-telomerase
I-Telomerase ingahlanganisa ama-telomere ukuze izinzise ubude nesakhiwo sama-telomere, ngaleyo ndlela ivikele ama-chromosome futhi ilibazise ukuguga kwamangqamuzana.

I-Anti-aging: I-activator ye-telomerase, edlala umphumela wokulwa nokuguga ngokwandisa i-telomerase ngaleyo ndlela ibambezele ukufinyezwa kwama-telomere.

Ama-Telomere ayizimbobo ezitholakala emaphethelweni ama-chromosome eseli eziwavikela ekulimaleni ngesikhathi sokuhlukana kwamaseli. Njengoba amaseli eqhubeka nokuhlukana, ama-telomere ayaqhubeka nokufinyela, afinyelele iphuzu elibalulekile lapho amaseli ezoguga noma afe. ​​I-Telomerase ingandisa ubude bama-telomere, futhi isikhathi sokuphila kwamaseli sizokhula ngokwemvelo ngokufanele.

Ukuguga kuyingxenye engenakugwenywa yokuphila; nokho, abacwaningi bafunda izindlela ezahlukene zokwelapha ukuze bazame ukugwema eminye yemiphumela yokuguga, okuhlanganisa nokufunda ngama-senolytics. Ama-senolytics ayizakhi eziqeda amangqamuzana agugile (aguga) futhi aboniswe ukuthi anciphisa imiphumela yokuguga. Ucwaningo olusha lusikisela ukuthi i-cycloastraganol inemiphumela yokulwa nokuguga.

Lolu cwaningo, oluvela eShayina futhi lwanyatheliswa kuyi-International Journal of Molecular Sciences, lugxile emangqamuzaneni abantu asebekhulile kanye namagundane anokukhula okubangelwa imisebe. I-Cycloastragenol yehlisa amangqamuzane asebekhulile ngaphandle kokuthinta amangqamuzane angewona asebekhulile. Ukwelashwa nge-Cycloastragenol kunciphisa namaprotheni kumangqamuzane asebekhulile adingekayo ekukhuleni nasekusindeni kwamangqamuzana. Ngaphezu kwalokho, kuvimbela ukunyakaza kwamangqamuzana okuhambisana namangqamuzana okuvuvukala ahlobene nokuguga kanye nezinqubo. Amagundane asebekhulile aphathwe nge-cycloastraganol atholakale enamangqamuzana ambalwa asebekhulile kanye nokukhubazeka komzimba okuhlobene nokuguga okuthuthukisiwe.

I-cycloastragenol yehlisa amaseli avuthiwe

Ukuguga kuyisici esaziwayo sokuguga, kodwa abacwaningi bathole ukuthi ukususa amangqamuzana avuthiwe kanye nama-molecule awo okubonisa ukuvuvukala kungasiza ekuvimbeleni izifo ezihlobene nokuguga ngisho nokuziguqula kwezinye izimo. Lapha, abacwaningi baphathe amangqamuzana abantu nge-cycloastraganol futhi bathola ukuthi iwaqeda ngempumelelo amangqamuzana avuthiwe ngaphandle kokuthinta amangqamuzana angewona avuthiwe. Ngaphezu kwalokho, izimpawu zamaseli amangqamuzana avuthiwe zancipha kakhulu ngemva kokwelashwa nge-cycloastraganol.

Ucwaningo lwangaphambilini lukhombisile ukuthi indlela ye-PI3K/AKT/mTOR—indlela yokubonisa ehilelekile ekukhuleni nasekusindeni kwamaseli—ihilelekile ezinqubweni zokuvuvukala eziqalwa amaseli asebekhulile, okusiza ekukhuthazeni ukuguga kumaseli azungezile. Abacwaningi bathole ukuthi i-cycloastragenol isize ekunciphiseni amaprotheni kule ndlela, okuphakamisa ukuthi inhlanganisela ingasebenza ngokuvimba indlela ye-PI3K/AKT/mTOR ukusiza ekuvimbeleni ukuguga. Ngaphezu kwalokho, i-cycloastragenol iboniswe ukuthi inciphisa ikhono lamaseli asebekhulile lokukhuthaza ukuguga ngokukhishwa kwama-molecule okuvuvukala, izici zokukhula, kanye nama-immunomodulators, okuhambisana neziphakamiso zokuthi ukunciphisa i-PI3K, i-AKT, kanye ne-mTOR signaling kunganciphisa imiphumela ekhuthaza ukuguga phakathi kwamaseli azungezile.

I-Cycloastragenol ingeyama-saponins e-triterpene futhi itholakala kakhulu ekugayweni kwe-astragaloside IV. Inesisindo esincane sama-molecule kanye ne-lipophilicity eqinile, okuzuzisa ukungena kwe-biofilm kanye nokumuncwa kwamathumbu ukuze kutholakale ukutholakala okungcono kwe-bioavailability. Ukusebenza kahle kwe-cycloastragalinol
1. Ukwelashwa kokulimala kobuchopho
2. Thuthukisa i-fibrosis yesibindi
3. Ukwelashwa kwe-osteoporosis
4. Umphumela wokulwa nokuguga
5. Ukulibazisa ukuguga kwamaseli

Kungani kudingeka ukwenziwa kwe-cycloastraganol?

① I-Cycloastraganol inemiphumela ehlukahlukene yezokwelapha njengokuvimbela i-apoptosis yamaseli obuchopho kanye nokuvuvukala kwe-neuroinflammation ngesikhathi sokuntuleka kwegazi ebuchosheni kanye nokugcina isithiyo segazi nobuchopho.
② I-cycloastragenol iyona kuphela i-molecule encane equkethe i-terpenoid compound enomsebenzi we-telomerase otholakale kuze kube manje futhi engelapha izifo eziwohlokayo zemizwa.
③ Inemiphumela yokuvimbela i-fibrosis ye-myocardial kanye nokuthuthukisa amasosha omzimba alwa nomdlavuza. Iyi-molecule ethandwayo ocwaningweni nasekuthuthukisweni kwemithi yokulwa nokuguga.

Izinkinga ezikhona

Okuqukethwe kwe-cycloastraganol ku-Astragalus membranaceus kuphansi kakhulu futhi kunzima ukukuthola ngqo. Isu lokukhiqiza i-cycloastraganol elikhona lincike ekukhishweni kwemithi yendabuko yaseShayina, okutholakala kakhulu ngokuguqula i-astragaloside IV ku-Astragalus membranaceus. Okusho ukuthi, i-astragaloside IV itholakala ngobuchwepheshe bokutshala i-astragalus kanye nokukhulisa izicubu, bese i-astragaloside IV iguqulwa ibe yi-cycloastragaloside kusetshenziswa i-acidolysis, i-Smith degradation, i-enzyme kanye ne-microbial hydrolysis. Kodwa-ke, lezi zindlela zokulungiselela ziyabiza, kulula ukubangela ukungcola kwemvelo, kunzima ukuzihlukanisa nokuzihlanza, futhi azivumeli ukusetshenziswa nokukhuthazwa. Ngakho-ke, abantu baphendukele ekuhlanganisweni kokwenziwa kwe-cycloastraganol.

Ungayisebenzisa kanjani i-synthetic biology ukuze uhlanganise? ---Synthetic Biology

I-Synthetic Biology ibhekisela ekwakhiweni okuqondiwe, ekuguqulweni, ngisho nasekudalweni "kokuphila okwenziwayo" ngemisebenzi engeyona eyemvelo ngaphansi kwesiqondiso semibono yobunjiniyela, okungukuthi, ubunjiniyela bebhayoloji. Ngokuvamile, ikhiqizwa kusetshenziswa izindlela zebhayoloji.