Uyini umehluko phakathi kwe-spermidine trihydrochloride kanye ne-spermidine? Zikhishwa kuphi?

I-Spermidine trihydrochloridekanye ne-spermidine kuyizinhlanganisela ezimbili ezihlobene, nakuba zifana ngesakhiwo, zinomehluko othile ezimpahleni zazo, ukusetshenziswa kwazo, kanye nemithombo yokukhipha.

I-Spermidine iyi-polyamine eyenzeka ngokwemvelo etholakala kakhulu ezintweni eziphilayo, ikakhulukazi edlala indima ebalulekile ekwandeni nasekukhuleni kwamaseli. Isakhiwo sayo sama-molecule siqukethe amaqembu amaningi ama-amino nama-imino futhi sinomsebenzi oqinile wezinto eziphilayo. Izinguquko zokuhlushwa kwe-spermidine emaseli zihlobene eduze nezinqubo ezahlukahlukene zomzimba, okuhlanganisa ukwanda kwamaseli, ukuhlukanisa, i-apoptosis kanye ne-anti-oxidation. Imithombo eyinhloko ye-spermidine ifaka izitshalo, izilwane kanye nezinambuzane ezincane, ikakhulukazi ekudleni okubilisiwe, ubhontshisi, amantongomane kanye neminye imifino.

I-Spermidine trihydrochloride iwuhlobo lukasawoti lwe-spermidine, oluvame ukutholakala ngokuxuba i-spermidine ne-hydrochloric acid. Uma kuqhathaniswa ne-spermidine, i-spermidine trihydrochloride inokuncibilika okuphezulu emanzini, okwenza kube nenzuzo kakhulu kwezinye izinhlelo zokusebenza. I-Spermidine trihydrochloride ivame ukusetshenziswa ocwaningweni lwezinto eziphilayo kanye nasembonini yemithi njengesithasiselo ekukhuleni kwamaseli kanye nokuhlolwa kwezinto eziphilayo. Ngenxa yokuncibilika kwayo okuhle, i-spermidine trihydrochloride isetshenziswa kabanzi emithonjeni yokukhulisa amaseli ukukhuthaza ukukhula nokwanda kwamaseli.

Ngokuphathelene nokukhipha, i-spermidine ivame ukutholakala ngokukhipha emithonjeni yemvelo, njengokukhipha izingxenye ze-polyamine ezitshalweni. Izindlela ezivamile zokukhipha zifaka phakathi ukukhipha amanzi, ukukhipha utshwala kanye nokukhipha nge-ultrasonic. Lezi zindlela zingahlukanisa ngempumelelo i-spermidine ezintweni zokusetshenziswa futhi ziyihlanze.

Ukukhishwa kwe-spermidine trihydrochloride kulula kakhulu futhi kuvame ukutholakala ngokwenziwa kwamakhemikhali ngaphansi kwezimo zelebhu. I-Spermidine trihydrochloride ingatholakala ngokuphendula i-spermidine ne-hydrochloric acid. Le ndlela yokwenziwa ayigcini nje ngokuqinisekisa ubumsulwa bomkhiqizo, kodwa futhi ivumela ukuhlushwa kwawo kanye nefomula ukuthi kulungiswe njengoba kudingeka.

Ngokuphathelene nokusetshenziswa, kokubili i-spermidine kanye ne-spermidine trihydrochloride zisetshenziswa kabanzi ocwaningweni lwezokwelapha. I-Spermidine ivame ukungezwa emikhiqizweni yezempilo kanye nezithasiselo zokudla ukuze isize ekuthuthukiseni ukusebenza kwamaseli futhi yehlise ijubane lenqubo yokuguga ngenxa yendima yayo ekwandeni kwamaseli kanye nokulwa nokuguga. I-Spermidine trihydrochloride ivame ukusetshenziswa ekuthuthukisweni kwamaseli kanye nasekuhlolweni kwezinto eziphilayo njengomgqugquzeli wokukhula kwamaseli ngenxa yokuncibilika kwayo okuhle kakhulu.

Ngokuvamile, kunomehluko othile phakathi kwe-spermidine ne-spermidine trihydrochloride ngesakhiwo kanye nezakhiwo. I-Spermidine iyi-polyamine eyenzeka ngokwemvelo, ekhishwa kakhulu ezitshalweni nasezicutshini zezilwane, kuyilapho i-spermidine trihydrochloride iwuhlobo lwayo lukasawoti, oluvame ukutholakala ngokwenziwa kwamakhemikhali. Zombili zinenani elibalulekile ocwaningweni lwezokwelapha kanye nokusetshenziswa kwazo. Ngokujula kocwaningo lwesayensi, amasimu azo okusetshenziswa azoqhubeka nokukhula, anikeze amathuba engeziwe ocwaningo lwezempilo nolwezokwelapha.