Odinga ukukwazi mayelana nokuguga nokuthi yiziphi izindlela ongazithatha ukuze ubambezele

Njengoba abantu bekhula, abaningi bafuna izindlela zokunciphisa inqubo nokugcina ukubukeka kobusha nobungqabavu. Kunezinhlobonhlobo zamasu namasu angasetshenziswa ukusiza ukubambezela inqubo yokuguga nokukhuthaza impilo yonke kanye nokuphila kahle.

Ucwaningo lwakamuva lubonisa ukuthi ukuguga akwenzeki kancane kancane, kodwa futhi kuqubuka esikhathini esithile esiphakathi kweminyaka engama-44 nengama-60.

Ekuqaleni kweminyaka engu-40, i-lipid ne-alcohol metabolism iyashintsha, kuyilapho ukusebenza kwezinso zakho, i-carbohydrate metabolism, nokulawulwa kokuzivikela komzimba kuqala ukwehla lapho usuneminyaka engama-60. Abacwaningi baphinde baqaphela izinguquko eziphawulekayo esikhumbeni, emisipha kanye nesifo senhliziyo phakathi kweminyaka engu-40 no-60. endala.

Ucwaningo lwaluhlanganisa kuphela abantu baseCalifornia abangu-108 abaneminyaka engu-25 kuya ku-75, futhi ucwaningo olwengeziwe luyadingeka ukuze kuqinisekiswe okutholakele. Kodwa-ke, lokhu okutholakele kungase kuholele ekuhlolweni okusha kokuxilonga kanye namasu okuvimbela izifo ezihlobene nokuguga.

Ukuphila isikhathi eside akusho ukuthi ukuphila kwabadala okunempilo noma okusebenzayo. Ngokusho kombhali omkhulu walolu cwaningo uDkt. Michael Snyder, umqondisi weCentre for Genomics and Personalized Medicine eStanford University, kubantu abaningi, isilinganiso sabo "sezempilo" - isikhathi abasichitha benempilo enhle - side kunesikhathi sabo sokuphila sifushane. Iminyaka engu-11-15.

I-Midlife ibalulekile ekugugeni okunempilo

Ucwaningo lwangaphambilini lubonise ukuthi impilo yakho phakathi nokuphila (imvamisa phakathi kweminyaka engama-40 nengama-65) idlala indima ebalulekile empilweni yakho kamuva ekuphileni. Ucwaningo lwango-2018 ephephabhukwini I-Nutrition luxhumanise izici ezithile zendlela yokuphila phakathi nesikhathi esiphakathi, njengesisindo esinempilo, ukuvivinya umzimba, ukudla ukudla okunempilo nokungabhemi, nokwenza ngcono impilo ngesikhathi sokuguga. 2

Umbiko oshicilelwe kujenali 2020 uphinde wakhombisa ukuthi i-midlife iyinkathi ebalulekile yoshintsho empilweni yobuchopho. Ukulawula umfutho wegazi kanye nokuhlala emphakathini, engqondweni nangokomzimba kulesi sigaba sokuphila kungasiza ekunciphiseni ingozi yokuwohloka komqondo kamuva ekuphileni, kusho umbiko.

Ucwaningo olusha lwengeza emkhakheni wocwaningo lwezempilo futhi lugqamisa ukubaluleka kokuthuthukisa imikhuba ethile yokuphila kusenesikhathi.

"Ukuthi unempilo kangakanani lapho uneminyaka engama-60, 70 noma 80 kuncike ngempela kulokho okwenzile emashumini eminyaka ngaphambi kwakho," kusho uKenneth Boockvar, MD, umqondisi weSikhungo Sokucwaninga Okudidiyelwe Ngokuguga eNyuvesi yase-Alabama. E-Birmingham. ” kodwa akazange ahileleke kulolu cwaningo.

Wengeze ngokuthi kusesekuseni kakhulu ukwenza izincomo ezithize ezisuselwe ocwaningweni olusha, kodwa ukuthi abantu abafuna ukuhlala bephilile abaseminyakeni yama-60 kufanele baqale ukunaka indlela abadla ngayo nendlela yokuphila lapho beneminyaka engu-40 no-50.

Ukuguga akunakugwenywa, kodwa ukuguqulwa kwendlela yokuphila kunganweba impilo enempilo

Ucwaningo olusha luthola ukuthi ama-molecule nama-microorganisms ahlotshaniswa nokuguga ayancipha phakathi nezigaba ezithile zomjikelezo wokuphila, kodwa ucwaningo lwesikhathi esizayo luyadingeka ukuze kutholwe ukuthi ingabe izinguquko ezifanayo zamangqamuzana zenzeka kubantu abahlukahlukene.

"Sifuna ukuhlaziya abantu abaningi ezweni lonke ukuze sibone ukuthi lokho esikubonile kusebenza kuwo wonke umuntu - hhayi nje abantu base-Bay Area," kusho uSnyder. "Sifuna ukuhlaziya umehluko phakathi kwabesilisa nabesifazane. Abesifazane baphila isikhathi eside futhi sifuna ukuqonda ukuthi kungani."

Ukuguga akunakugwenywa, kodwa izinguquko ezithile endleleni yokuphila zingasiza ekunciphiseni ingozi yezifo ezihlobene nokuguga. Kodwa-ke, ezinye izici eziningi ezifana nemvelo, ukuzinza kwezezimali, ukunakekelwa kwezempilo kanye namathuba emfundo nakho kunomthelela emiphumeleni yokuguga enempilo futhi kunzima ukuthi umuntu ngamunye akwazi ukulawula.

Abantu bangenza izinguquko ezincane zokuphila ezifana nokuhlala be-hydrated ukuze balondoloze impilo yezinso, ukwakha imisipha ngokuqeqeshwa kwesisindo nokuthatha imithi ye-cholesterol uma i-LDL cholesterol iphakanyisiwe, kusho uSnyder.

Wanezela: “Lokhu kungase kungakuyeki ukuguga, kodwa kuzonciphisa izinkinga esizibonayo futhi kusize ekwandiseni ukuphila kwabantu okunempilo.”

Yini engenziwa ukuze kubambezeleke ukuguga?

Esinye sezici ezibaluleke kakhulu ekunciphiseni ukuguga ukugcina indlela yokuphila enempilo. Lokhu kuhlanganisa ukudla ukudla okulinganiselayo okucebile izithelo, imifino, okusanhlamvu okuphelele kanye namaprotheni angenalutho. Ukugwema ukudla okugayiwe, ushukela oweqile, namafutha angenampilo kungasiza ekunciphiseni ukuvuvukala emzimbeni futhi kusekele impilo yonke. Ukuhlala unamanzi amaningi ngokuphuza amanzi amaningi nakho kubalulekile ekugcineni isikhumba nezitho zomzimba ezinempilo.

Ukuvivinya umzimba njalo kungenye ingxenye ebalulekile yendlela yokuphila enempilo futhi kungasiza ekubambezeleni inqubo yokuguga. Umsebenzi womzimba usiza ukuthuthukisa impilo yenhliziyo nemithambo yegazi, ugcine isisindo semisipha, futhi usekele ukuhamba nokuvumelana nezimo kukonke. Ukubamba iqhaza emisebenzini efana nokuhamba, ukubhukuda, i-yoga noma ukuqeqeshwa kwamandla kungasiza umzimba wakho ubukeke umncane futhi unamandla.

Ngaphezu kokudla nokuzivocavoca, ukulawula ukucindezeleka kubalulekile ekubambezeleni ukuguga. Ukucindezeleka okungapheli kungase kube nemiphumela emibi emzimbeni, okuholela ekwandeni kokuvuvukala kanye nesimiso somzimba sokuzivikela esibuthakathaka. Ukuzijwayeza amasu okunciphisa ukucindezeleka njengokuzindla, ukuphefumula okujulile, noma ukucabangela kungasiza ukukhuthaza ukuphumula kanye nokuphila kahle okuphelele.

Esinye isici esibalulekile sokunciphisa ukuguga ukulala ngokwanele. Ukulala kubalulekile ukuze umzimba ulungiswe futhi uvuselelwe, futhi ukungalali kahle kungaholela ekugugeni ngaphambi kwesikhathi. Ukumisa ishejuli yokulala evamile nokudala isikhathi sokulala esiphumuzayo kungasiza ukuthuthukisa ikhwalithi yokulala futhi kusekele impilo yonke.

Ngaphezu kwezici zendlela yokuphila, kunezindlela ezihlukahlukene zokwelapha ezingasiza ekubambezeleni inqubo yokuguga. Lokhu kungase kuhlanganise ukunakekelwa kwesikhumba, izinqubo zezimonyo, nokungenelela kwezokwelapha. Ukusebenzisa i-sunscreen kanye nokuthambisa isikhumba sakho kungasiza ekuvimbeleni ukulimala kwelanga nokugcina ukubukeka kobusha. Izinqubo zezimonyo ezifana ne-Botox, izigcwalisi, nokwelashwa nge-laser nakho kungasiza ekunciphiseni ukubukeka kwemibimbi nemigqa emihle.

Ukwengeza, kunezithako ezithile zokulwa nokuguga ezitholakalayo ezingase zisekele impilo yonke nobungqabavu. Phakathi kwezithako ezinobufakazi besayensi obuningi bokusekela indima yazo ekuthuthukiseni impilo ye-mitochondrial kanye nokunciphisa ukuguga kukhona izandulela ze-NAD+ kanye ne-urolithin A.

Izithako ze-NAD+

Lapho kune-mitochondria, kune-NAD+ (nicotinamide adenine dinucleotide), i-molecule edingekayo ukuze kukhuliswe ukukhiqizwa kwamandla. I-NAD+ ngokwemvelo yehla ngokukhula, okubonakala kuhambisana nokwehla okuhlobene nobudala emsebenzini we-mitochondrial.

Ucwaningo lukhombisa ukuthi ngokukhulisa i-NAD+, ungathuthukisa ukukhiqizwa kwamandla e-mitochondrial futhi uvimbele ingcindezi ehlobene neminyaka. I-NAD+ precursor supplements ingase ithuthukise ukusebenza kwemisipha, impilo yobuchopho, kanye ne-metabolism ngenkathi ilwa nezifo ze-neurodeergenerative. Ukwengeza, banciphisa ukuzuza kwesisindo, bathuthukise ukuzwela kwe-insulin, futhi benze amazinga e-lipid abejwayelekile, njengokwehlisa i-cholesterol ye-LDL.

I-Coenzyme Q10

Njenge-NAD+, i-coenzyme Q10 (CoQ10) idlala indima eqondile nebalulekile ekukhiqizeni amandla e-mitochondrial. Njenge-astaxanthin, i-CoQ10 yehlisa ukucindezelwa kwe-oxidative, i-byproduct yokukhiqizwa kwamandla e-mitochondrial okuba kubi kakhulu lapho i-mitochondria ingenampilo. Ukwengeza nge-CoQ10 kunciphisa ingozi yokuhlaselwa yinhliziyo, unhlangothi nokufa. Uma kucatshangelwa ukuthi i-CoQ10 yehla ngenxa yobudala, ukugcwalisa nge-CoQ10 kungase kunikeze izinzuzo zokuphila isikhathi eside kubantu abadala.

Urolithin A

I-Urolithin A (UA) ikhiqizwa amagciwane ethu amathumbu ngemva kokudla ama-polyphenols atholakala ekudleni okunjengamahalananda, ama-strawberry, nama-walnuts. Ukwengezwa kwe-UA kumagundane aneminyaka ephakathi kwenza ama-sirtuin asebenze futhi kukhulisa i-NAD+ namazinga wamandla eselula. Okubalulekile, i-UA ikhonjiswe ukuthi isusa i-mitochondria eyonakele emisipheni yomuntu, ngaleyo ndlela ithuthukisa amandla, ukumelana nokukhathala, nokusebenza kwezemidlalo. Ngakho-ke, ukwesekwa kwe-UA kungase kwandise isikhathi sokuphila ngokuphikisana nokuguga kwemisipha.

I-Spermidine

Njenge-NAD+ ne-CoQ10, i-spermidine iyi-molecule eyenzeka ngokwemvelo eyehla ngokuya ngeminyaka. Ngokufanayo ne-UA, i-spermidine ikhiqizwa amagciwane ethu amathumbu futhi ibangele i-mitophagy - ukususwa kwe-mitochondria engenampilo, eyonakele. Ucwaningo lwamagundane lubonisa ukuthi ukwesekwa kwe-spermidine kungavikela isifo senhliziyo nokuguga kokuzala kwabesifazane. Ukwengeza, i-spermidine yokudla (etholakala ekudleni okuhlukahlukene okuhlanganisa i-soy nezinhlamvu) ithuthukise inkumbulo kumagundane. Kudingeka ucwaningo olwengeziwe ukuze kutholwe ukuthi lokhu okutholakele kungenziwa yini kubantu.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngempushana ye-urolithin A yekhwalithi ephezulu nehlanzekile.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani angcono kakhulu. I-Urolithin A yethu powder ihlolwe ngokuqinile ukuhlanzeka namandla, iqinisekisa ukuthi uthola isengezo sekhwalithi ephezulu ongayethemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yeselula, ukuqinisa amasosha akho omzimba noma ukuthuthukisa impilo yonke, i-Urolithin A powder yethu iyisinqumo esihle kakhulu.

Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, i-Suzhou Myland Pharm isungule uhide lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izindawo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kuma-milligrams kuye kumathani esikalini, futhi ithobelane namazinga e-ISO 9001 kanye nokucaciswa kokukhiqiza kwe-GMP.