Okudingeka ukwazi ngokuguga nokuthi yiziphi izindlela ongazithatha ukuze unciphise ijubane lakho

Njengoba abantu bekhula, abaningi bafuna izindlela zokunciphisa ijubane lenqubo nokugcina ukubukeka kobusha kanye namandla. Kunezindlela ezahlukahlukene namasu angasetshenziswa ukusiza ekunciphiseni inqubo yokuguga nokukhuthaza impilo kanye nenhlalakahle iyonke.

Ucwaningo lwakamuva lubonisa ukuthi ukuguga akwenzeki kancane kancane, kodwa futhi kuqubuka esikhathini esithile phakathi kweminyaka engu-44 no-60.

Kusukela ekuqaleni kweminyaka yakho engama-40, i-lipid kanye ne-alcohol metabolism yakho iyashintsha, kuyilapho ukusebenza kwezinso zakho, i-carbohydrate kanye ne-immune system yakho kuqala ukwehla cishe eminyakeni engama-60. Abacwaningi baphinde baphawula izinguquko ezibalulekile engozini yesikhumba, imisipha kanye nesifo senhliziyo phakathi kweminyaka engama-40 nengama-60 ubudala.

Lolu cwaningo luhlanganise abantu baseCalifornia abayi-108 kuphela abaneminyaka ephakathi kuka-25 no-75, futhi kudingeka ucwaningo olwengeziwe ukuqinisekisa okutholakele. Kodwa-ke, lokhu okutholakele kungaholela ekuhlolweni okusha kokuxilonga kanye namasu okuvimbela izifo ezihlobene nokuguga.

Ukuphila isikhathi eside akusho ukuthi umuntu usekhulile futhi unempilo noma umatasa. Ngokusho kombhali omkhulu walolu cwaningo uDkt. Michael Snyder, umqondisi we-Center for Genomics and Personalized Medicine eStanford University, kubantu abaningi, isilinganiso sabo "sempilo" - isikhathi abasichitha benempilo enhle - side kunesikhathi sabo sokuphila esifushane seminyaka eyi-11-15.

Ubudala obuphakathi bubalulekile ekugugeni okunempilo

Ucwaningo lwangaphambilini lukhombisile ukuthi impilo yakho phakathi neminyaka yobudala (ngokuvamile ephakathi kweminyaka engama-40 no-65) idlala indima ebalulekile empilweni yakho kamuva ekuphileni. Ucwaningo lwango-2018 kumagazini i-Nutrition luxhumanise izici ezithile zendlela yokuphila phakathi kweminyaka yobudala, njengesisindo esinempilo, ukusebenza ngokomzimba, ukudla ukudla okuhle nokungabhemi, nokuthuthukisa impilo ngesikhathi sokuguga. 2

Umbiko owanyatheliswa kuyi-journal ka-2020 uphinde wabonisa ukuthi isikhathi sokuphila esiphakathi nesikhathi esibalulekile sokuguquka empilweni yobuchopho. Ukulawula umfutho wegazi nokuhlala usebenza emphakathini, engqondweni nangokomzimba phakathi nalesi sigaba sokuphila kungasiza ekunciphiseni ingozi ye-dementia kamuva ekuphileni, kusho umbiko.

Lolu cwaningo olusha lunezela emkhakheni wocwaningo lwe-healthspan futhi luqokomisa ukubaluleka kokuthuthukisa imikhuba ethile yokuphila kwasekuqaleni.

"Ukuthi uphilile kangakanani uma uneminyaka engu-60, 70 noma 80 kuncike kulokho okwenzile emashumini eminyaka ngaphambi kwakho," kusho uKenneth Boockvar, MD, umqondisi we-Center for Integrated Research on Aging e-University of Alabama eBirmingham.

Wanezela ngokuthi kusenesikhathi kakhulu ukwenza izincomo ezithile ngokusekelwe ocwaningweni olusha, kodwa ukuthi abantu abafuna ukuhlala bephilile eminyakeni yabo engama-60 kufanele baqale ukunaka ukudla kwabo nendlela yabo yokuphila eminyakeni yabo engama-40 nama-50.

Ukuguga akunakugwenywa, kodwa izinguquko zendlela yokuphila zingandisa isikhathi sokuphila esinempilo

Ucwaningo olusha luthola ukuthi ama-molecule nama-microorganisms ahlobene nokuguga ayancipha phakathi nezigaba ezithile zomjikelezo wokuphila, kodwa ucwaningo lwesikhathi esizayo luyadingeka ukuze kutholakale ukuthi izinguquko ezifanayo zama-molecule zenzeka yini ezinhlotsheni ezahlukene zabantu.

"Sifuna ukuhlaziya abantu abaningi ezweni lonke ukuze sibone ukuthi okubonile kuyasebenza yini kuwo wonke umuntu - hhayi kubantu baseBay Area kuphela," kusho uSnyder. "Sifuna ukuhlaziya umehluko phakathi kwabesilisa nabesifazane. Abesifazane baphila isikhathi eside futhi sifuna ukuqonda ukuthi kungani."

Ukuguga akunakugwenywa, kodwa izinguquko ezithile zendlela yokuphila zingasiza ekunciphiseni ingozi yezifo ezihlobene nokuguga. Kodwa-ke, ezinye izinto eziningi ezifana nendawo ezungezile, ukuzinza kwezezimali, ukunakekelwa kwempilo kanye namathuba emfundo nazo zithonya imiphumela yokuguga enempilo futhi kunzima ngabantu ukuzilawula.

Abantu bangenza izinguquko ezincane endleleni yokuphila njengokuhlala benamanzi ukuze balondoloze impilo yezinso, ukwakha imisipha ngokuqeqeshwa kwesisindo kanye nokuthatha imithi ye-cholesterol uma i-cholesterol ye-LDL iphakeme, kusho uSnyder.

Wanezela: "Lokhu kungase kungayekisi ukuguga, kodwa kuzonciphisa izinkinga esizibonayo futhi kusize ekwandiseni impilo yabantu enempilo."

Yini engenziwa ukuze kubambezeleke ukuguga?

Esinye sezici ezibaluleke kakhulu ekunciphiseni ukuguga ukugcina indlela yokuphila enempilo. Lokhu kuhlanganisa nokudla ukudla okunempilo okucebile ngezithelo, imifino, okusanhlamvu okuphelele kanye namaprotheni angenawo amafutha amaningi. Ukugwema ukudla okucutshungulwe, ushukela omningi, namafutha angenampilo kungasiza ekunciphiseni ukuvuvukala emzimbeni futhi kusekele impilo iyonke. Ukuhlala unamanzi ngokuphuza amanzi amaningi nakho kubalulekile ekugcineni isikhumba nezitho zomzimba ziphilile.

Ukuzivocavoca njalo kungenye ingxenye ebalulekile yendlela yokuphila enempilo futhi kungasiza ekunciphiseni inqubo yokuguga. Ukuzivocavoca umzimba kusiza ekuthuthukiseni impilo yenhliziyo nemithambo yegazi, ukugcina imisipha, nokusekela ukuhamba nokuguquguquka okuphelele. Ukuhlanganyela emisebenzini efana nokuhamba, ukubhukuda, i-yoga noma ukuqeqeshwa kwamandla kungasiza umzimba wakho ubukeke umusha futhi unamandla kakhudlwana.

Ngaphezu kokudla nokuzivocavoca, ukulawula ukucindezeleka kubalulekile ekunciphiseni ukuguga. Ukucindezeleka okungapheli kungaba nemiphumela emibi emzimbeni, okuholela ekuvuvukeni okukhulu kanye nokukhubazeka kwesistimu yomzimba yokuzivikela. Ukuzijwayeza amasu okunciphisa ukucindezeleka njengokuzindla, ukuphefumula okujulile, noma ukuqaphela kungasiza ekukhuthazeni ukuphumula kanye nenhlalakahle iyonke.

Esinye isici esibalulekile sokunciphisa ukuguga ukulala ngokwanele. Ukulala kubalulekile ekulungisweni nasekuvuseleleni umzimba, futhi ukuntuleka kokulala okuhle kungaholela ekugugeni ngaphambi kwesikhathi. Ukusungula isimiso sokulala esivamile nokudala isikhathi sokulala esiphumuzayo kungasiza ekuthuthukiseni ikhwalithi yokulala nokusekela impilo iyonke.

Ngaphezu kwezici zendlela yokuphila, kunezindlela zokwelapha ezahlukahlukene ezingasiza ekunciphiseni inqubo yokuguga. Lokhu kungafaka phakathi izindlela zokunakekela isikhumba, izinqubo zobuhle, kanye nokungenelela kwezokwelapha. Ukusebenzisa i-sunscreen kanye nokuthambisa isikhumba sakho kungasiza ekuvimbeleni ukulimala kwelanga nokugcina ukubukeka kwentsha. Izinqubo zobuhle ezifana ne-Botox, ama-filler, kanye nokwelashwa nge-laser nazo zingasiza ekunciphiseni ukubonakala kwemibimbi kanye nemigqa emincane.

Ngaphezu kwalokho, kunezithako ezithile zokulwa nokuguga ezitholakalayo ezingasekela impilo kanye namandla aphelele. Phakathi kwezithako ezinobufakazi besayensi obusekela indima yazo ekuthuthukiseni impilo ye-mitochondrial kanye nokunciphisa ukuguga kukhona izandulela ze-NAD+ kanye ne-urolithin A.

Izithasiselo ze-NAD+

Lapho kukhona i-mitochondria, kukhona i-NAD+ (nicotinamide adenine dinucleotide), i-molecule edingekayo ukuze kwandiswe ukukhiqizwa kwamandla. I-NAD+ iyancipha ngokwemvelo ngokuguga, okubonakala kuhambisana nokwehla kokusebenza kwe-mitochondrial okuhlobene nobudala.

Ucwaningo lubonisa ukuthi ngokukhulisa i-NAD+, ungathuthukisa ukukhiqizwa kwamandla e-mitochondrial futhi uvimbele ukucindezeleka okuhlobene nokuguga. Izithako zangaphambi kwe-NAD+ zingathuthukisa ukusebenza kwemisipha, impilo yobuchopho, kanye nokusetshenziswa kwe-metabolism ngenkathi zilwa nezifo eziwohlokayo. Ngaphezu kwalokho, zinciphisa ukukhuluphala, zithuthukisa ukuzwela kwe-insulin, futhi zijwayele amazinga e-lipid, njengokwehlisa i-cholesterol ye-LDL.

I-Coenzyme Q10

Njenge-NAD+, i-coenzyme Q10 (CoQ10) idlala indima eqondile nebalulekile ekukhiqizweni kwamandla e-mitochondrial. Njenge-astaxanthin, i-CoQ10 inciphisa ukucindezeleka kwe-oxidative, umkhiqizo ophuma ekukhiqizweni kwamandla e-mitochondrial oqhubeka uba mubi uma i-mitochondria ingaphilile. Ukwengeza i-CoQ10 kunciphisa ingozi yokuhlaselwa yinhliziyo, isifo sohlangothi kanye nokufa. Uma ubheka ukuthi i-CoQ10 iyancipha ngokuguga, ukwengeza i-CoQ10 kunganikeza izinzuzo zokuphila isikhathi eside kubantu abadala.

I-Urolithin A

I-Urolithin A (UA) ikhiqizwa yibhaktheriya yethu yamathumbu ngemuva kokudla ama-polyphenol atholakala ekudleni okufana namapomegranate, ama-strawberry, nama-walnuts. Ukwengezwa kwe-UA emagundwini asebekhulile kuvuselela ama-sirtuin futhi kwandisa amazinga e-NAD+ kanye namandla eseli. Okubalulekile, i-UA iboniswe ukuthi isusa i-mitochondria eyonakele emisipheni yabantu, ngaleyo ndlela ithuthukise amandla, ukumelana nokukhathala, kanye nokusebenza kwezemidlalo. Ngakho-ke, ukwengezwa kwe-UA kungandisa isikhathi sokuphila ngokulwa nokuguga kwemisipha.

I-Spermidine

Njenge-NAD+ kanye ne-CoQ10, i-spermidine iyi-molecule eyenzeka ngokwemvelo encipha ngokuguga. Ngokufanayo ne-UA, i-spermidine ikhiqizwa amabhaktheriya ethu esiswini futhi ibangela i-mitophagy - ukususwa kwe-mitochondria engaphili kahle, eyonakele. Izifundo zamagundane zibonisa ukuthi ukwengezwa kwe-spermidine kungavikela ezifweni zenhliziyo kanye nokuguga kokuzala kwabesifazane. Ngaphezu kwalokho, i-spermidine yokudla (etholakala ekudleni okuhlukahlukene okuhlanganisa i-soy kanye nokusanhlamvu) ithuthukise inkumbulo kumagundane. Ucwaningo olwengeziwe luyadingeka ukuze kutholakale ukuthi lokhu okutholakele kungaphindaphindwa yini kubantu.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe yi-FDA ohlinzeka nge-urolithin A powder esezingeni eliphezulu futhi emsulwa.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani amahle kakhulu. Impuphu yethu ye-Urolithin A ihlolwe ngokucophelela ukuhlanzeka kanye namandla, okuqinisekisa ukuthi uthola isithasiselo sekhwalithi ephezulu ongasithemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yamaseli, ukukhulisa amasosha omzimba wakho noma ukuthuthukisa impilo iyonke, impuphu yethu ye-Urolithin A iyisinqumo esifanele.

Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukisiwe kakhulu, i-Suzhou Myland Pharm ithuthukise imikhiqizo ehlukahlukene encintisanayo futhi yaba yinkampani yezinsizakalo zesayensi yokuphila entsha, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.