I-7,8-Dihydroxyflavone (7,8-DHF) iyi-flavonoid eyenzeka ngokwemvelo ebonisa isithembiso ezindaweni ezihlukahlukene zempilo. Uma uthanda izithasiselo zemvelo noma izithako zokudla ezingase zisekele impilo yobuchopho, isimo sengqondo, kanye nempilo enhle iyonke, i-7,8-DHF ingase ifaneleke ukuyihlola. I-7,8-Dihydroxyflavone Powder ehlinzekwe yi-Suzhou Myland inenombolo ye-CAS engu-38183-03-8 kanye nobumsulwa obufika ku-98%. Umkhiqizo uke walawulwa ngekhwalithi eqinile futhi uthobela izindinganiso zamazwe ngamazwe, uqinisekisa ukusebenza kahle nokuphepha komkhiqizo. , ilungele ucwaningo lwesayensi, ukuthuthukiswa kwezidakamizwa, ukukhiqizwa komkhiqizo wokunakekelwa kwezempilo kanye neminye imikhakha, ikunikeza ukukhetha okuthembekile.
7,8-Dihydroxyflavone (7,8-DHF)iyinhlanganisela ye-flavonoid eyivelakancane eyenzeka ngokwemvelo emvelweni. Itholwe ku-Astragalus pumila, Primula grandifolia kanye ne-Hubei crabapple. kuye kwavela njengenhlanganisela ethembisayo ye-nootropic. Ibonise uhla lwemiphumela ye-neuropharmacological ezifundweni zangaphambi komtholampilo,
I-Flavonoids iklasi lama-polyphenolic compounds atholakala ezinhlobonhlobo zezithelo, imifino, neminye imithombo yezitshalo. Eminyakeni yamuva nje, bathole ukunakwa okukhulu ngenxa yezakhiwo zabo ze-antioxidant, anti-inflammatory, kanye ne-neuroprotective.
Lezi zinhlanganisela zikhonjiswe ukuthi zinemiphumela enenzuzo ebuchosheni, okuhlanganisa nokuthuthukisa ukusebenza kwengqondo nokuvimbela izifo ze-neurodegenerative. I-7,8-DHF ingenye yezinhlanganisela ze-polyphenolic ezivelele kakhulu ezithola ukunakwa okukhulayo njenge-nootropic. Icutshungulwe ngemiphumela yayo engaba khona kumizwa, inkumbulo, ukufunda, ukukhathazeka, neminye imisebenzi yokuqonda.
Imiphumela yezinzwa ye-7,8-DHF kucatshangwa ukuthi ixhunyaniswa nokuxhumana kwayo nama-receptors athile. Kutholakale ukuthi i-TrkA, isamukeli esibandakanyeka ekuboniseni isici sokukhula kwezinzwa futhi sibalulekile ekusindeni kwe-neuronal kanye nepulasitiki.
I-7,8-DHF yenza ngokulawula ukuvezwa kwama-receptors ahlukahlukene, kufaka phakathi ama-subunits e-glutamate receptor kanye ne-BDNF. Iphinde ithinte ukwakheka kwe-synapse, i-metabolism yamandla, nokukhululwa kwe-acetylcholine ezindaweni ezithile zobuchopho.
Ngaphezu kwalokho, i-osteoporosis yaziwa ngokuthi "umbulali othule" womzimba womuntu, esongela kakhulu impilo yabantu abaneminyaka ephakathi kanye nasebekhulile, ikakhulukazi abesifazane be-postmenopausal. Ngaphansi kwezimo ezijwayelekile zomzimba, ukuguqulwa kwamathambo kusesimweni esilinganiselwe; kodwa uma kukhona ukungalingani phakathi kokwakheka kwamathambo e-osteoblast-mediated kanye ne-osteoclast-mediated bone resorption, futhi inani lethambo elakhiwe alanele ukwengeza isisindo samathambo esimuncwe, isisindo samathambo sizokwehla. , i-microstructure yezicubu zethambo iyabhujiswa, okubangela ukukhumuzeka kwamathambo.
I-7,8-Dihydroxyflavone (7,8-DHF) i-flavonoid etholakala esitshalweni engakwazi ukulingisa umsebenzi we-brain-derived neurotrophic factor (BDNF), yenza i-dimerization yama-receptors e-TrkB futhi isebenze ama-molecule ayo okusayina phansi. Ucwaningo luye lwabonisa ukuthi i-BDNF ingakhuthaza ukuhlukaniswa kwe-osteoblast nokufuduka futhi isheshise ukuphulukiswa kokuphuka.
I-7,8-DHF ingakhuthaza ukusabalala nokuhlukaniswa kwama-osteoblasts ngokusebenzisana ne-TrkB nokusebenzisa indlela yokubonisa i-Wnt/β-catenin, futhi ingavimbela ukukhiqizwa kwama-osteoclast ngokunciphisa i-transcription factor c-fos; ngaphezu kwalokho, i-7,8-DHF ingathuthukisa i-osteoporosis phenotype kumagundane aphethwe yi-ovariectomized.
Isakhiwo samakhemikhali kanye nezakhiwo ze-7,8-dihydroxyflavone
Iqukethe amaqembu amabili e-hydroxyl eringini ye-benzene kanye neqembu elilodwa le-hydroxyl eringini ye-pyrrolone. Ake sibhekisise ukwakheka kwamakhemikhali kwe-7,8-dihydroxyflavone:
I-molecular formula ye-7,8-DHF ithi C15H10O5, ebonisa ukuthi iqukethe ama-athomu e-carbon ayi-15, ama-athomu e-hydrogen angu-10, nama-athomu omoya-mpilo angu-5.
I-7,8-Dihydroxyflavone iyikristale ephuzi eqinile enesisindo semolekyuli esingu-286.24 g/mol. Incibilika kancane emanzini ngenxa yamaqembu amaningi e-hydroxyl akwazi ukuhlanganisa i-hydrogen nama-molecule amanzi.
7,8-DHF Indlela yokusebenza: Ukulawulwa kwe-BDNF kanye nokusebenza kwe-Trkb receptor
Ngokwendlela yokusebenza, i-7,8-DHF iyaziwa ngokukhuthaza ukukhiqizwa kwe-BDNF (i-brain-derived neurotrophic factor) ngokubophezela futhi isebenze i-TrkB ye-receptor yayo. Ngaphandle kokuthola ubuchwepheshe kakhulu, lokhu kuholela ekulandelaneni kwemisebenzi yeselula enenzuzo ekugcineni ukusebenza kahle kwe-neuronal kanye nokuthuthukisa i-neurogenesis.
Ake sibhekisise indlela enkulu yokusebenza ye-7,8-DHF ngezansi.
I-brain-derived neurotrophic factor (BDNF) kanye nendima yayo ku-neuroplasticity
Ngokuthola ukuthi isisho se-brain-derived neurotrophic factor (BDNF) siyehla ezifweni ze-neurodeergenerative, ikakhulukazi isifo i-Alzheimer's (AD), ukubaluleka kwaso ekugcineni nasekuthuthukiseni impilo yobuchopho kuya ngokuya kucaca. .
I-BDNF ibalulekile emisebenzini ehlukahlukene ye-neuronal njengoba ikhuthaza ukudluliswa kwe-synaptic, i-synaptogenesis, ne-synaptic plasticity ngokusebenzisa ukusayina nama-receptors e-TrkB. Lokhu kwenza indlela yokusayina ye-BDNF-TrkB ibe umgomo othembisayo wokuthuthukiswa kokungenelela kokwelapha okuhloswe ukulwa nezifo ze-neurodeergenerative.
Ucwaningo lwakamuva luhlolisise izinzuzo ezingaba khona ze-molecule encane i-TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) ekwehliseni imiphumela yokuqala ye-pathology ehlobene ne-AD. Ocwaningweni lwemodeli yegundane ye-5xFAD ye-AD, amagundane elashwe nge-7,8-DHF izinyanga ezimbili eqala enyangeni eyodwa ubudala.
Imiphumela yalolu phenyo yembula amandla okwelapha e-7,8-DHF ekubhekaneni nokuguqulwa kwe-neurochemical okuhlobene ne-AD kanye nezimpawu ze-pathological. Ngokuphawulekayo, ukwelashwa kwe-7,8-DHF kuholele ekuncishisweni koqweqwe lwe-cortical Aβ, uphawu olukhulu lwe-AD.
Ngaphezu kwalokho, ivikela ama-cortical neurons ekunciphiseni ubunzima be-dendritic arbor, isiza ekugcineni ukwakheka okuphelele kwe-neuronal. Kodwa-ke, akuzange kuthinte kakhulu ukuminyana komgogodla we-dendritic.
Ngokusho kuka-Aytan, uNurgul nabanye, ukwelashwa kuphinde kwabonisa imiphumela ye-neuroprotective ku-hippocampus, ukuvimbela amazinga aphakeme we-choline-containing compounds kanye nokulahlekelwa kwe-glutamate.
I-Tropomyosin receptor kinase B (Trkb) indlela yokubonisa isamukeli
Ngo-2010, iqembu likaProfessor Ye Keqiang wase-Emory University libike okokuqala ku-Proceedings of the National Academy of Sciences (PNAS) ukuthi i-7,8-DHF ingasetshenziswa njenge-molecule encane ye-agonist ye-tropomyosin receptor kinase B ( I-TrkB), engalingisa Umsebenzi we-neurotrophic factor (BDNF) esuselwa ebuchosheni (BDNF) iqhubekisela phambili isebenze izindlela zokusayina ezansi nomfula we-TrkB, njenge-MAPK/ERK, PI3K/Akt ne-PKC. Ngaphezu kwalokho, izifundo ezalandela zathola ukuthi i-7,8-DHF inganciphisa ukukhuluphala okubangelwa ukudla okunamafutha amaningi kumagundane wesifazane ngokuvula imisipha yamathambo e-TrkB, ebonisa umehluko obalulekile wobulili.
I-brain-derived neurotrophic factor (BDNF) ingakhuthaza ukuhlukaniswa kwe-osteoblast, ukufuduka kanye nokuphulukiswa kokuphuka. I-BDNF iyilungu lomndeni we-neurotrophic factor futhi ilawula izinqubo ezihlukahlukene zebhayoloji ikakhulukazi ngokubophezela ku-transmembrane receptor tyrosine kinase B (TrkB). Noma kunjalo, isignali ye-TrkB eyenziwe yi-BDNF yayinesikhashana ku-10 min futhi yafinyelela phezulu ku-60 min. Nokho, i-BDNF inohhafu wempilo emfushane futhi ayikwazi ukweqa kalula umgoqo wegazi nobuchopho.
I-7,8-dihydroxyflavone (7,8-DHF) iyi-flavonoid ephuma esitshalweni ekwazi ukunqoba imikhawulo engenhla ye-BDNF futhi yabonakala njenge-mimetic ye-BDNF esebenzayo futhi manje isisetshenziswa ezinhlelweni ezihlukahlukene ze-biochemical kanye namaselula Kwaqinisekiswa ukuthi ingakwazi ukuheha i-TrkB dimerization futhi isebenze ama-molecule ayo okusayinda phansi komfula.
I-tropomyosin receptor kinase B (TrkB) receptor idlala indima ebalulekile ekulamuleni imiphumela ye-BDNF kuma-neurons. Njengesamukeli se-transmembrane tyrosine kinase, i-TrkB iyisamukeli esiyinhloko se-BDNF futhi iqala uchungechunge lwezehlakalo zokusayina ze-intracellular lapho zibophezela izici ze-neurotrophic.
I-BDNF yenza i-TrkB isebenze ukuze iqalise izindlela ezimbalwa ezibalulekile ze-intracellular, okuhlanganisa i-phosphatidylinositol 3-kinase (PI3K)-Akt, i-mitogen-activated protein kinase (MAPK) -extracellular signal-regulated kinase (ERK), kanye ne-phospholipase Cγ (PLCγ) -protein kinase ( PKC) indlela. Ngayinye yalezi zindlela inomthelela esicini esihlukile somsebenzi we-neuronal kanye nokuphila kahle.
Indlela ye-PI3K-Akt ibalulekile ekukhuthazeni ukusinda kwe-neuronal kanye nokuvimbela i-apoptosis. Ukusayinda kwe-BDNF-TrkB kwenza le ndlela isebenze ukuze kwandiswe ukusinda kwamangqamuzana ngokuvimbela izici ze-pro-apoptotic kanye nezici ezikhuthazayo eziphikisana ne-apoptotic, ngaleyo ndlela kuqinisekiswe ukulondolozwa kwama-neurons anempilo.
Ngakolunye uhlangothi, indlela ye-MAPK-ERK idlala indima ebalulekile ekuhlukaniseni kwe-neuronal nokwanda. Ukusayinda kwe-BDNF-TrkB kukhuthaza ukwenziwa kusebenze kwendlela ye-MAPK-ERK, yona esekela ukuvuthwa kwe-neuronal nokuhlukaniswa kanye nokuhlanganiswa kwayo kumanethiwekhi akhona e-neuronal.
Indlela ye-PLCγ-PKC ibalulekile ekulawuleni i-synaptic plasticity, inqubo eyisisekelo yokufunda nenkumbulo. Ukusayinda kwe-BDNF-TrkB kulungisa umsebenzi wale ndlela, ekugcineni kuholele ezinguqukweni zamandla e-synaptic nokuxhumana.
Lokhu kuguquguquka kukhuthaza ukujwayela nokuhlelwa kabusha kwamasekhethi e-neural ukuphendula okuhlangenwe nakho okusha kanye nezisusa zemvelo.
Izici ze-Neuroprotective
Ucwaningo lubonisa ukuthi le flavonoid ivikela ama-neurons ekucindezelekeni kwe-oxidative kanye ne-apoptosis (ukufa kweseli okuhleliwe). Ingcindezi ye-oxidative iyisici esibalulekile ezifweni ze-neurodeergenerative njenge-Alzheimer's kanye nesifo sikaParkinson. Ngokukhipha ama-radicals mahhala kanye nokunciphisa ukulimala kwe-oxidative, i-7,8-DHF ingasiza ukuvikela ubuqotho nokusebenza kwe-neuronal.
Ezifundweni zezilwane, i-7,8-DHF iboniswe ukuthuthukisa ukusebenza kwengqondo nenkumbulo. Isibonelo, kumamodeli esifo i-Alzheimer's, i-7,8-DHF ikhonjiswe ukuthi ithuthukisa i-synaptic plasticity, ebaluleke kakhulu ekufundeni nasekukhumbuleni. Indlela yokwenza
Umphumela wokulwa nokuvuvukala
Ngaphezu kwezakhiwo zayo ze-neuroprotective, i-7,8-dihydroxyflavone nayo inemiphumela yokulwa nokuvuvukala. Ukuvuvukala okungapheli kuyisici esivamile sezifo eziningi, kuhlanganise nezifo ze-neurodeergenerative. Ngokulungisa izindlela zokuvuvukala, i-7,8-DHF ingasiza ekunciphiseni ukuvuvukala kwe-neuroinflammation, okuvame ukuhlotshaniswa nokuncipha kwengqondo.
Izakhiwo ze-Antioxidant: Ukukhishwa kwe-ROS kanye ne-lipid peroxidation
I-7,8-DHF inezinto zokulwa ne-antioxidant njengoba kufakazelwa ikhono layo lokuqothula izinhlobo ze-oxygen esebenzayo (ROS) nokunciphisa i-lipid peroxidation. Le miphumela inomthelela emiphumeleni yayo ye-neuroprotective ngokudambisa ukulimala kwe-neuronal okubangelwa i-oxidative kanye nokungasebenzi kahle.
Ucwaningo luye lwabonisa ukuthi i-7,8-DHF ivimbela ukukhiqizwa kwama-cytokines ane-pro-inflammatory futhi inciphisa ukusebenza kwe-microglia, amangqamuzana omzimba omzimba ohlelweni lwezinzwa oluphakathi. Lo mphumela wokulwa nokuvuvukala awugcini nje ngokuvikela ama-neurons kodwa futhi udala indawo ekahle yokusebenza kwengqondo.
Njengoba kunikezwe imiphumela yayo enenzuzo empilweni yobuchopho, i-7,8-dihydroxyflavone inezinhlelo zokusebenza ezingase zibe khona ezindaweni ezihlukahlukene zezempilo nemithi. Ezinye zezinhlelo zokusebenza ezidume kakhulu zifaka:
Ukuqinisa inkumbulo nokubuyiswa
I-7,8-DHF itholwe ithuthukisa ukuqiniswa kwenkumbulo kanye nokutholwa emisebenzini ehlukahlukene yokufunda encike ku-hippocampal nemisebenzi yenkumbulo kumamodeli wamagundane. Lokhu okutholakele kusikisela ukuthi i-7,8-DHF ingaba i-nootropic ethembisayo yokuthuthukisa umsebenzi wenkumbulo kubo bobabili abantu abanempilo kanye nalabo abanokukhubazeka kwenkumbulo.
I-synaptic plasticity: amandla esikhathi eside nokucindezeleka
Njengoba kushiwo ngaphambili, i-7,8-DHF ikhonjiswe ukuthi ishintsha ipulasitiki ye-synaptic ngokuthuthukisa i-LTP nokunciphisa i-LTD ku-hippocampus. Le miphumela kucatshangwa ukuthi ixhunyaniswa amandla ayo okwenza kusebenze ama-receptors e-TrkB futhi kamuva athuthukise indlela yokusayina ye-BDNF.
Lokhu kuguqulwa kwe-synaptic plasticity kunomthelela ekuthuthukisweni komsebenzi wokuqonda obonwa kulandela ukuphathwa kwe-7,8-DHF.
Ukuthuthukiswa kwengqondo
Njengoba kushiwo ngaphambili, i-7,8-DHF ikhombisa amandla okuthuthukisa ukusebenza kwengqondo nenkumbulo. Lokhu kuyenza ibe ikhandidethi lezithako ezihloselwe ukuthuthukisa ukusebenza kwengqondo, ikakhulukazi kubantu asebekhulile noma abantu abanokuncipha kwengqondo.
I-Absorption, Distribution, Metabolism, and Excretion (ADME): I-7,8-DHF ibonisa izakhiwo ezifanelekayo ze-pharmacokinetic, okuhlanganisa ukumuncwa okusheshayo, ukusabalalisa okubanzi, kanye nokungena kobuchopho okuphumelelayo. Ngokuyinhloko i-metabolized yisibindi, iningi le-compound likhishwa endle futhi inani elincane likhishwe emchameni.
Ukungena kwesithiyo sobuchopho begazi kanye nokungena kwezicubu zobuchopho. Esinye sezici ezibalulekile ze 7,8-DHFikhono layo lokuwela umgoqo wegazi nobuchopho (BBB) futhi lingene ezicutshini zobuchopho, okubalulekile ekusebenzeni kwayo njenge-nootropic.
Iphrofayili Yokuphepha Yangaphambi Komtholampilo - Izifundo Zobuthi Ezibucayi Nezingamahlalakhona: Ucwaningo lwezokuphepha lwangaphambi kwekliniki lubonise ukuthi i-7,8-DHF inephrofayili yokuphepha evumayo, engenayo imiphumela emibi ephawulekayo ebonwa ezifundweni zobuthi obuyingozi nobungapheli kumagundane. Kodwa-ke, ukuhlolwa okwengeziwe kokuphepha, okuhlanganisa izifundo ezilwaneni eziphakeme kanye nezihloko zabantu, kuyadingeka ukuze kunqunywe ukuphepha kwakho ukuze kusetshenziswe emtholampilo.
Nakuba ucwaningo lwangaphambi komtholampilo lubonise ukuthi i-7,8-DHF inephrofayili yokuphepha evumayo, imiphumela emibi engaba khona ezifundweni zabantu ihlala ingaziwa kakhulu. Njenganoma iyiphi inhlanganisela yenoveli, kufanele kuqashelwe futhi kuqashwe imiphumela emibi engaba khona lapho kuhlolwa ukusetshenziswa kwayo kubantu.
Kuye ngendlela ye-7,8-DHF yokusebenza kanye nemiphumela kuma-receptors e-TrkB, eminye imiphumela emibi engase ihlotshaniswe ne-7,8-DHF ingase ihlanganise:
Ikhanda elibuhlungu: I-BDNF kanye ne-TrkB receptor activation ilawula umsebenzi we-neuronal kanye nenjabulo; ukuphathwa kwe-7,8-DHF kungase kubangele ubuhlungu bekhanda kwabanye abantu.
Ukuqwasha: Ukwenyuka komsebenzi wezinzwa kanye ne-synaptic plasticity kungase kuthinte amaphethini okulala, okungase kubangele ukuqwasha noma ukuphazamiseka kokulala.
Izinkinga zamathumbu: Njengezinhlanganisela eziningi ze-bioactive, i-7,8-DHF ingase ibangele imiphumela emibi emathunjini, njengesicanucanu, ukuhlanza, noma isifo sohudo kwabanye abantu.
Kubalulekile ukuqaphela ukuthi le miphumela engemihle engaba khona kufanele iqhutshekwe kufundwe ezivivinyweni zomtholampilo. Njengoba kunikezwe ikhono layo lokulinganisa ukusayinda kwe-BDNF kanye nokusebenza kwe-TrkB receptor, ukuqapha kufanele futhi kusetshenziswe lapho kuhlanganiswa i-7,8-DHF nezinye izidakamizwa eziqondise lezi zindlela noma ezinezinqubo ezifanayo zokwenza.
Njengenhlanganisela ebalulekile, i-7,8-Dihydroxyflavone idonse ukunaka okukhulu ngenxa yemisebenzi yayo eyingqayizivele yezinto eziphilayo. Kubacwaningi besayensi namabhizinisi, kubalulekile ukuthola iPowder yekhwalithi ephezulu engu-7,8-Dihydroxyflavone. I-7,8-Dihydroxyflavone Powder ehlinzekwe yi-Suzhou Myland inenombolo ye-CAS engu-38183-03-8 kanye nobumsulwa obufika ku-98%. Umkhiqizo uke walawulwa ngekhwalithi eqinile futhi uthobela izindinganiso zamazwe ngamazwe, uqinisekisa ukusebenza kahle nokuphepha komkhiqizo. , ilungele ucwaningo lwesayensi, ukuthuthukiswa kwezidakamizwa, ukukhiqizwa komkhiqizo wokunakekelwa kwezempilo kanye neminye imikhakha, ikunikeza ukukhetha okuthembekile.
Ukuqinisekisa ikhwalithi
Siyazi ukuthi ikhwalithi yemikhiqizo yethu ithinta ngokuqondile ucwaningo lwamakhasimende ethu kanye nemiphumela yohlelo lokusebenza. Ngakho-ke, iSuzhou Myland ilandela ngokuqinile i-GMP (Umkhuba Omuhle Wokukhiqiza) kanye namazinga wokuqinisekisa izitifiketi ze-ISO phakathi nenqubo yokukhiqiza ukuze kuqinisekiswe ukuzinza nokuvumelana kweqoqo ngalinye lomkhiqizo. Ngaphezu kwalokho, ithimba lethu le-R&D liyaqhubeka nokwenza izinto ezintsha zobuchwepheshe futhi lilwela ukuqhubeka lithuthukisa ikhwalithi nokusebenza komkhiqizo.
Insizakalo yekhasimende
I-Suzhou Myland ayihlinzeki ngemikhiqizo yekhwalithi ephezulu kuphela, kodwa futhi inaka izidingo zamakhasimende. Sinethimba elichwepheshile lokusekela lobuchwepheshe elinganikeza amakhasimende iziphakamiso zokusetshenziswa komkhiqizo nesiqondiso sobuchwepheshe ukuze sisize amakhasimende athole imiphumela engcono ocwaningweni nasekusetshenzisweni kwayo. Kungakhathaliseki ukuthi ukuhlola okuncane noma ukukhiqizwa kwenani elikhulu, singanikeza izixazululo eziguquguqukayo ukuze sihlangabezane nezidingo zamakhasimende ahlukene.
Ungayithola Kanjani I-7,8-Dihydroxyflavone Powder
Uma ufuna iPowder yekhwalithi ephezulu engu-7,8-Dihydroxyflavone, iSuzhou Myland iyisinqumo sakho esifanele. Ungasithinta ngokuthi:
Iwebhusayithi esemthethweni: Vakashela iwebhusayithi esemthethweni ye-Suzhou Myland ukuze ufunde kabanzi mayelana nolwazi lomkhiqizo nokusekelwa kobuchwepheshe.
Ukubonisana nge-inthanethi: Xhumana ngokuqondile nethimba lethu elisebenzela amakhasimende ngokusebenzisa umsebenzi wokubonisana nge-inthanethi ohlinzekwa yiwebhusayithi ukuze uthole ulwazi lomkhiqizo namakhotheshini owadingayo.
Othintana naye ngocingo: Shayela inombolo yethu yokuxhumana ukuze uxhumane nabasebenzi bokuthengisa abaqeqeshiwe futhi uthole ulwazi oluningiliziwe lomkhiqizo kanye neziphakamiso zokuthenga.
Umbuzo we-imeyili: Ungaphinda usicele ulwazi lomkhiqizo nge-imeyili, futhi sizokuphendula ngokushesha okukhulu.
Ekuphetheni
Njengenhlanganisela ebalulekile enezinhlobonhlobo zemisebenzi yezinto eziphilayo, i-7,8-Dihydroxyflavone kancane kancane iba ingxenye ebalulekile ocwaningweni lwesayensi nasekusetshenzisweni kwezimboni. I-7,8-Dihydroxyflavone Powder ehlanzeke kakhulu ehlinzekwe yi-Suzhou Myland izokunikeza ukwesekwa okuqinile kocwaningo lwakho nokuthuthukiswa komkhiqizo ngekhwalithi yayo enhle kakhulu kanye nenkonzo ethembekile. Sibheke ngabomvu ekusebenzisaneni nawe ukuhlola amandla amaningi wohlelo lokusebenza lwe-7,8-Dihydroxyflavone.
Q: Iyini i-7,8-dihydroxyflavone?
A:7,8-Dihydroxyflavone iyi-flavonoid eyenzeka ngokwemvelo eyaziwa ngezici zayo ezingase zibe ne-neuroprotective futhi icwaningwa ngemiphumela yayo ekusebenzeni kwengqondo nasekuthuthukiseni isimo.
Q: Yiziphi izinzuzo ezingaba khona ze-7,8-dihydroxyflavone?
A: Ucwaningo lubonisa ukuthi i-7,8-dihydroxyflavone ingasiza ukuthuthukisa inkumbulo, ukunciphisa ukukhathazeka, nokuvimbela izifo ze-neurodegenerative. Izakhiwo zayo ze-antioxidant zingase futhi zikhuthaze impilo yonke ngokulwa nokucindezeleka okwenziwe nge-oxidative.
Q:Iyini i-bioavailability ye-7,8-DHF?
A:I-bioavailability ye-7,8-dihydroxyflavone (7,8-DHF) ezifundweni zezilwane icishe ibe ngu-5% (kumagundane) ngenxa yokungancibiliki kwayo okungalungile kanye nemetabolism esheshayo. Naphezu kokutholakala kwayo okuphansi kwe-bioavailability, i-7,8-DHF isengakwazi ukweqa umgoqo wegazi nobuchopho futhi ithinte ubuchopho. Ucwaningo olwengeziwe luyadingeka ukuze kutholwe i-bioavailability yayo kubantu futhi kuhlolwe izindlela zokuyithuthukisa.
Q:Ikwenza uzizwe kanjani i-7,8-DHF?
A:Njenge-nootropic, i-7,8-dihydroxyflavone (7,8-DHF) inemiphumela emihle emsebenzini wokuqonda kanye nomuzwa. Abantu ngabanye bathola inkumbulo engcono, ukugxilisa ingqondo ephakeme, namakhono okufunda athuthukisiwe.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Oct-14-2024
