Yini i-N-Boc-O-Benzyl-D-Serine futhi Kungani Ibalulekile?

Ezimbonini zamakhemikhali nezemithi, i-N-Boc-O-benzyl-D-serine iyingxenye ebalulekile ye-amino acid ngenxa yokusetshenziswa kwayo ekuhlanganiseni ama-molecule e-bioactive nezidakamizwa. Idonse ukunaka okukhulu ekusebenziseni kwayo okubanzi ekuthuthukisweni."I-N-Boc" ibhekisela eqenjini elivikelayo le-tert-butoxycarbonyl (Boc), elivame ukusetshenziselwa ukuvikela iqembu lama-amino acid ekuhlanganiseni kwe-peptide. I-"O-Benzyl" isho ukuthi iqembu le-benzyl lixhunywe eqenjini le-hydroxyl le-serine, ngaleyo ndlela lithuthukisa ukuzinza nokuncibilika kwalo.

I-N-Boc-O-benzyl-D-serine Isingeniso

I-N-Boc-O-benzyl-D-serine (CAS:47173-80-8), ibonakala njengempushana emhlophe ukuya kokumhlophe, i-N- Boc-O-Benzyl-D-serine iphuma ku-amino acid D-serine. Ngenxa yezakhiwo zayo eziyingqayizivele, idlala indima ebalulekile ekuhlanganiseni kwamakhemikhali kanye ne-peptide chemistry. Okulandelayo incazelo enemininingwane yezingxenye zayo: lapho i-N-Boc ibhekisela eqenjini elivikelayo le-tert-butoxycarbonyl (Boc).

Amaqembu okuvikela asetshenziswa ku-organic synthesis ukuvikela okwesikhashana amaqembu asebenzayo, okuvumela ukusabela okukhethiwe ngaphandle kokuphazanyiswa kwezinye izingosi zokusabela. I-O-benzyl ibonisa ukuthi iqembu le-benzyl linamathele ku-oksijini yeqembu le-hydroxyl le-serine. I-Benzyl iyindawo evamile enephunga elimnandi engathinta ukunyibilika nokusebenza kabusha kwezinhlanganisela. I-D-serine ingenye yama-enantiomers amabili e-serine futhi ingeyomndeni we-methionine. I-Serine iyi-amino acid ebalulekile ye-biosynthesis, ukukhiqizwa kwamandla kanye nokukhiqizwa kwe-ejenti yokunciphisa i-intracellular. Lezi zinqubo zibalulekile ekukhuleni nasekusakazekeni kwamangqamuzana omdlavuza.

I-N-Boc-O-benzyl-D-serine Isingeniso Somsebenzi

1. I-D-serine inganciphisa izimpawu zokuncipha kwengqondo.

Ukusayinwa kwe-Glutaminergic kwaziwa ngokuthuthukisa ukwakheka kwenkumbulo ngoba ukusebenza kwama-NMDA receptors kubangela ukungena kwe-calcium nokugqugquzelwa kwe-calodulin-dependent kinase (CaMK) kanye ne-CREB-binding proteins, eyenza ukuheha amandla esikhathi eside (LTP), okwenza isisekelo indlela eyaziwa ngokuthi inkumbulo, futhi iphumela ekwenyukeni kokusayina kwe-NMDA (ikakhulukazi nge-subunit ye-NR2B) okubangela ukwanda kwenkumbulo ne-LTP. Lena futhi indlela yokuthuthukisa inkumbulo ebonwa nge-magnesium L-threonate. Ngenxa yokuthi i-D-serine ingathuthukisa ukusayinda ngama-NMDA receptors, abhangqwe nomsebenzi we-D-serine kule nqubo kanye nokuzwela okwaziwayo kwamaseli e-hippocampal ekukhuthazeni i-D-serine, kukholakala ukuthi ukugcwalisa i-D-serine kungakhuthaza inkumbulo nokufunda.

2.Ucwaningo luthole ukuthi ukulahlekelwa amaprotheni e-Menin ku-hypothalamus kuyisici esibalulekile esiholela ekugugeni, futhi ukwengeza i-D-serine kungathuthukisa ukukhubazeka kwengqondo kumagundane asebekhulile.

Ucwaningo luthole ukuthi i-hypothalamus nayo idlala indima ebalulekile ekukhubazekeni kwengqondo okubangelwa ukuguga. Phakathi nenqubo yokuguga, iphrotheni ye-Menin ku-hypothalamus (ngemuva kwalokhu ebizwa ngokuthi i-Menin) izokwehla kancane kancane ngenqubo yokuguga, ithinte ukuhlanganiswa kwe-D-serine, iqhubeke nokusheshisa inqubo yokuguga kanye nokungasebenzi kahle kwengqondo. Ngaphezu kwalokho, i-D-serine supplementation ingathuthukisa kakhulu i-phenotype yokuguga futhi inciphise ukukhubazeka kwengqondo kumagundane asebekhulile.

Imiphumela yocwaningo ibonise ukuthi ngemuva kokwengeza i-D-serine, amazinga e-D-serine ku-hypothalamus kanye ne-hippocampus yamaqembu amathathu amagundane akhuphuke kakhulu uma kuqhathaniswa nohlobo olufanayo lwamagundane angazange ahlanganiswe ne-D-serine (p. <0.01), futhi isimo sabo somqondo sithuthukisiwe. Ukuthuthukiswa okuphawulekayo (p<0.05), okubonisa ukuthi ukwesekwa kwe-D-serine kungase kube inketho yokwelapha yokuthuthukisa ukukhubazeka kwengqondo okuhlobene nokuguga.

I-N-Boc-O-Benzyl-D-Serine vs. Amanye Ama-Amino Acid: Uyini Umehluko?

1. Ukwehluka kwesakhiwo

Umehluko osobala kakhulu phakathi kwe-N-Boc-O-benzyl-D-serine namanye ama-amino acid yisakhiwo sayo. Nakuba ama-amino acid ajwayelekile anomgogodla olula ohlanganisa amaqembu e-amino, amaqembu e-carboxyl namaketanga aseceleni, i-N-Boc-O-benzyl-D-serine inamaqembu engeziwe asebenzayo ashintsha izici zayo.

Isibonelo, iqembu le-Boc lihlinzeka ngokuvikeleka ngesikhathi sokuhlanganiswa kwe-peptide, okuvumela ukusabela okuyinkimbinkimbi kakhulu ukuthi kwenziwe ngaphandle kokusabela okungafuneki ohlangothini. Amaqembu e-Benzyl athuthukisa ukusebenzisana kwe-hydrophobic, ngaleyo ndlela kuthinte ukugoqa nokuzinza kwama-peptide namaprotheni.

2. Izici ezisebenzayo

I-N-Boc-O-Benzyl-D-Serine ibonisa izici zokusebenza eziyingqayizivele uma kuqhathaniswa namanye ama-amino acid. Ukucushwa kwayo kwe-D kuyivumela ukuthi ihlanganyele ngokuhlukile nezinhlelo zebhayoloji uma kuqhathaniswa nokucushwa okuvamile kwe-L okutholakala kumaphrotheni amaningi. Lokhu kungaholela ezinguqukweni zomsebenzi webhayoloji, kuyenze ibe ithuluzi elibalulekile ekwakhiweni kwezidakamizwa nasekuthuthukisweni.

Ngokuphambene, ama-amino acid alula, ajwayeleke kakhulu njenge-glycine noma i-alanine ayinalo izinga elifanayo lobunkimbinkimbi noma ukucaciswa ekusebenzelaneni kwawo. Lokhu kwenza i-N-Boc-O-Benzyl-D-Serine isebenziseke ikakhulukazi ezifundweni ze-neuropharmacology kanye nokusebenzisana kwama-receptor.

3. Izicelo ocwaningweni nakwezokwelapha

I-N-Boc-O-Benzyl-D-Serine idonse ukunaka emikhakheni ehlukahlukene, ikakhulukazi emikhakheni yamakhemikhali ezokwelapha kanye ne-neurobiology. Ikhono layo lokushintsha umsebenzi we-NMDA receptor kuyenza ibe isidakamizwa esikhethiwe sokutadisha ukuphazamiseka kwemizwa njenge-schizophrenia nesifo i-Alzheimer's. Abacwaningi bahlola amandla ayo njenge-ejenti yokwelapha yokuthuthukisa ukusebenza kwengqondo noma ukunciphisa izinqubo ze-neurodegenerative.

Ngokuphambene, ama-amino acid avamile anjenge-leucine noma i-valine avame ukufundelwa indima yawo ekuhlanganiseni kwezicubu zomzimba kanye nokuhlanganiswa kwamaprotheni. Nakuba zibalulekile empilweni nasenhlalakahleni yonke, izicelo zazo ezihlosiwe ku-neuropharmacology ziyahluka kune-N-Boc-O-Benzyl-D-Serine.

4. Ukuhlanganiswa Nokuzinza

Ukuhlanganiswa kwe-N-Boc-O-benzyl-D-serine kuhilela ukusabela kwamakhemikhali okuyinkimbinkimbi kunama-amino acid ajwayelekile. Ukwethulwa kwamaqembu avikelayo kanye nesidingo sezimo ezithile zokusabela kungenza ukuhlanganiswa kwawo kube inselele. Nokho, lezi zinguquko ziphinde zithuthukise ukuzinza kwayo, ziyenze ifanelekele izimo ezihlukahlukene zokuhlola.

Ngokuphambene, ama-amino acid ajwayelekile atholakala kalula futhi kulula ukuwahlanganisa, kodwa angase anganikezi izinga elifanayo lokuzinza noma ukucaciswa okudingekayo ezinhlelweni zocwaningo ezithuthukisiwe.

Izicelo ze-D-Real-Life ze-N-Boc-O-Benzyl-D-Serine

I-Serine idlala imisebenzi ebalulekile yokuphila emzimbeni womuntu, ikakhulukazi ukulawulwa nokuvikelwa kwesimiso sezinzwa. I-N-Boc-O-benzyl-D-serine njenge-serine derivative iyisigaba esibalulekile sama-molecule e-bioactive asetshenziswa kaningi ekuhlanganiseni kwe-peptide nezinye izinhlelo zokusebenza ze-organic chemistry, ikakhulukazi ekuthuthukisweni kwezidakamizwa nezinhlanganisela ze-bioactive. Iqembu elivikelayo lingasuswa ngaphansi kwezimo ezithile ukuze kutholwe ama-amino acid amahhala noma okunye okuphuma ku-derivatives ukuze kwenziwe ucwaningo olwengeziwe noma ukusetshenziswa. Isetshenziswa kabanzi ocwaningweni lwezokwelapha nolwebhayoloji.

1. Ukuhlanganiswa kwamakhemikhali kanye ne-peptide chemistry

I-N-Boc-O-benzyl-D-serine isetshenziswa njengebhlokhi yokwakha ekuhlanganiseni kwamakhemikhali kwezinhlanganisela ezihlukahlukene futhi iphinde ibe yingxenye eyinhloko kumakhemikhali e-peptide. Ukusetshenziswa kwalo kulo mkhakha kungenxa yekhono layo lokufakwa ezakhiweni ezinkulu zamangqamuzana, okusiza ukuthuthukiswa kwemithi emisha nama-molecule e-bioactive.

2. Imboni yezemithi

I-N-Boc-O-benzyl-D-serine isetshenziswe njengesandulela sokulungiswa kwama-naphthodiazolidinone afakwe esikhundleni. Lezi zinhlanganisela zisebenza njenge-protein tyrosine phosphatase degraders futhi zinezicelo ezingaba zokwelapha ekwelapheni umdlavuza kanye nezifo ze-metabolic. Ukuwohloka kwalezi phosphatase kusiza ukulawula izindlela zokubonisa amaseli, ngaleyo ndlela kunikeze indlela yokwelapha yokulwa nalezi zifo.

3. Ucwaningo nentuthuko

Ocwaningweni nasekuthuthukisweni, i-N-Boc-O-benzyl-D-serine isetshenziselwa ukuhlanganisa ama-molecule amasha anomsebenzi webhayoloji ongaba khona. Isakhiwo sayo esiyingqayizivele sivumela ososayensi ukuthi bahlole izakhiwo zayo kanye nezinhlelo zokusebenza ukuze bakhe imithi emisha kanye nokwelashwa kwezimo ezihlukahlukene zezokwelapha.

Ungathenga kuphi i-N-Boc-O-benzyl-D-serine?

Njengomkhiqizi we-N-Boc-O-benzyl-D-serine powder, i-Suzhou Myland iwine ukwethenjwa kwamakhasimende amaningi ngemikhiqizo yayo ehlanzekile kakhulu kanye nokulawulwa kwekhwalithi okuqinile. Inkampani izibophezele ekuhlinzekeni amakhasimende ngezinto zokusetshenziswa zekhwalithi ephezulu nokubasiza ukuthi baphumelele ezimbonini zabo.

1. Ikhwalithi yomkhiqizo ethembekile

I-N-Boc-O-benzyl-D-serine powder yaseSuzhou Myland ibhekana nezivivinyo eziningi ukuze kuqinisekiswe ubumsulwa nekhwalithi yayo ihlangabezana nezindinganiso zomkhakha. Le nkampani inethimba lokuhlola ikhwalithi elichwepheshile elenza ukuhlola okungahleliwe kwemikhiqizo njalo ukuze kuqinisekiswe ikhwalithi ezinzile yeqoqo ngalinye lemikhiqizo.

2. Amakhono okunikezela aguquguqukayo

Kungakhathaliseki ukuthi iqoqo elincane noma i-oda elikhulu, i-Suzhou Mailun Biotechnology ingaphendula ngokuguquguqukayo ukuze kuqinisekiswe ukuthi izidingo zamakhasimende ziyahlangatshezwa. Inkampani isungule uhlelo oluphelele lwezokuthutha ukuze ilethe ngokushesha imikhiqizo kumakhasimende.

3. Ukusekelwa kochwepheshe bezobuchwepheshe

Ithimba le-R&D le-Suzhou Myland lakhiwe ochwepheshe abaningi bemboni futhi linganikeza amakhasimende ukubonisana nobuchwepheshe obuchwepheshile ukuze lisize amakhasimende aqonde kangcono futhi asebenzise i-N-Boc-O-benzyl-D-serine.

4. Intengo yokuncintisana

Ngokwesisekelo sokuqinisekisa ikhwalithi yomkhiqizo, iSuzhou Myland inikeza amanani ancintisanayo ukuze isize amakhasimende ehlise izindleko zokuthenga futhi athuthukise ukuncintisana kwemakethe.

Ukukhetha umphakeli ofanele we-N-Boc-O-benzyl-D-serine kuyisihluthulelo sokuqinisekisa ikhwalithi nokuphepha komkhiqizo. I-Suzhou Myland isiphenduke inketho enokwethenjelwa embonini ngemikhiqizo yayo ehlanzekile, ukulawula okuqinile kwekhwalithi kanye nezinsizakalo zochwepheshe. Kungakhathaliseki ukuthi uyinkampani eyenza imithi noma isikhungo socwaningo lwesayensi, i-Suzhou Myland ingakunikeza i-N-Boc-O-benzyl-D-serine powder yekhwalithi ephezulu ukuze usize ucwaningo lwakho nentuthuko. Ukuze uthole imininingwane eyengeziwe, sicela uvakashele iwebhusayithi esemthethweni ye-Suzhou Myland.