Umkhiqizi wempuphu ye-N-Boc-O-Benzyl-D-serine Inombolo ye-CAS:47173-80-8 Ubumsulwa obungu-98% obuncane be-Intermediate
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-N-Boc-O-Benzyl-D-serine |
| Elinye igama | i-N-Boc-O-benzyl-D-serine; I-Boc-O-benzyl-D-serine; i-O-Benzyl-N-(tert-butoxycarbonyl)-D-serine; i-Boc-(R)-2-amino-3-benzyloxypropionic acid; I-Boc-D-Ser(Bzl)-OH;Nat.-Boc-O-benzyl-D-serine; i-N-tert-butyloxycarbonyl-O-benzyl-D-serine; I-Nalpha-t-butoxycarbonyl-O-benzyl-D-serine; |
| Inombolo ye-CAS | 47173-80-8 |
| Ifomula yama-molecule | C15H21NO5 |
| Isisindo sama-molecule | 295.33 |
| Ubumsulwa | 98% |
| Ukupakisha | 1kg/isikhwama; 25kg/isigubhu |
| Isicelo | Abaphakathi |
Isingeniso somkhiqizo
I-N-Boc-O-Benzyl-D-serine iyinhlanganisela ethole ukunakwa okukhulu emkhakheni we-organic chemistry kanye nocwaningo lwemithi. Le nhlanganisela, eyaziwa nangokuthi i-Boc-D-serine, iyinhlanganisela ye-amino acid D-serine futhi isetshenziswa kabanzi ekuhlanganiseni imithi ehlukahlukene kanye nama-molecule asebenzayo. I-N-Boc-O-Benzyl-D-serine iyimpuphu yekristalu emhlophe kuya kwemhlophe encibilika kancane emanzini futhi incibilika ezinyibilikisweni ze-organic ezifana ne-methanol ne-ethanol. Iyinhlanganisela ye-D-serine, okuyi-amino acid engeyona i-proteinogenic edlala indima ebalulekile ohlelweni lwezinzwa oluphakathi njenge-co-agonist ye-N-methyl-D-aspartate (NMDA) receptor. Amaqembu e-N-Boc (tert-butoxycarbonyl) kanye ne-O-Benzyl kule nhlanganisela asebenza njengamaqembu avikelayo, okuvumela ukuphathwa okukhethiwe kwe-amino acid ngesikhathi sokwenziwa kwamakhemikhali. I-N-Boc-O-Benzyl-D-serine isetshenziswa kakhulu njengesisekelo sokwakha ekwakhiweni kwama-peptide kanye nama-peptidomimetics. Ama-peptide ayimicu emifushane yama-amino acid adlala indima eyahlukahlukene ezinqubweni zebhayoloji futhi anentshisekelo enkulu ekutholakaleni nasekuthuthukisweni kwemithi. Ngokufaka i-N-Boc-O-Benzyl-D-serine kuchungechunge lwama-peptide, osokhemisi bangashintsha izakhiwo nemisebenzi yama-peptide aphumayo, okwenza kube ithuluzi eliwusizo ekwakhiweni kwama-ejenti amasha emithi. Ngaphezu kwalokho, i-N-Boc-O-Benzyl-D-serine isetshenziswa ekulungiseleleni ama-intermediate emithi kanye nezithako ezisebenzayo zemithi (ama-API). Ukusebenza kwayo okuguquguqukayo kanye nokuhambisana kwayo nezindlela ezahlukene zamakhemikhali kwenza kube yingxenye efunwa kakhulu ekwakhiweni kwama-molecule ayinkimbinkimbi e-organic anamandla okwelapha.
Isici
(1) Ubumsulwa obuphezulu: I-N-Boc-O-Benzyl-D-serine ingathola imikhiqizo yobumsulwa obuphezulu ngezinqubo zokukhiqiza zokucwenga. Ubumsulwa obuphezulu busho ukutholakala okungcono kwe-bioavailability kanye nokusabela okuncane okubi.
(2) Ukuphepha: Ukuphepha okuphezulu, ukusabela okungekuhle okumbalwa.
(3) Ukuzinza: I-N-Boc-O-Benzyl-D-serine inokuqina okuhle futhi ingagcina umsebenzi wayo kanye nomphumela ngaphansi kwezimo ezahlukene zokugcinwa.
Izicelo
Ukufakwa kwe-N-Boc-O-Benzyl-D-serine kuma-molecule ezidakamizwa kuye kwabonakala kunikeza izakhiwo ezifiselekayo ze-pharmacokinetic kanye ne-pharmacodynamic. Ama-Peptidomimetics atholakala ku-N-Boc-O-Benzyl-D-serine abonise ukuzinza okuthuthukisiwe, ukutholakala kwe-bioavailability, kanye nokucaciswa kwenhloso, okwenza kube yiziguli ezithembisayo zokwelapha izifo ezahlukahlukene, okuhlanganisa umdlavuza, izifo ezithelelanayo, kanye nezinkinga zezinzwa. Ngaphezu kwalokho, ikhono lokushintsha ngokukhetha ingxenye ye-N-Boc-O-Benzyl-D-serine livumela ukulungiswa kahle kweziguli ezifuna imithi, okwenza ngcono ukusebenza kwazo kanye namaphrofayili okuphepha.
