Iyiphi i-amino acid eguqulwa isidoda? Uyini umsebenzi wayo?

I-spermineiyinhlanganisela ebalulekile ye-polyamine etholakala kakhulu ezintweni eziphilayo, ikakhulukazi edlala indima ebalulekile ekwandeni kwamangqamuzana nokukhula. I-Spermine iguqulwa isuka kuma-amino acids i-arginine ne-ornithine. Lesi sihloko sizohlola umthombo, umsebenzi kanye nokubaluleka kwe-spermine ezintweni eziphilayo.

Imithombo ye-Spermine

Ukwakheka kwe-spermine ikakhulukazi kuncike ekusetshenzisweni kwama-amino acid. Okokuqala, i-ornithine iyisandulela se-spermine synthesis, engakhiqizwa ukusabela kwe-decarboxylation ye-arginine. Inqubo ethize imi kanje:

I-Arginine iguqulwa ibe yi-ornithine: Ngaphansi kwe-catalysis yama-enzyme, i-arginine i-decarboxylated ukukhiqiza i-ornithine.
Ukuguqulwa kwe-ornithine ibe yi-spermine: I-Ornithine iphinde ihlanganiswe ne-amino acid (imvamisa i-amino acid i-alanine) futhi, ngochungechunge lokusabela kwe-enzymatic, ekugcineni yakhe isidoda.
Le nqubo yokuguqulwa ayibandakanyi nje kuphela ukuguqulwa kwama-amino acid, kodwa futhi ihlobene eduze nokukhula kwamangqamuzana, ukuhlukana nokulungisa.

Imiphumela ye-biological ye-spermine

I-Spermine inemisebenzi eminingi ebalulekile yebhayoloji ephilayo, ikakhulukazi kufaka phakathi izici ezilandelayo:

Ukwanda kwamangqamuzana nokukhula: I-Spermine idlala indima ebalulekile ekulawuleni umjikelezo weseli. Ucwaningo luye lwabonisa ukuthi i-spermine ingakhuthaza ukwanda kwamangqamuzana, ikakhulukazi ohlelweni lokulungiswa kwezicubu nokuvuselelwa. Ikhuthaza ukuhlukana kwamaseli nokukhula ngokulawula ukuvezwa kwamaprotheni ahlobene nomjikelezo wamaseli.

Umphumela we-Antioxidant: I-Spermine inezakhiwo ze-antioxidant, ezingasusa ama-radicals mahhala emzimbeni futhi zinciphise ukulimala kwamaseli okubangelwa ukucindezeleka okwenziwe nge-oxidative. Lesi sakhiwo senza isidoda sibe nenani lesicelo esingaba khona ekubambezeleni ukuguga nokuvimbela izifo ezihlobene neminyaka.

Ukulawula ukubonakaliswa kofuzo: I-Spermine ingalawula ukubonakaliswa kofuzo ngokubopha ku-DNA ne-RNA. Lo mphumela wokulawula ubalulekile ekusebenzeni kwamaseli kanye nesimo sokuphila, ikakhulukazi ekuphenduleni izisusa zangaphandle kanye nengcindezi.

Ithuthukisa i-apoptosis: Ngaphansi kwezimo ezithile, isidoda singase futhi sikhuthaze i-apoptosis (ukufa kweseli okuhleliwe), okubalulekile ekugcineni i-homeostasis yamaselula nempilo yezicubu.

I-Immunomodulation: I-Spermine nayo idlala indima ebalulekile emasosheni omzimba. Ingathuthukisa ukusebenza kwamangqamuzana omzimba futhi ithuthukise ukumelana komzimba nokutheleleka kanye nezifo.

Isidoda kanye Nempilo

Njengoba ucwaningo lwe-spermine lujula, ubufakazi obuningi bubonisa ukuthi i-spermine ihlobene eduze nezinkinga ezihlukahlukene zempilo. Isibonelo, amazinga e-spermine ahlobene eduze nokuvela nokuthuthukiswa kwezifo ezihlukahlukene ezifana nokuguga, isifo senhliziyo, nomdlavuza.

Ukuguga: Ucwaningo luye lwathola ukuthi amazinga e-spermine ayancipha kancane kancane ngesikhathi sokuguga, futhi ukuxhaswa kwe-spermine kungasiza ekubambezeleni inqubo yokuguga futhi kuthuthukise impilo yabantu abadala.

Impilo Yenhliziyo: I-Spermine idlala indima yokuvikela ohlelweni lwenhliziyo, ithuthukise umsebenzi we-endothelial futhi inciphise ingozi yesifo senhliziyo.

Ekuphetheni

Njenge-molecule yebhayoloji ebalulekile, i-spermine itholakala ikakhulukazi ku-metabolism yama-amino acid, ikakhulukazi ukuguqulwa kwe-arginine ne-ornithine. I-Spermine idlala indima ebalulekile ekwandeni kwamangqamuzana, i-anti-oxidation, ukulawulwa kwe-gene expression, njll., futhi ibalulekile ekugcineni impilo nokusebenza kwezinto eziphilayo. Ngokucwaninga okujulile kwe-spermine, ulwazi olwengeziwe mayelana nendima yalo empilweni nezifo lungase lutholakale esikhathini esizayo, lunikeze imibono emisha nezindlela zokuvimbela nokwelashwa kwezifo ezihlobene.

Ngokuqonda umsuka nomsebenzi we-spermine, singaqonda kangcono ukubaluleka kwayo emisebenzini yokuphila futhi sinikeze isisekelo sesayensi sokugqugquzela impilo kanye nokubambezela ukuguga. Kwethenjwa ukuthi ucwaningo lwesikhathi esizayo luzophinde lwembule ukusetshenziswa okungenzeka kwe-spermine futhi lube negalelo elikhulu empilweni yomuntu.

Umshwana wokuzihlangula: Le webhusayithi ishicilela noma iphrinte kabusha lesi sihloko kuphela ngenjongo yokuletha nokwabelana ngolwazi olwengeziwe, futhi akusho ukuthi ivumelana nemibono yayo noma iqinisekisa incazelo yayo. Uma kukhona iphutha ekumaka umthombo noma lephula amalungelo akho asemthethweni, sicela uxhumane nale webhusayithi ngobufakazi bobunikazi, futhi sizoyilungisa noma siyisuse ngesikhathi. Ngiyabonga.