Kungani i-Alpha Ketoglutarate Magnesium Ibalulekile Empilweni Yakho

I-Calcium Alpha ketoglutarate (AKG) iyi-metabolite emaphakathi yomjikelezo we-tricarboxylic acid futhi ibamba iqhaza ekuhlanganiseni ama-amino acid, amavithamini nama-acids ephilayo kanye ne-energy metabolism. Ingasetshenziswa njengesengezo sokudla futhi inamathuba amaningi okusebenza. Ngaphezu kwemisebenzi yayo yezinto eziphilayo emzimbeni womuntu, i-calcium alpha-ketoglutarate nayo isetshenziswa kabanzi emkhakheni wezokwelapha futhi isibe yingxenye ebalulekile yemikhiqizo eminingi yezempilo nezixazululo zezokwelapha.

Iyini i-alpha-ketoglutarate?

I-AKG iyi-metabolite engokwemvelo eyenzeka ngokwemvelo eyingxenye yomjikelezo we-Krebs, okusho ukuthi imizimba yethu iyayikhiqiza. Imboni yezithasiselo iphinde ikhiqize inguqulo yokwenziwa efana ngamakhemikhali ne-AKG ekhiqizwa ngokwemvelo.

I-AKG yenzani?

I-AKG iyi-molecule ebandakanyeka ezindleleni eziningi ze-metabolic kanye namaselula. Isebenza njengomnikeli wamandla, isandulela sokukhiqizwa kwe-amino acid kanye ne-molecule yesignali yeseli, futhi iyimoduli yezinqubo ze-epigenetic. Kuyi-molecule eyinhloko kumjikelezo we-Krebs, elawula isivinini esiphelele somjikelezo we-citric acid womzimba. Isebenza ngezindlela ezihlukahlukene emzimbeni ukusiza ukwakha imisipha kanye nosizo ekwelapheni kwesilonda, okungesinye sezizathu ezenza idume emhlabeni wokwakha umzimba.

I-AKG iphinde isebenze njenge-nitrogen scavenger, ivimbele ukugcwala kwe-nitrogen futhi ivimbele ukwakheka kwe-ammonia eyeqile. Futhi iwumthombo omkhulu we-glutamate ne-glutamine, evuselela ukwakheka kwamaprotheni emisipha futhi ivimbele ukuwohloka kwamaprotheni.

Ngaphezu kwalokho, ilawula i-enzyme ye-10-11 translocation (TET) ebandakanyeka ku-DNA demethylation kanye nesizinda se-Jumonji C esine-lysine demethylase, okuyi-histone demethylase enkulu. Ngale ndlela, ingumdlali obalulekile ekulawuleni izakhi zofuzo nasekukhulumeni.

Ingabe i-AKG ingabambezela ukuguga?

Kunobufakazi bokuthi i-AKG ingathonya ukuguga, futhi ucwaningo oluningi lubonisa ukuthi lokhu kunjalo. Ucwaningo lwango-2014 lwabonisa ukuthi i-AKG yelula isikhathi sokuphila kwabantu abadala C. elegans cishe ngo-50% ngokuvimbela i-ATP synthase kanye nethagethi ye-rapamycin (TOR).

Kulolu cwaningo, sithole ukuthi i-AKG ayigcini nje ngokunweba isikhathi sokuphila kodwa futhi ibambezela ama-phenotypes athile ahlobene nobudala, njengokulahlekelwa ukunyakaza komzimba okuhlelekile okuvamile okuvamile kuma-C. elegans asekhulile. Ukuze siqonde ukuthi i-AKG ikuthinta kanjani ukuguga, sizochaza izindlela i-AKG evimbela ngazo i-ATP synthase kanye ne-TOR ukuze kunwetshwe isikhathi sokuphila ku-C. elegans futhi mhlawumbe nezinye izinhlobo zezilwane.

Isebenza kanjani i-calcium alpha-ketoglutarate

Okokuqala, i-calcium alpha-ketoglutarate idlala indima ebalulekile kumetabolism yamandla. Njengomkhiqizo omaphakathi womjikelezo we-tricarboxylic acid (umjikelezo we-TCA), i-calcium α-ketoglutarate ibamba iqhaza kunqubo yokukhiqiza amandla e-intracellular. Ngomjikelezo we-TCA, izakhi ezinjengama-carbohydrate, amafutha, namaprotheni afakwa i-oxidized futhi abola ukuze akhiqize i-ATP (i-adenosine triphosphate) ukuze inikeze amandla kumaseli. Njengesiphakathi esibalulekile emjikelezweni we-TCA, i-calcium α-ketoglutarate ingakhuthaza i-cell metabolism, ikhulise izinga lamandla omzimba, isize ukuthuthukisa amandla omzimba nokukhuthazela, futhi ithuthukise ukukhathala ngokomzimba.

Okwesibili, i-calcium α-ketoglutarate idlala indima ebalulekile ku-amino acid metabolism. Ama-amino acid angamayunithi ayisisekelo amaprotheni, futhi i-calcium α-ketoglutarate ihilelekile ekuguquleni nasekusetshenzisweni kwama-amino acid. Enqubweni yokuguqula ama-amino acid abe amanye ama-metabolite, i-calcium α-ketoglutarate idlulisa ngama-amino acid ukuze ikhiqize ama-amino acid amasha noma ama-α-keto acid, ngaleyo ndlela ilawule ibhalansi nokusetshenziswa kwama-amino acid. Ngaphezu kwalokho, i-calcium α-ketoglutarate ingase futhi isebenze njenge-oxidation substrate yama-amino acid, ibambe iqhaza ekusetshenzisweni kwe-oxidative yama-amino acids, futhi ikhiqize amandla ne-carbon dioxide. Ngakho-ke, i-calcium α-ketoglutarate ibaluleke kakhulu ekugcineni i-homeostasis yama-amino acid kanye ne-protein metabolism emzimbeni.

Ngaphezu kwalokho, i-calcium alpha-ketoglutarate isebenza njenge-antioxidant ekhipha ama-radicals mahhala futhi ivikele amaseli emonakalweni we-oxidative. Ngesikhathi esifanayo, i-calcium α-ketoglutarate ingaphinde ilawule ukusebenza kwamasosha omzimba, ikhuthaze ukusebenza nokwanda kwamangqamuzana omzimba omzimba, futhi ithuthukise ukumelana komzimba nezifo nokutheleleka. Ngakho-ke, i-calcium α-ketoglutarate ibaluleke kakhulu ekugcineni ibhalansi yamasosha omzimba kanye nokumelana nezifo.

Ucwaningo ngemiphumela ye-calcium α-ketoglutarate ekugugeni

Ukuguga kusithinta sonke futhi kuyisici esiyingozi sezifo eziningi, futhi ngokusho kwezibalo zemboni ye-Medicare, amathuba okugula akhula ngokukhula.

I-calcium alpha-ketoglutarate iyi-metabolite ebalulekile emzimbeni wethu, eyaziwa ngendima yeseli kumjikelezo we-Krebs, umjikelezo obalulekile ekwenziweni kwe-oxidation yama-fatty acids nama-amino acid, okuvumela i-mitochondria ukuthi ikhiqize i-ATP (i-ATP ingumthombo wamandla wamaseli).

Okubandakanya ukulayishwa kwenqubo ye-calcium alpha-ketoglutarate, ngakho-ke i-calcium alpha-ketoglutarate ingabuye iguqulwe ibe yi-glutamate bese iba yi-glutamine, engasiza ukuvuselela ukwakheka kwamaprotheni kanye ne-collagen (i-collagen iyiphrotheni ene-fibrous eyenza i-1/3 yawo wonke amaprotheni emzimbeni futhi asiza ukusekela impilo yamathambo, isikhumba nemisipha).

I-Calcium α-ketoglutarate, njengesithasiselo sokudla okunomsoco esisebenza ngezindlela eziningi, inamathuba amaningi okusebenza emikhiqizweni yokunakekelwa kwezempilo. Imisebenzi yayo ehlukahlukene yezinto eziphilayo ezifana ne-antioxidant, anti-aging, regulation immune system kanye ne-amino acid metabolism iyenza ibe ithuluzi elinamandla lokuthuthukisa impilo yabantu. Ngokuqwashisa okwandayo kokunakekelwa kwezempilo kanye nokujula kocwaningo lwesayensi, kukholakala ukuthi ukusetshenziswa kwe-α-ketoglutarate calcium emkhakheni wemikhiqizo yokunakekelwa kwezempilo kuzothola ukunakwa nokuthuthukiswa okwengeziwe.