Kungani Kufanele Uthenge I-Spermidine Powder? Izinzuzo Eziyinhloko Zichaziwe

I-Spermidine,eyaziwa nangokuthi i-spermidine, iyisithako se-triamine polyamine esitholakala kakhulu ezitshalweni ezinjengokolweni, ubhontshisi wesoya, namazambane, ama-microorganisms afana ne-lactobacilli ne-bifidobacteria, nezicubu zezilwane ezahlukahlukene. I-Spermidine iyi-hydrocarbon enohlaka lwekhabhoni olumise okwezigzag olwakhiwe ama-athomu ekhabhoni ayi-7 kanye namaqembu e-amino kuzo zombili iziphetho namaphakathi.

Ucwaningo lwanamuhla luye lwafakazela ukuthi i-spermidine ihileleke ezinqubweni ezibalulekile zokuphila ezifana nokuphindaphinda kwe-DNA yeselula, ukubhalwa kwe-mRNA, nokuhumusha kwamaprotheni, kanye nezinqubo eziningi ze-pathophysiological ezifana nokuvikelwa kwengcindezi yomzimba kanye ne-metabolism. Inokuvikelwa kwenhliziyo nemithambo yegazi kanye ne-neuroprotection, i-anti-tumor, nokulawulwa kokuvuvukala, njll. Umsebenzi obalulekile wezinto eziphilayo.

I-Spermidine ibhekwa njenge-activator enamandla ye-autophagy, inqubo yokubuyisela kabusha kwe-intracellular lapho amangqamuzana amadala azivuselela futhi aphinde asebenze. I-Spermidine idlala indima ebalulekile ekusebenzeni kweseli nasekuphileni kwayo. Emzimbeni, i-spermidine ikhiqizwa kusukela ku-precursor putrescine, yona eyisandulela kwenye i-polyamine ebizwa ngokuthi i-spermine, ebaluleke kakhulu ekusebenzeni kweseli.

I-Spermidine ne-purescine ivuselela i-autophagy, uhlelo oludiliza imfucuza ye-intracellular futhi luvuselele izingxenye zeselula futhi iyindlela yokulawula ikhwalithi ye-mitochondria, izindlu zamandla zeseli. I-Autophagy iyaphuka futhi ilahle i-mitochondria eyonakele noma engasebenzi, futhi ukulahlwa kwe-mitochondrial kuyinqubo elawulwa ngokuqinile. Ama-polyamines ayakwazi ukuhlanganisa izinhlobo eziningi zama-molecule, okwenza kube nezinto ezihlukahlukene. Basekela izinqubo ezifana nokukhula kwamaseli, ukuzinza kwe-DNA, ukwanda kwamaseli, kanye ne-apoptosis. Ama-Polyamines abonakala esebenza ngokufana nezici zokukhula ngesikhathi sokuhlukaniswa kwamaseli, yingakho i-purescine ne-spermidine zibalulekile ekukhuleni nasekusebenzeni kwezicubu ezinempilo.

Abacwaningi bafunde ukuthi i-spermidine ivikela kanjani amangqamuzana ekucindezelekeni kwe-oxidative, okungalimaza amangqamuzana futhi kuholele ezifweni ezihlukahlukene. Bathole ukuthi i-spermidine ivula i-autophagy. Ucwaningo luhlonze izakhi zofuzo ezimbalwa ezibalulekile ezithintwa i-spermidine ezinciphisa ukucindezeleka kwe-oxidative futhi zikhuthaze i-autophagy kulawa maseli. Ngaphezu kwalokho, bathole ukuthi ukuvimbela indlela ye-mTOR, evame ukuhileleka ekuvimbeleni i-autophagy, kuthuthukise nakakhulu imiphumela yokuvikela ye-spermidine.

Yikuphi ukudla okune-spermidine ephezulu?

I-Spermidine iyi-polyamine ebalulekile. Ngaphezu kokukhiqizwa ngumzimba womuntu ngokwawo, imithombo yawo yokudla eningi kanye nama-microorganisms amathumbu nawo ayindlela ebalulekile yokuhlinzeka. Inani le-spermidine ekudleni okuhlukahlukene liyahlukahluka kakhulu, igciwane likakolweni liwumthombo wezitshalo owaziwayo. Eminye imithombo yokudla ihlanganisa i-grapefruit, imikhiqizo yesoya, ubhontshisi, ummbila, okusanhlamvu, uphizi, uphizi, upelepele oluhlaza, i-broccoli, amawolintshi, itiye eluhlaza, bran zerayisi kanye nopelepele oluhlaza. Ngaphezu kwalokho, ukudla okufana namakhowe e-shiitake, imbewu ye-amaranth, ukholifulawa, ushizi ovuthiwe kanye ne-durian nakho kuqukethe i-spermidine.

Kuyaphawuleka ukuthi ukudla kwaseMedithera kuqukethe ukudla okuningi okune-spermidine, okungasiza ukuchaza "indawo eluhlaza okwesibhakabhaka" lapho abantu behlala isikhathi eside ezindaweni ezithile. Kodwa-ke, kubantu abangakwazi ukudla i-spermidine eyanele ngokudla, izithako ze-spermidine ziyindlela ephumelelayo. I-spermidine kulezi zithako ziyi-molecule efanayo ngokwemvelo, okwenza kube enye indlela ephumelelayo.

Iyini i-purescine?

Ukukhiqizwa kwe-purescine kuhilela izindlela ezimbili, zombili eziqala nge-amino acid arginine. Emzileni wokuqala, i-arginine iqala ukuguqulwa ibe i-agmatine ecutshungulwa yi-arginine decarboxylase. Kamuva, i-agmatine iphinde iguqulwe ibe yi-N-carbamoylputrescine ngesenzo se-agmatine iminohydroxylase. Ekugcineni, i-N-carbamoylputrescine iguqulwa ibe yi- putrescine, iphothula inqubo yoguquko. Indlela yesibili ilula ngokuqhathaniswa, iguqula ngokuqondile i-arginine ibe i-ornithine, bese iguqula i-ornithine ibe yi-purescine ngokusebenzisa isenzo se-ornithine decarboxylase. Nakuba lezi zindlela ezimbili zinezinyathelo ezihlukene, zombili ekugcineni zifinyelela ukuguqulwa kusuka ku-arginine kuya ku-purescine.

I-Putrescine i-diamine etholakala ezithweni ezihlukahlukene ezifana namanyikwe, i-thymus, isikhumba, ubuchopho, isibeletho nama-ovari. I-Putrescine ivame ukutholakala ekudleni okufana negciwane likakolweni, upelepele oluhlaza, ubhontshisi wesoya, ama-pistachio namawolintshi. Ucwaningo lwakamuva lubonise ukuthi i-purescine iyinto ebalulekile elawula ukwakheka kwe-metabolic engakwazi ukusebenzisana nama-macromolecule ebhayoloji njenge-DNA ene-negative charge, i-RNA, ama-ligand ahlukahlukene (njenge-β1 kanye ne-β2 adrenergic receptors), kanye namaprotheni olwelwesi. , okuholela ochungechungeni lwezinguquko zomzimba noma ze-pathological emzimbeni.

Umphumela we-Spermidine

Umsebenzi we-Antioxidant: I-Spermidine inomsebenzi oqinile we-antioxidant futhi ingasabela ngama-radicals mahhala ukuze inciphise ukulimala kwe-oxidative kumaseli okubangelwa ama-radicals mahhala. Emzimbeni, i-spermidine ingabuye ikhuthaze ukubonakaliswa kwama-enzyme e-antioxidant futhi ithuthukise umthamo we-antioxidant.

Ukulawulwa kwe-metabolism yamandla: I-Spermidine ihileleke ekulawuleni ukuguqulwa kwamandla ezinto eziphilayo, ingakhuthaza ukumuncwa nokusetshenziswa kweglucose ngemva kokudla ukudla, futhi ithinte isilinganiso se-aerobic metabolism kanye ne-anaerobic metabolism ngokulawula ukusebenza kahle kokukhiqizwa kwamandla emitochondrial.

umphumela wokulwa nokuvuvukala

I-Spermidine inemiphumela elwa nokuvuvukala futhi ingalawula ukubonakaliswa kwezinto ezivuthayo futhi inciphise ukuvela kokuvuvukala okungapheli. Ihlobene kakhulu nendlela ye-nuclear factor-κB (NF-κB).

Ukukhula, ukuthuthukiswa kanye nokulawulwa kokuzivikela komzimba: I-Spermidine nayo idlala indima ebalulekile ekukhuleni, ekuthuthukiseni nasekulawuleni amasosha omzimba. Kungakhuthaza ukukhiqizwa kwe-hormone yokukhula emzimbeni womuntu futhi kusize ukuthuthukisa ukuthuthukiswa kwezicubu nezitho ezihlukahlukene zomzimba. Ngesikhathi esifanayo, ekulawuleni amasosha omzimba, i-spermidine ithuthukisa ukumelana komzimba namagciwane nezifo ngokulawula ukukhiqizwa kwamangqamuzana amhlophe egazi futhi ikhuthaze ukususwa kwezinhlobo ze-oxygen esebenzayo.

Ukulibaziseka ukuguga: I-Spermidine ingakhuthaza i-autophagy, inqubo yokuhlanza ngaphakathi kwamaseli esiza ukususa ama-organelles alimele namaprotheni, ngaleyo ndlela ibambezele ukuguga.

Ukulawulwa kwamaseli e-Glial: I-Spermidine idlala indima ebalulekile yokulawula kumaseli e-glial. Ingabamba iqhaza ezinhlelweni zokubonisa amaseli kanye nokuxhumana okusebenzayo phakathi kwamaseli ezinzwa, futhi idlala indima ebalulekile yokulawula ekuthuthukisweni kwe-neuron, ukudluliswa kwe-synaptic, kanye nokumelana ne-neuropathy.

Ukuvikelwa kwenhliziyo nemithambo yegazi: Emkhakheni wenhliziyo nemithambo yegazi, i-spermidine inganciphisa ukunqwabelana kwe-lipid kuma-atherosclerotic plaque, yehlise i-hypertrophy yenhliziyo, futhi ithuthukise ukusebenza kwe-diastolic, ngaleyo ndlela izuze ukuvikeleka kwenhliziyo. Ngaphezu kwalokho, ukudla okudlayo kwe-spermidine kuthuthukisa umfutho wegazi futhi kunciphisa ukugula kwenhliziyo nokufa.

Ngo-2016, ucwaningo olwanyatheliswa ku-Atherossteosis lwaqinisekisa ukuthi i-spermidine inganciphisa ukuqoqwa kwe-lipid kuma-atherosclerotic plaques. Ngawo lowo nyaka, ucwaningo olwanyatheliswa kuyi-Nature Medicine lwaqinisekisa ukuthi i-spermidine inganciphisa i-hypertrophy yenhliziyo futhi ithuthukise umsebenzi we-diastolic, ngaleyo ndlela ivikele inhliziyo futhi yandise isikhathi sokuphila samagundane.

Thuthukisa isifo i-Alzheimer's

Ukungena kwe-Spermidine kunenzuzo ekusebenzeni kwenkumbulo yomuntu. Ithimba likaSolwazi Reinhart wase-Australia lithole ukuthi ukwelashwa nge-spermidine kungathuthukisa ukusebenza kwengqondo kwasebekhulile. Ucwaningo lwamukele umklamo ohlanganisa izikhungo eziningi ezingaboni kahle futhi lwabhalisa abantu abadala abangu-85 emakhaya asebekhulile angu-6, abahlukaniswa ngokungahleliwe baba amaqembu amabili futhi basebenzisa imithamo ehlukene ye-spermidine. Umsebenzi wabo wokuqonda wahlolwa ngokuhlolwa kwenkumbulo futhi wahlukaniswa ngamaqembu amane: akukho ukuwohloka komqondo, ukuwohloka komqondo okuncane, ukuwohloka komqondo okumaphakathi kanye nokuwohloka komqondo okunzima. Amasampula egazi aqoqwa ukuze kuhlolwe ukugcwala kwe-spermidine egazini labo. Imiphumela yabonisa ukuthi ukuhlushwa kwe-spermidine kwakuhlobene kakhulu nokusebenza kwengqondo eqenjini elingewona ukuwohloka komqondo, futhi izinga lokuqonda labantu asebekhulile abanokukhubazeka okuncane kuya kokulinganisela lithuthuke kakhulu ngemva kokungenisa amanani aphezulu e-spermidine.

I-Autophagy

I-Spermidine ingakhuthaza i-autophagy, njenge-mTOR (target of rapamycin) inhibitory pathway. Ngokukhuthaza i-autophagy, isiza ukususa ama-organelles alimele namaprotheni kumaseli futhi igcina impilo yeseli.

I-Spermidine hydrochloride isetshenziswa emikhakheni ehlukahlukene

Emkhakheni wemithi, i-spermidine hydrochloride isetshenziswa njengesidakamizwa se-hepatoprotective esingathuthukisa ukusebenza kwesibindi futhi sinciphise ukulimala kwesibindi. Ngaphezu kwalokho, i-spermidine hydrochloride ingasetshenziswa ukwelapha izimo ezifana ne-cholesterol ephezulu, i-hypertriglyceridemia, nesifo senhliziyo.

I-Spermidine hydrochloride isebenza ngokunciphisa amazinga e-plasma homocysteine ​​​​(Hcy), ngaleyo ndlela yehlisa ingozi yesifo senhliziyo. Ucwaningo luye lwabonisa ukuthi i-spermidine hydrochloride ingakhuthaza umzimba we-Hcy futhi inciphise ingozi yesifo senhliziyo ngokunciphisa amazinga e-plasma Hcy.

Ucwaningo ngemiphumela ye-spermidine hydrochloride engozini yesifo senhliziyo lubonise ukuthi i-spermidine hydrochloride inganciphisa amazinga e-plasma Hcy, ngaleyo ndlela inciphise ingozi yesifo senhliziyo. Ocwaningweni, abacwaningi bahlukanise ababambiqhaza ngamaqembu amabili, oyedwa ethola i-spermidine hydrochloride supplementation kanti omunye ethola i-placebo.

Imiphumela yocwaningo ibonise ukuthi ababambiqhaza abathola i-spermidine hydrochloride supplementation babe namazinga e-plasma e-Hcy aphansi kakhulu kanye nokunciphisa okuhambisanayo engozini yesifo senhliziyo. Ukwengeza, kunezinye izifundo ezisekela indima ye-spermidine hydrochloride ekunciphiseni ingozi yesifo senhliziyo.

Emkhakheni wokudla, i-spermidine hydrochloride isetshenziswa njengesithuthukisi ukunambitheka kanye ne-humectant ukuthuthukisa ukunambitheka kokudla nokugcina umswakama wokudla. Ngaphezu kwalokho, i-spermidine hydrochloride ingasetshenziswa futhi njengesengezo sokudla ukuze kuthuthukiswe izinga lokukhula kanye nekhwalithi yemisipha yezilwane.

Ezimonyoni, i-spermidine hydrochloride isetshenziswa njenge-humectant ne-antioxidant ukuze kugcinwe umswakama wesikhumba futhi kunciphise ukulimala kwama-radical mahhala. Ngaphezu kwalokho, i-spermidine hydrochloride ingasetshenziswa futhi kuma-sunscreen ukunciphisa umonakalo wemisebe ye-ultraviolet esikhumbeni.

Emkhakheni wezolimo, i-spermidine hydrochloride isetshenziswa njengesilawuli sokukhula kwezitshalo ukukhuthaza ukukhula kwezitshalo nokwandisa isivuno.