Kungani Kufanele Uthenge I-Spermidine Powder? Izinzuzo Eziyinhloko Zichazwa

I-Spermidine,eyaziwa nangokuthi i-spermidine, iyi-triamine polyamine etholakala kabanzi ezitshalweni ezifana nokolweni, ubhontshisi, namazambane, izinto ezincane ezifana ne-lactobacilli ne-bifidobacteria, kanye nezicubu zezilwane ezahlukahlukene. I-Spermidine iyi-hydrocarbon ene-skeleton yekhabhoni efana ne-zigzag eyakhiwe ngama-athomu ekhabhoni ayi-7 namaqembu ama-amino kuzo zombili izinhlangothi naphakathi.

Ucwaningo lwanamuhla luye lwafakazela ukuthi i-spermidine ihilelekile ezinqubweni ezibalulekile zokuphila njengokuphindaphinda kwe-DNA yeselula, ukubhalwa kwe-mRNA, kanye nokuhumusha amaprotheni, kanye nezinqubo eziningi ze-pathophysiological ezifana nokuvikelwa kokucindezeleka komzimba kanye ne-metabolism. Inezivikelo zenhliziyo kanye nokuvikelwa kwemizwa, ukulwa nomdlavuza, kanye nokulawula ukuvuvukala, njll. Umsebenzi obalulekile webhayoloji.

I-Spermidine ibhekwa njengesishukumisi esinamandla se-autophagy, inqubo yokuvuselela kabusha yangaphakathi kwamangqamuzana lapho amangqamuzana amadala ezivuselela khona futhi aphinde athole umsebenzi. I-Spermidine idlala indima ebalulekile ekusebenzeni kweseli nasekusindeni. Emzimbeni, i-spermidine ikhiqizwa kusuka ku-putrescine yayo eyandulelayo, okuyiyona eyandulela enye i-polyamine ebizwa ngokuthi i-spermine, nayo ebaluleke kakhulu ekusebenzeni kweseli.

I-Spermidine ne-putrescine zivuselela i-autophagy, uhlelo oluhlukanisa imfucuza yangaphakathi kweseli futhi luphinde lusebenzise izingxenye zeseli futhi luyindlela yokulawula ikhwalithi ye-mitochondria, izikhungo zamandla zeseli. I-Autophagy iyahlukana futhi ilahle i-mitochondria eyonakele noma enephutha, kanti ukulahla i-mitochondria kuyinqubo elawulwa ngokuqinile. Ama-polyamine ayakwazi ukubopha ezinhlotsheni eziningi ezahlukene zama-molecule, okwenza abe nezimo ezihlukahlukene. Asekela izinqubo ezifana nokukhula kweseli, ukuzinza kwe-DNA, ukwanda kweseli, kanye ne-apoptosis. Ama-polyamine abonakala esebenza ngendlela efanayo nezici zokukhula ngesikhathi sokuhlukaniswa kweseli, yingakho i-putrescine ne-spermidine zibalulekile ekukhuleni nasekusebenzeni kwezicubu ezinempilo.

Abacwaningi bafunde ukuthi i-spermidine ivikela kanjani amangqamuzana ekucindezelekeni kwe-oxidative, okungalimaza amangqamuzana futhi kuholele ezifweni ezahlukahlukene. Bathole ukuthi i-spermidine ivuselela i-autophagy. Ucwaningo luthole izakhi zofuzo eziningana ezibalulekile ezithintwa yi-spermidine ezinciphisa ukucindezeleka kwe-oxidative futhi zikhuthaze i-autophagy kula maseli. Ngaphezu kwalokho, bathole ukuthi ukuvimba indlela ye-mTOR, evame ukuhileleka ekuvimbeleni i-autophagy, kwathuthukisa kakhulu imiphumela yokuvikela ye-spermidine.

Yikuphi ukudla okune-spermidine eningi?

I-Spermidine iyi-polyamine ebalulekile. Ngaphezu kokukhiqizwa ngumzimba womuntu uqobo, imithombo yayo yokudla eningi kanye nezinambuzane zamathumbu nazo ziyizindlela ezibalulekile zokutholakala. Inani le-spermidine ekudleni okuhlukahlukene liyahlukahluka kakhulu, kanti i-wheat germ iyisitshalo esaziwayo. Eminye imithombo yokudla ifaka phakathi i-grapefruit, imikhiqizo ye-soy, ubhontshisi, ummbila, okusanhlamvu okuphelele, ama-chickpeas, uphizi, upelepele oluhlaza, i-broccoli, amawolintshi, itiye eliluhlaza, i-rice bran kanye nopelepele oluhlaza omusha. Ngaphezu kwalokho, ukudla okufana namakhowe e-shiitake, imbewu ye-amaranth, i-cauliflower, ushizi ovuthiwe kanye ne-durian nakho kuqukethe i-spermidine.

Kuyaphawuleka ukuthi ukudla kwaseMedithera kuqukethe ukudla okuningi okucebile nge-spermidine, okungasiza ekuchazeni isimo "sendawo eluhlaza okwesibhakabhaka" lapho abantu behlala khona isikhathi eside ezindaweni ezithile. Kodwa-ke, kubantu abangakwazi ukudla i-spermidine eyanele ngokudla, izithasiselo ze-spermidine ziyindlela ehlukile ephumelelayo. I-spermidine kulezi zithasiselo iyi-molecule efanayo eyenzeka ngokwemvelo, okwenza kube yindlela ehlukile ephumelelayo.

Kuyini i-putrescine?

Ukukhiqizwa kwe-putrescine kuhilela izindlela ezimbili, zombili eziqala nge-amino acid arginine. Endleleni yokuqala, i-arginine iguqulwa kuqala ibe yi-agmatine eqhutshwa yi-arginine decarboxylase. Ngemva kwalokho, i-agmatine iguqulwa ibe yi-N-carbamoylputrescine ngesenzo se-agmatine iminohydroxylase. Ekugcineni, i-N-carbamoylputrescine iguqulwa ibe yi-putrescine, iqedela inqubo yokuguqulwa. Indlela yesibili ilula kakhulu, iguqula i-arginine ngqo ibe yi-ornithine, bese iguqula i-ornithine ibe yi-putrescine ngesenzo se-ornithine decarboxylase. Nakuba lezi zindlela ezimbili zinezinyathelo ezihlukene, zombili ekugcineni zifinyelela ukuguqulwa kusuka ku-arginine kuya ku-putrescine.

I-Putrescine iyi-diamine etholakala ezithweni ezahlukahlukene njenge-pancreas, i-thymus, isikhumba, ubuchopho, isibeletho kanye nama-ovari. I-Putrescine ivame ukutholakala ekudleni okufana ne-wheat germ, upelepele oluhlaza, ubhontshisi, ama-pistachios, nama-orenji. Izifundo zakamuva zibonise ukuthi i-putrescine iyisithako esibalulekile sokulawula i-metabolic esingasebenzisana nama-macromolecule e-biological njenge-DNA eshajeke kabi, i-RNA, ama-ligand ahlukahlukene (njenge-β1 kanye ne-β2 adrenergic receptors), kanye namaprotheni e-membrane. , okuholela ochungechungeni lwezinguquko zomzimba noma ze-pathological emzimbeni.

Umphumela we-Spermidine

Umsebenzi we-Antioxidant: I-Spermidine inomsebenzi onamandla we-antioxidant futhi ingasabela nama-free radicals ukunciphisa umonakalo we-oxidative kumaseli obangelwa ama-free radicals. Emzimbeni, i-spermidine ingakhuthaza nokuvezwa kwama-enzyme e-antioxidant futhi ithuthukise amandla e-antioxidant.

Ukulawulwa kokusetshenziswa kwamandla: I-Spermidine ihilelekile ekulawuleni ukusetshenziswa kwamandla kwezinto eziphilayo, ingakhuthaza ukumuncwa nokusetshenziswa kwe-glucose ngemva kokudla, futhi ithinta isilinganiso sokusetshenziswa kwamandla kagesi kanye nokusetshenziswa kwamandla kagesi kagesi ngokulawula ukusebenza kahle kokukhiqizwa kwamandla e-mitochondrial.

umphumela wokulwa nokuvuvukala

I-Spermidine inemiphumela yokulwa nokuvuvukala futhi ingalawula ukuvezwa kwezinto ezibangela ukuvuvukala futhi inciphise ukuvela kokuvuvukala okungapheli. Ihlobene kakhulu nendlela ye-nuclear factor-κB (NF-κB).

Ukukhula, intuthuko kanye nokulawulwa kwamasosha omzimba: I-Spermidine nayo idlala indima ebalulekile ekukhuleni, intuthuko kanye nokulawulwa kwamasosha omzimba. Ingakhuthaza ukukhiqizwa kwe-hormone yokukhula emzimbeni womuntu futhi isize ekuthuthukiseni izicubu nezitho zomzimba ezahlukahlukene. Ngesikhathi esifanayo, ekulawulweni kwamasosha omzimba, i-spermidine ithuthukisa ukumelana komzimba namagciwane nezifo ngokulawula ukukhiqizwa kwamangqamuzana amhlophe egazi kanye nokukhuthaza ukususwa kwezinhlobo ze-oxygen ezisebenzayo.

Ukuguga okulibazisayo: I-Spermidine ingakhuthaza i-autophagy, inqubo yokuhlanza ngaphakathi kwamaseli esiza ukususa ama-organelle namaprotheni alimele, ngaleyo ndlela ibambezele ukuguga.

Ukulawulwa kwamaseli e-Glial: I-Spermidine idlala indima ebalulekile yokulawula kumaseli e-glial. Ingabamba iqhaza ezinhlelweni zokubonisana kwamaseli kanye nokuxhumana okusebenzayo phakathi kwamaseli ezinzwa, futhi idlala indima ebalulekile yokulawula ekuthuthukisweni kwama-neuron, ukudluliselwa kwe-synaptic, kanye nokumelana ne-neuropathy.

Ukuvikelwa kwenhliziyo: Ensimini yenhliziyo, i-spermidine inganciphisa ukunqwabelana kwamafutha kuma-plaque e-atherosclerotic, inciphise i-hypertrophy yenhliziyo, futhi ithuthukise ukusebenza kwe-diastolic, ngaleyo ndlela ifinyelele ukuvikelwa kwenhliziyo. Ngaphezu kwalokho, ukudla i-spermidine kuthuthukisa umfutho wegazi futhi kunciphisa ukugula kwenhliziyo nokufa.

Ngo-2016, ucwaningo olwanyatheliswa kuyi-Atherosclerosis luqinisekisile ukuthi i-spermidine inganciphisa ukunqwabelana kwamafutha kuma-plaque e-atherosclerotic. Ngonyaka ofanayo, ucwaningo olwanyatheliswa kuyi-Nature Medicine luqinisekisile ukuthi i-spermidine inganciphisa i-hypertrophy yenhliziyo futhi ithuthukise ukusebenza kwe-diastolic, ngaleyo ndlela ivikele inhliziyo futhi yandise isikhathi sokuphila samagundane.

Thuthukisa isifo se-Alzheimer

Ukuthatha i-spermidine kuyasiza ekusebenzeni kwenkumbulo yomuntu. Ithimba likaSolwazi uReinhart wase-Australia lithole ukuthi ukwelashwa nge-spermidine kungathuthukisa ukusebenza kwengqondo yabantu asebekhulile. Ucwaningo lwamukele umklamo we-multi-blind-blind ohlanganisa izindawo eziningi futhi lwabhalisa abantu asebekhulile abangu-85 emakhaya ayisithupha asebekhulile, abahlukaniswa ngokungahleliwe baba amaqembu amabili futhi basebenzisa imithamo ehlukene ye-spermidine. Ukusebenza kwabo kwengqondo kwahlolwa ngokuhlolwa kwenkumbulo futhi kwahlukaniswa ngamaqembu amane: ukungabi ne-dementia, i-dementia encane, i-dementia ephakathi nendawo kanye ne-dementia enzima. Amasampula egazi aqoqwe ukuze kuhlolwe ukuhlushwa kwe-spermidine egazini labo. Imiphumela ibonise ukuthi ukuhlushwa kwe-spermidine kwakuhlobene kakhulu nokusebenza kwengqondo eqenjini elingelona i-dementia, futhi izinga lokuhlushwa kwengqondo labantu asebekhulile abane-dementia encane kuya kwephakathi lathuthuka kakhulu ngemva kokudla imithamo ephezulu ye-spermidine.

I-Autophagy

I-Spermidine ingakhuthaza i-autophagy, njengendlela yokuvimbela i-mTOR (target of rapamycin). Ngokukhuthaza i-autophagy, isiza ukususa ama-organelle namaprotheni alimele emaseli futhi igcine impilo yamaseli.

I-Spermidine hydrochloride isetshenziswa emikhakheni eyahlukahlukene

Emkhakheni wezokwelapha, i-spermidine hydrochloride isetshenziswa njengomuthi ovikela isibindi ongathuthukisa ukusebenza kwesibindi futhi unciphise ukulimala kwesibindi. Ngaphezu kwalokho, i-spermidine hydrochloride ingasetshenziswa ukwelapha izimo ezifana ne-cholesterol ephezulu, i-hypertriglyceridemia, kanye nesifo senhliziyo.

I-Spermidine hydrochloride isebenza ngokunciphisa amazinga e-plasma homocysteine ​​​​(Hcy), ngaleyo ndlela inciphise ingozi yesifo senhliziyo. Izifundo zibonise ukuthi i-spermidine hydrochloride ingakhuthaza i-metabolism ye-Hcy futhi inciphise ingozi yesifo senhliziyo ngokunciphisa amazinga e-plasma Hcy.

Ucwaningo ngemiphumela ye-spermidine hydrochloride engcupheni yesifo senhliziyo lubonise ukuthi i-spermidine hydrochloride inganciphisa amazinga e-plasma Hcy, ngaleyo ndlela inciphise ingozi yesifo senhliziyo. Kulolu cwaningo, abacwaningi bahlukanise ababambiqhaza baba amaqembu amabili, elinye lithola i-spermidine hydrochloride supplementation kanti elinye lithola i-placebo.

Imiphumela yocwaningo ibonise ukuthi ababambiqhaza abathole ukwengezwa kwe-spermidine hydrochloride babenamazinga aphansi kakhulu e-plasma Hcy kanye nokwehla okuhambisanayo kwengozi yesifo senhliziyo. Ngaphezu kwalokho, kunezinye izifundo ezisekela indima ye-spermidine hydrochloride ekunciphiseni ingozi yesifo senhliziyo.

Emkhakheni wokudla, i-spermidine hydrochloride isetshenziswa njengesithuthukisi se-flavour kanye ne-humectant ukuthuthukisa ukunambitheka kokudla nokugcina umswakama wokudla. Ngaphezu kwalokho, i-spermidine hydrochloride ingasetshenziswa futhi njengesengezo sokudla ukuthuthukisa izinga lokukhula kanye nekhwalithi yemisipha yezilwane.

Ezimonyweni, i-spermidine hydrochloride isetshenziswa njenge-humectant kanye ne-antioxidant ukugcina umswakama wesikhumba nokunciphisa umonakalo wama-free radical. Ngaphezu kwalokho, i-spermidine hydrochloride ingasetshenziswa nasezikhungweni zelanga ukunciphisa umonakalo wemisebe ye-ultraviolet esikhumbeni.

Emkhakheni wezolimo, i-spermidine hydrochloride isetshenziswa njengomlawuli wokukhula kwezitshalo ukukhuthaza ukukhula kwezitshalo nokwandisa isivuno.