I-NAD+ (Beta-Nicotinamide Adenine Dinucleotide) iyi-coenzyme etholakala kuwo wonke amangqamuzana aphilayo futhi ibalulekile ezinqubweni ezihlukahlukene zebhayoloji, okuhlanganisa ukukhiqizwa kwamandla nokulungisa i-DNA. Njengoba sikhula, amazinga ethu e-NAD+ ayehla, okuholela ezinhlobonhlobo zezinkinga zempilo. Ukulwa nale nkinga, abantu abaningi baphendukela ezithasiselweni ze-NAD+ ngendlela eyimpushana. Kodwa-ke, ngezinketho eziningi laphaya, ukuthola ukuthi iyiphi i-NAD+ powder engcono kakhulu kuwe kungaba inselele. Ukukhetha i-NAD+ powder engcono kakhulu kudinga ukucatshangelwa ngokucophelela kokuhlanzeka, i-bioavailability, umthamo, ukucaca, kanye nempendulo yekhasimende. Ngokubeka phambili lezi zici, ungenza isinqumo esinolwazi futhi ukhethe izinga eliphezulu le-NAD + powder elisekela impilo nempilo yakho.
I-NAD yenzeka ngokwemvelo kumaseli ethu,ngokuyinhloko ku-cytoplasm yabo kanye ne-mitochondria, noma kunjalo, amazinga emvelo e-NAD ayancipha njengoba sikhula (njalo eminyakeni engu-20, eqinisweni), okubangela imiphumela evamile yokuguga, Njengokuncipha kwamazinga wamandla nokwanda kobuhlungu nobuhlungu. Ngaphezu kwalokho, ukwehla okuhlobene nokuguga ku-NAD kuhlotshaniswa nezinye izifo ezihlobene neminyaka, njengomdlavuza, ukuncipha kwengqondo, nobuthakathaka.
I-NAD+ ayiyona i-hormone, iyi-coenzyme. I-NAD+ ingathuthukisa ikhono le-DNA lokuzilungisa, inwebe isikhathi sokuphila ngokuhlehlisa ukwehla kwe-mitochondria, futhi ivikele i-DNA kanye nomonakalo we-mitochondrial. Futhi ingathuthukisa ukuzinza kwechromosome. I-NAD+ yaziwa nangokuthi "i-molecule eyisimangaliso" ebuyisela futhi igcine impilo yamaseli. Ezifundweni zezilwane, kuqinisekisiwe ukuthi kunamandla aqinile okwelapha izifo ezihlukahlukene ezifana nesifo senhliziyo, isifo sikashukela, isifo se-Alzheimer, kanye nokukhuluphala.
I-NAD+ ibamba iqhaza ekuphenduleni okuhlukahlukene kwamakhemikhali e-biochemical ngaphakathi kwamaseli, njenge-glycolysis, i-fatty acid oxidation, umjikelezo we-tricarboxylic acid, iketango lokuphefumula, njll. Kulezi zinqubo, i-NAD+ isebenza njengesidluliseli se-hydrogen, yamukela ama-electron ne-hydrogen kusuka kuma-substrates bese iwadlulisela Amanye ama-molecule, njenge-NADH ne-FAD, ukugcina ibhalansi ye-redox ye-intracellular. I-NAD+ idlala indima ebalulekile ekukhiqizweni kwamandla eselula, ukuvikela ama-radical mahhala, ukulungiswa kwe-DNA, nokusayina.
Ngaphezu kwalokho, i-NAD+ nayo ihlobene eduze nokuguga, futhi amazinga ayo ehla ngokuya ngeminyaka. Ngakho-ke, ukugcinwa kwamazinga e-NAD+ kudlala indima ebalulekile ekubambezeleni ukuguga, ukuqinisa amandla, ukukhuthaza ukulungiswa kwamaseli, ukuthuthukisa ukusebenza kwengqondo, nokulawula imetabolism.
Ngokuphawulekayo, ukuguga kuhambisana nokwehla okuqhubekayo kwezicubu kanye namazinga e-NAD+ yamaselula ezinhlobonhlobo zezinto eziphilayo, okuhlanganisa amagundane nabantu.
Ngakho-ke, ukugcwalisa ngesikhathi esifanele okuqukethwe kwe-NAD+ emzimbeni kungabambezela ukuguga futhi kuqinisekise impilo. Uma ufuna iminyaka ibe yinombolo nje, yengeza i-NAD+ kusenesikhathi ukuze ubukeke umncane kusuka ngaphakathi ngaphandle.
Amazinga e-NAD+ ehla ngokuya ngeminyaka, ikakhulukazi ngenxa yokuthi izinga layo lokukhiqiza alikwazi ukuhambisana nezinga elisetshenziswayo.
Inani elikhulu lezifundo likhombisile ukuthi ukwehla kwamazinga e-NAD + kuhlobene nezifo eziningi ezihlobene nokuguga, okubandakanya ukuncipha kwengqondo, ukuvuvukala, umdlavuza, izifo ze-metabolic, i-sarcopenia, izifo ze-neurodeergenerative, njll.
Yingakho sidinga izithasiselo ze-NAD+. Njenge-collagen yethu yohlobo 3, ihlezi ilahleka.
I-NAD+ ingamelana nokuguga. Isiphi isimiso esisekelwe kuso?
I-nad+ yenza i-parp1 isebenze i-enzyme yokulungisa izakhi zofuzo
Isiza ekulungiseni i-DNA Enye yezimbangela zokuguga ukulimala kwe-DNA. Izinwele zakho ezimhlophe, i-ovarian nezinye izitho zokwehla, konke kuhlobene nokulimala kwe-DNA. Ukuhlala kuze kube sebusuku futhi ucindezelekile kuzobhebhethekisa ukulimala kwe-DNA.
Ucwaningo luthole ukuthi i-NAD+ isiza ukusebenzisa isakhi sofuzo se-PARP1 (esisebenza njengesiphenduli sokuqala ukuze sithole umonakalo we-DNA bese sikhuthaza ukukhethwa kwezindlela zokulungisa. I-PARP1 iholela ekuwohlokeni kwesakhiwo se-chromatin nge-ADP ribosylation of histones, futhi ibandakanyeka ku-DNA ehlukahlukene. ukulungisa Izinto ziyasebenzisana futhi ziziguqule, ngaleyo ndlela kuthuthukiswe ukusebenza kahle kokulungisa), ngaleyo ndlela kulungiswe umonakalo we-DNA futhi kugqugquzelwe ukuqalwa kwamashifu e-metabolic.
Kafushane, i-NAD+ ingathinta ngokuqondile nangokungaqondile imisebenzi eminingi ebalulekile yamaselula, okuhlanganisa izindlela ze-metabolic, ukulungiswa kwe-DNA, ukulungiswa kabusha kwe-chromatin, ukuvela kwamaselula, ukusebenza kwamangqamuzana omzimba omzimba, njll., ngaleyo ndlela kwehlise inqubo yokuguga komuntu.
NAD+ isifinyezo sesiNgisi se-Nicotinamide adenine dinucleotide. Igama layo eliphelele ngesiShayina i-nicotinamide adenine dinucleotide, noma i-Coenzyme I ngamafuphi. Njenge-coenzyme ehambisa ama-ion e-hydrogen, i-NAD+ idlala indima ezicini eziningi ze-metabolism yomuntu, okuhlanganisa i-glycolysis, i-Gluconeogenesis, umjikelezo we-tricarboxylic acid, njll. Olunye ucwaningo luye lwabonisa ukuthi ukuncipha kwe-NAD+ kuhlobene nobudala, kanye nezinqubo ze-physiological mediated. nge-NAD+ zihlobene nokuguga, izifo ze-metabolic, i-neuropathy kanye nomdlavuza, okuhlanganisa ukulawula i-cell homeostasis, ama-sirtuin aziwa ngokuthi "izakhi zofuzo zokuphila isikhathi eside", ukulungisa i-DNA, amaprotheni omndeni we-PARPs ahlobene ne-necroptosis ne-CD38 esiza ekuboniseni i-calcium.
Anti-Ukuguga
Ukuguga kusho inqubo lapho amaseli ayeka ukuhlukana ngokungenakulungiseka. Ukulimala kwe-DNA okungalungisiwe noma ukucindezeleka kwamaselula kungabangela ukuzwela. Ukuguga ngokuvamile kuchazwa njengenqubo yokuwohloka kancane kancane kwemisebenzi yomzimba ngokuya ngeminyaka; ukubonakaliswa kwangaphandle yizinguquko zomzimba ezibangelwa ukulahlekelwa kwemisipha namathambo, futhi ukubonakaliswa kwangaphakathi kuyancipha i-basal metabolism kanye nokusebenza komzimba.
Ososayensi baye bahlola abantu abaphila isikhathi eside, futhi imiphumela yocwaningo ibonisa ukuthi kukhona isakhi sofuzo esihlobene nokuphila isikhathi eside kubantu abaphila isikhathi eside - "i-Sirtuins gene". Lesi sakhi sofuzo sizobamba iqhaza ohlelweni lokulungiswa kokunikezwa kwamandla omzimba kanye nokuphindaphinda kwe-DNA ukuze kugcinwe ubuqotho nokuzinza kwesakhi sofuzo, ukususa amangqamuzana aguga, kuthuthukise amasosha omzimba ngokusebenzisa imiphumela elwa nokuvuvukala kanye ne-antioxidant, futhi kubambezele ukuguga kwamangqamuzana avamile.
Ukuphela kokusebenza okuhlosiwe kwezakhi zofuzo zesikhathi eside "Sirtuins" -NAD+
I-NAD+ ibalulekile ekugcineni impilo nokulinganisela komzimba. I-Metabolism, i-redox, ukugcinwa nokulungiswa kwe-DNA, ukuzinza kwezakhi zofuzo, ukulawulwa kwe-epigenetic, njll. konke kudinga ukubamba iqhaza kwe-NAD+.
I-NAD+ igcina ukuxhumana kwamakhemikhali phakathi kwe-nucleus ne-mitochondria, futhi ukuxhumana okubuthakathaka kuyimbangela ebalulekile yokuguga kwamaselula.
I-NAD+ ingasusa inani elandayo lamakhodi e-DNA ayiphutha ngesikhathi se-cell metabolism, igcine ukubonakaliswa okuvamile kwezakhi zofuzo, igcine ukusebenza okujwayelekile kwamaseli, futhi yehlise ukuguga kwamangqamuzana omuntu.
Lungisa umonakalo we-DNA
I-NAD+ iyingxenye ebalulekile ye-enzyme yokulungisa i-DNA i-PARP, enomthelela omkhulu ekulungisweni kwe-DNA, ukubonakaliswa kofuzo, ukuthuthukiswa kwamaseli, ukusinda kwamaseli, ukwakhiwa kabusha kwekhromozomi, nokuzinza kwezakhi zofuzo.
Yenza kusebenze amaprotheni okuphila isikhathi eside
Ama-Sirtuin avame ukubizwa ngokuthi umndeni wamaprotheni wesikhathi eside futhi adlala indima ebalulekile yokulawula ekusebenzeni kwamaseli, njengokuvuvukala, ukukhula kwamaseli, isigqi se-circadian, i-metabolism yamandla, umsebenzi we-neuronal, kanye nokumelana nengcindezi, kanti i-NAD+ iyi-enzyme ebalulekile yokuhlanganiswa kwamaprotheni okuphila isikhathi eside. . Yenza kusebenze wonke amaprotheni esikhathi eside we-7 emzimbeni womuntu, edlala indima ebalulekile ekuphikisweni kokucindezeleka kwamaselula, i-metabolism yamandla, ukuvimbela ukuguqulwa kwamaseli, i-apoptosis nokuguga.
Nikeza amandla
Igqugquzela ukukhiqizwa kwamandla angaphezu kwama-95% adingekayo emisebenzini yokuphila. I-Mitochondria emangqamuzaneni omuntu ayizitshalo zamandla zamaseli. I-NAD+ iyi-coenzyme ebalulekile ku-mitochondria ukukhiqiza i-molecule yamandla i-ATP, iguqule izakhi zibe amandla adingwa umzimba womuntu.
Khuthaza ukuvuselelwa kwemithambo yegazi futhi ugcine ukunwebeka kwemithambo yegazi
Imithambo yegazi iyizicubu ezibalulekile emisebenzini yokuphila. Njengoba sikhula, imithambo yegazi kancane kancane ilahlekelwa ukuguquguquka kwayo futhi iba nzima, iminyene, futhi ibe mincane, okubangela "i-arteriosclerosis." I-NAD+ ingakhuphula umsebenzi we-elastin emithanjeni yegazi, ngaleyo ndlela igcine ukunwebeka kwemithambo yegazi nokugcina impilo yemithambo yegazi.
Thuthukisa i-metabolism
I-Metabolism iyisamba sokuphendula kwamakhemikhali okuhlukahlukene emzimbeni. Umzimba uzoqhubeka nokushintshanisa izinto namandla. Lapho lokhu kushintshana kuma, ukuphila komzimba nakho kuzophela.
USolwazi u-Anthony nethimba lakhe labacwaningi eNyuvesi yaseCalifornia, e-U.S.A., bathole ukuthi i-NAD+ ingathuthukisa ngempumelelo ukwehla kwe-cell metabolism ehambisana nokuguga, ngaleyo ndlela ithuthukise impilo yabantu futhi yandise isikhathi sokuphila.
Vikela impilo yenhliziyo
Inhliziyo iyisitho esibaluleke kakhulu kubantu, futhi izinga le-NAD+ emzimbeni lidlala indima ebalulekile ekugcineni ukusebenza okujwayelekile kwenhliziyo. Ukwehliswa kwe-NAD+ kungase kuhlobane ne-pathogenesis yezifo eziningi zenhliziyo nemithambo yegazi, futhi inani elikhulu lezifundo eziyisisekelo nalo liqinisekisile umphumela wokwengeza i-NAD+ ezifweni zenhliziyo.
Vimbela izifo zenhliziyo kanye ne-cerebrovascular
Ucwaningo luye lwabonisa ukuthi cishe zonke izinhlobo eziyisikhombisa ze-sirtuin (SIRT1-SIRT7) zihlobene nokuvela kwesifo senhliziyo. Ama-Sirtuin abhekwa njengezinhloso ze-agonistic ekwelapheni izifo zenhliziyo, ikakhulukazi i-SIRT1.
I-NAD+ ukuphela kwe-substrate ye-Sirtuins. Ukwengezwa ngesikhathi kwe-NAD+ emzimbeni womuntu kungenza kusebenze ngokugcwele umsebenzi we-subtype ngayinye ye-Sirtuins, ngaleyo ndlela kuvikelwe impilo yenhliziyo nemithambo yegazi futhi kuvimbele izifo zenhliziyo.
Khuthaza ukukhula kwezinwele
Imbangela enkulu yokulahleka kwezinwele ukulahleka kokuqina kwamangqamuzana omama wezinwele, futhi ukulahleka kwamandla kamama wezinwele kungenxa yokuthi izinga le-NAD+ emzimbeni womuntu liyehla. Amaseli kamama ezinwele awanayo i-ATP eyanele yokwenza ukwakheka kwamaprotheni ezinwele, ngaleyo ndlela alahlekelwe ubungqabavu bawo futhi aholele ekuqothukeni kwezinwele. Ngakho-ke, ukugcwalisa i-NAD+ kungaqinisa umjikelezo we-asidi futhi kukhiqize i-ATP, ukuze amangqamuzana omama wezinwele abe nekhono elanele lokukhiqiza amaprotheni ezinwele, ngaleyo ndlela enze ngcono ukulahleka kwezinwele.
Ukwelashwa kwe-molecule ye-NAD+
Njengoba iminyaka ikhula, izinga le-NAD+ (Coenzyme I) emzimbeni lizokwehla eweni, okuholela ngqo ekusebenzeni komzimba nokuguga kwamangqamuzana! Ngemuva kweminyaka ephakathi, izinga le-NAD+ emzimbeni womuntu liyehla unyaka nonyaka. Eminyakeni engu-50, izinga le-NAD+ emzimbeni liwuhhafu kuphela walokho lapho uneminyaka engu-20. Uma uneminyaka engu-80, amazinga e-NAD+ acishe abe ngu-1% kuphela walokho ayeyikho eneminyaka engu-20.
Ngakho-ke, ihluke kanjani i-NAD+ powder kwezinye izithasiselo emakethe? Ake sibhekisise amaphuzu athile abalulekile okufanele uwacabangele:
1. I-Bioavailability:
Omunye umehluko omkhulu phakathi kwe-NAD+ powder nezinye izithasiselo yi-bioavailability yayo. I-NAD+ powder imuncwa kalula ngumzimba futhi isebenzise ama-coenzymes ngempumelelo. Ngokuphambene, ezinye izithasiselo zingase zibe ne-bioavailability ephansi, okusho ukuthi umzimba ungase ungakwazi ukumunca nokusebenzisa izithako ezisebenzayo ngempumelelo.
2. Indlela yokwenza:
I-NAD+ powder isebenza ngokugcwalisa amazinga e-NAD+ emzimbeni, ngaleyo ndlela isekele imisebenzi ehlukahlukene yamaselula. Ezinye izithasiselo zingase zibe nezindlela ezahlukahlukene zokwenza, eziqondise izindlela ezithile noma amasistimu emzimbeni. Ukuqonda izindlela ezithile zokwenza izithasiselo ezahlukene kungakusiza ukuthi unqume ukuthi yiziphi ezilungele izidingo zakho zomuntu ngamunye.
3. Ucwaningo nobufakazi:
Uma kucutshungulwa noma yisiphi isengezo, kubalulekile ukubuyekeza ucwaningo olukhona kanye nobufakazi obusekela ukusebenza kahle nokuphepha kwaso. I-NAD+ powder ibe yisihloko sezifundo eziningi, eqokomisa izinzuzo zayo ezingaba khona zempilo yeselula nokuphila isikhathi eside. Ngakolunye uhlangothi, ezinye izithasiselo zingase zibe nocwaningo olulinganiselwe ukuze zisekele izimangalo zazo. Ukuqonda ubufakazi besayensi ngemuva kwesengezo kungakusiza wenze izinqumo ezinolwazi mayelana nokusetshenziswa kwaso.
4. Izidingo kanye nemigomo yomuntu siqu:
Ekugcineni, isinqumo sokusebenzisa i-NAD+ powder noma ezinye izithako kufanele sisekelwe ezidingweni zakho zomuntu siqu kanye nemigomo yezempilo. Cabangela ukubonisana nochwepheshe bezokunakekelwa kwempilo noma isazi sokudla okunempilo ukuze uthole ukuthi yiziphi izithasiselo ezingase zibe yinzuzo kakhulu kuwe. Izinto ezinjengobudala, indlela yokuphila, kanye nezimo zempilo ezikhona zingadlala indima ekunqumeni uhlobo lomuthi olufaneleka kakhulu.
I-NAD+, ososayensi sebeyifunde iminyaka eyi-100. I-NAD+ ayiyona into entsha etholakele, kodwa into efundwe iminyaka engaphezu kweyi-100.
I-NAD+ yaqala ukutholwa ngo-1904 yisazi samakhemikhali ezinto eziphilayo saseBrithani uSir Arthur Harden, kamuva owazuza umklomelo weNobel kuChemistry ngo-1929.
Ngo-1920, u-Hans von Euler-Chelpin wahlukanisa futhi wahlanza i-NAD+ okokuqala futhi wathola isakhiwo sayo se-dinucleotide, wabe esewina uMklomelo KaNobel kuKhemistry ngo-1929.
Ngo-1930, u-Otto Warburg waqala ukuthola indima ebalulekile ye-NAD+ njenge-coenzyme kumetabolism yezinto ezibonakalayo namandla, futhi kamuva wawina uMklomelo KaNobel Kwezokwelapha ngo-1931.
Ngo-1980, uGeorge Birkmayer, uprofesa eMnyangweni Wezokwelapha Chemistry eNyuvesi yaseGraz e-Austria, waqala ukufaka isicelo sokunciphisa i-NAD+ ekwelapheni izifo.
Ngo-2012, iqembu locwaningo lika-Leonard Guarente, iqembu locwaningo likasokhemisi owaziwayo emhlabeni uStephen L. Helfand, kanye neqembu locwaningo lika-Haim Y. Cohen ngokulandelana bathola ukuthi i-NAD+ ingalula izinduku ze-Caenorhabditis elegans. Isikhathi sokuphila se-nematodes sicishe sibe ngama-50%, singanweba isikhathi sokuphila kwezimpukane cishe ngo-10% -20%, futhi singanweba isikhathi sokuphila samagundane angamaduna ngaphezu kuka-10%.
Ukuhlola nokucwaninga kososayensi ngempilo kuye kwabuyekezwa njalo futhi kwaphindwaphindwa. NgoZibandlela wezi-2013, uDavid Sinclair, uprofesa wezofuzo eYunivesithi yaseHarvard, washicilela "Ukwengeza i-NAD nge-NAD" kujenali yezemfundo ephezulu emhlabeni ethi "Cell". "Ngemuva kwesonto elilodwa lokwandisa i-NAD nge-ejenti, isikhathi sokuphila samagundane sanwetshwa ngo-30%. Imiphumela yocwaningo yembule okokuqala ukuthi izithasiselo ze-NAD+ zingahlehlisa kakhulu ukuguga futhi andise ubude bempilo. Lolu cwaningo lwashaqisa umhlaba futhi lwavula umgwaqo wodumo lwezithako ze-NAD njengezinto ezilwa nokuguga. .
Ngalokhu kutholakala okumangalisayo, i-NAD+ isungule ukuxhumana okungenakuhlukaniswa nokulwa nokuguga. Eminyakeni yamuva nje, ucwaningo lwe-NAD+ selucishe lwalawula amajenali ezemfundo e-SCI aphezulu njengeSayensi, Imvelo, kanye neCell, okube ukutholwa okuhlaba umxhwele kakhulu emphakathini wezokwelapha. Kuthiwa lokhu Kuyisinyathelo esiyingqopha-mlando esathathwa isintu ohambweni lokulwa nokuguga nokwelula isikhathi sokuphila.
1. Cwaninga isithunzi somkhiqizo nokungafihli lutho
Uma ucubungula uhlobo oluthile lwempushana ye-NAD+, kufanelekile ukucwaninga isithunzi senkampani nokungafihli lutho. Bheka amabhrendi abeka phambili ukubeka izinto obala ezinqubweni zabo zokuthola nokukhiqiza. Imikhiqizo ehlonishwayo izohlinzeka ngemininingwane enemininingwane mayelana nokutholwa kwayo kwempushana ye-NAD+, okuhlanganisa ikhwalithi yezinto ezingavuthiwe namazinga okukhiqiza abanamathela kuwo. Ukwengeza, bheka ukubuyekezwa kwamakhasimende kanye nobufakazi ukuze ulinganise ukwaneliseka kukonke kwabanye abasebenzisi kanye nolwazi ngemikhiqizo yomkhiqizo.
2. Linganisa ubumsulwa be-NAD+ powder
Ukuhlanzeka kuyisici esibalulekile lapho ukhetha umkhiqizo we-NAD + powder. I-NAD+ yekhwalithi ephezulu kufanele ingabi nakungcola kanye nezigcwalisi, iqinisekise ukuthi uthola umkhiqizo ohlanzekile futhi osebenzayo. Bheka amabhrendi enza ukuhlola kwezinkampani zangaphandle ukuze uqinisekise ubumsulwa be-NAD+ yabo powder. Ukuhlola okuvela eceleni kunikeza isiqinisekiso esengeziwe sokuthi imikhiqizo ihlangabezana nezindinganiso eziphakeme zokuhlanzeka futhi ayinazo izinto eziyingozi.
3. Cabangela izinqubo zokukhiqiza kanye namazinga ekhwalithi
Inqubo yokukhiqiza idlala indima ebalulekile kwikhwalithi ye-NAD + powder. Khetha amabhrendi alandela izinyathelo eziqinile zokulawula ikhwalithi futhi anamathele ku-Good Manufacturing Practices (GMP). Isitifiketi se-GMP siqinisekisa ukuthi imikhiqizo ikhiqizwa endaweni ehlanzekile nelawulwayo, kunciphisa ubungozi bokungcola kanye nokuqinisekisa ikhwalithi engaguquki. Ukwengeza, buza ngokuzibophezela komkhiqizo ekusimameni nasezinkambisweni zokuthola izinto ezilungile, njengoba lezi zici zingaphinda zibonise ikhwalithi yomkhiqizo.
4. Hlola i-bioavailability kanye nokumuncwa kwe-NAD+ powder
I-Bioavailability isho ikhono lomzimba lokumunca nokusebenzisa izithako ezisebenzayo esenzweni. Lapho ukhetha uhlobo lwe-NAD+ powder, cabangela i-bioavailability yomkhiqizo. Bheka amabhrendi asebenzisa amasistimu okulethwa okuthuthukile noma ubuchwepheshe ukukhulisa i-NAD+ bioavailability. Lokhu kungafaka izici ezifana ne-micronization noma i-encapsulation, engathuthukisa ukumuncwa kwe-NAD+ emzimbeni, ekugcineni kukhulise ukusebenza kwayo kahle.
5. Funa ucwaningo lwesayensi kanye nocwaningo lomtholampilo
Imikhiqizo yempushana ehlonishwayo ye-NAD+ ngokuvamile ihlinzeka ngezifundo zesayensi nezomtholampilo ukuze zisekele ukusebenza kahle nokuphepha kwemikhiqizo yazo. Bheka izinhlobo ezitshala imali ocwaningweni nasekuthuthukisweni, njengoba lokhu kukhombisa ukuzibophezela ekukhiqizeni imikhiqizo esezingeni eliphezulu nesekelwe ebufakazini. Ukuqinisekiswa kwesayensi kuqinisekisa ukuthi i-NAD+ powder iye yahlolwa futhi yahlolwa kanzima, futhi iqinisekisa ikhwalithi nobumsulwa bayo.
I-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lesengezo sokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, iSuzhou Myland Pharm & Nutrition Inc. iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ithobelane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.
Q: Zisetshenziselwa ini izithasiselo ze-NAD+?
A:Isengezo se-NAD+ siyisithasiselo sokudla okunomsoco esifaka i-coenzyme NAD+ (nicotinamide adenine dinucleotide). I-NAD+ idlala indima ebalulekile kumetabolism yamandla kanye nokulungiswa kwamaseli ngaphakathi kwamaseli.
Q: Ingabe izithasiselo ze-NAD+ ziyasebenza ngempela?
A: Olunye ucwaningo luphakamisa ukuthi izithasiselo ze-NAD+ zingasiza ukuthuthukisa i-metabolism yamandla eselula futhi zehlise inqubo yokuguga.
Q:Yimiphi imithombo yokudla ye-NAD+?
A: Imithombo yokudla ye-NAD+ ihlanganisa inyama, inhlanzi, imikhiqizo yobisi, ubhontshisi, amantongomane nemifino. Lokhu kudla kuqukethe i-niacinamide ne-niacin eyengeziwe, engaguqulwa ibe yi-NAD+ emzimbeni.
Q: Ngisikhetha kanjani isengezo se-NAD+?
IMP: Uma ukhetha izithasiselo ze-NAD+, kunconywa ukuthi uqale ufune iseluleko kudokotela noma isazi sokudla okunomsoco ukuze uqonde izidingo zakho zokudla okunomsoco nesimo sezempilo. Ngaphezu kwalokho, khetha uhlobo olunegama elihle, hlola izithako zomkhiqizo kanye nomthamo, bese ulandela isiqondiso somthamo ekufakweni komkhiqizo.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Aug-05-2024
