I-NAD+ (i-Beta-Nicotinamide Adenine Dinucleotide) iyi-coenzyme etholakala kuwo wonke amaseli aphilayo futhi ibalulekile ezinqubweni ezahlukahlukene zezinto eziphilayo, okuhlanganisa ukukhiqizwa kwamandla kanye nokulungiswa kwe-DNA. Njengoba siguga, amazinga ethu e-NAD+ ayancipha, okuholela ezinkingeni eziningi zempilo. Ukuze silwe nale nkinga, abantu abaningi baphendukela ezithasiselweni ze-NAD+ ngesimo sempuphu. Kodwa-ke, njengoba kunezinketho eziningi kangaka ezikhona, ukunquma ukuthi iyiphi i-NAD+ powder engcono kakhulu kuwe kungaba yinselele. Ukukhetha i-NAD+ powder engcono kakhulu kudinga ukucatshangelwa ngokucophelela ubumsulwa, ukutholakala kwezinto eziphilayo, umthamo, ukucaca, kanye nempendulo yamakhasimende. Ngokubeka lezi zici phambili, ungenza isinqumo esinolwazi futhi ukhethe i-NAD+ powder esezingeni eliphezulu esekela impilo yakho kanye nenhlalakahle yakho.
I-NAD yenzeka ngokwemvelo emaseli ethu,ikakhulukazi ku-cytoplasm yabo kanye ne-mitochondria, nokho, amazinga emvelo e-NAD ayancipha njengoba siguga (njalo eminyakeni engama-20, empeleni), okubangela imiphumela evamile yokuguga, Njengokwehla kwamazinga amandla kanye nokwanda kobuhlungu nobuhlungu. Ngaphezu kwalokho, ukwehla okuhlobene nokuguga ku-NAD kuhlotshaniswa nezinye izifo ezihlobene nokuguga, njengomdlavuza, ukwehla kwengqondo, kanye nobuthakathaka.
I-NAD+ akuyona i-hormone, iyi-coenzyme. I-NAD+ ingathuthukisa ikhono le-DNA lokuzilungisa, yandise isikhathi sokuphila ngokuguqula ukwehla kwe-mitochondria, futhi ivikele i-DNA kanye nomonakalo we-mitochondrial. Futhi ingathuthukisa ukuzinza kwe-chromosome. I-NAD+ yaziwa nangokuthi "i-molecule yezimangaliso" ebuyisela futhi igcine impilo yamaseli. Ezifundweni zezilwane, kuye kwaqinisekiswa ukuthi inamandla amakhulu okwelapha izifo ezahlukahlukene ezifana nesifo senhliziyo, isifo sikashukela, isifo i-Alzheimer's, kanye nokukhuluphala.
I-NAD+ ihlanganyela ezinhlobonhlobo zezindlela zokusabela kwamakhemikhali ngaphakathi kwamaseli, njenge-glycolysis, i-fatty acid oxidation, umjikelezo we-tricarboxylic acid, uchungechunge lokuphefumula, njll. Kulezi zinqubo, i-NAD+ isebenza njengomthumeli we-hydrogen, yamukela ama-electron kanye ne-hydrogen kusuka kuma-substrates bese iwadlulisela kwamanye ama-molecule, njenge-NADH kanye ne-FAD, ukuze kugcinwe ibhalansi ye-redox yangaphakathi kweseli. I-NAD+ idlala indima ebalulekile ekukhiqizweni kwamandla eseli, ekuvikelweni kwama-free radical, ekulungisweni kwe-DNA, nasekusayineni.
Ngaphezu kwalokho, i-NAD+ nayo ihlobene kakhulu nokuguga, futhi amazinga ayo ayancipha ngokuguga. Ngakho-ke, ukugcina amazinga e-NAD+ kudlala indima ebalulekile ekubambezeleni ukuguga, ukuthuthukisa amandla, ukukhuthaza ukulungiswa kwamaseli, ukuthuthukisa ukusebenza kwengqondo, kanye nokulawula imetabolism.
Okuphawulekayo ukuthi ukuguga kuhambisana nokwehla okuqhubekayo kwamazinga e-NAD+ ezicutshini kanye namangqamuzana ezinhlobonhlobo zezinto eziphilayo eziyisibonelo, okuhlanganisa amagundane nabantu.
Ngakho-ke, ukugcwalisa okuqukethwe yi-NAD+ ngesikhathi esifanele emzimbeni kungalibazisa ukuguga futhi kuqinisekise impilo. Uma ufuna ubudala bube yinombolo nje, engeza i-NAD+ kusenesikhathi ukuze ubukeke umusha kusukela ngaphakathi kuya ngaphandle.
Amazinga e-NAD+ ehla ngokweminyaka, ikakhulukazi ngoba izinga lokukhiqiza kwayo alikwazi ukuhambisana nezinga lokusetshenziswa kwayo.
Ucwaningo oluningi lukhombisile ukuthi ukwehla kwamazinga e-NAD+ kuhlobene nezifo eziningi ezihlobene nokuguga, okuhlanganisa ukwehla kwengqondo, ukuvuvukala, umdlavuza, izifo ze-metabolic, i-sarcopenia, izifo ze-neurodegenerative, njll.
Yingakho sidinga izithasiselo ze-NAD+. Njenge-collagen yethu yohlobo lwesithathu, ilahleka njalo.
I-NAD+ ingamelana nokuguga. Iyini isimiso sayo?
i-nad+ isebenzisa i-enzyme yokulungisa izakhi zofuzo ze-parp1
Isiza ekulungisweni kwe-DNA Enye yezimbangela zokuguga ukulimala kwe-DNA. Izinwele zakho ezimhlophe, ukwehla kwesibeletho kanye nezinye izitho zomzimba, konke kuhlobene nokulimala kwe-DNA. Ukuhlala uphapheme kuze kube sebusuku kanye nokucindezeleka kuzokwandisa umonakalo we-DNA.
Izifundo zithole ukuthi i-NAD+ isiza ekusebenziseni i-PARP1 gene (esebenza njengomphenduli wokuqala ukuthola umonakalo we-DNA bese ikhuthaza ukukhethwa kwezindlela zokulungisa. I-PARP1 iholela ekunciphisweni kwesakhiwo se-chromatin nge-ADP ribosylation yama-histone, futhi ihilelekile ezintweni ezahlukahlukene zokulungisa i-DNA ezisebenzisana futhi ziwashintshe, ngaleyo ndlela kuthuthukiswe ukusebenza kahle kokulungisa), ngaleyo ndlela kulungiswe umonakalo we-DNA futhi kukhuthazwe ukuqala kokushintsha kwe-metabolic.
Ngamafuphi, i-NAD+ ingathinta ngqo nangokungaqondile imisebenzi eminingi ebalulekile yamaseli, okuhlanganisa izindlela ze-metabolic, ukulungiswa kwe-DNA, ukulungiswa kwe-chromatin, ukuguga kwamaseli, ukusebenza kwamaseli omzimba, njll., ngaleyo ndlela kunciphise inqubo yokuguga komuntu.
I-NAD+ isifinyezo sesiNgisi se-Nicotinamide adenine dinucleotide. Igama layo eliphelele ngesiShayina yi-nicotinamide adenine dinucleotide, noma i-Coenzyme I ngamafuphi. Njenge-coenzyme edlulisa ama-ion e-hydrogen, i-NAD+ idlala indima ezicini eziningi ze-metabolism yomuntu, okuhlanganisa i-glycolysis, i-Gluconeogenesis, umjikelezo we-tricarboxylic acid, njll. Ezinye izifundo zikhombe ukuthi ukuncipha kwe-NAD+ kuhlobene nobudala, futhi izindlela zomzimba eziqondiswa yi-NAD+ zihlobene nokuguga, izifo ze-metabolic, i-neuropathy kanye nomdlavuza, okuhlanganisa nokulawula i-homeostasis yamaseli, ama-sirtuin aziwa ngokuthi "ama-gene okuphila isikhathi eside", ukulungisa i-DNA, amaprotheni omndeni we-PARP ahlobene ne-necroptosis kanye ne-CD38 esiza ekudluliseleni kwe-calcium.
Ukulwa nokuguga
Ukuguga kubhekisela enkambisweni lapho amangqamuzana eyeka khona ukuhlukana ngokungenakulungiseka. Ukulimala kwe-DNA okungalungiswanga noma ukucindezeleka kwamaseli kungabangela ukuguga. Ukuguga ngokuvamile kuchazwa njengenqubo yokuwohloka kancane kancane kwemisebenzi yomzimba njengoba ukhula; izimpawu zangaphandle ziyizinguquko zomzimba ezibangelwa ukulahlekelwa yimisipha namathambo, kanti izimpawu zangaphakathi ziwukuncipha kwe-basal metabolism kanye nokusebenza komzimba.
Ososayensi baye bafunda abantu abaphila isikhathi eside, futhi imiphumela yocwaningo ikhombisa ukuthi kukhona i-gene ehlobene nokuphila isikhathi eside kubantu abaphila isikhathi eside - i-"Sirtuins gene". Le gene izobamba iqhaza enqubweni yokulungiswa kokuhlinzekwa kwamandla emzimbeni kanye nokuphindaphinda kwe-DNA ukuze kulondolozwe ubuqotho nokuqina kwe-gene, kususwe amangqamuzana agugayo, kuthuthukiswe amasosha omzimba ngokusebenzisa imiphumela yokulwa nokuvuvukala kanye ne-antioxidant, futhi kubambezele ukuguga kwamangqamuzana avamile.
Ukuvuselelwa okuqondiwe kuphela kwezakhi zofuzo zobude besikhathi eside "amaSirtuins" -I-NAD+
I-NAD+ ibalulekile ekugcineni impilo yomzimba kanye nokulinganisela. I-metabolism, i-redox, ukugcinwa nokulungiswa kwe-DNA, ukuzinza kwezakhi zofuzo, ukulawulwa kwe-epigenetic, njll. konke kudinga ukuhlanganyela kwe-NAD+.
I-NAD+ igcina ukuxhumana kwamakhemikhali phakathi kwe-nucleus ne-mitochondria, futhi ukuxhumana okubuthakathaka kuyimbangela ebalulekile yokuguga kwamangqamuzana.
I-NAD+ ingasusa inani elikhulayo lamakhodi e-DNA anephutha ngesikhathi sokusebenza kweseli, igcine ukubonakaliswa okuvamile kwezakhi zofuzo, igcine ukusebenza okuvamile kwamaseli, futhi yehlise ijubane lokuguga kwamaseli abantu.
Lungisa umonakalo we-DNA
I-NAD+ iyi-substrate ebalulekile ye-enzyme yokulungisa i-DNA i-PARP, enomthelela omkhulu ekulungisweni kwe-DNA, ukubonakaliswa kwezakhi zofuzo, ukuthuthukiswa kwamaseli, ukusinda kwamaseli, ukwakhiwa kabusha kwama-chromosome, kanye nokuqina kwezakhi zofuzo.
Yenza kusebenze iphrotheni yokuphila isikhathi eside
Ama-Sirtuin avame ukubizwa ngokuthi umndeni wamaprotheni okuphila isikhathi eside futhi adlala indima ebalulekile yokulawula emisebenzini yamaseli, njengokuvuvukala, ukukhula kwamaseli, isigqi se-circadian, i-metabolism yamandla, umsebenzi we-neuronal, kanye nokumelana nokucindezeleka, kanti i-NAD+ iyi-enzyme ebalulekile yokwenziwa kwamaprotheni okuphila isikhathi eside. Ivuselela wonke amaprotheni okuphila isikhathi eside angu-7 emzimbeni womuntu, idlala indima ebalulekile ekumelaneni nokucindezeleka kwamaseli, i-metabolism yamandla, ukuvimbela ukuguquka kwamaseli, i-apoptosis kanye nokuguga.
Nikeza amandla
Ikhuthaza ukukhiqizwa kwamandla angaphezu kuka-95% adingekayo emisebenzini yokuphila. I-Mitochondria emangqamuzaneni abantu iyizitshalo zamandla zamaseli. I-NAD+ iyi-coenzyme ebalulekile ku-mitochondria ukukhiqiza i-molecule yamandla i-ATP, iguqula izakhamzimba zibe amandla adingwa umzimba womuntu.
Khuthaza ukuvuselelwa kwemithambo yegazi futhi ugcine ukuqina kwemithambo yegazi
Imithambo yegazi iyizicubu ezibalulekile emisebenzini yokuphila. Njengoba sikhula, imithambo yegazi ilahlekelwa kancane kancane ukuguquguquka kwayo futhi iba lukhuni, ijiye, futhi ibe mincane, okubangela "i-arteriosclerosis." I-NAD+ ingandisa umsebenzi we-elastin emithanjeni yegazi, ngaleyo ndlela igcine ukuqina kwemithambo yegazi futhi igcine impilo yemithambo yegazi.
Khuthaza i-metabolism
I-metabolism iyinhlanganisela yezindlela ezahlukahlukene zokusabela kwamakhemikhali emzimbeni. Umzimba uzoqhubeka nokushintshanisa izinto kanye namandla. Uma lokhu kushintshana kuyeka, impilo yomzimba nayo izophela.
USolwazi Anthony kanye nethimba lakhe locwaningo eNyuvesi yaseCalifornia, e-USA, bathole ukuthi i-NAD+ ingathuthukisa ngempumelelo ukwehla kokusebenza kweseli okuhambisana nokuguga, ngaleyo ndlela ithuthukise impilo yabantu futhi yandise isikhathi sokuphila.
Vikela impilo yenhliziyo
Inhliziyo iyisitho esibaluleke kakhulu kubantu, futhi izinga le-NAD+ emzimbeni lidlala indima ebalulekile ekugcineni ukusebenza okuvamile kwenhliziyo. Ukwehla kwe-NAD+ kungase kuhlobane nokuqala kwezifo eziningi zenhliziyo, futhi inani elikhulu lezifundo eziyisisekelo nalo liqinisekisile umphumela wokwengeza i-NAD+ ezifweni zenhliziyo.
Vimbela izifo zenhliziyo nemithambo yegazi
Izifundo zibonise ukuthi cishe zonke izinhlobo eziyisikhombisa ze-sirtuin (SIRT1-SIRT7) zihlobene nokuvela kwesifo senhliziyo. Ama-Sirtuin abhekwa njengezinhloso eziqinile zokwelapha izifo zenhliziyo, ikakhulukazi i-SIRT1.
I-NAD+ yiyona kuphela isisekelo se-Sirtuins. Ukwengezwa kwe-NAD+ ngesikhathi esifanele emzimbeni womuntu kungenza umsebenzi we-subtype ngayinye ye-Sirtuins usebenze ngokugcwele, ngaleyo ndlela kuvikelwe impilo yenhliziyo nokuvimbela izifo zenhliziyo.
Khuthaza ukukhula kwezinwele
Imbangela eyinhloko yokulahleka kwezinwele ukulahlekelwa amandla eseli likamama wezinwele, kanti ukulahlekelwa amandla eseli likamama wezinwele kungenxa yokuthi izinga le-NAD+ emzimbeni womuntu liyehla. Amaseli omama wezinwele awanawo i-ATP eyanele yokwenza ukwakheka kwamaprotheni ezinwele, ngaleyo ndlela alahlekelwe amandla awo futhi kuholele ekulahlekelweni kwezinwele. Ngakho-ke, ukwengeza i-NAD+ kungaqinisa umjikelezo we-asidi futhi kukhiqize i-ATP, ukuze amaseli omama wezinwele abe namandla anele okukhiqiza amaprotheni ezinwele, ngaleyo ndlela kuthuthukiswe ukulahleka kwezinwele.
Ukwelashwa kwama-molecule eseli le-NAD+
Njengoba iminyaka ikhula, izinga le-NAD+ (i-Coenzyme I) emzimbeni lizokwehla eweni, okuholela ngqo ekusebenzeni komzimba kanye nokuguga kwamaseli! Ngemva kweminyaka ephakathi, izinga le-NAD+ emzimbeni womuntu liyancipha unyaka nonyaka. Lapho eneminyaka engu-50, izinga le-NAD+ emzimbeni liyingxenye nje yalokho lapho eneminyaka engu-20. Lapho eneminyaka engu-80, amazinga e-NAD+ acishe abe yi-1% kuphela yalokho ayeyikho lapho eneminyaka engu-20.
Ngakho-ke, i-NAD+ powder ihluke kanjani kwezinye izithako ezikhona emakethe? Ake sibheke kabanzi amaphuzu athile abalulekile okufanele uwacabangele:
1. Ukutholakala kwezinto eziphilayo:
Omunye umehluko omkhulu phakathi kwempuphu ye-NAD+ nezinye izithako ukuthi i-bioavailability yayo. Impuphu ye-NAD+ imuncwa kalula ngumzimba futhi isebenzisa ama-coenzymes ngempumelelo. Ngakolunye uhlangothi, ezinye izithako zingase zibe ne-bioavailability ephansi, okusho ukuthi umzimba ungase ungakwazi ukumunca nokusebenzisa izithako ezisebenzayo ngempumelelo.
2. Indlela yokusebenza:
Impuphu ye-NAD+ isebenza ngokugcwalisa amazinga e-NAD+ emzimbeni, ngaleyo ndlela isekele imisebenzi ehlukahlukene yamaseli. Ezinye izithako zingase zibe nezindlela ezahlukene zokusebenza, ziqondise izindlela noma izinhlelo ezithile emzimbeni. Ukuqonda izindlela ezithile zokusebenza kwezithako ezahlukene kungakusiza ukuthi unqume ukuthi yiziphi ezilungele izidingo zakho.
3. Ucwaningo nobufakazi:
Uma ucabangela noma yisiphi isithasiselo, kubalulekile ukubuyekeza ucwaningo olukhona kanye nobufakazi obusekela ukusebenza kahle nokuphepha kwaso. Impuphu ye-NAD+ ibilokhu ifundwa ngezifundo eziningi, iqokomisa izinzuzo zayo ezingaba khona empilweni yamaseli kanye nokuphila isikhathi eside. Ngakolunye uhlangothi, ezinye izithasiselo zingase zibe nocwaningo olulinganiselwe ukusekela izimangalo zazo. Ukuqonda ubufakazi besayensi obungemuva kwesithasiselo kungakusiza ukuthi wenze izinqumo ezinolwazi mayelana nokusetshenziswa kwaso.
4. Izidingo zomuntu siqu kanye nemigomo:
Ekugcineni, isinqumo sokusebenzisa i-NAD+ powder noma ezinye izithako kufanele sisekelwe ezidingweni zakho siqu kanye nemigomo yezempilo. Cabanga ngokubonisana nochwepheshe wezempilo noma isazi sokudla okunempilo esiqeqeshiwe ukuze unqume ukuthi yiziphi izithako ezingaba usizo kakhulu kuwe. Izici ezifana nobudala, indlela yokuphila, kanye nezimo zempilo ezikhona zonke zingadlala indima ekunqumeni uhlelo lokudla olufanele kakhulu.
I-NAD+, ososayensi bebelokhu beyihlola iminyaka eyi-100. I-NAD+ akuyona into entsha sha etholakele, kodwa yinto efundwe iminyaka engaphezu kweyi-100.
I-NAD+ yaqala ukutholwa ngo-1904 yisazi samakhemikhali ezinto eziphilayo saseBrithani uSir Arthur Harden, kamuva owathola uMklomelo weNobel kuKhemistri ngo-1929.
Ngo-1920, uHans von Euler-Chelpin wahlukanisa futhi wahlanza i-NAD+ okokuqala ngqa futhi wathola isakhiwo sayo se-dinucleotide, wabe esewina uMklomelo KaNobel KwezeKhemistri ngo-1929.
Ngo-1930, u-Otto Warburg waqala ukuthola indima ebalulekile ye-NAD+ njenge-coenzyme ekusetshenzisweni kwezinto ezibonakalayo namandla, futhi kamuva wathola uMklomelo KaNobel Kwezokwelapha ngo-1931.
Ngo-1980, uGeorge Birkmayer, uprofesa eMnyangweni Wezokwelapha eNyuvesi yaseGraz e-Austria, waqala ukusebenzisa i-NAD+ encishisiwe ekwelapheni izifo.
Ngo-2012, iqembu locwaningo likaLeonard Guarente, iqembu locwaningo losokhemisi odumile emhlabeni uStephen L. Helfand, kanye neqembu locwaningo likaHaim Y. Cohen ngokulandelana bathole ukuthi i-NAD+ ingandisa izinduku ze-Caenorhabditis elegans. Isikhathi sokuphila sama-nematode sicishe sibe ngu-50%, singandisa isikhathi sokuphila sama-fruit fly cishe ngo-10%-20%, futhi singandisa isikhathi sokuphila samagundane angamaduna ngaphezu kuka-10%.
Ukuhlola nokucwaninga kososayensi ngokuphila kuye kwabuyekezwa njalo futhi kwaphindwaphindwa. NgoDisemba 2013, uDavid Sinclair, uprofesa wezakhi zofuzo eHarvard University, washicilela i-"Supplementing NAD with NAD" ephephabhukwini lezemfundo eliphezulu emhlabeni elithi "Cell". "Ngemuva kwesonto elilodwa lokwandisa i-NAD nge-ejenti, isikhathi sokuphila samagundane sandiswa ngo-30%." Imiphumela yocwaningo yembule okokuqala ukuthi izithako ze-NAD+ zingaguqula kakhulu ukuguga futhi zandise isikhathi sokuphila. Lolu cwaningo lwashaqisa umhlaba futhi lwavula indlela eya odumo lwezithasiselo ze-NAD njengezinto ezilwa nokuguga. .
Ngalesi sitholo esimangalisayo, i-NAD+ isungule uxhumano olungenakuhlukaniswa nokulwa nokuguga. Eminyakeni yamuva nje, ucwaningo nge-NAD+ seluvele luvelele kakhulu emaphephandabeni ezifundo aphezulu e-SCI njengeSayensi, Imvelo, kanye neSeli, lwaba ukutholwa okumangalisayo kakhulu emphakathini wezokwelapha. Kuthiwa lokhu kuyisinyathelo somlando esithathwe isintu ohambweni lokulwa nokuguga nokwandisa isikhathi sokuphila.
1. Cwaninga idumela lomkhiqizo kanye nokungafihli lutho kwawo
Uma ucabangela uhlobo oluthile lwempuphu ye-NAD+ impuphu, kufanelekile ukucwaninga idumela kanye nokucaca kwenkampani. Funa izinhlobo ezibeka phambili ukucaca ezinqubweni zazo zokuthola nokukhiqiza. Izinhlobo ezidumile zizohlinzeka ngolwazi oluningiliziwe mayelana nokuthola kwazo impuphu ye-NAD+ impuphu, okuhlanganisa ikhwalithi yezinto zokusetshenziswa kanye nezindinganiso zokukhiqiza ezizinamathelayo. Ngaphezu kwalokho, funa ukubuyekezwa kwamakhasimende kanye nobufakazi ukuze ulinganise ukwaneliseka kanye nolwazi lwabanye abasebenzisi ngemikhiqizo yomkhiqizo.
2. Hlola ubumsulwa be-NAD+ powder
Ubumsulwa buyisici esibalulekile lapho ukhetha uhlobo lwempuphu ye-NAD+. Impuphu ye-NAD+ esezingeni eliphezulu kufanele ingabi namagciwane kanye nezigcwalisi, iqinisekise ukuthi uthola umkhiqizo omsulwa futhi osebenzayo. Funa izinhlobo ezenza ukuhlolwa komuntu wesithathu ukuqinisekisa ubumsulwa bempuphu yazo ye-NAD+. Ukuhlolwa komuntu wesithathu kunikeza isiqinisekiso esengeziwe sokuthi imikhiqizo ihlangabezana nezindinganiso eziphakeme kakhulu zobumsulwa futhi ayinazo izinto eziyingozi.
3. Cabanga ngezinqubo zokukhiqiza kanye nezindinganiso zekhwalithi
Inqubo yokukhiqiza idlala indima ebalulekile ekhwalithini yempuphu ye-NAD+. Khetha izinhlobo ezilandela izinyathelo eziqinile zokulawula ikhwalithi futhi ezinamathela kwiMikhuba Emihle Yokukhiqiza (i-GMP). Isitifiketi se-GMP siqinisekisa ukuthi imikhiqizo ikhiqizwa endaweni ehlanzekile nelawulwayo, kunciphisa ingozi yokungcola futhi kuqinisekiswe ikhwalithi eqhubekayo. Ngaphezu kwalokho, buza ngokuzibophezela komkhiqizo ekusimeni nasekutholeni imikhiqizo ngendlela yokuziphatha, njengoba lezi zici zingabonisa nekhwalithi iyonke yomkhiqizo.
4. Hlola ukutholakala kanye nokumuncwa kwempuphu ye-NAD+
Ukutholakala kwe-bioavailability kubhekisela ekhonweni lomzimba lokumunca nokusebenzisa izithako ezisebenzayo esithasiselweni. Uma ukhetha uhlobo lwe-NAD+ powder, cabanga ngokutholakala kwe-bioavailability komkhiqizo. Bheka izinhlobo ezisebenzisa izinhlelo zokulethwa ezithuthukisiwe noma ubuchwepheshe ukwandisa ukutholakala kwe-NAD+. Lokhu kungafaka izici ezifana ne-micronization noma i-encapsulation, ezingathuthukisa ukumuncwa kwe-NAD+ emzimbeni, ekugcineni kwandise ukusebenza kwayo.
5. Funa ucwaningo lwesayensi kanye nocwaningo lwezokwelapha
Imikhiqizo yempuphu ye-NAD+ edumile ivame ukunikeza izifundo zesayensi nezokwelapha ukusekela ukusebenza kahle nokuphepha kwemikhiqizo yayo. Funa imikhiqizo etshala imali ocwaningweni nasekuthuthukisweni, njengoba lokhu kubonisa ukuzibophezela ekukhiqizeni imikhiqizo esezingeni eliphezulu nesekelwe ebufakazini. Ukuqinisekiswa kwesayensi kuqinisekisa ukuthi impuphu ye-NAD+ iye yahlolwa futhi yahlolwa kanzima, okuqinisekisa ikhwalithi nobumsulwa bayo.
I-Suzhou Myland Pharm & Nutrition Inc. ibilokhu ibandakanyeka ebhizinisini lezithako zokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokuthengisa okukhishwe kwembewu yamagilebhisi.
Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye nesu le-R&D elithuthukisiwe kakhulu, inkampani ithuthukise imikhiqizo ehlukahlukene yokuncintisana futhi yaba yinkampani yezinsizakalo ezintsha zesayensi yokuphila, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.
Ngaphezu kwalokho, iSuzhou Myland Pharm & Nutrition Inc. nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.
U: Zisetshenziselwa ini izithasiselo ze-NAD+?
Isengezo se-NAD+ siyisengezo sokudla esinezela i-coenzyme NAD+ (i-nicotinamide adenine dinucleotide). I-NAD+ idlala indima ebalulekile ekugayweni kwamandla kanye nokulungiswa kwamaseli ngaphakathi kwamaseli.
U: Ingabe izithasiselo ze-NAD+ ziyasebenza ngempela?
A: Ucwaningo oluthile lusikisela ukuthi izithasiselo ze-NAD+ zingasiza ekuthuthukiseni ukusebenza kahle kwamandla eseli futhi zinciphise inqubo yokuguga.
U: Yiziphi izindlela zokudla ze-NAD+?
A: Imithombo yokudla ye-NAD+ ifaka phakathi inyama, inhlanzi, imikhiqizo yobisi, ubhontshisi, amantongomane nemifino. Lokhu kudla kuqukethe i-niacinamide ne-niacin eningi, engaguqulwa ibe yi-NAD+ emzimbeni.
U: Ngingayikhetha kanjani i-NAD+ supplement?
A: Uma ukhetha izithasiselo ze-NAD+, kunconywa ukuthi uqale ufune iseluleko kudokotela noma kuchwepheshe wezokudla ukuze uqonde izidingo zakho zokudla okunempilo kanye nesimo sakho sempilo. Ngaphezu kwalokho, khetha uhlobo lomkhiqizo olunedumela elihle, hlola izithako zomkhiqizo kanye nomthamo, bese ulandela isiqondiso somthamo esifakweni somkhiqizo.
Isixwayiso: Lesi sihloko senzelwe ulwazi olujwayelekile kuphela futhi akufanele sithathwe njenganoma yisiphi iseluleko sezokwelapha. Olunye ulwazi lweposi lebhulogi luvela kwi-inthanethi futhi alulona ochwepheshe. Le webhusayithi inesibopho sokuhlunga, ukufometha nokuhlela izihloko kuphela. Inhloso yokudlulisa ulwazi olwengeziwe akusho ukuthi uyavumelana nemibono yayo noma uqinisekisa ubuqiniso bokuqukethwe kwayo. Njalo xhumana nochwepheshe wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukwenza izinguquko ohlelweni lwakho lokunakekelwa kwempilo.
Isikhathi sokuthunyelwe: Agasti-05-2024
