I-NR iwuhlobo lwevithamini B3, uhlobo oluncishisiwe lwe-nicotinamide riboside, i-NRH, edume ngezinzuzo zayo zezempilo ezingaba khona, okuhlanganisa ukusekela ukukhiqizwa kwamandla kwamaselula nokukhuthaza ukuguga okunempilo. Njengoba isidingo sezithasiselo ze-NRH siqhubeka sikhula, kubalulekile ukuqonda ukuthi ungasikhethela kanjani isithasiselo esifanele. Ukukhetha isithasiselo esincishisiwe se-nicotinamide riboside esingcono kakhulu sezidingo zakho kudinga ukucatshangelwa ngokucophelela ubumsulwa, i-bioavailability, umthamo, ukwakheka, izici zokukhiqiza ezifana nesithunzi sebhizinisi kanye nenani lilonke. Ngokubeka lezi zici ezibalulekile kuqala futhi wenze ucwaningo olunzulu, ungakhetha isithasiselo se-NRH sekhwalithi ephezulu ukuze usekele izinjongo zakho zempilo nokuphila kahle.
I-Nicotinamide riboside (NR) ithola ukunakwa emphakathini wezempilo nokuphila kahle ngezinzuzo zayo ezingaba khona ekusekeleni ukukhiqizwa kwamandla amaselula kanye nempilo enhle iyonke. Njengomanduleli we-nicotinamide adenine dinucleotide (NAD+), i-NR idlala indima ebalulekile ezinqubweni ezihlukahlukene zebhayoloji, okuhlanganisa imetabolism, ukulungiswa kwe-DNA, nokubonakaliswa kofuzo. Kodwa-ke, olunye uhlobo lwe-NR kube yisihloko selukuluku nentshisekelo: ifomu layo elincishisiwe.
Ngakho-ke, liyini ngempela uhlobo oluncishisiwe lwe-nicotinamide riboside? Ihluke kanjani efomini elijwayelekile? Ake sithole ndawonye!
I-Nicotinamide riboside, eyaziwa nangokuthi i-NR, iwuhlobo lwevithamini B3 olufundelwe amandla ayo okusekela ukukhiqizwa kwamandla kwamaselula kanye nempilo yonke ye-metabolic. Ingumanduleli we-nicotinamide adenine dinucleotide (NAD+), i-coenzyme edlala indima ebalulekile ezinqubweni ezihlukahlukene zebhayoloji, okuhlanganisa amandla e-metabolism kanye nokulungiswa kwe-DNA. kanye nenkulumo yofuzo. Amazinga e-NAD+ ehla ngokuya ngeminyaka, futhi lokhu kwehla kuye kwaxhunyaniswa nohlu lwezinkinga zempilo ezihlobene nobudala.
Ifomu elincishisiwe le-nicotinamide riboside, evame ukubizwa ngokuthi i-NRH, iphuma ku-NR ebhekana nenqubo yokunciphisa, okuholela ekushintsheni kwesakhiwo samakhemikhali. Le nqubo yokunciphisa ihilela ukungezwa kwama-athomu e-hydrogen ku-molecule ye-NR, okuholela ekushintsheni kwezakhiwo zayo kanye nemiphumela engaba khona yezinto eziphilayo.
Omunye umehluko omkhulu phakathi kwe-NR kanye nefomu layo elincishisiwe i-NRH ulele emandleni ayo ahlukahlukene e-redox. Amandla e-Redox abhekisela ekuthambekeni kwe-molecule ukuzuza noma ukulahlekelwa ama-electron, okuyingxenye eyisisekelo yomsebenzi wayo webhayoloji. Ukwehliswa kwe-NR kuya ku-NRH kushintsha amandla ayo e-redox, okungase kuthinte ikhono layo lokubamba iqhaza ekuphenduleni kwe-redox yeselula nezindlela zokusayina.
Ucwaningo lokuqala luphakamisa ukuthi i-NRH ingase ibonise izakhiwo ze-antioxidant futhi ingase ibambe iqhaza ekulawuleni i-redox yamaselula.
Ngaphezu kwemiphumela engaba khona ye-antioxidant, i-NRH ingase futhi ibe nemiphumela kumetabolism yamandla eselula. Njengokususelwe ku-NR, i-NRH yaziwa ngendima yayo ku-NAD+ biosynthesis, lapho ingasiza ekugcineni amazinga e-NAD+ futhi isekele umsebenzi we-mitochondrial. I-Mitochondria yimithombo yamandla yeseli, enesibopho sokukhiqiza amandla amaningi eseli ngendlela ye-adenosine triphosphate (ATP). Ngokusekela ukusebenza kwe-mitochondrial, i-NRH ingase ibe nomthelela ekukhiqizeni amandla eselula jikelele kanye nempilo ye-metabolic.
Ukwengeza, uhlobo oluncishisiwe lwe-nicotinamide riboside lungase lube nemiphumela ezindleleni zokubonisa amaseli kanye nokubonakaliswa kofuzo. I-NAD + i-coenzyme ebalulekile ehilelekile ezinqubweni ezihlukahlukene zokubonisa izimpawu, kuhlanganise nalezo ezihlotshaniswa nama-sirtuin, umndeni wamaprotheni ahlotshaniswa nokuphila isikhathi eside nempilo yeselula. Ngokuthinta amazinga e-NAD+, i-NRH ingase ilungise umsebenzi we-sirtuin futhi isize ukulawula izinqubo zamaselula ezihlobene nokuguga kanye nezifo ezihlobene nobudala.
Ifomu elincishisiwe le-nicotinamide riboside, elivame ukubizwa ngokuthi i-NRH, liphuma ku-NR futhi liyisandulela esinamandla (NAD+), lapho i-NRH iholela ekuhlanganiseni kwe-NAD+ ngendlela entsha, ezimele ye-NR. Le ngqamuzana idlala indima ebalulekile ezinqubweni ezihlukahlukene zezinto eziphilayo, okuhlanganisa amandla e-metabolism kanye nokulungiswa kwe-DNA. Eminyakeni yamuva nje, ucwaningo lubonise ukuthi izithasiselo ze-NRH zinganikeza uhla lwezinzuzo zezempilo.
I-NRH ingase isekele amandla okukhiqiza amandla eselula. I-NAD+ ibalulekile ekuguquleni imisoco ibe yi-adenosine triphosphate (ATP), imali eyinhloko yeseli. Njengoba sikhula, amazinga e-NAD+ avame ukwehla, okuthinta ukukhiqizwa kwamandla eselula kanye nomsebenzi wonke we-metabolic. Ngokufaka i-NRH, abantu ngabanye bangasekela amazinga e-NAD+ futhi bakhuthaze i-metabolism yamandla enempilo, okungase kuthuthukise ubungqabavu nempilo iyonke.
Ngaphezu kwendima yayo ku-energy metabolism, I-NRH iye yacwaningwa ngemiphumela yayo engaba khona ekugugeni nasekuncipheni okuhlobene nobudala. Ucwaningo lubonisa ukuthi amazinga e-NAD+ ehla ngokukhula, futhi lokhu kwehla kuhlotshaniswa nezici ezihlukahlukene zokuguga, okuhlanganisa ukungasebenzi kahle kwe-mitochondrial kanye nokubonakala kwamaselula. Ngokusekela amazinga e-NAD+, izithasiselo ze-NRH zingasiza ekwehliseni eminye yemiphumela yokuguga, okungenzeka ikhuthaze ukuguga okunempilo nokuphila isikhathi eside.
Ukwengeza, i-NRH iye yacwaningwa ngendima yayo engaba khona ekusekeleni impilo yenhliziyo nemithambo yegazi. I-NAD+ idlala indima ebalulekile ekugcineni ukusebenza kwemithambo yegazi kanye nokusekela ukujikeleza okunempilo. Ngokwandisa amazinga e-NAD+, i-NRH ingase isize ukusekela ukusebenza kwenhliziyo nemithambo yegazi futhi ibe nomthelela empilweni yonke yenhliziyo.
Ngaphezu kwendima yayo kumetabolism yamandla nokuguga, i-NRH iphinde yacwaningwa ngemiphumela engaba khona ekusebenzeni kwengqondo. I-NAD+ ibandakanyeka ezinqubweni ezehlukene ezihlobene nempilo yobuchopho, okuhlanganisa ukusayina kwe-neuronal kanye nokulungiswa kwe-DNA. Ngokusekela amazinga e-NAD+, izithako ze-NRH zingasiza ukukhuthaza ukusebenza kwengqondo futhi zisekele impilo yobuchopho iyonke. Lokhu kuye kwavusa isithakazelo ku-NRH njengesithasiselo esingase sinciphise ukuncipha kwengqondo okuhlobene nobudala.
Eyehlisiwe i-nicotinamide riboside (NRH)
I-NRH, uhlobo oluncishisiwe lwe-nicotinamide riboside, kukhonjisiwe ukuthi yenyusa amazinga e-NAD+ emzimbeni. Ithathwa njengesandulela ku-NAD+, okusho ukuthi iguqulwa ibe yi-NAD+ uma ingena emzimbeni. I-NRH isithole ukunakwa ngemiphumela yayo engaba khona yokulwa nokuguga kanye nekhono lokusekela ukuguga okunempilo. Ucwaningo lubonisa ukuthi izithasiselo ze-NRh zingathuthukisa ukusebenza kwe-mitochondrial, zandise ukukhuthazela, futhi zisekele impilo yonke yamaselula.
I-NAD+ evamile
Izithako ezijwayelekile ze-NAD+, ngakolunye uhlangothi, zinikeza i-coenzyme ngqo emzimbeni. Lolu hlobo lwe-NAD+ luhlolisiswe amandla ayo okuthuthukisa ukusebenza kwengqondo, ukusekela impilo yenhliziyo nemithambo yegazi, nokukhuthaza ukuguga okunempilo. I-NAD+ ibandakanyeka ezinqubweni ezihlukene zamaselula, futhi ukwengezwa okuqondile kwe-NAD+ kungasiza ekugcineni amazinga afanele emzimbeni.
Iyiphi engcono empilweni yakho?
Lapho unquma ukuthi yiluphi uhlobo lwesithasiselo se-NAD+ esingcono empilweni yakho, i-bioavailability nokusebenza kwenketho ngayinye kufanele kucatshangelwe. I-NRH yaziwa ngokutholakala kwayo okuphezulu kwe-bioavailability, okusho ukuthi imuncwa kalula futhi isetshenziswe ngumzimba. Lena inketho ekhangayo yabantu abafuna ukukhulisa ngempumelelo amazinga e-NAD+.
Izithako ezijwayelekile ze-NAD+, ngakolunye uhlangothi, zihlinzeka nge-coenzyme ngokuqondile, zidlula isidingo sokuguqulwa. Lokhu kungase kube inketho eqonde kakhudlwana nesebenza ngempumelelo kubantu abafuna ukwesekwa ngezinkinga ezithile zempilo, ezifana nokusebenza kwengqondo noma impilo yenhliziyo nemithambo yegazi.
Kubalulekile ukuqaphela ukuthi umuntu ngamunye angase aphendule ngendlela ehlukile ezithasiselweni ze-NAD+, futhi lokho okusebenza kangcono kumuntu oyedwa kungase kungafani komunye. Izinto ezinjengobudala, impilo iyonke, kanye nemikhuba yokuphila kungaba nomthelela ekusebenzeni kwezithasiselo ze-NAD+.
Izinzuzo ezingaba khona ze-NAD+ Supplementation
Kokubili i-NRH kanye nokwengeza okujwayelekile kwe-NAD+ kunezinhlobonhlobo zezinzuzo zezempilo ezingaba khona. Lokhu kungase kuhlanganise:
●Sekela ukuguga okunempilo
●Thuthukisa umsebenzi we-mitochondrial
●Isekela impilo yenhliziyo nemithambo yegazi
●Thuthukisa amazinga okubekezela namandla
●Thuthukisa impilo yamaselula iyonke
1. Ubumsulwa kanye Nekhwalithi
Lapho ukhetha umkhiqizo, kubalulekile ukubeka phambili ubumsulwa nekhwalithi. Bheka imikhiqizo ehlolelwe ukuhlanzeka namandla. Lokhu kuqinisekisa ukuthi umkhiqizo uqukethe inani elishiwo le-NRH futhi awunakho ukungcola. Ukwengeza, cabanga ukukhetha imikhiqizo eyenziwe ezimbonini ezilandela i-Good Manufacturing Practices (GMP) ukuze uqinisekise ikhwalithi nokuphepha.
2. Ifomu le-NRH
I-NRH iza ngezinhlobo eziningi, okuhlanganisa amaphilisi, impushana, noketshezi. Lapho ukhetha ifomethi ekahle kakhulu, cabangela okuncamelayo komuntu siqu kanye nendlela yokuphila. Amaphilisi kulula ukuhamba nawo, kuyilapho izimpushana noketshezi kungaxutshwa kalula kube iziphuzo noma ukudla. Abanye abantu bangase futhi babe nezintandokazi ezisekelwe ekugayeni kalula noma ukumuncwa, ngakho-ke cabanga ukuthi yiliphi ifomu elizifanela kangcono izidingo zakho.
3. Umthamo kanye nokugxilisa ingqondo
Umthamo we-NRH nokugxila kuyehluka ngomkhiqizo. Lapho ukhetha umkhiqizo oyisilinganiso esifanele wena, kubalulekile ukucabangela imigomo yakho yezempilo kanye nanoma yiziphi izincomo ezithile ezivela kuchwepheshe wakho wezokunakekelwa kwempilo. Abanye abantu bangase bazuze ekugxiliseni okuphezulu kwe-NRH, kuyilapho abanye bangakhetha imithamo ephansi yokunakekelwa. Qiniseka ukuthi ulandela umthamo onconyiwe kulebula yomkhiqizo futhi ukhulume nomhlinzeki wakho wokunakekelwa kwezempilo uma unemibuzo.
4. I-Bioavailability
I-Bioavailability isho ikhono lomzimba lokumunca nokusebenzisa into ethile. Lapho ukhetha umkhiqizo we-NRH, cabangela i-bioavailability yefomu le-NRH eliqukethe. Eminye imikhiqizo ingase ibe nezinhlobo ezithuthukisiwe ze-NRH eziklanyelwe ukuthuthukisa ukumuncwa. Bheka imikhiqizo esebenzisa amasistimu okulethwa athuthukile noma izithako zokuthuthukisa i-bioavailability, engakhulisa izinzuzo zokungezelelwa kwe-NRH.
5. Izithako ezengeziwe
Eminye imikhiqizo ye-NRH ingase ibe nezithako ezengeziwe ezihambisana nemiphumela ye-NRH noma inikeze izinzuzo ezengeziwe. Isibonelo, eminye imikhiqizo ingaba namanye amavithamini B noma ama-antioxidants ukuze asekele ukukhiqizwa kwamandla nempilo yeselula. Ngokusekelwe ezidingweni zakho zezempilo kanye nemigomo, cabanga ukuthi ungakhetha yini imikhiqizo ye-NRH ezimele yodwa noma imikhiqizo equkethe izithako ezengeziwe.
6. Idumela Lomkhiqizo kanye Nokungafihli
Lapho ukhetha imikhiqizo ye-NRH, cabangela isithunzi somkhiqizo nokungafihli lutho. Bheka izinkampani ezisobala mayelana nokutholakala kwazo, izinqubo zokukhiqiza, nezinqubo zokuhlola. Ukwengeza, cabanga ukufunda izibuyekezo zekhasimende kanye nokufuna iseluleko emithonjeni ethembekile ukuze uhlole isithunzi somkhiqizo kanye nempumelelo yemikhiqizo yalo.
7. Inani kanye nenani
Nakuba intengo kungafanele kube ukuphela kwesici esinqumayo, kubalulekile ukucabangela inani eliphelele lemikhiqizo ye-NRH. Qhathanisa izindleko ngokuphakelwa kwemikhiqizo ehlukene ukuze unqume ukuthi iyiphi inketho evumelana kangcono nesabelomali sakho. Khumbula ukuthi imikhiqizo ebiza kakhulu ingase inikeze izici ezengeziwe noma ukugxila okuphezulu kwe-NRH, ngakho-ke cabangela inani eliphelele ngokusekelwe ezidingweni zakho siqu nokuncamelayo.
I-Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lesengezo sokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, i-Myland Pharm & Nutrition Inc. iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izindawo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini futhi ihambisane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.
Q: Yiziphi izinzuzo ezingaba khona zokusebenzisana ne-Palmitoylethanolamide (PEA) powder factory ethembekile?
A: Ukubambisana nefekthri ethembekile ye-PEA powder kunganikeza izinzuzo ezifana nokuhlinzekwa komkhiqizo wekhwalithi ephezulu, ukuthobela imithetho, ukusebenza kahle kwezindleko, kanye nenkonzo yamakhasimende ethembekile.
Q: Isithunzi semboni ye-PEA powder sithinta kanjani isinqumo sokubambisana nabo?
IMP: Isithunzi sefekthri sibonisa ukwethembeka kwayo, ikhwalithi yomkhiqizo, nokwaneliseka kwamakhasimende, okuyenza ibe yisici esibalulekile ekuthathweni kwezinqumo.
Q: Ubambiswano nefekthri ye-PEA powder kungaba nomthelela kanjani ekuhambisaneni komkhiqizo nokuthembeka?
IMP: Ukusebenzisana nefekthri ehloniphekile kungaqinisekisa ikhwalithi yomkhiqizo engaguquki nethembekile, ehlangabezana namazinga adingekayo ekusebenzeni kahle nokuphepha.
Q: Yiziphi izici zokuthobela umthetho okufanele zicatshangelwe lapho usebenzisana nefekthri ye-PEA powder?
IMP: Ukuthobela izindinganiso zokulawula, njengokugunyazwa kwe-FDA, ukubambelela kumazinga omhlaba jikelele wemithi, kanye nezitifiketi ezifanele, kubalulekile ukuze kuqinisekiswe ukuba semthethweni nokuphepha komkhiqizo.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Apr-22-2024
