I-NR uhlobo lwe-vitamin B3, uhlobo oluncishisiwe lwe-nicotinamide riboside, i-NRH, ethandwa ngenxa yezinzuzo zayo zezempilo ezingaba khona, okuhlanganisa nokusekela ukukhiqizwa kwamandla eseli nokukhuthaza ukuguga okunempilo. Njengoba isidingo sezithako ze-NRH siqhubeka nokukhula, kubalulekile ukuqonda ukuthi ungakhetha kanjani isithako esifanele. Ukukhetha isithako se-nicotinamide riboside esincishisiwe esingcono kakhulu sezidingo zakho kudinga ukucatshangelwa ngokucophelela ubumsulwa, ukutholakala kwezinto eziphilayo, umthamo, ukwakheka, izici zokukhiqiza ezifana nedumela lebhizinisi kanye nenani eliphelele. Ngokubeka lezi zici phambili nokwenza ucwaningo olunzulu, ungakhetha isithako se-NRH sekhwalithi ephezulu ukusekela imigomo yakho yezempilo kanye nenhlalakahle.
I-Nicotinamide riboside (NR) ithola ukunakwa emphakathini wezempilo kanye nenhlalakahle ngenxa yezinzuzo zayo ezingaba khona ekusekeleni ukukhiqizwa kwamandla eseli kanye nenhlalakahle iyonke. Njengesandulela se-nicotinamide adenine dinucleotide (NAD+), i-NR idlala indima ebalulekile ezinqubweni ezahlukahlukene zebhayoloji, okuhlanganisa i-metabolism, ukulungiswa kwe-DNA, kanye nokubonakaliswa kwezakhi zofuzo. Kodwa-ke, olunye uhlobo lwe-NR lube yindaba yokufuna ukwazi kanye nentshisekelo: isimo sayo esinciphile.
Ngakho-ke, iyini ngempela indlela encishisiwe ye-nicotinamide riboside? Ihluke kanjani kuleyo ejwayelekile? Ake sithole ndawonye!
I-Nicotinamide riboside, eyaziwa nangokuthi i-NR, iwuhlobo lwe-vitamin B3 oluye lwacwaningwa ngamandla alo okusekela ukukhiqizwa kwamandla eseli kanye nempilo ye-metabolic iyonke. Iyisandulela se-nicotinamide adenine dinucleotide (NAD+), i-coenzyme edlala indima ebalulekile ezinqubweni ezahlukahlukene zebhayoloji, okuhlanganisa i-metabolism yamandla kanye nokulungiswa kwe-DNA. kanye nokubonakaliswa kwezakhi zofuzo. Amazinga e-NAD+ ayancipha ngokuguga, futhi lokhu kwehla kuye kwaxhunyaniswa nezinkinga eziningi zempilo ezihlobene nokuguga.
Uhlobo oluncishisiwe lwe-nicotinamide riboside, evame ukubizwa ngokuthi i-NRH, iyi-derivative ye-NR edlula enkambisweni yokunciphisa, okuholela ekushintsheni kwesakhiwo samakhemikhali. Le nqubo yokunciphisa ihilela ukungezwa kwama-athomu e-hydrogen ku-molecule ye-NR, okuholela ekushintsheni kwezakhiwo zayo kanye nemiphumela engaba khona yezinto eziphilayo.
Omunye wemehluko omkhulu phakathi kwe-NR kanye nesimo sayo esinciphile i-NRH usezindleleni zayo ze-redox. I-Redox potential ibhekisela ekuthambekeleni kwe-molecule ukuthola noma ukulahlekelwa ama-electron, okuyisici esiyisisekelo somsebenzi wayo webhayoloji. Ukwehla kwe-NR ibe yi-NRH kushintsha amandla ayo e-redox, okungathinta ikhono layo lokubamba iqhaza ekuphenduleni kwe-redox yamaseli kanye nezindlela zokubonisa izimpawu.
Izifundo zokuqala ziphakamisa ukuthi i-NRH ingabonisa izakhiwo ze-antioxidant futhi ingadlala indima ekulawulweni kwe-redox yamaseli.
Ngaphezu kwemiphumela yayo engaba khona yokulwa ne-antioxidant, i-NRH ingaba nemiphumela ekusetshenzisweni kwamandla eseli. Njenge-derivative ye-NR, i-NRH yaziwa ngendima yayo ekuhlanganisweni kwe-NAD+, lapho ingasiza khona ukugcina amazinga e-NAD+ nokusekela umsebenzi we-mitochondrial. I-Mitochondria iyizikhumulo zamandla zeseli, ezibhekene nokukhiqiza iningi lamandla eseli ngesimo se-adenosine triphosphate (ATP). Ngokusekela umsebenzi we-mitochondrial, i-NRH ingathinta ukukhiqizwa kwamandla eseli kanye nempilo ye-metabolic.
Ngaphezu kwalokho, uhlobo oluncishisiwe lwe-nicotinamide riboside lungaba nemiphumela ezindleleni zokubonisana kwamaseli kanye nokubonakaliswa kwezakhi zofuzo. I-NAD+ iyi-coenzyme ebalulekile ehilelekile ezinqubweni ezahlukahlukene zokubonisana, okuhlanganisa nalezo ezihlotshaniswa nama-sirtuin, umndeni wamaprotheni ahlotshaniswa nokuphila isikhathi eside kanye nempilo yamaseli. Ngokuthinta amazinga e-NAD+, i-NRH ingashintsha umsebenzi we-sirtuin futhi isize ukulawula izinqubo zamaseli ezihlotshaniswa nokuguga kanye nezifo ezihlobene nokuguga.
Uhlobo oluncishisiwe lwe-nicotinamide riboside, oluvame ukubizwa ngokuthi i-NRH, luyi-derivative ye-NR futhi luyisandulela esinamandla (i-NAD+), lapho i-NRH iholela ekuhlanganisweni kwe-NAD+ ngendlela entsha, ezimele ye-NR. Le molekyuli idlala indima ebalulekile ezinqubweni ezahlukahlukene zebhayoloji, okuhlanganisa i-metabolism yamandla kanye nokulungiswa kwe-DNA. Eminyakeni yamuva nje, ucwaningo luye lwabonisa ukuthi izithasiselo ze-NRH zinganikeza izinzuzo ezahlukene zezempilo.
I-NRH ingasekela amandla okukhiqizwa kwamandla eseli. I-NAD+ ibalulekile ekuguquleni izakhamzimba zibe yi-adenosine triphosphate (ATP), imali yamandla eyinhloko yeseli. Njengoba sikhula, amazinga e-NAD+ avame ukwehla, okuthinta ukukhiqizwa kwamandla eseli kanye nomsebenzi wokusebenza kwe-metabolic jikelele. Ngokunezela nge-NRH, abantu ngabanye bangasekela amazinga e-NAD+ futhi bakhuthaze ukusebenza kwe-metabolism yamandla okunempilo, okungenzeka kuthuthukise amandla kanye nempilo iyonke.
Ngaphezu kwendima yayo ekusetshenzisweni kwamandla, I-NRH kuye kwacwaningwa ngemiphumela yayo engaba khona ekugugeni nasekuwohlokeni okuhlobene nokuguga. Ucwaningo lubonisa ukuthi amazinga e-NAD+ ayancipha ngokuguga, futhi lokhu kwehla kuhlotshaniswa nezici ezahlukahlukene zokuguga, okuhlanganisa ukungasebenzi kahle kwe-mitochondrial kanye nokuguga kwamaseli. Ngokusekela amazinga e-NAD+, izithasiselo ze-NRH zingasiza ekunciphiseni eminye yemiphumela yokuguga, okungenzeka kukhuthaze ukuguga okunempilo kanye nokuphila isikhathi eside.
Ngaphezu kwalokho, i-NRH ihlolwe ngendima yayo engaba khona ekusekeleni impilo yenhliziyo nemithambo yegazi. I-NAD+ idlala indima ebalulekile ekugcineni ukusebenza kwemithambo yegazi nokusekela ukujikeleza kwegazi okunempilo. Ngokwandisa amazinga e-NAD+, i-NRH ingasiza ekusekeleni ukusebenza kwenhliziyo nemithambo yegazi futhi inikele empilweni yenhliziyo iyonke.
Ngaphezu kwendima yayo ekusetshenzisweni kwamandla kanye nokuguga, i-NRH iphinde yacwaningwa ngemiphumela yayo engaba khona ekusebenzeni kwengqondo. I-NAD+ ihilelekile ezinqubweni ezahlukahlukene ezihlobene nempilo yobuchopho, okuhlanganisa ukusayinwa kwe-neuronal kanye nokulungiswa kwe-DNA. Ngokusekela amazinga e-NAD+, izithasiselo ze-NRH zingasiza ekukhuthazeni ukusebenza kwengqondo futhi zisekele impilo yobuchopho iyonke. Lokhu kudale intshisekelo ku-NRH njengesengezo esingase sinciphise ukwehla kwengqondo okuhlobene nokuguga.
I-riboside ye-nicotinamide encishisiwe (NRH)
I-NRH, uhlobo oluncishisiwe lwe-nicotinamide riboside, iboniswe ukuthi inyusa amazinga e-NAD+ emzimbeni. Ibhekwa njengesandulela se-NAD+, okusho ukuthi iguqulwa ibe yi-NAD+ uma ingena emzimbeni. I-NRH ithole ukunakwa ngemiphumela yayo engaba khona yokulwa nokuguga kanye nekhono lokusekela ukuguga okunempilo. Ucwaningo lubonisa ukuthi izithasiselo ze-NRh zingathuthukisa ukusebenza kwe-mitochondrial, zandise ukukhuthazela, futhi zisekele impilo yonke yamaseli.
I-NAD+ evamile
Ngakolunye uhlangothi, izithasiselo ze-NAD+ ezivamile zinikeza i-coenzyme ngqo emzimbeni. Lolu hlobo lwe-NAD+ luye lwacwaningwa ngenxa yamandla alo okuthuthukisa ukusebenza kwengqondo, ukusekela impilo yenhliziyo, nokukhuthaza ukuguga okunempilo. I-NAD+ ihilelekile ezinqubweni ezahlukahlukene zamaseli, futhi ukwengezwa kwe-NAD+ okuqondile kungasiza ekugcineni amazinga afanele emzimbeni.
Yikuphi okungcono empilweni yakho?
Uma kunqunywa ukuthi yiluphi uhlobo lwesithasiselo se-NAD+ olungcono empilweni yakho, ukutholakala kwe-bioavailability kanye nokusebenza kahle kwenketho ngayinye kumele kucatshangelwe. I-NRH yaziwa ngokutholakala kwayo okuphezulu kwe-bioavailability, okusho ukuthi imuncwa kalula futhi isetshenziswe ngumzimba. Lena inketho ekhangayo kubantu abafuna ukwandisa amazinga e-NAD+ ngempumelelo.
Ngakolunye uhlangothi, izithasiselo ezivamile ze-NAD+ zinikeza i-coenzyme ngqo, zidlula isidingo sokuguqulwa. Lokhu kungaba yindlela eqondile nephumelelayo kubantu abafuna ukwesekwa ngezinkinga ezithile zempilo, njengokusebenza kwengqondo noma impilo yenhliziyo.
Kubalulekile ukuqaphela ukuthi umuntu ngamunye angasabela ngendlela ehlukile ezithasiselweni ze-NAD+, futhi okusebenza kahle komunye umuntu kungase kungafani komunye. Izici ezifana nobudala, impilo iyonke, kanye nemikhuba yokuphila kungathinta ukusebenza kahle kwezithasiselweni ze-NAD+.
Izinzuzo Ezingaba Khona Zokwengezwa Kwe-NAD+
Kokubili i-NRH kanye nokwengezwa kwe-NAD+ okuvamile kunezinzuzo eziningi ezingaba khona kwezempilo. Lokhu kungafaka:
●Sekela ukuguga okunempilo
●Thuthukisa umsebenzi we-mitochondrial
●Isekela impilo yenhliziyo nemithambo yegazi
●Thuthukisa amazinga okukhuthazela namandla
●Khuthaza impilo yamaseli iyonke
1. Ubumsulwa kanye nekhwalithi
Uma ukhetha umkhiqizo, kubalulekile ukubeka phambili ubumsulwa nekhwalithi. Funa imikhiqizo ehlolwe ngumuntu wesithathu ukuze ithole ubumsulwa namandla. Lokhu kuqinisekisa ukuthi umkhiqizo uqukethe inani elibekiwe le-NRH futhi awunazo izinto ezingcolisayo. Ngaphezu kwalokho, cabanga ngokukhetha imikhiqizo eyenziwe emafektri alandela i-Good Manufacturing Practices (GMP) ukuqinisekisa ikhwalithi nokuphepha.
2. Ifomu le-NRH
I-NRH iza ngezindlela eziningi, okuhlanganisa ama-capsule, i-powder, kanye noketshezi. Uma ukhetha ifomethi elula kakhulu, cabanga ngezintandokazi zakho nendlela yakho yokuphila. Ama-capsule kulula ukuwaphatha nawe, kuyilapho ama-powder kanye noketshezi kungaxutshwa kalula eziphuzweni noma ekudleni. Abanye abantu bangase babe nezintandokazi ngokusekelwe ekutheni kulula yini ukugaya noma ukumunca, ngakho cabanga ukuthi yiluphi uhlobo olufanelana nezidingo zakho.
3. Isilinganiso kanye nokuhlushwa
Isilinganiso kanye nokuhlushwa kwe-NRH kuyahlukahluka ngomkhiqizo. Lapho ukhetha umkhiqizo owumthamo ofanele wena, kubalulekile ukucabangela imigomo yakho yezempilo kanye nanoma yiziphi izincomo ezithile ezivela kuchwepheshe wakho wezempilo. Abanye abantu bangase bazuze ekuhlushweni okuphezulu kwe-NRH, kanti abanye bangase bathande imithamo ephansi yokunakekelwa. Qiniseka ukuthi ulandela umthamo onconywayo ngelebula lomkhiqizo bese ukhuluma nomhlinzeki wakho wezempilo uma unemibuzo.
4. Ukutholakala kwezinto eziphilayo
Ukutholakala kwe-bioavailability kubhekisela ekhonweni lomzimba lokumunca nokusebenzisa into ethile. Lapho ukhetha umkhiqizo we-NRH, cabanga ngokutholakala kwe-bioavailability kwefomu le-NRH eliqukethe. Eminye imikhiqizo ingaqukatha izinhlobo ezithuthukisiwe ze-NRH ezenzelwe ukuthuthukisa ukumuncwa. Funa imikhiqizo esebenzisa izinhlelo zokulethwa ezithuthukisiwe noma izithako ukuthuthukisa ukutholakala kwe-bioavailability, okungakhulisa izinzuzo zokwengezwa kwe-NRH.
5. Izithako ezengeziwe
Eminye imikhiqizo ye-NRH ingaqukatha izithako ezengeziwe ukuze ihambisane nemiphumela ye-NRH noma inikeze izinzuzo ezengeziwe. Isibonelo, eminye imikhiqizo ingaqukatha amanye amavithamini B noma ama-antioxidants ukusekela ukukhiqizwa kwamandla kanye nempilo yamaseli. Ngokusekelwe ezidingweni zakho zempilo kanye nemigomo, cabanga ukuthi ungathanda yini imikhiqizo ye-NRH ezimele noma imikhiqizo equkethe izithako ezengeziwe.
6. Idumela Lomkhiqizo Nokucaca
Uma ukhetha imikhiqizo ye-NRH, cabangela idumela lomkhiqizo kanye nokungafihli lutho kwawo. Funa izinkampani ezisobala mayelana nokuthola kwazo, izinqubo zokukhiqiza, kanye nezinqubo zokuhlola. Ngaphezu kwalokho, cabangela ukufunda ukubuyekezwa kwamakhasimende kanye nokufuna iseluleko emithonjeni ethembekile ukuze ulinganise idumela lomkhiqizo kanye nokusebenza kahle kwemikhiqizo yawo.
7. Intengo kanye nenani
Nakuba intengo kungafanele ibe yisona kuphela isici esinqumayo, kubalulekile ukucabangela inani eliphelele lemikhiqizo ye-NRH. Qhathanisa izindleko ngokuphakelwa kwemikhiqizo ehlukene ukuze unqume ukuthi iyiphi inketho efanelana kahle nesabelomali sakho. Khumbula ukuthi imikhiqizo ebiza kakhulu inganikeza izici ezengeziwe noma amazinga aphezulu e-NRH, ngakho-ke cabanga ngenani eliphelele ngokusekelwe ezidingweni zakho kanye nezintandokazi zakho.
I-Myland Pharm & Nutrition Inc. ibilokhu ibandakanyeka ebhizinisini lezithako zokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokuthengisa okukhishwe kwembewu yamagilebhisi.
Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye nesu le-R&D elithuthukisiwe kakhulu, inkampani ithuthukise imikhiqizo ehlukahlukene yokuncintisana futhi yaba yinkampani yezinsizakalo ezintsha zesayensi yokuphila, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.
Ngaphezu kwalokho, i-Myland Pharm & Nutrition Inc. nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu futhi zihambisane nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.
U: Yiziphi izinzuzo ezingaba khona zokubambisana nefektri yempuphu yePalmitoylethanolamide (PEA) ethembekile?
A: Ukubambisana nefektri yempuphu ye-PEA ethembekile kunganikeza izinzuzo ezifana nokuhlinzekwa komkhiqizo osezingeni eliphezulu, ukuthobela imithetho, ukusebenza kahle kwezindleko, kanye nensizakalo yamakhasimende ethembekile.
U: Idumela lefektri yempuphu ye-PEA lithinta kanjani isinqumo sokusebenzisana nabo?
A: Idumela lefektri libonisa ukwethembeka kwayo, ikhwalithi yomkhiqizo, kanye nokwaneliseka kwamakhasimende, okwenza kube yinto ebalulekile enkambisweni yokwenza izinqumo.
U: Ukubambisana nefektri yempuphu ye-PEA kungasiza kanjani ekuqineni nasekuthembekeni komkhiqizo?
A: Ukubambisana nefektri ethembekile kungaqinisekisa ikhwalithi yomkhiqizo eqhubekayo nethembekile, kuhlangatshezwane nezindinganiso ezidingekayo ukuze kusebenze kahle futhi kuphephe.
Q: Yiziphi izici zokuthobela imithetho okufanele uzicabangele lapho usebenzisana nefektri yempuphu ye-PEA?
A: Ukuthobela izindinganiso zomthetho, njengokuvunyelwa yi-FDA, ukunamathela ezindinganisweni zamazwe ngamazwe zemithi, kanye nezitifiketi ezifanele, kubalulekile ukuqinisekisa ukuba semthethweni nokuphepha komkhiqizo.
Isixwayiso: Lesi sihloko senzelwe ulwazi olujwayelekile kuphela futhi akufanele sithathwe njenganoma yisiphi iseluleko sezokwelapha. Olunye ulwazi lweposi lebhulogi luvela kwi-inthanethi futhi alulona ochwepheshe. Le webhusayithi inesibopho sokuhlunga, ukufometha nokuhlela izihloko kuphela. Inhloso yokudlulisa ulwazi olwengeziwe akusho ukuthi uyavumelana nemibono yayo noma uqinisekisa ubuqiniso bokuqukethwe kwayo. Njalo xhumana nochwepheshe wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukwenza izinguquko ohlelweni lwakho lokunakekelwa kwempilo.
Isikhathi sokuthunyelwe: Ephreli-22-2024
