Ukuguga kuyinqubo yonke into ephilayo ehamba kuyo. Abantu abakwazi ukuvimbela ukuguga, kodwa bangathatha izinyathelo zokunciphisa inqubo yokuguga kanye nokuvela kwezifo ezihlobene nobudala. Inhlanganisela eyodwa ithole ukunakwa okukhulu—i-nicotinamide riboside, eyaziwa nangokuthi i-NR. Njengesandulela se-NAD+, i-nicotinamide riboside kucatshangwa ukuthi inomphumela omangalisayo wokulwa nokuguga.Ngokwandisa amazinga e-NAD+, i-nicotinamide riboside ithuthukisa umsebenzi we-sirtuin, ithuthukise ukusebenza kwe-mitochondrial, futhi ivule izindlela ezahlukahlukene zamaselula ezibandakanyekayo enqubweni yokulwa nokuguga.
I-Nicotinamide riboside (NR) iwuhlobo lwevithamini B3, eyaziwa nangokuthi i-nicotinic acid noma i-nicotinic acid. Kuyinhlanganisela eyenzeka ngokwemvelo etholakala ngamanani amancane ekudleni okuthile, njengobisi, imvubelo, nemifino ethile.
I-NR iyisandulela se-nicotinamide adenine dinucleotide (NAD+), i-coenzyme ekhona kuwo wonke amangqamuzana aphilayo. I-NAD+ idlala indima ebalulekile ezinqubweni ezihlukahlukene zebhayoloji, okuhlanganisa ukukhiqizwa kwamandla, ukulungiswa kwe-DNA, kanye nokulawulwa kwe-metabolic metabolism. Njengoba sikhula, amazinga ethu e-NAD+ avame ukwehla, okungathinta le misebenzi ebalulekile. Izithasiselo ze-NR ziye zahlongozwa njengendlela yokwandisa amazinga e-NAD+ futhi ngokunokwenzeka yehlise ijubane inqubo yokuguga.
Enye yezinzuzo ezinkulu ze-NR supplementation yikhono layo lokuthuthukisa umsebenzi we-mitochondrial. I-Mitochondria yimithombo yamandla yeseli, enesibopho sokukhiqiza amandla amaningi eseli ngendlela ye-adenosine triphosphate (ATP). I-NR ikhonjiswe ukuthi ikhuthaza ukukhiqizwa kwe-ATP ngokwandisa amazinga e-NAD+, ngaleyo ndlela ikhuthaze ukukhiqizwa kwamandla okusebenzayo kanye nokugayeka kokudla kwamaselula. Lokhu kwanda kokukhiqizwa kwamandla kungase kuzuze izicubu nezitho ezihlukahlukene, okuhlanganisa ubuchopho, inhliziyo, nemisipha.
●Thuthukisa amandla eselula
I-Nicotinamide riboside idlala indima ebalulekile ekunikezeni amandla kumandla weseli, i-mitochondria. Le nhlanganisela iyisandulela se-nicotinamide adenine dinucleotide (NAD+), i-coenzyme ebalulekile ehilelekile ezinqubweni eziningi zamaselula, ikakhulukazi i-energy metabolism. Ucwaningo lubonisa ukuthi ukugcwalisa nge-NR kungakhuphula amazinga e-NAD+ futhi kukhuthaze ukuphefumula kwamaselula okusebenzayo nokukhiqizwa kwamandla.
Amazinga e-NAD+ avame ukwehla njengoba sikhula, okuholela ekusebenzeni okubuthakathaka kwe-mitochondrial kanye namazinga aphansi aphelele wamandla. Kodwa-ke, ngokwengeza i-nicotinamide riboside, kungenzeka ukuhlehlisa lokhu kwehla futhi ubuyisele amazinga wamandla obusha. I-NR iphinde yatholakala ukuthi ithuthukisa ukukhuthazela ngokomzimba futhi ithuthukise ukusebenza kwezemidlalo, iyenze ibe inhlanganisela ekhangayo kubasubathi kanye nabantu abafuna impilo enhle.
●Thuthukisa ukulungiswa kwamaseli kanye nokulwa nokuguga
Esinye isici esithakazelisayo se-nicotinamide riboside amandla ayo okukhuthaza ukulungiswa kwe-DNA nokulwisana nomonakalo ohlobene nobudala. I-NAD+ iyingxenye ebalulekile yenqubo yokulungisa i-DNA. Ngokwengeza i-NR ukuze kukhuliswe amazinga e-NAD+, singathuthukisa ikhono leseli lokulungisa i-DNA, ngaleyo ndlela livikeleke ngempumelelo ekugugeni.
Ukwengeza, i-NR iye yathinteka ekulawuleni izindlela ezibalulekile zokuphila isikhathi eside, njengama-sirtuin, adlala indima ebalulekile ekugcineni ukusebenza kwamaselula okunempilo. Lezi zakhi zofuzo zesikhathi eside zisiza ukwenza ngcono izindlela zokuvikela amaselula ekucindezelekeni futhi zikhuthaze impilo ende yonke. Ngokuvula ama-sirtuin, i-nicotinamide riboside ingasiza ukubambezeleka kwezifo ezihlobene nobudala futhi ibe namandla okunweba impilo yethu.
●Vimbela izifo ze-neurodeergenerative
Izifo ze-Neurodegenerative ezifana ne-Alzheimer's kanye ne-Parkinson ziya ngokuya ziba ziningi emphakathini wethu. Ucwaningo luphakamisa ukuthi i-nicotinamide riboside ingaba nethemba ekuvimbeleni lezi zifo ezithena amandla. Ucwaningo luthole ukuthi ukuphathwa kwe-NR kuthuthukisa ukusebenza kwe-mitochondrial, kunciphisa ukucindezeleka kwe-oxidative, futhi kuthuthukisa i-neuroplasticity, konke okunomthelela ebuchosheni obunempilo.
Ukwengeza, ukwesekwa kwe-NR kuxhunywe ekusebenzeni okuthuthukisiwe kwengqondo, ukugcinwa kwenkumbulo, nokugxila okuthuthukisiwe nesikhathi sokunaka. Yize ucwaningo olwengeziwe ludingeka, lokhu okutholakele kokuqala kusikisela ukuthi i-nicotinamide riboside ingase ibe yindlela yokuvimbela engaba khona noma ukusekelwa kwabantu abasengozini yokuwohloka kwemizwa.
●Thuthukisa ukuzwela kwe-insulin
Ucwaningo oluningi lubonise ukuthi i-NR inamandla okuthuthukisa impilo yonke ye-metabolic. Kuye kwaboniswa ukuthuthukisa ukuzwela kwe-insulin, isici esibalulekile ekugcineni amazinga kashukela egazi enempilo kanye nokuvimbela ukuthuthukiswa kwesifo sikashukela sohlobo 2. Ucwaningo luye lwathola nokuthi ukwesekwa kwe-NR kungathuthukisa i-lipid metabolism, ngaleyo ndlela kunciphise ukujikeleza kwe-cholesterol namazinga e-triglyceride. Le miphumela ibaluleke kakhulu kubantu abanezinkinga ze-metabolic noma labo abakhuluphele ngokweqile noma abakhuluphele.
●Inamandla okulwa ne-antioxidant
Ukwengeza, i-NR ikhonjisiwe ukuthuthukisa ukuzivikela kwamaselula ekucindezelekeni kwe-oxidative. Ukucindezeleka kwe-oxidative kwenzeka lapho kunokungalingani phakathi kokukhiqizwa kwezinhlobo ze-oxygen esebenzayo (ROS) kanye nekhono lomzimba lokuzinciphisa ngama-antioxidants. Amazinga aphezulu okucindezeleka okwenziwe nge-oxidative angalimaza amangqamuzana futhi abe nomthelela ekuqhubekeleni phambili kwezifo ezihlukahlukene, okuhlanganisa umdlavuza, isifo senhliziyo, kanye nezifo ze-neurodegenerative. Ucwaningo luthole ukuthi ukwengeza i-NR kungathuthukisa amandla e-antioxidant wamaseli futhi kunciphise umthelela wengcindezi ye-oxidative emzimbeni.
Ucwaningo lukhombisa ukuthi i-nicotinamide riboside inamandla okunciphisa ukuguga ngokwandisa amazinga e-molecule ye-nicotinamide adenine dinucleotide (NAD+). I-NAD+ iyi-molecule eyinhloko edlala indima ebalulekile kumetabolism yamaselula.
Amazinga e-NAD+ ehla ngokwemvelo njengoba sikhula. Lokhu kuncipha kubhekwa njengembangela enkulu yenqubo yokuguga. Ngokwandisa amazinga e-NAD+, i-nicotinamide riboside ingasiza ukulungisa lokhu kwehla futhi ibambezele imiphumela yokuguga.
I-NAD+ ibandakanyeka ezinqubweni eziningi ezibalulekile zamaselula, okuhlanganisa ukukhiqizwa kwamandla, ukulungiswa kwe-DNA, nokubonakaliswa kofuzo. Ngokwandisa amazinga e-NAD+, i-nicotinamide riboside ingakwazi ukuthuthukisa lezi zinqubo futhi ithuthukise ukusebenza kwamaselula jikelele.
Ucwaningo oluningana lubonise imiphumela ethembisayo kumaseli ezilwane nawomuntu. Ocwaningweni olulodwa, abacwaningi bathola ukuthi ukwesekwa kwe-nicotinamide riboside kwenyusa amazinga e-NAD+ ezicutshini zemisipha, ngaleyo ndlela kuthuthukisa ukusebenza kwe-mitochondrial nokusebenza kokuzivocavoca kumagundane.
Olunye ucwaningo lwathola ukuthi i-nicotinamide riboside supplementation ithuthukise ukuzwela kwe-insulin nokubekezelela i-glucose kumagundane akhuluphele, ane-prediabetes. Lokhu kuphakamisa ukuthi i-nicotinamide riboside ingaba nezinzuzo ezingaba khona empilweni ye-metabolic.
Ocwaningweni olulodwa oluncane lwabantu abadala abaphakathi nabadala, i-nicotinamide riboside supplementation inyuse amazinga e-NAD+ nomfutho wegazi othuthukisiwe nokuqina kwe-arterial, izimpawu ezimbili ezibalulekile zempilo yenhliziyo nemithambo yegazi.
Kolunye ucwaningo, abacwaningi bathola ukuthi i-nicotinamide riboside supplementation ithuthukise ukusebenza kwemisipha futhi yavimbela ukulahleka kwemisipha kubantu abadala asebekhulile. Lokhu kuphakamisa ukuthi i-nicotinamide riboside ingaba nezinzuzo ezingaba khona ngokumelene nokwehla kwemisipha okuhlobene neminyaka.
Kuyaphawuleka ukuthi ukuguga kuyinqubo eyinkimbinkimbi ethonywa izici eziningi, okuhlanganisa ufuzo, indlela yokuphila nendawo ezungezile. I-Nicotinamide riboside kufanele ibhekwe njengesengezo esingasiza ukuguga kancane futhi sisekele ukuguga okunempilo kunenhlamvu yomlingo.
EzininganaNAD+ ama-precursors ahlonziwe, okuhlanganisa i-nicotinamide riboside (NR), i-nicotinamide mononucleotide (NMN), ne-nicotinic acid (NA). Lezi zandulela ziguqulelwa ku-NAD+ uma zingaphakathi kweseli.
Phakathi kwalezi zandulela, i-nicotinamide riboside ithole ukunakwa okusabalele ngenxa yokuqina kwayo, i-bioavailability, kanye nekhono lokukhulisa ngempumelelo amazinga e-NAD+. I-NR iwuhlobo olungokwemvelo lwevithamini B3 futhi itholakala ngamanani amancane obisini nokunye ukudla. Kukhonjisiwe ukuthuthukisa ukuhlanganiswa kwe-NAD+ futhi ikhuthaze umsebenzi wama-sirtuin, iqembu lamaprotheni ahlotshaniswa nokuphila isikhathi eside.
Enye yezinzuzo ze-nicotinamide riboside amandla ayo okudlula izinyathelo eziphakathi nendawo ezidingekayo ku-NAD+ synthesis. Ingaguqulelwa ngqo ku-NAD+ ngaphandle kwesidingo sama-enzyme engeziwe. Ngokuphambene, ezinye izandulela ezifana ne-nicotinamide mononucleotide zidinga izinyathelo ezengeziwe ze-enzymatic ezibandakanya i-nicotinamide phosphoribosyltransferase (NAMPT) ukuze ziguqulelwe ku-NAD+.
Ucwaningo oluningi luqhathanise ukusebenza kwe-nicotinamide riboside nezinye izandulela ze-NAD+, futhi i-NR ihlezi iphuma phezulu. Ocwaningweni lwangaphambi komtholampilo kumagundane asebekhulile, i-nicotinamide riboside supplementation yatholakala ukuthi yenyusa amazinga e-NAD+, ithuthukise ukusebenza kwe-mitochondrial, futhi ithuthukise ukusebenza kwemisipha.
Ucwaningo olungahleliwe, olungaboni kabili, olulawulwa yi-placebo kubantu abadala abanempilo futhi lubonise imiphumela ethembisayo. Amazinga e-NAD+ anyuswe kakhulu kubahlanganyeli abathatha i-nicotinamide riboside uma kuqhathaniswa neqembu le-placebo. Ukwengeza, babike ukusebenza okuthuthukisiwe kwengqondo nokunciphisa ukukhathala okuzimele.
Nakuba abanye abanduleli be-NAD+, njenge-nicotinamide mononucleotide ne-niacin, babonise imiphumela emihle kumazinga e-NAD+ kwezinye izifundo, abakakabonisi izinga elifanayo lokusebenza njenge-nicotinamide riboside.
Kubalulekile ukuqaphela ukuthi nakuba i-nicotinamide riboside ibonakala isebenza kangcono emazingeni akhulayo e-NAD+, izimpendulo ngazinye zingahluka. Abanye abantu bangathola ukuthi ezinye izandulela, njenge-nicotinamide mononucleotide noma i-niacin, zifaneleka kakhulu izidingo zabo ezithile.
Izithasiselo ze-Nicotinamide riboside ziyatholakala kumathebhulethi, i-capsule, namafomu empushana. Ukuthola isilinganiso esifanele se-NR kuncike kakhulu ezintweni ezihlukahlukene, okuhlanganisa iminyaka, impilo, nemiphumela oyifunayo. Ngakho-ke, kuwukuhlakanipha ngaso sonke isikhathi ukubonana nochwepheshe bezokunakekelwa kwempilo ngaphambi kokuqala noma yiluphi uhlobo lwemithi yokwelapha entsha, njengoba bengakunikeza izeluleko eziqondene nawe ngokusekelwe ezidingweni zakho ezithile.
Futhi, ngokuduma okukhulayo kwe-NR kanye nenqwaba yemikhiqizo egcwala emakethe, kubalulekile ukukhetha umthombo othembekile nohloniphekile. Nazi ezinye izici ezibalulekile okufanele uzicabangele lapho ukhetha isithasiselo se-NR:
1. Ubumsulwa Nekhwalithi: Bheka imikhiqizo ehloliwe yaphinde yaqinisekiswa ukuze uqinisekise ukuthi ihlangabezana nezindinganiso eziqinile zekhwalithi. Bheka izithasiselo ezingenazo izigcwalisi, izithasiselo eziyingozi, nezinto ezingaba ukungcola.
2. Imikhuba Yokukhiqiza: Khetha izithasiselo ezikhiqizwa ezindaweni ezibhaliswe yi-FDA futhi ulandele imihlahlandlela Yomkhuba Omuhle Wokukhiqiza (GMP). Lokhu kuqinisekisa ukungaguquguquki komkhiqizo, ukuphepha nokusebenza ngempumelelo.
4. Idumela Nokubuyekezwa Kwekhasimende: Hlola ukubuyekezwa kwekhasimende nezilinganiso ukuze uthole ukuqonda mayelana nokusebenza kahle kwesithasiselo kanye nokwaneliseka okuphelele kwamakhasimende.
Q: Isebenza kanjani iNicotinamide Riboside (NR)?
A: I-Nicotinamide Riboside (NR) isebenza ngokwandisa amazinga e-NAD+ emzimbeni. I-NAD+ ibandakanyeka ekukhiqizweni kwamandla eselula, ukulungiswa kwe-DNA, nokugcina impilo nokusebenza kwe-mitochondria.
Q: Yimiphi imiphumela engaba khona yokulwa nokuguga ye-Nicotinamide Riboside (NR)?
A: I-Nicotinamide Riboside (NR) ibonise imiphumela ethembisayo yokulwa nokuguga ngendima yayo ekukhuliseni amazinga e-NAD+. Amazinga e-NAD+ anyusiwe angathuthukisa ukusebenza kwe-mitochondrial, athuthukise ukukhiqizwa kwamandla eselula, futhi akhuthaze ukulungiswa kwe-DNA, konke okungaba nomthelela ekulweni nokwehla okuhlobene nobudala kanye nokwenza ngcono impilo yonke.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Nov-10-2023
