Njengoba sikhula, ukugcina impilo yethu iyonke kuba kubaluleke kakhulu. Ucwaningo oluhlobene lubonisa ukuthi i-nicotinamide riboside, uhlobo lwevithamini B3, ingalwa nokuguga kwamaselula futhi ikhuthaze ukuguga okunempilo. I-Nicotinamide Riboside Ngaphezu kokuvuselela amangqamuzana asebekhulile, i-nicotinamide riboside iphinde ibonise isithembiso ekwenzeni ngcono impilo yonke nokuphila isikhathi eside. Ucwaningo lwezilwane lubonisa ukuthi izithasiselo ze-NR zingandisa isikhathi sokuphila futhi zithuthukise impilo ezimeni ezihlukahlukene ezihlobene neminyaka, okuhlanganisa ukukhuluphala, isifo senhliziyo nemithambo yegazi, kanye nezifo ze-neurodegenerative.
Ukuguga kuyinqubo yemvelo etholwa yizo zonke izinto eziphilayo. Njengabantu, imizimba nezingqondo zethu ziba nezinguquko eziningi njengoba sikhula.
Ushintsho olusobala kakhulu yilolu lwesikhumba, esinemibimbi, amabala obudala, njll. Ngaphezu kwalokho, imisipha iba buthakathaka, amathambo alahlekelwa ukuminyana, amalunga ayaqina, nokuhamba komuntu kulinganiselwe.
Esinye isici esibalulekile sokuguga ukwanda kwengozi yezifo ezingamahlalakhona njengesifo senhliziyo, isifo sikashukela, nezinhlobo ezithile zomdlavuza. Ukwengeza, ukuncipha kwengqondo kungenye inkinga evamile. Ukulahlekelwa inkumbulo, ubunzima bokugxilisa ingqondo, nokuncipha kokuqina kwengqondo kungathinta ukuphila kwethu kwansuku zonke.
Abaningi asebekhulile nabo baba nemizwa yesizungu, ukucindezeleka, noma ukukhathazeka, ikakhulukazi uma bebhekene nezinkinga zempilo noma beshonelwe othandekayo. Kulesi simo, kubalulekile ukufuna ukusekelwa ngokomzwelo emndenini, kubangane, ngisho nochwepheshe.
Nakuba singeke sikwazi ukumisa inqubo yokuguga, kunezindlela esinganciphisa ngayo futhi sigcine ukubukeka kobusha isikhathi eside. Izithako ezilwa nokuguga zingenye yezindlela ezinhle.
I-NAD+ iyi-coenzyme ebalulekile etholakala kuwo wonke amaseli aphilayo. Umsebenzi wayo oyinhloko ukukhuthaza umzimba weselula ngokusiza ukudluliswa kwama-electron ezinqubweni eziningi zebhayoloji njengokukhiqizwa kwamandla. Kodwa-ke, njengoba sikhula, amazinga e-NAD+ emizimbeni yethu ehla ngokwemvelo. Olunye ucwaningo luphakamisa ukuthi ukwehla kwamazinga e-NAD+ kungaba nomthelela enqubweni yokuguga.
Okunye okubaluleke kakhulu ocwaningweni lwe-NAD+ ukutholakala kwe-molecule ye-NAD+ ebizwa ngokuthi i-nicotinamide riboside (NR). I-NR iwuhlobo lwevithamini B3 eguqulwa ibe yi-NAD+ ngaphakathi kwamaseli ethu. Izifundo zezilwane eziningi zibonise imiphumela ethembisayo, ephakamisa ukuthi ukwesekwa kwe-NR kungakhuphula amazinga e-NAD+ futhi okungenzeka kuhlehlise ukwehla okuhlobene nobudala.
Izifo eziningi ezihlobene nobudala, njengezifo ze-neurodeergenerative kanye nokungasebenzi kahle kwe-metabolic, zihlotshaniswa nokungasebenzi kahle kwe-mitochondrial. I-Mitochondria yimithombo yamandla yamaseli ethu, anesibopho sokukhiqiza amandla. I-NAD+ idlala indima ebalulekile ekugcineni umsebenzi ofanele we-mitochondrial. Ngokuvikela impilo ye-mitochondrial, i-NAD+ inamandla okunciphisa ubungozi bezifo ezihlobene nobudala futhi yandise isikhathi sokuphila.
Ngaphezu kwalokho, i-NAD+ ibandakanyeka emsebenzini wama-sirtuins, umndeni wamaprotheni ahlobene nokuphila isikhathi eside. Ama-Sirtuin alawula izinqubo ezihlukahlukene zebhayoloji, okuhlanganisa ukulungiswa kwe-DNA, izimpendulo zokucindezeleka kwamaselula, nokuvuvukala. I-NAD+ ibalulekile ekusebenzeni kwe-Sirtuin, isebenza njenge-coenzyme eyenza kusebenze umsebenzi wayo we-enzymatic. Ngokwengeza i-NAD+ nokuthuthukisa umsebenzi we-Sirtuin, singakwazi ukubambezela ukuguga futhi sikhuthaze impilo nokuphila isikhathi eside.
Ucwaningo oluningi lubonise ukuthi ukwesekwa kwe-NAD + kunemiphumela emihle kumamodeli ezilwane. Isibonelo, ucwaningo olulodwa kumagundane lubonise ukuthi ukugcwalisa nge-NR kuthuthukisa ukusebenza kwemisipha nokukhuthazela. Olunye ucwaningo luye lwabonisa ukuthi ukwesekwa kwe-NR kungathuthukisa ukusebenza kwe-metabolic kumagundane asebekhulile, okwenza kufane nokwamagundane amancane. Lokhu okutholakele kusikisela ukuthi ukwesekwa kwe-NAD+ kungase kube nemiphumela efanayo kubantu, nakuba ucwaningo olwengeziwe luyadingeka.
I-Nicotinamide riboside(eyaziwa nangokuthi i-niagen) ingolunye uhlobo lwe-niacin (eyaziwa nangokuthi uvithamini B3) futhi itholakala ngokwemvelo ngamanani amancane obisini nokunye ukudla. Ingaguqulwa ibeNAD+ ngaphakathi kwamaseli. Njengesandulela, i-NR imuncwa kalula futhi ithuthelwe kumaseli, lapho iguqulelwa ku-NAD+ ngochungechunge lokusabela kwe-enzymatic.
Izifundo zokwengeza ze-NR kuzo zombili izifundo zezilwane nezabantu zibonise imiphumela ethembisayo. Kumagundane, ukwesekwa kwe-NR kwatholakala ukwandisa amazinga e-NAD+ ezicutshini ezihlukahlukene futhi kuthuthukise umsebenzi we-metabolic kanye ne-mitochondrial.
I-NAD+ ibandakanyeka ezinqubweni ezihlukahlukene zamaselula ezehla ngokukhula, okuhlanganisa ukulungiswa kwe-DNA, ukukhiqizwa kwamandla, nokulawulwa kokuvezwa kofuzo. Kucatshangelwa ukuthi ukugcwalisa amazinga e-NAD+ nge-NR kungabuyisela ukusebenza kwamaselula, ngaleyo ndlela kuthuthukise impilo nokwelula isikhathi sokuphila.
Ukwengeza, ocwaningweni lwamadoda akhuluphele nakhuluphele ngokweqile, ukwesekwa kwe-NR kukhuphule amazinga e-NAD+, ngaleyo ndlela kuthuthukisa ukuzwela kwe-insulin nokusebenza kwe-mitochondrial. Lokhu okutholakele kusikisela ukuthi ukwesekwa kwe-NR kungase kube nezicelo ezingase zibe khona ekubhekaneni nezifo ze-metabolic ezifana nesifo sikashukela sohlobo 2 nokukhuluphala.
1. Imithombo yokudla yemvelo ye-nicotinamide riboside
Omunye umthombo ongaba khona we-NR imikhiqizo yobisi. Ezinye izifundo zibonise ukuthi imikhiqizo yobisi iqukethe amanani amancane e-NR, ikakhulukazi ubisi oluqiniswe nge-NR. Nokho, okuqukethwe kwe-NR kule mikhiqizo kuphansi futhi ukuthola amanani anele ngokudla kuphela kungase kube inselele.
Ngaphezu kwemithombo yokudla, izithasiselo ze-NR ziyatholakala nge-capsule noma ifomu lempushana. Lezi zithako zivame ukutholakala emithonjeni yemvelo efana nemvubelo noma ukuvutshelwa kwamagciwane. I-NR etholakala kumvubelo ngokuvamile ibhekwa njengomthombo onokwethenjelwa futhi oqhubekayo ngenxa yokuthi ingakhiqizwa ngobuningi ngaphandle kokuthembela emithonjeni yezilwane. I-NR ekhiqizwe ngamabhaktheriya ingenye inketho, evame ukutholakala ezinhlotsheni ezithile zamabhaktheriya akhiqiza i-NR ngokwemvelo.
2. Faka i-nicotinamide riboside
Umthombo ovame kakhulu futhi onokwethenjelwa we-nicotinamide riboside ngokusebenzisa izithasiselo zokudla. Izithasiselo ze-NR zinikeza indlela elula nephumelelayo yokuqinisekisa ukuthathwa okuphelele kwalesi sithako esibalulekile. Lapho ukhetha i-NR engcono kakhulu, kubalulekile ukucabangela izici ezilandelayo:
a) Ukuqinisekisa Ikhwalithi: Bheka izithasiselo ezenziwe izinkampani ezinedumela elihle futhi zinamathele kumazinga aqinile okulawula ikhwalithi. Lokhu kuzoqinisekisa ukuthi uthola umkhiqizo wekhwalithi ephezulu ongenakho ukungcola noma ukungcola.
b) I-Bioavailability: Izithasiselo ze-NR zisebenzisa amasistimu okulethwa athuthukile afana ne-encapsulation noma ubuchwepheshe be-liposome ukuze kuthuthukiswe i-bioavailability ye-NR ukuze imunceke kangcono futhi isetshenziswe umzimba. Khetha lolu hlobo lwesithasiselo ukuze ukhulise izinzuzo ozithola ku-NR.
c) Ubumsulwa: Qiniseka ukuthi isithasiselo se-NR osikhethayo simsulwa futhi asinazo izithasiselo ezingadingekile, izigcwalisi noma izilondolozi. Ukufunda amalebula nokuqonda izithako kungakusiza wenze isinqumo unolwazi.
1. Thuthukisa ukukhiqizwa kwamandla kwamaselula
I-NR idlala indima ebalulekile ekukhiqizweni kwe-molecule ebalulekile i-nicotinamide adenine dinucleotide (NAD+). I-NAD+ ibandakanyeka ezinqubweni ezihlukene zamaselula, okuhlanganisa i-energy metabolism. Njengoba sikhula, amazinga e-NAD+ emizimbeni yethu ayancipha, okuholela ekunciphiseni kokukhiqizwa kwamandla. Ngokuphromotha ukuhlanganiswa kwe-NAD+, i-NR isiza ukuvuselela amaseli futhi inike amandla ukukhiqizwa kwamandla okusebenzayo. La mandla eselula athuthukisiwe anyusa amandla, athuthukisa ukusebenza komzimba, futhi anciphise nokukhathala.
2. Ukuvimbela ukuguga kanye nokulungiswa kwe-DNA
Ukwehla kwamazinga e-NAD+ kuhlotshaniswa nokuguga kanye nezifo ezihlobene nobudala. I-NR ingakhuphula amazinga e-NAD+ emzimbeni, iyenze ibe i-ejenti evimbela ukuguga. I-NAD+ ibandakanyeka ezindleleni zokulungisa i-DNA, iqinisekisa ubuqotho bempahla yethu yofuzo. Ngokuphromotha ukulungiswa kwe-DNA, i-NR ingasiza ekuvimbeleni ukulimala kwe-DNA ehlobene neminyaka futhi isekele ukuguga okunempilo. Ukwengeza, indima ye-NR ekwenzeni kusebenze ama-sirtuin, ikilasi lamaprotheni elaziwa ngokulawula impilo yamangqamuzana nokuphila isikhathi eside, lithuthukisa futhi amandla awo okulwa nokuguga.
3. Impilo yenhliziyo nemithambo yegazi
Ukugcina uhlelo lwenhliziyo olunempilo kubalulekile empilweni yonke. INicotinamide riboside ikhombise imiphumela ethembisayo empilweni yenhliziyo nemithambo yegazi. Isekela umsebenzi wamangqamuzana e-vascular endothelial, ikhuthaza ukugeleza kwegazi futhi inciphise ukuvuvukala. I-NR iphinde ithuthukise umsebenzi we-mitochondrial kumaseli enhliziyo, ivimbele ukucindezelwa kwe-oxidative nokwandisa ukukhiqizwa kwamandla. Le miphumela ingasiza ekunciphiseni ubungozi bezifo zenhliziyo nemithambo yegazi njenge-atherosclerosis nesifo senhliziyo.
4. I-Neuroprotection kanye nokusebenza kwengqondo
I-NR ikhonjiswe ukuthi inezakhiwo ze-neuroprotective, okuyenza ibe umngane ongaba khona ekugcineni impilo yobuchopho. Kungaba nomthelela omuhle ekusebenzeni kwe-neuronal futhi kuvikele ekunciphiseni kwengqondo okuhlobene neminyaka. Ngokwandisa amazinga e-NAD+, i-NR isekela ukusebenza kwe-mitochondrial kumangqamuzana obuchopho, ithuthukisa ukukhiqizwa kwamandla futhi ikhuthaze ukulungiswa kwamaselula. Ukuthuthukisa umsebenzi we-mitochondrial kungathuthukisa amakhono okuqonda njengenkumbulo, ukugxilisa ingqondo, kanye nokucaca kwengqondo okuphelele.
5. Ukulawulwa Kwesisindo kanye Nempilo Ye-Metabolic
Ukugcina isisindo esinempilo kanye nebhalansi ye-metabolic kubalulekile empilweni yethu yonke. I-NR ixhunyaniswe nemiphumela enenzuzo kumetabolism, okwenza kube usizo olungaba khona ekulawuleni isisindo. I-NR yenza kusebenze iphrotheni ebizwa nge-Sirtuin 1 (SIRT1), elawula izinqubo ze-metabolic ezifana ne-glucose metabolism kanye nokugcinwa kwamafutha. Ngokuvula i-SIRT1, i-NR ingasiza ekunciphiseni isisindo futhi ithuthukise impilo ye-metabolic, ngaleyo ndlela yehlise ubungozi bezifo ezinjengokukhuluphala kanye nesifo sikashukela sohlobo 2.
Q: Iyini iNicotinamide Riboside (NR)?
A: I-Nicotinamide Riboside (NR) iyisandulela se-Nicotinamide Adenine Dinucleotide (NAD+), i-coenzyme edlala indima ebalulekile ezinqubweni ezihlukahlukene zebhayoloji, okuhlanganisa ukukhiqizwa kwamandla kanye nokulawula imisebenzi ye-metabolic kanye neselula.
Q: Ingabe iNicotinamide Riboside (NR) ingazuza kumetabolism?
A: Yebo, iNicotinamide Riboside (NR) itholakale izuzisa umzimba. Ngokwandisa amazinga e-NAD+, i-NR ingasebenzisa ama-enzyme athile abandakanyeka kumetabolism, njengama-sirtuin. Lokhu kuvula kungase kuthuthukise ukusebenza kahle kwe-metabolic, kuthuthukise ukuzwela kwe-insulin, futhi kusekele ukuphathwa kwesisindo esinempilo.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Nov-13-2023
