I-7,8-Dihydroxyflavone iyinhlanganisela eyenzeka ngokwemvelo etholakala ezitshalweni ezithole ukunakwa okubalulekile ngezinzuzo zayo ezingaba khona ekusebenzeni kobuchopho nenkumbulo. Le nhlanganisela ye-flavone ingeyesigaba samakhemikhali abizwa ngokuthi ama-flavonoid, aziwa ngezici zawo zokulwa ne-antioxidant kanye ne-anti-inflammatory. Ucwaningo selukhombisile ukuthi i-7,8-dihydroxyflavone ingaba nemiphumela eminingi emihle ebuchosheni.
I-7,8-Dihydroxyflavone iyinhlanganisela enamandla futhi eguquguqukayo eyingxenye yomndeni we-flavonoid. I-Flavonoid yizinhlanganisela zemvelo ezisatshalaliswa kabanzi ezitshalweni futhi zidlala indima ebalulekile ezinqubweni ezahlukahlukene zebhayoloji. Enye yezimfanelo eziphawulekayo ze-7,8-dihydroxyflavone yikhono layo lokusebenzisana nokulawula amaprotheni nama-enzyme emzimbeni, okuvuse isithakazelo esikhulu emphakathini wesayensi.
Ucwaningo luye lwabonisa ukuthi i-compound 7,8-dihydroxyflavone inezinzuzo zezempilo ezingase zibe khona, enezinto ezilwa nokuvuvukala, ezilwa nokuvuvukala kanye ne-neuroprotective. Phakathi kwazo, umsebenzi oqinile we-antioxidant we-7,8-dihydroxyflavone uwenza akwazi ukukhipha ama-radicals mahhala ayingozi emzimbeni futhi avimbele ukucindezeleka okwenziwe nge-oxidative ekubangeleni ukulimala kwamangqamuzana nezifo ezihlukahlukene. Ucwaningo olwenziwe kuze kube manje ku-7,8-dihydroxyflavones luyakhuthaza, kodwa ucwaningo olwengeziwe luyadingeka ukuze kutholakale ukusebenza nokuphepha kwe-7,8-dihydroxyflavones ukuze isetshenziswe kubantu. Noma kunjalo, le nhlanganisela ye-flavonoid inesithembiso esihle njengesengezo sokudla esingaba khona noma ikhandidethi yezidakamizwa esikhathini esizayo.
I-7,8-Dihydroxyflavone iyinhlanganisela yemvelo, eyaziwa nangokuthi i-7,8-DHF, esithole ukunakwa okukhulu eminyakeni yamuva nje ngezinzuzo zayo ezingaba khona empilweni yabantu.
Le nhlanganisela eyenzeka ngokwemvelo ingeyomndeni we-flavonoid futhi itholakala ezinhlobonhlobo zezitshalo, okuhlanganisa impande ye-Scutellaria baikalensis.
1. Thuthukisa ukusebenza kwengqondo
Ucwaningo lubonisa ukuthi le nhlanganisela isebenza njenge-agonist ye-TrkB, okusho ukuthi yenza i-TrkB receptors isebenze ebuchosheni. Lawa ma-receptors anesibopho sokuthuthukisa ukukhula nokuphila kwama-neurons, kanye nokuthuthukisa i-synaptic plasticity -- ikhono lobuchopho lokuzivumelanisa nokushintsha. Ngokuvuselela ama-TrkB receptors, i-7,8-dihydroxyflavone iye yaboniswa ukuthuthukisa inkumbulo nokuqonda. Lokhu kuyenza ibe i-ejenti yokwelapha engaba khona yokwelapha izifo ze-neurodeergenerative njengesifo i-Alzheimer's.
2. Umphumela we-antidepressant
Ngokuvula ama-receptors e-TrkB, inhlanganisela ikhuthaza ukukhula kwama-neurons amasha ku-hippocampus, indawo yobuchopho ehilelekile ekulawulweni kwemizwa. Ucwaningo lwemodeli yezilwane lubonise ukuthi i-7,8-dihydroxyflavone inganciphisa izimpawu zokucindezeleka futhi ithuthukise ukumelana nokucindezeleka. Lokhu okutholakele kusikisela ukuthi le nhlanganisela ingasetshenziswa njengenye indlela yemvelo kuma-antidepressants endabuko.
3. Izakhiwo zokulwa nokuvuvukala kanye nomthamo we-antioxidant
I-7,8-Dihydroxyflavone iyi-antioxidant enamandla esiza ukuvikela amangqamuzana ekucindezelekeni kwe-oxidative okubangelwa ama-radicals mahhala. Lesi sivikelo sinciphisa ingozi yesifo esingelapheki futhi sibambezela inqubo yokuguga.
Ukuvuvukala kobuchopho kungase kube nomthelela ekuthuthukiseni nasekuqhubekeleni phambili kwezifo ezihlukahlukene zezinzwa, kuhlanganise nesifo sikaParkinson kanye ne-multiple sclerosis. Ucwaningo lubonisa ukuthi i-7,8-DHF inezinto zokulwa nokuvuvukala ezisiza ukunciphisa ukuvuvukala ebuchosheni futhi kuvimbele ukubola kwe-neurodegeneration. Ngokuvimbela ukukhiqizwa kwama-molecule e-pro-inflammatory, i-compound ingase ibe namandla okunciphisa izimpawu futhi ibambezele ukuqhubeka kwalezi zifo ezithena amandla.
4. Inamandla Okwelapha Izinkinga Zokukhathazeka
Ucwaningo lwezilwane lubonise ukuthi i-compound inganciphisa ukuziphatha okufana nokukhathazeka ngokuvula ama-TrkB receptors ku-amygdala, indawo yobuchopho ebandakanyeka ekwesabeni nasekuphenduleni ukukhathazeka. Ngokuguqula umsebenzi walezi zimukeli, i-7,8-dihydroxyflavones ingase inikeze indlela engokwemvelo nephumelelayo yokuphatha ukukhathazeka ngaphandle kwemiphumela emibi ehambisana nemithi yendabuko yokulwa nokukhathazeka.
Ngaphambi kokungena emithonjeni yokudla, ake siqonde ukuthi iyini ngempela i-7,8-dihydroxyflavone. Kuyi-flavonoid eyenzeka ngokwemvelo eyingxenye ye-flavonoid. I-Flavonoids yizinhlanganisela ezisekelwe ezitshalweni ezaziwa ngezakhiwo zazo zokulwa ne-antioxidant, ezisiza ukuvikela amangqamuzana kuma-radicals mahhala ayingozi.
Manje, ake sihlole okunye ukudla okuqukethe amanani aphezulu we-7,8-dihydroxyflavone:
1. Izithelo ezisawolintshi
Omunye wemithombo engcono kakhulu ye-7,8-dihydroxyflavones izithelo ezisawolintshi ezifana namawolintshi, ulamula, i-grapefruit nama-lime. Lezi zithelo azigcini nje ngokucebile ku-vitamin C, kodwa futhi ziqukethe izinhlobonhlobo ze-flavonoids, kuhlanganise ne-7,8-dihydroxyflavone.
2. Amajikijolo
Amajikijolo afana nama-blueberries, ama-strawberry, ama-raspberries, nama-blackberries aziwa ngokuqukethwe kwawo okuphezulu kwe-antioxidant. Lezi zithelo ezimnandi ziwumthombo omuhle kakhulu we-7,8-dihydroxyflavone, ezikunikeza izinzuzo zezempilo eziphindwe kabili.
3. Ushokoledi Omnyama
Izindaba ezimnandi zabathandi bakashokoledi! Ushokoledi omnyama, ikakhulukazi one-cocoa ephezulu, uqukethe amanani aphezulu we-7,8-dihydroxyflavonoids. Kodwa-ke, khetha izinhlobo ezinenani elincane likashukela owengeziwe ukuze uthole izinzuzo ezigcwele.
4. Itiye elihlaza
Ngaphezu kokuba isiphuzo esidumile, itiye eliluhlaza licebile ngama-flavonoid, kuhlanganise ne-7,8-dihydroxyflavone. Ukusetshenziswa njalo kwetiye eliluhlaza kungasiza ukwandisa ukudla kwakho kwe-antioxidant futhi kusekele impilo yonke.
5. Isoya
Uma ufuna umthombo wesitshalo we-7,8-dihydroxyflavone, isoya iyisinqumo esihle. Akuwona kuphela amaprotheni amaningi, kodwa futhi aqukethe ama-flavonoid ahlukahlukene afaka isandla ekwakhekeni kwawo okuzuzisayo.
6. Imifino enamahlamvu aluhlaza
Imifino efana ne-kale, isipinashi, ne-broccoli ayigcini nje ngama-kilojoule aphansi, kodwa futhi inothile ngama-antioxidants. Lezi zitshalo eziluhlaza ziwumthombo omuhle kakhulu we-7,8-dihydroxyflavone, kanye nezinye izakhamzimba ezibalulekile.
7. Iwayini elibomvu
Sanibonani! Ukuphuza iwayini elibomvu ngokusesilinganisweni kuqukethe uhlobo lwe-flavonoid olubizwa nge-resveratrol, ehlanganisa i-7,8-dihydroxyflavone. Le nhlanganisela kucatshangwa ukuthi inomthelela ezinzuzweni zenhliziyo ezihambisana nokusetshenziswa kwewayini elibomvu okusesilinganisweni.
Ukufaka lokhu kudla ekudleni kwakho kungakunikeza inqwaba yezinzuzo ezihambisana ne-7,8-dihydroxyflavone.
I-7,8-Dihydroxyflavone, eyaziwa nangokuthi i-DHF noma i-baicalein, i-flavonoid eyenzeka ngokwemvelo etholakala ezinhlobonhlobo zezitshalo, okuhlanganisa impande ye-Scutellaria baikalensis. Le nhlanganisela ithole ukunakwa okuningi eminyakeni yamuva ngezinzuzo zayo zezempilo ezingaba khona kanye nezakhiwo zokwelapha. Nokho, lapho kubhekwa ukuphepha kwanoma iyiphi into, kubalulekile ukuhlola ubufakazi besayensi obukhona. Ngakho-ke, ingabe i-7,8-dihydroxyflavone iphephile?
Ngokuphathelene nokuphepha kwayo, ucwaningo olulinganiselwe lwenziwe ekusetshenzisweni komuntu ngokuqondile kwe-7,8-dihydroxyflavone. Ngakho-ke, ukwenza izitatimende eziqinile mayelana nokuphepha kwayo kuyinselele. Kodwa-ke, izifundo zezilwane zinikeze ukuqonda okubalulekile ngobuthi obungase bube khona. Amamodeli ezilwane ahlukahlukene abike ukuthi ayikho imiphumela emibi ebalulekile elandela ukuphathwa kwe-DHF, ngisho nangemithamo ephezulu uma kuqhathaniswa. Lokhu kuphakamisa ukuthi i-7,8-dihydroxyflavone ingase ibekezelelwe kahle, okungenani ngaphakathi kwemingcele efundwayo.
Nokho, kufanele kuqashelwe uma kwenziwa iziphetho ngokusekelwe ezifundweni zezilwane kuphela. Imiphumela yezinto ingase ihluke kakhulu phakathi kwezinhlobo zezilwane, ngakho-ke, ukuqapha kuyadingeka lapho kukhishwa imiphumela kubantu. Ngaphezu kwalokho, ukuntuleka kwezifundo eziphelele zabantu zesikhathi eside kuvimbele ukuhlolwa okucacile kokuphepha kwayo.
I-7,8-Dihydroxyflavone (7,8-DHF) iyi-flavonoid eyenzeka ngokwemvelo esithole ukunakwa okukhulu ngezinzuzo zayo zezempilo ezingaba khona, nokho, kubaluleke kakhulu ukwazi umthamo onconywayo kanye nezincomo lapho usebenzisa i-7,8-DHF. kubalulekile.
Kubalulekile ukubonana nochwepheshe bezempilo uma kuziwa esikalini se-7,8-DHF, njengoba imithamo efanelekile ingase ihluke ngokusekelwe ezintweni eziningi ezinjengobudala, isisindo kanye nezimo ezithile zezokwelapha. Ucwaningo lwamanje luphakamisa uhla lwezinketho zomthamo, ngokuvamile 20 kuya ku-60 mg ngosuku. Kodwa-ke, kufanele kuqashelwe ukuthi lezi zincomo azibekwe etsheni futhi zingashintsha njengoba ubufakazi obengeziwe besayensi buqoqwa.
Lapho uthenga izithasiselo zokudla eziyi-7,8-DHF, kubalulekile ukukhetha umkhiqizi othembekile nothembekile ukuze uqinisekise ukuphepha nokusebenza komkhiqizo. Ukufunda izibuyekezo zekhasimende kanye nokuhlola ukuhlolwa kwelebhu yenkampani yangaphandle nakho kungasiza ekunqumeni ukwethembeka komkhiqizo. Kubaluleke kakhulu ukulandela iseluleko sikachwepheshe wakho wezempilo. Bazokwazi ukukunikeza isiqondiso somuntu siqu ngokusekelwe emlandweni wakho wezokwelapha kanye nezimo zempilo zamanje. Kuhlale kunconywa ukuthi kuqalwe ngethamo elisebenza ngempumelelo eliphansi futhi kancane kancane kwenyuke njengoba kudingeka ngaphansi kokugadwa uchwepheshe wezokunakekelwa kwempilo.
Ngaphambi kokufaka i-7,8-DHF ohlelweni lwakho lwansuku zonke, kubalulekile ukuqaphela noma yimiphi imiphumela emibi engaba khona noma ukusebenzisana kwezidakamizwa. Nakuba i-7,8-DHF ngokuvamile ibekezelelwa kahle, abanye abantu bangase babe nokucindezeleka okuncane kwesisu noma ukungezwani komzimba. Futhi, qiniseka ukuthi wazisa uchwepheshe wakho wezokunakekelwa kwempilo nganoma yimiphi imithi noma izithasiselo ozithathayo njengamanje ukuze ugweme noma yikuphi ukusebenzisana okungenzeka. Khumbula ukuthi ukuthatha noma yiziphi izithasiselo kufanele ngaso sonke isikhathi kube ngaphansi kokuqondisa kochwepheshe bezempilo ukuze wandise impilo yakho.
Q: Kuthatha isikhathi esingakanani ukuthi i-7,8-dihydroxyflavoneor isebenze?
A: Isivinini i-7,8-dihydroxyflavone (7,8-DHF) eqala ukusebenza ngaso singahluka kuye ngezinto ezimbalwa. Ezifundweni zesayensi, i-7,8-DHF ibonise ukuthi inemiphumela ehlukahlukene, njengokukhuthaza ukukhululwa kwe-neurotrophic factor and neuroprotection. Isikhathi esisithathayo ukuze le miphumela ibonakale singasuka emahoreni siye ezinsukwini noma ngisho nangaphezulu, kuye ngenqubo ethile yesenzo nokuhlosiwe kwenhlanganisela.
Umshwana wokuzihlangula: Lesi sihloko senzelwe izinjongo zokwaziswa kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukushintsha uhlobo lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Jul-04-2023
