I-7,8-Dihydroxyflavone iyinhlanganisela yemvelo etholakala ezitshalweni eye yathola ukunakwa okukhulu ngenxa yezinzuzo zayo ezingaba khona ekusebenzeni kobuchopho kanye nenkumbulo. Le nhlanganisela ye-flavone ingeyesigaba samakhemikhali abizwa ngokuthi ama-flavonoid, aziwa ngezakhiwo zawo zokulwa ne-antioxidant kanye nokulwa nokuvuvukala. Ucwaningo lukhombisile ukuthi i-7,8-dihydroxyflavone ingaba nemiphumela eminingi emihle ebuchosheni.
I-7,8-Dihydroxyflavone iyinhlanganisela enamandla futhi eguquguqukayo eyingxenye yomndeni wama-flavonoid. Ama-Flavonoid ayizinhlanganisela zemvelo ezisatshalaliswa kabanzi ezitshalweni futhi adlala indima ebalulekile ezinqubweni ezahlukahlukene zezinto eziphilayo. Enye yezimfanelo eziphawulekayo ze-7,8-dihydroxyflavone yikhono layo lokusebenzisana nokulawula amaprotheni nama-enzyme emzimbeni, okuvuse isithakazelo esikhulu emphakathini wesayensi.
Ucwaningo lukhombisile ukuthi i-compound engu-7,8-dihydroxyflavone inezinzuzo ezingaba khona kwezempilo, inezakhiwo zokulwa nokuvuvukala, ukulwa nokuvuvukala kanye nokuvikela imizwa. Phakathi kwazo, umsebenzi onamandla we-antioxidant we-7,8-dihydroxyflavone uvumela ukuthi ikwazi ukukhipha ama-free radical ayingozi emzimbeni futhi ivimbele ukucindezeleka kwe-oxidative ekubangeleni umonakalo wamangqamuzana kanye nezifo ezahlukahlukene. Ucwaningo olwenziwe kuze kube manje kuma-7,8-dihydroxyflavones luyakhuthaza, kodwa kudingeka ucwaningo olwengeziwe ukuze kutholakale ukusebenza kahle kanye nokuphepha kwama-7,8-dihydroxyflavones okusetshenziswa kubantu. Noma kunjalo, le compound ye-flavonoid inesithembiso esikhulu njengesengezo sokudla esingaba khona noma ukhetho lwemithi esikhathini esizayo.
I-7,8-Dihydroxyflavone iyinhlanganisela yemvelo, eyaziwa nangokuthi i-7,8-DHF, eye yathola ukunakwa okukhulu eminyakeni yamuva ngenxa yezinzuzo zayo ezingaba khona empilweni yabantu.
Le nhlanganisela yemvelo ingeyomndeni we-flavonoid futhi itholakala ezitshalweni ezahlukahlukene, kufaka phakathi impande ye-Scutellaria baicalensis.
1. Thuthukisa ukusebenza kwengqondo
Ucwaningo lubonisa ukuthi le nhlanganisela isebenza njenge-agonist ye-TrkB, okusho ukuthi ivuselela ama-receptor e-TrkB ebuchosheni. Lawa ma-receptor anesibopho sokukhuthaza ukukhula nokusinda kwama-neurons, kanye nokuthuthukisa i-synaptic plasticity -- ikhono lobuchopho lokuzivumelanisa nezimo nokushintsha. Ngokuvuselela ama-receptor e-TrkB, i-7,8-dihydroxyflavone iboniswe ukuthi ithuthukisa inkumbulo nokuqonda. Lokhu kuyenza ibe yi-ejenti yokwelapha engaba khona yokwelapha izifo eziwohlokayo ze-neurological njengesifo i-Alzheimer's.
2. Umphumela wokunciphisa ukucindezeleka
Ngokusebenzisa ama-receptor e-TrkB, le nhlanganisela ikhuthaza ukukhula kwama-neurons amasha ku-hippocampus, indawo yobuchopho ehilelekile ekulawulweni kwemizwa. Izifundo zemodeli yezilwane zibonise ukuthi i-7,8-dihydroxyflavone inganciphisa izimpawu zokucindezeleka futhi ithuthukise ukumelana nokucindezeleka. Lokhu okutholakele kusikisela ukuthi le nhlanganisela ingasetshenziswa njengendlela yemvelo esikhundleni semithi yokucindezeleka yendabuko.
3. Izakhiwo zokulwa nokuvuvukala kanye namandla okulwa ne-antioxidant
I-7,8-Dihydroxyflavone iyi-antioxidant enamandla esiza ukuvikela amaseli ekucindezelekeni kwe-oxidative okubangelwa ama-free radicals. Lokhu kuvikela kunciphisa ingozi yezifo ezingamahlalakhona futhi kubambezele inqubo yokuguga.
Ukuvuvukala kobuchopho kungasiza ekuthuthukisweni nasekuqhubekeni kwezifo ezahlukahlukene zezinzwa, okuhlanganisa nesifo sikaParkinson kanye ne-multiple sclerosis. Ucwaningo lubonisa ukuthi i-7,8-DHF inezakhiwo zokulwa nokuvuvukala ezisiza ekunciphiseni ukuvuvukala ebuchosheni futhi zivimbele ukuwohloka kwemizwa. Ngokuvimbela ukukhiqizwa kwama-molecule abangela ukuvuvukala, le nhlanganisela ingaba namandla okunciphisa izimpawu futhi inciphise ukuqhubeka kwalezi zifo eziqeda amandla.
4. Inamandla Okwelapha Izinkinga Zokukhathazeka
Izifundo zezilwane zikhombisile ukuthi le nhlanganisela inganciphisa ukuziphatha okufana nokukhathazeka ngokusebenzisa ama-receptor e-TrkB ku-amygdala, indawo yobuchopho ehilelekile ekwesabeni nasekuphenduleni ukukhathazeka. Ngokushintsha umsebenzi walezi zi-receptor, ama-7,8-dihydroxyflavones anganikeza indlela yemvelo nephumelelayo yokuphatha ukukhathazeka ngaphandle kwemiphumela emibi ehlotshaniswa nemithi yendabuko yokulwa nokukhathazeka.
Ngaphambi kokuhlola imithombo yokudla, ake siqonde ukuthi iyini ngempela i-7,8-dihydroxyflavone. Iyi-flavonoid eyenzeka ngokwemvelo eyingxenye yesigaba sama-flavonoid. Ama-Flavonoid ayizakhi ezisekelwe ezitshalweni ezaziwa ngezakhiwo zawo zokulwa nama-antioxidant, ezisiza ukuvikela amaseli kuma-free radical ayingozi.
Manje, ake sihlole ukudla okuqukethe inani eliphezulu le-7,8-dihydroxyflavone:
1. Izithelo ze-citrus
Omunye wemithombo emihle kakhulu yama-flavone angu-7,8-dihydroxy yizithelo ze-citrus ezifana nama-orange, ulamula, i-grapefruit kanye nama-lime. Lezi zithelo azigcini nje ngokucebile nge-vitamin C, kodwa futhi ziqukethe ama-flavonoid ahlukahlukene, okuhlanganisa ne-7,8-dihydroxyflavone.
2. Amajikijolo
Amajikijolo afana nama-blueberry, ama-strawberry, ama-raspberry, nama-blackberry aziwa ngokuqukethwe kwawo okuphezulu kwe-antioxidant. Lezi zithelo ezimnandi nazo ziwumthombo omuhle we-7,8-dihydroxyflavone, okukunikeza izinzuzo zezempilo eziphindwe kabili.
3. Ushokoledi Omnyama
Izindaba ezinhle kubathandi betshokolethi! Ushokoledi omnyama, ikakhulukazi oqukethe i-cocoa ephezulu, uqukethe inani eliphezulu lama-flavonoid angu-7,8. Kodwa-ke, khetha izinhlobo ezinoshukela omncane kakhulu ukuze uthole izinzuzo ezigcwele.
4. Itiye eliluhlaza
Ngaphezu kokuba isiphuzo esidumile, itiye eliluhlaza licebile ngama-flavonoid, okuhlanganisa ne-7,8-dihydroxyflavone. Ukudla itiye eliluhlaza njalo kungasiza ekwandiseni ukudla kwakho ama-antioxidant futhi kusekele impilo iyonke.
5. Isoya
Uma ufuna umthombo wesitshalo we-7,8-dihydroxyflavone, i-soy iyisinqumo esihle kakhulu. Ayigcini nje ngokuba namaprotheni amaningi, kodwa futhi iqukethe ama-flavonoid ahlukahlukene afaka isandla ezicini zawo ezizuzisayo.
6. Imifino eluhlaza enamaqabunga
Imifino efana ne-kale, isipinashi, ne-broccoli ayigcini nje ngokuba nama-calories aphansi, kodwa futhi icebile ngama-antioxidants. Lawa maqabunga aluhlaza angumthombo omuhle kakhulu we-7,8-dihydroxyflavone, kanye nezinye izakhamzimba ezibalulekile.
7. Iwayini elibomvu
Hawu! Ukuphuza iwayini elibomvu ngokulinganisela kuqukethe uhlobo lwe-flavonoid olubizwa ngokuthi i-resveratrol, oluhlanganisa i-7,8-dihydroxyflavone. Kucatshangwa ukuthi le nhlanganisela inegalelo ezinzuzweni zenhliziyo ezihambisana nokusetshenziswa kwewayini elibomvu ngokulinganisela.
Ukufaka lokhu kudla ekudleni kwakho kungakunikeza izinzuzo eziningi ezihambisana ne-7,8-dihydroxyflavone.
I-7,8-Dihydroxyflavone, eyaziwa nangokuthi i-DHF noma i-baicalein, iyi-flavonoid eyenzeka ngokwemvelo etholakala ezitshalweni ezahlukahlukene, kufaka phakathi impande ye-Scutellaria baicalensis. Le nhlanganisela ithole ukunakwa okukhulu eminyakeni yamuva ngenxa yezinzuzo zayo zezempilo kanye nezakhiwo zokwelapha. Kodwa-ke, uma ucabangela ukuphepha kwanoma iyiphi into, kubalulekile ukuhlola ubufakazi besayensi obutholakalayo. Ngakho-ke, ingabe i-7,8-dihydroxyflavone iphephile?
Ngokuphepha kwayo, kwenziwe ucwaningo olulinganiselwe mayelana nokusetshenziswa ngqo kwe-7,8-dihydroxyflavone kubantu. Ngakho-ke, ukwenza izitatimende eziqinisekisayo ngokuphepha kwayo kuyinselele. Kodwa-ke, izifundo zezilwane zinikeze ukuqonda okubalulekile ngobuthi bayo obungaba khona. Amamodeli ahlukahlukene ezilwane awazange abike imiphumela emibi ebalulekile ngemuva kokuphathwa kwe-DHF, ngisho noma kumthamo ophezulu. Lokhu kusikisela ukuthi i-7,8-dihydroxyflavone ingase ibekezelelwe kahle, okungenani ngaphakathi kwemingcele efundwe.
Kodwa-ke, kufanele kuqashelwe lapho kufinyelelwa eziphethweni ngokusekelwe ezifundweni zezilwane kuphela. Imiphumela yezinto ingahluka kakhulu phakathi kwezinhlobo, ngakho-ke, kudingeka ukuqaphelisisa lapho kucatshangelwa imiphumela kubantu. Ngaphezu kwalokho, ukuntuleka kwezifundo zabantu zesikhathi eside eziphelele kuye kwavimbela ukuhlolwa okucacile kokuphepha kwazo.
I-7,8-Dihydroxyflavone (7,8-DHF) iyi-flavonoid eyenzeka ngokwemvelo eye yathola ukunakwa okukhulu ngezinzuzo zayo zezempilo ezingaba khona, noma kunjalo, kubaluleke kakhulu ukwazi umthamo onconywayo kanye nezincomo uma usebenzisa i-7,8-DHF ebalulekile.
Kubalulekile ukubonisana nochwepheshe bezempilo uma kukhulunywa ngomthamo we-7,8-DHF, njengoba umthamo ofanele ungahluka ngokusekelwe ezintweni eziningi ezifana nobudala, isisindo kanye nezimo ezithile zezokwelapha. Ucwaningo lwamanje luphakamisa izinketho ezahlukene zomthamo, ngokuvamile u-20 kuya ku-60 mg ngosuku. Kodwa-ke, kufanele kuqashelwe ukuthi lezi zincomo azikabekwa phansi futhi zingashintsha njengoba kuqoqwa ubufakazi obengeziwe besayensi.
Uma uthenga izithako zokudla ze-7,8-DHF, kubalulekile ukukhetha umenzi othembekile nothembekile ukuqinisekisa ukuphepha nokusebenza kahle komkhiqizo. Ukufunda ukubuyekezwa kwamakhasimende nokuhlola izivivinyo zelebhu ezivela eceleni kungasiza ekunqumeni ukuthembeka komkhiqizo. Kubaluleke kakhulu ukulandela iseluleko sochwepheshe wakho wezempilo. Bazokwazi ukukunikeza isiqondiso esiqondene nawe ngokusekelwe emlandweni wakho wezokwelapha kanye nezimo zempilo zamanje. Kunconywa njalo ukuthi uqale ngomthamo ophansi kakhulu osebenzayo bese ukhuphula kancane kancane njengoba kudingeka ngaphansi kokugadwa kochwepheshe wezempilo.
Ngaphambi kokufaka i-7,8-DHF ohlelweni lwakho lwansuku zonke, kubalulekile ukuqaphela noma yimiphi imiphumela emibi engaba khona noma ukusebenzisana kwezidakamizwa. Nakuba i-7,8-DHF ivame ukubekezelelwa kahle, abanye abantu bangase babe nokucindezeleka okuncane kwesisu noma ukusabela kokungezwani komzimba. Futhi, qiniseka ukuthi wazisa uchwepheshe wakho wezempilo nganoma yimiphi imithi noma izithasiselo ozithathayo njengamanje ukuze ugweme noma yikuphi ukusebenzisana okungenzeka. Khumbula ukuthi ukuthatha noma yiziphi izithasiselo kufanele kube ngaphansi kwesiqondiso sochwepheshe wezempilo ukuze uthuthukise impilo yakho.
Q: Kuthatha isikhathi esingakanani ukuthi i-7,8-dihydroxyflavone noma isebenze?
A: Isivinini lapho i-7,8-dihydroxyflavone (7,8-DHF) isebenza khona singahluka kuye ngezici eziningana. Ezifundweni zesayensi, i-7,8-DHF ikhombisile ukuthi inemiphumela ehlukahlukene, njengokukhuthaza ukukhululwa kwe-neurotrophic factor kanye nokuvikelwa kwemizwa. Isikhathi esithathayo ukuze le miphumela ibonakale singasukela emahoreni kuya ezinsukwini noma ngisho nangaphezulu, kuye ngendlela ethile yesenzo kanye nomgomo wenhlanganisela.
Isixwayiso: Lesi sihloko senzelwe ulwazi kuphela futhi akufanele sibhekwe njengeseluleko sezokwelapha. Njalo xhumana nochwepheshe wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukushintsha uhlelo lwakho lwezempilo.
Isikhathi sokuthunyelwe: Julayi-04-2023
