Yini okudingeka uyazi nge-nicotinamide adenine dinucleotide (NAD+)?

I-NAD+ ibizwa nangokuthi i-coenzyme, futhi igama layo eliphelele yi-nicotinamide adenine dinucleotide. Kuyi-coenzyme ebalulekile emjikelezweni we-tricarboxylic acid. Ikhuthaza umzimba kashukela, amafutha, nama-amino acid, ibamba iqhaza ekuhlanganiseni amandla, futhi ibambe iqhaza ezinkulungwaneni zokusabela kuwo wonke amangqamuzana. Inani elikhulu lemininingwane yokuhlola likhombisa ukuthi i-NAD+ ibandakanyeka kakhulu emisebenzini ehlukahlukene eyisisekelo yomzimba ephilayo, ngaleyo ndlela ingenelela emisebenzini ebalulekile yamaselula efana ne-energy metabolism, ukulungiswa kwe-DNA, ukuguqulwa kofuzo, ukuvuvukala, isigqi sebhayoloji, nokumelana nengcindezi.

Ngokocwaningo olufanele, izinga le-NAD+ emzimbeni womuntu lizokwehla ngokuhamba kweminyaka. Ukuncipha kwamazinga e-NAD+ kungaholela ekwehleni kwezinzwa, ukulahlekelwa umbono, ukukhuluphala, ukwehla kokusebenza kwenhliziyo nokunye ukwehla kokusebenza. Ngakho-ke, indlela yokukhulisa izinga le-NAD+ emzimbeni womuntu bekulokhu kungumbuzo. Isihloko socwaningo esishisayo emphakathini we-biomedical.

Kungani i-NAD+ yehla?

Ngoba, njengoba sikhula, umonakalo we-DNA uyanda. Ngesikhathi senqubo yokulungisa i-DNA, isidingo se-PARP1 siyakhuphuka, umsebenzi we-SIRT unomkhawulo, ukusetshenziswa kwe-NAD+ kuyanda, futhi inani le-NAD+ liyehla ngokwemvelo.

Uma sengeza ngokwaneleNAD+, sizothola ukuthi imisebenzi eminingi yomzimba iqala ukubuyisela ubusha.

Amaseli aqukethe i-NAD+. Ingabe sisadinga ukunezela?

Umzimba wethu wakhiwe cishe ngamaseli angama-37 trillion. Amaseli kufanele aqedele "umsebenzi" omningi noma ukusabela kwamaselula ukuze azinakekele. Iseli lakho ngalinye lamatriliyoni angama-37 lincike ku-NAD+ ukwenza umsebenzi wayo oqhubekayo.

Njengoba inani labantu emhlabeni liguga, izifo ezihlobene nokuguga njengesifo i-Alzheimer's, isifo senhliziyo, izinkinga zamalunga, ukulala nezinkinga zenhliziyo seziphenduke izifo ezibalulekile ezisongela impilo yabantu.

Ngakho-ke, njengoba i-NAD yatholwa ososayensi baseMelika, i-NAD ingene ezimpilweni zabantu, futhi i-NAD+ nezithako zayo zibonise amathuba amahle okusebenza ekuvimbeleni izifo ezihlobene nokuguga.

① I-NAD+ isebenza njenge-coenzyme ku-mitochondria ukukhuthaza ibhalansi ye-metabolic. I-NAD+ idlala indima ebaluleke kakhulu ezinqubweni ze-metabolic ezifana ne-glycolysis, umjikelezo we-TCA (umjikelezo we-Krebs noma umjikelezo we-citric acid) kanye neketango lokuthutha lama-electron. Kuyindlela amangqamuzana athola ngayo amandla. Ukuguga nokudla okunekhalori ephezulu kunciphisa amazinga e-NAD+ emzimbeni.

Ucwaningo lubonise ukuthi kumagundane amadala, ukuthatha izithasiselo ze-NAD+ kunciphisa ukudla- noma ukuzuza kwesisindo okuhlobene neminyaka kanye nomthamo wokuzivocavoca othuthukisiwe. Ukwengeza, ucwaningo seluze lwayibuyisela emuva imiphumela yesifo sikashukela kumagundane abesifazane, lubonisa amasu amasha okulwa nezifo ze-metabolic ezifana nokukhuluphala.

I-NAD+ ibophezela kuma-enzyme futhi idlulisela ama-electron phakathi kwama-molecule. Ama-electron ayisisekelo samandla eselula. I-NAD+ isebenza kumaseli njengokushaja kabusha ibhethri. Uma ama-electron ephela, ibhethri liyafa. Kumaseli, i-NAD+ ingakhuthaza ukudluliswa kwama-electron futhi inikeze amandla kumaseli. Ngale ndlela, i-NAD+ inganciphisa noma yandise umsebenzi we-enzyme, ikhuthaze ukubonakaliswa kofuzo nokusayina kweseli.

② I-NAD+ isiza ukulawula ukulimala kwe-DNA

Njengoba izinto eziphilayo zikhula, izici zemvelo ezimbi njengemisebe, ukungcola, nokuphindaphindeka kwe-DNA enganembile kungalimaza i-DNA. Lena enye yemibono yokuguga. Cishe wonke amangqamuzana aqukethe "imishini yamangqamuzana" yokulungisa lo monakalo.

Lokhu kulungiswa kudinga i-NAD+ namandla, ngakho-ke ukulimala kwe-DNA ngokweqile kudla izinsiza ezibalulekile zamaselula. Umsebenzi we-PARP, iphrotheni ebalulekile yokulungisa i-DNA, nayo incike ku-NAD+. Ukuguga okuvamile kubangela ukulimala kwe-DNA emzimbeni, i-RARP iyanda, ngakho-ke ukugxila kwe-NAD+ kuyehla. Ukulimala kwe-Mitochondrial DNA kunoma yisiphi isinyathelo kuzokwandisa lokhu kuncipha.

③ NAD+ithinta umsebenzi we-longevity gene Sirtuins futhi ivimbela ukuguga

Izakhi zofuzo ezisanda kutholwa eziphila isikhathi eside ama-sirtuin, ezaziwa nangokuthi "abaqaphi bezakhi zofuzo," zidlala indima ebalulekile ekugcineni impilo yamangqamuzana. Ama-Sirtuin awumndeni wama-enzyme abandakanyeka ekuphenduleni kokucindezeleka kwamaselula nokulungisa umonakalo. Baphinde babambe iqhaza ekukhiqizweni kwe-insulin, inqubo yokuguga, kanye nezimo zezempilo ezihlobene nokuguga njengezifo ze-neurodeergenerative nesifo sikashukela.

I-NAD+ inguphethiloli osiza ama-sirtuin ukuthi agcine ubuqotho be-genome futhi akhuthaze ukulungiswa kwe-DNA. Njengemoto ayikwazi ukuphila ngaphandle kukaphethiloli, amaSirtuins adinga i-NAD+ ukuze isebenze. Imiphumela evela ocwaningweni lwezilwane ikhombisa ukuthi ukwanda kwamazinga e-NAD+ emzimbeni kwenza amaprotheni e-sirtuin asebenze futhi andise isikhathi sokuphila kumvubelo namagundane.

④ Umsebenzi wenhliziyo

Ukuphakamisa amazinga e-NAD+ kuvikela inhliziyo futhi kuthuthukisa ukusebenza kwenhliziyo. Umfutho wegazi ophakeme ungabangela ukukhuliswa kwenhliziyo kanye nemithambo evalekile, okungaholela ekushayweni kohlangothi. Ngemuva kokugcwalisa izinga le-NAD+ enhliziyweni ngezithako ze-NAD+, umonakalo wenhliziyo odalwe ukuphindwaphindwa uyavinjwa. Olunye ucwaningo lubonise ukuthi izithasiselo ze-NAD+ futhi zivikela amagundane ekwandiseni kwenhliziyo okungavamile.

⑤ I-Neurodegeneration

Emagundaneni anesifo i-Alzheimer's, ukwanda kwamazinga e-NAD+ kuthuthukise ukusebenza kwengqondo ngokunciphisa ukunqwabelana kwamaprotheni aphazamisa ukuxhumana kobuchopho. Ukwenyusa amazinga e-NAD+ futhi kuvikela amangqamuzana obuchopho ekufeni lapho lingekho igazi elanele eligelezela ebuchosheni. I-NAD+ ibonakala inesithembiso esisha ekuvikeleni ngokumelene ne-neurodegeneration kanye nokuthuthukisa inkumbulo.

⑥ Amasosha omzimba

Njengoba sikhula, amasosha ethu omzimba ayancipha futhi sisengozini yokugula. Ucwaningo lwakamuva luphakamisa ukuthi amazinga e-NAD+ adlala indima ebalulekile ekulawuleni izimpendulo zamasosha omzimba kanye nokuvuvukala kanye nokusinda kwamaseli ngesikhathi sokuguga. Ucwaningo lugqamisa amandla okwelapha e-NAD+ okungasebenzi kahle kwamasosha omzimba.

Ubudlelwano phakathi kwendima ye-NAD+ nokuguga

Ama-coenzymes abamba iqhaza kumetabolism yezinto ezibalulekile njengoshukela, amafutha, namaprotheni emzimbeni womuntu, futhi adlala indima ebalulekile ekulawuleni umzimba wezinto ezibonakalayo namandla kanye nokugcina imisebenzi evamile yomzimba. I-NAD iyi-coenzyme ebaluleke kakhulu emzimbeni womuntu, ebizwa nangokuthi i-coenzyme I. Ibamba iqhaza ezinkulungwaneni zokusabela kwe-redox enzymatic emzimbeni womuntu. Kuyinto edingekayo ukuze i-metabolism yawo wonke amaseli. Inemisebenzi eminingi, imisebenzi esemqoka yile:

1. Khuthaza ukukhiqizwa kwe-bioenergy

I-NAD+ ikhiqiza i-ATP ngokuphefumula kwamaselula, igcwalise ngokuqondile amandla eseli futhi ithuthukise ukusebenza kwamangqamuzana;

2. Lungisa izakhi zofuzo

I-NAD+ ukuphela kwe-substrate ye-enzyme yokulungisa i-DNA i-PARP. Lolu hlobo lwe-enzyme lubamba iqhaza ekulungiseni i-DNA, lusiza ukulungisa i-DNA namaseli awonakele, lunciphisa ithuba lokuguqulwa kwamangqamuzana, futhi luvimbele ukuvela komdlavuza;

3. Yenza kusebenze wonke amaprotheni okuphila isikhathi eside

I-NAD+ ingenza kusebenze wonke amaprotheni angu-7 okuphila isikhathi eside, ngakho-ke i-NAD+ inomthelela obaluleke kakhulu ekulweni nokuguga nokwandisa ubude bempilo;

4. Qinisa amasosha omzimba

I-NAD+ iqinisa amasosha omzimba futhi ithuthukise ukungatheleleki kwamaselula ngokuthinta ngokukhethekile ukusinda nokusebenza kwamaseli e-T alawulayo.

5. Khuthaza ukukhula kwezinwele

Imbangela enkulu yokulahleka kwezinwele ukulahleka kokuqina kwamangqamuzana omama wezinwele, futhi ukulahleka kwamandla kamama wezinwele kungenxa yokuthi izinga le-NAD+ emzimbeni womuntu liyehla. Amaseli kamama ezinwele awanayo i-ATP eyanele yokwenza ukwakheka kwamaprotheni ezinwele, ngaleyo ndlela alahlekelwe ubungqabavu bawo futhi aholele ekuqothukeni kwezinwele.

6. Ukuphathwa kwesisindo, ukukhuthaza umzimba

Ngo-2017, uSolwazi David Sinclair we-Harvard Medical School kanye nethimba elivela e-Australian Medical College benza uhlolo oluqhathaniswayo kumagundane esifazane akhuluphele ajima ku-treadmill amasonto ayi-9 futhi ethatha i-NMN nsuku zonke izinsuku eziyi-18. Ucwaningo lwathola ukuthi i-NMN ithinta i-fat metabolism yesibindi. Futhi umphumela we-synthesis ngokusobala mkhulu kunowokuzivocavoca.

Ngokuphawulekayo, ukuguga kuhambisana nokwehla okuqhubekayo kwezicubu kanye namazinga e-NAD+ yamaselula ezinhlobonhlobo zezinto eziphilayo, okuhlanganisa amagundane nabantu. Ukwehla kwamazinga e-NAD+ kuhlobene nezifo eziningi ezihlobene nokuguga, okuhlanganisa ukuncipha kwengqondo, umdlavuza, isifo se-metabolic, i-sarcopenia, kanye nobuthakathaka.

Ngingayingeza kanjani i-NAD+ nsuku zonke?

Akukho ukuhlinzekwa okungapheli kwe-NAD+ emzimbeni wethu. Okuqukethwe kanye nomsebenzi we-NAD+ emzimbeni womuntu kuzokwehla ngokuhamba kweminyaka, futhi kuzokwehla ngokushesha ngemuva kweminyaka engama-30, okuholela ekugugeni kwamaseli, i-apoptosis kanye nokulahlekelwa amandla okuvuselela. .

Ngaphezu kwalokho, ukuncishiswa kwe-NAD+ kuzophinde kubangele uchungechunge lwezinkinga zempilo, ngakho-ke uma i-NAD+ ingakwazi ukugcwaliswa ngesikhathi, imiphumela ingacatshangwa.

1.Isengezo esivela ekudleni

Ukudla okufana neklabishi, i-broccoli, ukwatapheya, isiteki, amakhowe, ne-edamame kuqukethe izandulela ze-NAD+, ezingaguqulelwa ku-NAD* esebenzayo emzimbeni ngemva kokumuncwa.

2.Nciphisa ukudla kanye nama-calories

Ukukhawulelwa kwekhalori okumaphakathi kungenza kusebenze izindlela zokuzwa amandla ngaphakathi kwamaseli futhi kukhuphule amazinga e-NAD* ngokungaqondile. Kodwa qiniseka ukuthi udla ukudla okunomsoco ukuze uhlangabezane nezidingo zokudla okunomsoco zomzimba wakho

3. Hlala ukhuthele futhi uzivocavoce

Ukuzivocavoca kwe-aerobic okumaphakathi njengokugijima nokubhukuda kungakhuphula amazinga e-NAD+ e-intracellular, kusize ukukhulisa ukutholakala komoyampilo emzimbeni futhi kuthuthukise i-metabolism yamandla.

4. Landela imikhuba yokulala enempilo

Ngesikhathi sokulala, umzimba womuntu wenza izinqubo eziningi ezibalulekile ze-metabolic kanye nokulungisa, okuhlanganisa ukuhlanganiswa kwe-NAD*. Ukulala ngokwanele kusiza ukugcina amazinga ajwayelekile e-NAD

5. Faka izinto ezandulela i-NAD+

I-Nicotinic acid (NA) ne-nicotinamide (NAM) zombili zingamanduleli we-NAD+. Angahlanganiswa futhi aguqulwe abe yi-NAD emzimbeni womuntu, ngaleyo ndlela akhulise okuqukethwe kwawo. Kodwa-ke, ngenxa yemikhawulo yendlela yokuhlanganisa kanye nama-enzyme anciphisa isilinganiso, i-bioavailability iphansi. .

6 Yengeza ngokuqondile i-NAD+

Ukwengezwa kwangaphandle kwe-NAD+ kungabuyisela ngokushesha amazinga e-NAD+ emzimbeni, okuvumela izitho ezibalulekile njengenhliziyo nobuchopho ukuthi zithole ukwesekwa okusebenzayo kwe-NAD+.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngempushana eyisithako se-NAD+ yekhwalithi ephezulu nehlanzeke kakhulu.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani angcono kakhulu. Izimpushana zethu zesithasiselo se-NAD+ zihlolelwa ngokuqinile ubumsulwa namandla, kuqinisekisa ukuthi uthola isithasiselo sekhwalithi ephezulu ongasethemba. Ukuthi ufuna ukusekela impilo yamaselula, ukuqinisa amasosha akho omzimba noma uthuthukise impilo yonke, i-NAD+ yethu yempushana iyisinqumo esihle kakhulu.

Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, iSuzhou Myland Pharm isungule uhide lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ihambisane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.