Yini okudingeka uyazi nge-nicotinamide adenine dinucleotide (NAD+)?

I-NAD+ ibizwa nangokuthi i-coenzyme, futhi igama layo eliphelele yi-nicotinamide adenine dinucleotide. Iyi-coenzyme ebalulekile emjikelezweni we-tricarboxylic acid. Ikhuthaza ukwakheka kukashukela, amafutha, nama-amino acid, ihlanganyela ekwakhiweni kwamandla, futhi ihlanganyela ezinkulungwaneni zezenzo kuwo wonke amaseli. Inani elikhulu ledatha yokuhlola libonisa ukuthi i-NAD+ ihileleke kakhulu emisebenzini ehlukahlukene eyisisekelo yomzimba emzimbeni, ngaleyo ndlela ingenelela emisebenzini ebalulekile yamaseli njengokwakheka kwamandla, ukulungiswa kwe-DNA, ukuguqulwa kwezakhi zofuzo, ukuvuvukala, izigqi zezinto eziphilayo, kanye nokumelana nokucindezeleka.

Ngokusho kocwaningo olufanele, izinga le-NAD+ emzimbeni womuntu lizokwehla njengoba iminyaka ikhula. Ukwehla kwamazinga e-NAD+ kungaholela ekuwohlokeni kwezinzwa, ukulahlekelwa umbono, ukukhuluphala, ukwehla kokusebenza kwenhliziyo kanye nokunye ukwehla kokusebenza. Ngakho-ke, indlela yokwandisa izinga le-NAD+ emzimbeni womuntu ibilokhu ingumbuzo. Isihloko socwaningo esishisayo emphakathini wezokwelapha.

Kungani i-NAD+ incipha?

Ngoba, njengoba siguga, umonakalo we-DNA uyanda. Ngesikhathi senqubo yokulungisa i-DNA, isidingo se-PARP1 siyanda, umsebenzi we-SIRT unqunyelwe, ukusetshenziswa kwe-NAD+ kuyanda, futhi inani le-NAD+ liyancipha ngokwemvelo.

Uma sinezela ngokwaneleI-NAD+, sizothola ukuthi imisebenzi eminingi yomzimba iqala ukubuyisela ubusha.

Amaseli aqukethe i-NAD+. Ingabe kusadingeka siwangeze?

Umzimba wethu wakhiwe ngamaseli angaba yizigidigidi ezingu-37. Amaseli kumele aqedele "ukusebenza" okuningi noma ukusabela kwamaseli ukuze azigcine. Iseli ngalinye lamaseli akho ayizigidigidi ezingu-37 lincike ku-NAD+ ukuze lenze umsebenzi walo oqhubekayo.

Njengoba inani labantu emhlabeni likhula, izifo ezihlobene nokuguga njengesifo i-Alzheimer's, isifo senhliziyo, izinkinga zamalunga, ubuthongo nezinkinga zenhliziyo nemithambo yegazi sezibe yizifo ezibalulekile ezisongela impilo yabantu.

Ngakho-ke, selokhu i-NAD yatholakala ososayensi baseMelika, i-NAD isingene ezimpilweni zabantu, kanti i-NAD+ kanye nezithasiselo zayo zibonise amathuba amakhulu okusetshenziswa ekuvimbeleni izifo ezihlobene nokuguga.

① I-NAD+ isebenza njenge-coenzyme ku-mitochondria ukukhuthaza ibhalansi ye-metabolic. I-NAD+ idlala indima esebenzayo kakhulu ezinqubweni ze-metabolic ezifana ne-glycolysis, umjikelezo we-TCA (owaziwa nangokuthi umjikelezo we-Krebs noma umjikelezo we-citric acid) kanye nochungechunge lokuthuthwa kwama-electron. Yindlela amaseli athola ngayo amandla. Ukuguga nokudla okunama-calories amaningi kunciphisa amazinga e-NAD+ emzimbeni.

Izifundo zibonise ukuthi kumagundane amadala, ukuthatha izithasiselo ze-NAD+ kunciphisa ukukhuluphala okuhlobene nokudla noma ukuguga kanye nokuthuthukiswa kwamandla okuzivocavoca. Ngaphezu kwalokho, izifundo zize zaguqula imiphumela yesifo sikashukela kumagundane abesifazane, zikhombisa amasu amasha okulwa nezifo ze-metabolic ezifana nokukhuluphala ngokweqile.

I-NAD+ ibopha kuma-enzyme futhi idlulise ama-electron phakathi kwama-molecule. Ama-electron ayisisekelo samandla eselula. I-NAD+ isebenza kumaseli njengokuphinda ishaje ibhethri. Uma ama-electron esephelile, ibhethri liyafa. Emaseli, i-NAD+ ingakhuthaza ukudluliselwa kwama-electron futhi inikeze amandla kumaseli. Ngale ndlela, i-NAD+ inganciphisa noma yandise umsebenzi wama-enzyme, ikhuthaze ukuvezwa kwezakhi zofuzo kanye nokusabalalisa amaseli.

② I-NAD+ isiza ukulawula umonakalo we-DNA

Njengoba izinto eziphilayo ziguga, izici ezimbi zemvelo ezifana nemisebe, ukungcola, kanye nokuphindaphinda kwe-DNA okungaqondile kungalimaza i-DNA. Lena ingenye yemibono yokuguga. Cishe wonke amaseli aqukethe "imishini yama-molecule" yokulungisa lo monakalo.

Lokhu kulungiswa kudinga i-NAD+ namandla, ngakho-ke umonakalo omkhulu we-DNA udla izinsizakusebenza zamaseli ezibalulekile. Umsebenzi we-PARP, iphrotheni ebalulekile yokulungisa i-DNA, uncike naku-NAD+. Ukuguga okuvamile kubangela ukuthi umonakalo we-DNA uqoqeke emzimbeni, i-RARP iyanda, ngakho-ke amazinga e-NAD+ ayancipha. Umonakalo we-DNA ye-Mitochondrial kunoma yisiphi isinyathelo uzokwandisa lokhu kuncipha.

③ I-NAD+kuthinta umsebenzi we-gene ende i-Sirtuins futhi kuvimbela ukuguga

Ama-gene asanda kutholakala ama-sirtuin okuphila isikhathi eside, aziwa nangokuthi "abagcini bezakhi zofuzo," adlala indima ebalulekile ekugcineni impilo yamaseli. Ama-Sirtuin awumndeni wama-enzyme ahilelekile ekuphenduleni ukucindezeleka kwamaseli kanye nokulungisa umonakalo. Aphinde ahileleke ekukhiqizweni kwe-insulin, inqubo yokuguga, kanye nezimo zempilo ezihlobene nokuguga njengezifo eziwohlokayo zemizwa nesifo sikashukela.

I-NAD+ inguphethiloli osiza ama-sirtuin ukuthi agcine ubuqotho be-genome futhi akhuthaze ukulungiswa kwe-DNA. Njengoba nje imoto ingenakuphila ngaphandle kukaphethiloli, ama-Sirtuin adinga i-NAD+ ukuze isebenze. Imiphumela evela ezifundweni zezilwane ikhombisa ukuthi ukwanda kwamazinga e-NAD+ emzimbeni kuvuselela amaprotheni e-sirtuin futhi kwandise isikhathi sokuphila emvubelo nasemagundwini.

④ Ukusebenza kwenhliziyo

Ukuphakamisa amazinga e-NAD+ kuvikela inhliziyo futhi kuthuthukisa ukusebenza kwenhliziyo. Umfutho wegazi ophezulu ungabangela ukwandiswa kwenhliziyo kanye nokuvaleka kwemithambo yegazi, okungaholela ekushayweni yisifo sohlangothi. Ngemva kokugcwalisa kabusha izinga le-NAD+ enhliziyweni ngezithako ze-NAD+, umonakalo enhliziyweni obangelwa ukuphinda kufakwe igazi uyavinjelwa. Ezinye izifundo zibonise ukuthi izithako ze-NAD+ zivikela namagundane ekukhuleni kwenhliziyo okungavamile.

⑤ Ukuwohloka kwemizwa

Kumagundane anesifo i-Alzheimer's, ukwandisa amazinga e-NAD+ kuthuthukisa ukusebenza kwengqondo ngokunciphisa ukunqwabelana kwamaprotheni aphazamisa ukuxhumana kobuchopho. Ukuphakamisa amazinga e-NAD+ kuvikela namaseli obuchopho ekufeni lapho kungekho igazi elanele eligeleza ebuchosheni. Kubonakala sengathi i-NAD+ inesithembiso esisha sokuvikela ekuwohlokeni kwezinzwa nokuthuthukisa inkumbulo.

⑥ Isimiso somzimba sokuzivikela

Njengoba siguga, amasosha ethu omzimba ayawohloka futhi sisengozini enkulu yokugula. Ucwaningo lwamuva lubonisa ukuthi amazinga e-NAD+ adlala indima ebalulekile ekulawuleni izimpendulo zamasosha omzimba kanye nokuvuvukala kanye nokusinda kwamaseli ngesikhathi sokuguga. Ucwaningo luqokomisa amandla okwelapha e-NAD+ ekungasebenzi kahle kwamasosha omzimba.

Ubudlelwano phakathi kwendima ye-NAD+ nokuguga

Ama-coenzyme ahlanganyela ekusetshenzisweni kwezinto ezibalulekile njengoshukela, amafutha, kanye namaprotheni emzimbeni womuntu, futhi adlala indima ebalulekile ekulawuleni ukusetshenziswa kwezinto zomzimba kanye namandla kanye nokugcina imisebenzi evamile yomzimba. I-NAD iyi-coenzyme ebaluleke kakhulu emzimbeni womuntu, ebizwa nangokuthi i-coenzyme I. Ihlanganyela ezinkulungwaneni zezimpendulo ze-redox enzyme emzimbeni womuntu. Iyinto ebalulekile ekusetshenzisweni kokusebenza kwawo wonke amaseli. Inemisebenzi eminingi, imisebenzi eyinhloko yile:

1. Khuthaza ukukhiqizwa kwamandla emvelo

I-NAD+ ikhiqiza i-ATP ngokuphefumula kwamaseli, inezela ngqo amandla amaseli futhi ithuthukise ukusebenza kwamaseli;

2. Ukulungisa izakhi zofuzo

I-NAD+ iyona kuphela i-substrate ye-enzyme yokulungisa i-DNA i-PARP. Lolu hlobo lwe-enzyme luhlanganyela ekulungisweni kwe-DNA, lusiza ekulungiseni i-DNA namaseli alimele, lunciphisa amathuba okuguquka kweseli, futhi luvimbele ukwenzeka komdlavuza;

3. Yenza kusebenze wonke amaprotheni okuphila isikhathi eside

I-NAD+ ingasebenza wonke amaprotheni angu-7 okuphila isikhathi eside, ngakho-ke i-NAD+ inomthelela obaluleke kakhulu ekulweni nokuguga kanye nokwandisa isikhathi sokuphila;

4. Qinisa amasosha omzimba

I-NAD+ iqinisa isimiso somzimba sokuzivikela futhi ithuthukisa ukuzivikela kwamangqamuzana ngokuthinta ngokukhetha ukusinda kanye nokusebenza kwamaseli e-T alawulayo.

5. Khuthaza ukukhula kwezinwele

Imbangela eyinhloko yokulahlekelwa izinwele ukulahlekelwa amandla eseli likamama wezinwele, kanti ukulahlekelwa amandla eseli likamama wezinwele kungenxa yokuthi izinga le-NAD+ emzimbeni womuntu liyehla. Amaseli kamama wezinwele awanawo i-ATP eyanele yokwenza ukwakheka kwamaprotheni ezinwele, ngaleyo ndlela alahlekelwe amandla awo futhi kuholele ekulahlekelweni amandla ezinwele.

6. Ukuphathwa kwesisindo, ukukhuthaza imetabolism

Ngo-2017, uSolwazi uDavid Sinclair waseHarvard Medical School kanye nethimba elivela e-Australian Medical College benze ucwaningo lokuqhathanisa ngamagundane abesifazane abakhuluphele abavocavoca ku-treadmill amasonto angu-9 futhi bathatha i-NMN nsuku zonke izinsuku ezingu-18. Ucwaningo luthole ukuthi i-NMN ithinta i-metabolism yamafutha esibindi. Futhi umphumela wokwenziwa kwawo ngokusobala mkhulu kunowokuzivocavoca.

Okuphawulekayo ukuthi ukuguga kuhambisana nokwehla okuqhubekayo kwamazinga e-NAD+ ezicutshini kanye nawamangqamuzana ezinhlobonhlobo zezinto eziphilayo eziyisibonelo, okuhlanganisa amagundane nabantu. Ukwehla kwamazinga e-NAD+ kuhlotshaniswa nezifo eziningi ezihlotshaniswa nokuguga, okuhlanganisa ukwehla kwengqondo, umdlavuza, isifo se-metabolic, i-sarcopenia, kanye nobuthakathaka.

Ngingayinezela kanjani i-NAD+ nsuku zonke?

Akukho ukutholakala okungapheli kwe-NAD+ emzimbeni wethu. Okuqukethwe kanye nomsebenzi we-NAD+ emzimbeni womuntu kuzoncipha njengoba iminyaka ikhula, futhi kuzoncipha ngokushesha ngemva kweminyaka engama-30, okuholela ekugugeni kwamaseli, ukuphelelwa amandla kanye nokulahlekelwa ikhono lokuvuselela.

Ngaphezu kwalokho, ukuncishiswa kwe-NAD+ kuzophinde kubangele uchungechunge lwezinkinga zempilo, ngakho-ke uma i-NAD+ ingenakukwazi ukugcwaliswa ngesikhathi, imiphumela ingacatshangwa.

1. Isengezo sokudla

Ukudla okufana neklabishi, i-broccoli, i-avocado, i-steak, amakhowe, kanye ne-edamame kuqukethe izandulela ze-NAD+, ezingaguqulwa zibe yi-NAD* esebenzayo emzimbeni ngemva kokumuncwa.

2. Nciphisa ukudla nama-calories

Ukuvinjelwa kwama-calories okumaphakathi kungavuselela izindlela zokuzwa amandla ngaphakathi kwamaseli futhi kwandise amazinga e-NAD* ngokungaqondile. Kodwa qiniseka ukuthi udla ukudla okulinganiselayo ukuze uhlangabezane nezidingo zomzimba wakho zokudla okunempilo

3. Hlala umatasa futhi uvivinya umzimba

Ukuzivocavoca okulinganiselwe kwe-aerobic njengokugijima nokubhukuda kungakhuphula amazinga e-NAD+ angaphakathi kwamangqamuzana, kusize ekwandiseni ukuhlinzekwa komoya-mpilo emzimbeni futhi kuthuthukise ukusebenza kahle kwamandla.

4. Landela imikhuba yokulala enempilo

Ngesikhathi sokulala, umzimba womuntu wenza izinqubo eziningi ezibalulekile ze-metabolic kanye nokulungisa, okuhlanganisa ukwenziwa kwe-NAD*. Ukulala ngokwanele kusiza ukugcina amazinga ajwayelekile e-NAD

5. Engeza izinto ezandulela i-NAD+

I-Nicotinic acid (NA) kanye ne-nicotinamide (NAM) zombili ziyizandulela ze-NAD+. Zingakhiwa futhi ziguqulwe zibe yi-NAD emzimbeni womuntu, ngaleyo ndlela zandise okuqukethwe kwayo. Kodwa-ke, ngenxa yemikhawulo yendlela yokwenziwa kanye nama-enzyme anciphisa izinga, ukutholakala kwezinto eziphilayo kuphansi.

6 Isengezo ngqo se-NAD+

Ukwengezwa kwe-NAD+ ngaphandle kungabuyisela amazinga e-NAD+ ngokushesha emzimbeni, okuvumela izitho ezibalulekile njengenhliziyo nobuchopho ukuthola ukwengezwa kwe-NAD+ okuphumelelayo kakhulu.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe yi-FDA ohlinzeka ngempuphu yezithasiselo ze-NAD+ esezingeni eliphezulu futhi emsulwa kakhulu.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani amahle kakhulu. Izimpushana zethu ze-NAD+ zihlolwe ngokucophelela ukuze zibonakale zimsulwa futhi zinamandla, okuqinisekisa ukuthi uthola isithasiselo sekhwalithi ephezulu ongasithemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yamaseli, ukukhulisa amasosha omzimba wakho noma ukuthuthukisa impilo iyonke, i-NAD+ supplement powder yethu iyisinqumo esifanele.

Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukisiwe kakhulu, iSuzhou Myland Pharm ithuthukise imikhiqizo ehlukahlukene futhi yaba yinkampani yezinsizakalo zesayensi yokuphila entsha, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.