Iyini i-7,8-Dihydroxyflavone futhi Kungani Kufanele Unakekele?

7,8-Dihydroxyflavone (7,8-DHF)i-flavonoid eyenzeka ngokwemvelo, isakhi se-polyphenolic esitholakala ezinhlobonhlobo zezitshalo. Ama-Flavonoid aziwa ngezakhiwo zawo zokulwa ne-antioxidant futhi adlala indima ebalulekile ezindleleni zokuvikela izitshalo. I-7,8-Dihydroxyflavone itholakala ikakhulukazi ezitshalweni ezifana ne-Godmania aesculifolia kanye ne-Tridax procumbens.

I-7,8-Dihydroxyflavone ihluke kwamanye ama-flavonoid ngokukwazi ukulingisa umsebenzi we-brain-derived neurotrophic factor (BDNF). I-BDNF iphrotheni esekela ukusinda, ukuthuthukiswa, nokusebenza kwama-neurons ebuchosheni. Idlala indima ebalulekile ku-neuroplasticity, ikhono lobuchopho lokuzihlela kabusha ngokwenza ukuxhumana okusha kwemizwa. Lesi sakhiwo se-7,8-DHF sivula izindlela eziningi zocwaningo, ikakhulukazi emkhakheni wesayensi yezinzwa.

Indlela yokwenza

Indlela eyinhloko i-7,8-Dihydroxyflavone eyenza ngayo imiphumela yayo ukwenza kusebenze i-TrkB (tropomyosin receptor kinase B) receptor. I-TrkB iyi-high-affinity receptor ye-BDNF. Uma i-7,8-Dihydroxyflavone ibophezela ku-TrkB, iqala uchungechunge lwezindlela zokubonisa i-intracellular ezikhuthaza ukusinda kwe-neuronal, ukukhula, nokuhlukanisa.

Ucwaningo lwangaphambi komtholampilo lubonise ukuthi i-7,8-dihydroxyflavone ingalingisa i-BDNF (i-neurotrophic factor ephuma ebuchosheni) futhi ikhulise ukusho kwayo namazinga ku-hippocampus. Ezilwaneni, inamandla okwelapha ezifweni eziningana zemizwa noma ukuphazamiseka, okungukuthi unhlangothi, ukucindezeleka, nesifo sikaParkinson. Ezifundweni ezimbili ezihlukene, i-7,8-dihydroxyflavone ibonise i-bioavailability ebalulekile yomlomo futhi itholakale iwela umgoqo wegazi lobuchopho (BBB). Ngoba isebenza endleleni yokubonisa i-nitric oxide kanye nesamukeli se-TrkB esicushiwe (i-tropomyosin receptor kinase B)

I-neurotrophic factor BDNF ngokuyinhloko idlulisela amasignali ngokubopha kuma-receptors athile, ngaleyo ndlela ithinte izinqubo zomzimba zama-neurons. Nakuba i-7,8-DHF ingakwazi ukulingisa umphumela we-neurotrophic factor BDNF, ukhiye usezindleleni zayo zokusebenzisana nesamukeli se-BDNF. Ucwaningo luye lwabonisa ukuthi i-7,8-DHF ingabophezela ku-BDNF receptor TrkB futhi ivule izindlela zokusayina ezansi nomfula.

Ngokukhethekile, uma i-7,8-DHF ibophezela ku-TrkB, icupha uchungechunge lwemicimbi yokudlulisa isignali ye-intracellular. Lokhu kubandakanya ukwenziwa kusebenze kwama-protein kinases afana nezindlela ze-PI3K/Akt ne-MAPK/ERK. Ukwenza kusebenze lezi zindlela kubalulekile ekukhuthazeni ukusinda kwe-neuronal, ukukhula, kanye ne-synaptic plasticity. Ngokulingisa ukwenziwa kwalezi zindlela nge-BDNF, i-7,8-DHF isiza ukuthuthukisa ukuguquguquka kwe-neuronal nokumelana nokucindezeleka kwangaphandle.

I-7,8-DHF iphinde ilawule ukubonakaliswa kofuzo ngaphakathi kwama-neurons. Kungathinta ukulotshwa kwezakhi zofuzo ezihlobene ne-neurodevelopment, neuroprotection kanye nokwakheka kwe-synapse, ngaleyo ndlela kulingisa imiphumela ye-BDNF ezingeni lamangqamuzana. Lokhu kuguqulwa kwesimo sofuzo kusekela futhi indima ye-7,8-DHF ekukhuthazeni impilo yezinzwa.

I-7,8-Dihydroxyflavone (7,8-DHF) iyi-flavonoid ye-monophenolic enemiphumela eminingi. Isebenza njenge-agonist ye-neurotrophic tyrosine kinase receptor TrkB (Kd=320nM) futhi ivikela ama-neurons aveza i-TrkB ku-apoptosis. I-brain-derived neurotrophic factor (BDNF) iphrotheni enemiphumela ye-neurotrophic ebalulekile ekwakhekeni kobuchopho, ukufunda kanye nenkumbulo.

• I-Neuroprotection: I-7,8-DHF iyi-neuroprotective kumamodeli ezilwane ze-Parkinson's disease, isekela ukufunda ngokomzwelo kumagundane futhi ihlehlisa ukuntula inkumbulo kumamodeli wamagundane esifo i-Alzheimer's, futhi ingathuthukisa ukusebenza kwemisipha futhi yelule isikhathi sokusinda sokuzingela kwezilwane ezigulayo. I-BDNF ingathuthukisa i-neuroplasticity kanye nokusinda kwe-neuron, isize ubuchopho bukhiqize ukuxhumana okusha kwe-neural, ukulungisa amangqamuzana obuchopho ahlulekayo, futhi ivikele amangqamuzana obuchopho anempilo. Ibalulekile ekwakhekeni kobuchopho, ukufunda kanye nenkumbulo, futhi ingavikela ubuchopho ekukhubazekeni kwengqondo okuhlobene nobudala. Yehla emandleni okuqonda futhi uvikele ezifweni ze-neurodeergenerative ezifana nesifo i-Alzheimer's nesifo sika-Parkinson.

• Ilawula ukusinda kwe-neuronal: I-7,8-DHF ingabophezela ku-TrkB futhi yenze kusebenze izindlela zokusayina ezansi nomfula, njengezindlela ze-PI3K/Akt ne-MAPK/ERK. Ukusebenza kwalezi zindlela kubalulekile ekukhuthazeni ukusinda kwe-neuronal, ukukhula kanye ne-synaptic plasticity. kubalulekile. I-BDNF futhi iyisici se-neurotrophic esingenza kusebenze izindlela zokusayina ze-intracellular ngokubophezela kuma-receptors e-TrkB futhi ikhuthaze ukusinda nokukhula kwama-neurons.

• Ukuthuthukisa i-synaptic plasticity: I-7,8-DHF ingakhuthaza ukwakheka nokuqiniswa kwama-synapse ngokuvula ama-TrkB receptors, ngaleyo ndlela ithuthukise ukusebenza kahle kokudluliselwa kwe-synaptic. I-BDNF kucatshangwa ukuthi ikhuthaza ukwakheka nokuqinisa ama-synapses, ngaleyo ndlela ikhulise ukusebenza kahle kokudluliselwa kwe-synaptic futhi ngaleyo ndlela ithuthukise amakhono okufunda nenkumbulo.

• Imithelela yokufunda nenkumbulo: I-7,8-DHF ingathuthukisa amakhono okufunda nenkumbulo kumagundane, okungenzeka ahlobane nemiphumela yawo ekusindeni kwe-neuronal kanye ne-synaptic plasticity. I-BDNF iphinde ibambe iqhaza elibalulekile ezinqubweni zokufunda nenkumbulo ngokukhuthaza ukusinda kwama-neurons nokwakheka kwama-synapse, ngaleyo ndlela ithuthukise amakhono okufunda nenkumbulo.

• Ishintsha ukuma kwenhliziyo: I-7,8-DHF inemiphumela yokuguqula isimo, okungenzeka ihlobane nemithelela yayo ekusindeni kwe-neuronal kanye ne-synaptic plasticity. I-BDNF kucatshangwa ukuthi idlala indima ekulawuleni imizwelo ngokulawula ukusinda kwama-neurons kanye nokwakheka kwama-synapses, ngaleyo ndlela kuthinte ukuvezwa kwemizwelo.

Ngamafuphi, i-7,8-DHF ne-BDNF inezindlela ezifanayo zokwenza ku-neuroprotection, ukulawula ukusinda kwe-neuronal, ukukhuthaza i-synaptic plasticity, okuthinta ukufunda nokukhumbula, nokulawula imizwelo.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngekhwalithi ephezulu nokuhlanzeka okuphezulu kwe-7,8-Dihydroxyflavone.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani angcono kakhulu. I-7,8-Dihydroxyflavone yethu ihlolwe ngokuqinile ukuhlanzeka namandla, iqinisekisa ukuthi uthola isengezo sekhwalithi ephezulu ongasethemba. Ukuthi ufuna ukusekela impilo yamaselula, ukuqinisa amasosha akho omzimba noma uthuthukise impilo yonke, i-7,8-Dihydroxyflavone yethu iyisinqumo esihle kakhulu.

Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, i-Suzhou Myland Pharm isungule uhide lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ihambisane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.