Iyini i-7,8-Dihydroxyflavone futhi Kungani Kufanele Ukhathalele?

I-7,8-Dihydroxyflavone (7,8-DHF)iyi-flavonoid eyenzeka ngokwemvelo, i-polyphenolic compound etholakala ezitshalweni ezahlukahlukene. Ama-Flavonoid aziwa ngezakhiwo zawo zokulwa nama-antioxidant futhi adlala indima ebalulekile ezindleleni zokuzivikela ezitshalweni. I-7,8-Dihydroxyflavone itholakala ikakhulukazi ezitshalweni ezifana ne-Godmania aesculifolia kanye ne-Tridax procumbens.

I-7,8-Dihydroxyflavone ihlukile kwamanye ama-flavonoid ngekhono layo lokulingisa umsebenzi we-brain-derived neurotrophic factor (BDNF). I-BDNF iyiprotheni esekela ukusinda, intuthuko, kanye nokusebenza kwama-neurons ebuchosheni. Idlala indima ebalulekile ekuqineni kwe-neuroplasticity, ikhono lobuchopho lokuzihlela kabusha ngokwakha ukuxhumana okusha kwe-neural. Le mpahla ye-7,8-DHF ivula izindlela eziningi zocwaningo, ikakhulukazi emkhakheni we-neuroscience.

Indlela yokwenza

Indlela eyinhloko i-7,8-Dihydroxyflavone eveza ngayo imiphumela yayo ukusebenza kwe-TrkB (tropomyosin receptor kinase B) receptor. I-TrkB iyi-receptor ehambisana kakhulu ne-BDNF. Uma i-7,8-Dihydroxyflavone ibopha i-TrkB, ibangela uchungechunge lwezindlela zokuthumela izimpawu ngaphakathi kweseli ezikhuthaza ukusinda, ukukhula, kanye nokwehluka kwe-neuronal.

Izifundo zangaphambi kokwelashwa zibonise ukuthi i-7,8-dihydroxyflavone ingalingisa i-BDNF (i-neurotrophic factor etholakala ebuchosheni) futhi inyuse ukubonakaliswa kwayo kanye namazinga ku-hippocampus. Ezilwaneni, inamandla okwelapha izifo eziningana zemizwa noma izinkinga, okungukuthi isifo sohlangothi, ukucindezeleka, kanye nesifo sikaParkinson. Ezifundweni ezimbili ezahlukene, i-7,8-dihydroxyflavone ibonise ukutholakala okukhulu komlomo futhi yatholakala ukuthi iwela isithiyo segazi lobuchopho (BBB). Ngoba isebenza endleleni yokubonisana kwe-nitric oxide kanye ne-TrkB receptor esebenzayo (tropomyosin receptor kinase B)

I-neurotrophic factor BDNF idlulisela kakhulu izimpawu ngokubopha kuma-receptor athile, ngaleyo ndlela ithinta izinqubo zomzimba zama-neurons. Ngenkathi i-7,8-DHF ingalingisa umphumela we-neurotrophic factor BDNF, isihluthulelo sisekusebenzeni kwayo nokusebenzisana ne-BDNF receptor. Izifundo zibonise ukuthi i-7,8-DHF ingabopha kwi-BDNF receptor TrkB futhi isebenze izindlela zokuthumela izimpawu ezingezansi.

Ngokukhethekile, uma i-7,8-DHF ibopha ku-TrkB, ibangela uchungechunge lwezehlakalo zokudluliselwa kwesignali ngaphakathi kweseli. Lokhu kufaka phakathi ukusebenza kwe-protein kinase njengezindlela ze-PI3K/Akt kanye ne-MAPK/ERK. Ukusebenza kwalezi zindlela kubalulekile ekukhuthazeni ukusinda kwe-neuronal, ukukhula, kanye ne-synaptic plasticity. Ngokulingisa ukusebenza kwalezi zindlela yi-BDNF, i-7,8-DHF isiza ukuthuthukisa ukuzivumelanisa nezimo kwe-neuronal kanye nokumelana nokucindezeleka kwangaphandle.

I-7,8-DHF iphinde ilawule ukuvezwa kwezakhi zofuzo ngaphakathi kwama-neurons. Ingathinta ukubhalwa kwezakhi zofuzo ezihlobene nokuthuthukiswa kwe-neuro, ukuvikelwa kwe-neuro kanye nokwakheka kwe-synapse, ngaleyo ndlela ilingise imiphumela ye-BDNF ezingeni lama-molecule. Lokhu kuguqulwa kokubonakaliswa kwezakhi zofuzo kusekela indima ye-7,8-DHF ekukhuthazeni impilo yezinzwa.

I-7,8-Dihydroxyflavone (7,8-DHF) iyi-flavonoid ye-monophenolic enemiphumela eminingi. Isebenza njenge-agonist ye-neurotrophic tyrosine kinase receptor TrkB (Kd=320nM) futhi ivikela ama-neurons aveza i-TrkB ekushayweni yi-apoptosis. I-neurotrophic factor etholakala ebuchosheni (BDNF) iyiprotheni enemiphumela ye-neurotrophic ebalulekile ekwakhekeni kobuchopho, ekufundeni nasekukhumbuleni.

• Ukuvikelwa kwe-Neuro: I-7,8-DHF ivikela imizwa kumamodeli ezilwane zesifo sikaParkinson, isekela ukufunda ngokomzwelo kumagundane futhi ibuyisela emuva ukushoda kwenkumbulo kumamodeli egundane esifo sika-Alzheimer, futhi ingathuthukisa nokusebenza kwemisipha futhi yandise isikhathi sokusinda kwe-huntingtin kumamodeli ezilwane ezinesifo. I-BDNF ingathuthukisa i-neuroplasticity kanye nokusinda kwama-neuron, isize ubuchopho ukuthi bukhiqize ukuxhumana okusha kwemizwa, ilungise amangqamuzana obuchopho ahlulekayo, futhi ivikele amangqamuzana obuchopho anempilo. Kubalulekile ekwakhekeni kobuchopho, ekufundeni nasekukhumbuleni, futhi ingavikela ubuchopho ekukhubazekeni kwengqondo okuhlobene nokuguga. Yehlisa amakhono okuqonda futhi ivikele ezifweni ze-neurodegenerative ezifana nesifo sika-Alzheimer kanye nesifo sikaParkinson.

• Ilawula ukusinda kwe-neuronal: I-7,8-DHF ingabopha ku-TrkB futhi isebenze izindlela zokudlulisela izimpawu ezingezansi, njengezindlela ze-PI3K/Akt kanye ne-MAPK/ERK. Ukusebenza kwalezi zindlela kubalulekile ekukhuthazeni ukusinda kwe-neuronal, ukukhula kanye ne-synaptic plasticity. Kubalulekile. I-BDNF futhi iyisici se-neurotrophic esingasebenzisa izindlela zokudlulisela izimpawu ezingaphakathi kweseli ngokubopha kuma-receptor e-TrkB futhi sikhuthaze ukusinda nokukhula kwama-neurons.

• Khuthaza ukwakheka kwe-synaptic plasticity: I-7,8-DHF ingakhuthaza ukwakheka nokuqiniswa kwama-synapses ngokusebenzisa ama-receptor e-TrkB, ngaleyo ndlela ithuthukise ukusebenza kahle kokudluliselwa kwe-synaptic. I-BDNF kucatshangwa ukuthi ikhuthaza ukwakheka nokuqiniswa kwama-synapses, ngaleyo ndlela ikhulise ukusebenza kahle kokudluliselwa kwe-synaptic futhi ngaleyo ndlela ithuthukise amakhono okufunda nokukhumbula.

• Imiphumela ekufundeni nasekukhumbuleni: I-7,8-DHF ingathuthukisa amakhono okufunda nokukhumbula kumagundane, okungase kuhlotshaniswe nemiphumela yayo ekusindeni kwe-neuronal kanye nokwakheka kwe-synapse. I-BDNF idlala indima ebalulekile ezinqubweni zokufunda kanye nenkumbulo ngokukhuthaza ukusinda kwama-neurons kanye nokwakheka kwama-synapse, ngaleyo ndlela ithuthukise amakhono okufunda kanye nenkumbulo.

• Iguqula isimo sengqondo: I-7,8-DHF inemiphumela yokuguqula isimo sengqondo, engase ihlotshaniswe nemiphumela yayo ekusindeni kwe-neuronal kanye ne-synaptic plasticity. I-BDNF kucatshangwa ukuthi idlala indima ekulawulweni kwemizwelo ngokulawula ukusinda kwama-neurons kanye nokwakheka kwama-synapses, ngaleyo ndlela ithinte ukuvezwa kwemizwelo.

Ngamafuphi, i-7,8-DHF kanye ne-BDNF zinezindlela ezifanayo zokusebenza ekuvikeleni izinzwa, zilawula ukusinda kwezinzwa, zikhuthaza ukwakheka kwe-synaptic, zithinta ukufunda kanye nenkumbulo, futhi zilawula imizwa.

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe yi-FDA ohlinzeka nge-7,8-Dihydroxyflavone esezingeni eliphezulu futhi emsulwa kakhulu.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani amahle kakhulu. I-7,8-Dihydroxyflavone yethu ihlolwe ngokucophelela ukuthi ihlanzekile futhi inamandla kangakanani, okuqinisekisa ukuthi uthola isithasiselo sekhwalithi ephezulu ongasithemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yamaseli, ukukhulisa amasosha omzimba wakho noma ukuthuthukisa impilo iyonke, i-7,8-Dihydroxyflavone yethu iyisinqumo esifanele.

Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukisiwe kakhulu, i-Suzhou Myland Pharm ithuthukise imikhiqizo ehlukahlukene encintisanayo futhi yaba yinkampani yezinsizakalo zesayensi yokuphila entsha, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.