Iyini i-NAD + futhi Kungani Uyidinga Ngempilo Yakho?

Ezweni elikhula njalo lezempilo nokuphila kahle, i-NAD+ isiphenduke inkulumo-ze, idonsa ukunaka kososayensi nabathandi bezempilo ngokufanayo. Kodwa yini ngempela i-NAD+? Kungani kubaluleke kangaka empilweni yakho? Masifunde kabanzi mayelana nolwazi olufanele ngezansi!

Yini i-NAD+?

Igama lesayensi le-NAD yi-nicotinamide adenine dinucleotide. I-NAD+ ikhona kuwo wonke amangqamuzana omzimba wethu. Kuyi-metabolite ebalulekile kanye ne-coenzyme ezindleleni ezahlukahlukene ze-metabolic. Ilamula futhi ibambe iqhaza ezinqubweni ezihlukahlukene zezinto eziphilayo. Ngaphezu kwama-enzyme angama-300 ancike ku-NAD+ Ukusebenza.

NAD+isifinyezo sesiNgisi se-Nicotinamide adenine dinucleotide. Igama layo eliphelele ngesiShayina i-nicotinamide adenine dinucleotide, noma i-Coenzyme I ngamafuphi. Njenge-coenzyme ehambisa ama-ion e-hydrogen, i-NAD+ idlala indima ezicini eziningi ze-metabolism yomuntu, okuhlanganisa i-glycolysis, i-Gluconeogenesis, umjikelezo we-tricarboxylic acid, njll. Olunye ucwaningo luye lwabonisa ukuthi ukuncipha kwe-NAD+ kuhlobene nobudala, kanye nezinqubo ze-physiological mediated. nge-NAD+ zihlobene nokuguga, izifo ze-metabolic, i-neuropathy kanye nomdlavuza, okuhlanganisa ukulawula i-cell homeostasis, ama-sirtuin aziwa ngokuthi "izakhi zofuzo zokuphila isikhathi eside", ukulungisa i-DNA, amaprotheni omndeni we-PARPs ahlobene ne-necroptosis ne-CD38 esiza ekuboniseni i-calcium.

I-NAD+ isebenza njengebhasi elihambayo, elithwala ama-electron ukusuka kwelinye ingqamuzana ukuya kwelinye. Kanye nozakwabo wamangqamuzana i-NADH, ibamba iqhaza ekuphenduleni okuhlukahlukene kwe-metabolic ngokushintshana kwama-electron akhiqiza i-adenosine triphosphate (ATP), i-molecule "yamandla" omzimba.

Kalula nje, i-NAD+ ibalulekile ekugcineni impilo yomzimba nokulinganisela. I-Metabolism, i-redox, ukugcinwa nokulungiswa kwe-DNA, ukuzinza kwezakhi zofuzo, ukulawulwa kwe-epigenetic, njll. konke kudinga ukubamba iqhaza kwe-NAD+.

Ngakho-ke, imizimba yethu inesidingo esikhulu se-NAD +. I-NAD+ ihlanganiswa ngokuqhubekayo, idilizwe futhi igaywe kabusha kumaseli ukuze kugcinwe amazinga ezinzile we-NAD+ yeselula.

I-NAD+ iyingxenye ebalulekile yomsebenzi wamaselula futhi ibandakanyeka ekunikeni amandla nasekulungiseni i-DNA, kokubili okuhlobene eduze nokuguga okunempilo.

1) Isatshalaliswa kabanzi kuwo wonke amaseli omzimba womuntu futhi ibamba iqhaza ezinkulungwaneni zokusabela kwe-biocatalytic. Ingakhuthaza ukugaywa koshukela, amafutha kanye nama-amino acid, futhi ibambe iqhaza ekuhlanganiseni amandla. Kuyi-coenzyme ebalulekile edingekayo emzimbeni womuntu.

2) I-NAD+ iyona kuphela i-substrate yama-enzyme adla i-coI (okuwukuphela kwe-substrate ye-enzyme yokulungisa i-DNA i-PARP, okuwukuphela kwe-substrate ye-protein yesikhathi eside i-Sirtuins, kanye ne-substrate kuphela ye-cyclic ADP ribose synthase CD38/157).

Kodwa-ke, njengoba iminyaka ikhula, izinga le-NAD + emzimbeni lehla ngokushesha. Izokwehla ngo-50% njalo eminyakeni engama-20. Cishe eminyakeni engama-40 ubudala, okuqukethwe kwe-NAD+ emzimbeni womuntu kungamaphesenti angama-25 kuphela ayeyikho ezinganeni.

Uma amangqamuzana omuntu entula i-NAD +, ukungasebenzi kahle kwe-mitochondrial kuyancishiswa, ikhono lokulungisa umonakalo we-DNA liyancishiswa, futhi umndeni ophila isikhathi eside wamaprotheni e-Sirtuin nawo awusebenzi, njll. Lezi zici ezingezinhle zingaholela ku-apoptosis, isifo somuntu, ukuguga ngisho nokufa.

Iqhaza le-NAD+ empilweni yakho iyonke

Anti-ukuguga

I-NAD+ igcina ukuxhumana kwamakhemikhali phakathi kwe-nucleus ne-mitochondria, futhi ukuxhumana okubuthakathaka kuyimbangela ebalulekile yokuguga kwamaselula.

I-NAD+ ingasusa inani elandayo lamakhodi e-DNA ayiphutha ngesikhathi se-cell metabolism, igcine ukubonakaliswa okuvamile kwezakhi zofuzo, igcine ukusebenza okujwayelekile kwamaseli, futhi yehlise ukuguga kwamangqamuzana omuntu.

Lungisa umonakalo we-DNA

I-NAD+ iyingxenye ebalulekile ye-enzyme yokulungisa i-DNA i-PARP, enomthelela omkhulu ekulungisweni kwe-DNA, ukubonakaliswa kofuzo, ukuthuthukiswa kwamaseli, ukusinda kwamaseli, ukwakhiwa kabusha kwekhromozomi, nokuzinza kwezakhi zofuzo.

Yenza kusebenze amaprotheni okuphila isikhathi eside

Ama-Sirtuin avame ukubizwa ngokuthi umndeni wamaprotheni wesikhathi eside futhi adlala indima ebalulekile yokulawula ekusebenzeni kwamaseli, njengokuvuvukala, ukukhula kwamaseli, isigqi se-circadian, i-metabolism yamandla, umsebenzi we-neuronal, kanye nokumelana nengcindezi, kanti i-NAD+ iyi-enzyme ebalulekile yokuhlanganiswa kwamaprotheni okuphila isikhathi eside. .

Yenza kusebenze wonke amaprotheni esikhathi eside we-7 emzimbeni womuntu, edlala indima ebalulekile ekuphikisweni kokucindezeleka kwamaselula, i-metabolism yamandla, ukuvimbela ukuguqulwa kwamaseli, i-apoptosis nokuguga.

Nikeza amandla

Igqugquzela ukukhiqizwa kwamandla angaphezu kwama-95% adingekayo emisebenzini yokuphila. I-Mitochondria kumaseli womuntu yizitshalo zamandla zamaseli. I-NAD+ iyi-coenzyme ebalulekile ku-mitochondria ukukhiqiza i-molecule yamandla i-ATP, iguqule izakhi zibe amandla adingwa umzimba womuntu.

Khuthaza ukuvuselelwa kwemithambo yegazi futhi ugcine ukunwebeka kwemithambo yegazi

Imithambo yegazi iyizicubu ezibalulekile emisebenzini yokuphila. Njengoba sikhula, imithambo yegazi kancane kancane ilahlekelwa ukuguquguquka kwayo futhi iba nzima, iminyene, futhi ibe mincane, okubangela "i-arteriosclerosis."

I-NAD+ ingakhuphula umsebenzi we-elastin emithanjeni yegazi, ngaleyo ndlela igcine ukunwebeka kwemithambo yegazi nokugcina impilo yemithambo yegazi.

Thuthukisa i-metabolism

I-Metabolism iyisamba sokuphendula kwamakhemikhali okuhlukahlukene emzimbeni. Umzimba uzoqhubeka nokushintshanisa izinto namandla. Uma lokhu kushintshana kuma, impilo yomzimba nayo izophela.

USolwazi u-Anthony nethimba lakhe labacwaningi eNyuvesi yaseCalifornia, e-U.S.A., bathole ukuthi i-NAD+ ingathuthukisa ngempumelelo ukwehla kwe-cell metabolism ehambisana nokuguga, ngaleyo ndlela ithuthukise impilo yabantu futhi yandise isikhathi sokuphila.

Vikela impilo yenhliziyo

Inhliziyo iyisitho esibaluleke kakhulu kubantu, futhi izinga le-NAD+ emzimbeni lidlala indima ebalulekile ekugcineni ukusebenza okujwayelekile kwenhliziyo.

Ukwehliswa kwe-NAD+ kungase kuhlobane ne-pathogenesis yezifo eziningi zenhliziyo nemithambo yegazi, futhi inani elikhulu lezifundo eziyisisekelo nalo liqinisekisile umphumela wokwengeza i-NAD+ ezifweni zenhliziyo.

Vimbela izifo zenhliziyo kanye ne-cerebrovascular

Ucwaningo luye lwabonisa ukuthi cishe zonke izinhlobo eziyisikhombisa ze-sirtuin (SIRT1-SIRT7) zihlobene nokuvela kwesifo senhliziyo. Ama-Sirtuin abhekwa njengezinhloso ze-agonistic ekwelapheni izifo zenhliziyo, ikakhulukazi i-SIRT1.

I-NAD+ ukuphela kwe-substrate ye-Sirtuins. Ukwengezwa ngesikhathi kwe-NAD+ emzimbeni womuntu kungenza kusebenze ngokugcwele umsebenzi we-subtype ngayinye ye-Sirtuins, ngaleyo ndlela kuvikelwe impilo yenhliziyo nokuvikela izifo zenhliziyo.

Khuthaza ukukhula kwezinwele

Imbangela enkulu yokulahleka kwezinwele ukulahleka kokuqina kwamangqamuzana omama wezinwele, futhi ukulahleka kwamandla kamama wezinwele kungenxa yokuthi izinga le-NAD+ emzimbeni womuntu liyehla. Amaseli kamama ezinwele awanayo i-ATP eyanele yokwenza ukwakheka kwamaprotheni ezinwele, ngaleyo ndlela alahlekelwe ubungqabavu bawo futhi aholele ekuqothukeni kwezinwele.

Ngakho-ke, ukwengeza i-NAD+ kungaqinisa umjikelezo we-asidi futhi kukhiqize i-ATP, ukuze amangqamuzana omama wezinwele abe namandla anele okukhiqiza amaprotheni ezinwele, ngaleyo ndlela enze ngcono ukulahleka kwezinwele.

Ungathenga kuphi Isengezo se-Beta-NAD+ Ngokuphephile Ku-inthanethi

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe we-FDA ohlinzeka ngempushana ye-NAD+ Supplement yekhwalithi ephezulu nemsulwa.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani angcono kakhulu. Impushana yethu ye-NAD+ Supplement ihlolelwa ngokuqinile ubumsulwa namandla, iqinisekisa ukuthi uthola isengezo sekhwalithi ephezulu ongasethemba. Ukuthi ufuna ukusekela impilo yamaselula, uthuthukise amasosha akho omzimba noma uthuthukise impilo yakho yonke, i-NAD+ Supplement powder yethu iyisinqumo esihle kakhulu.

Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, i-Suzhou Myland Pharm isungule uhide lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi, futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ihambisane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.