Iyini i-NAD+ futhi kungani uyidinga empilweni yakho?

Ezweni elikhula njalo lempilo nokuphila kahle, i-NAD+ isibe yigama elidumile, elidonsela ukunaka kososayensi kanye nabathandi bezempilo ngokufanayo. Kodwa iyini ngempela i-NAD+? Kungani ibaluleke kangaka empilweni yakho? Ake sifunde kabanzi ngolwazi olufanele ngezansi!

Kuyini i-NAD+?

Igama lesayensi le-NAD yi-nicotinamide adenine dinucleotide. I-NAD+ ikhona kuwo wonke amaseli omzimba wethu. Iyi-metabolite ebalulekile kanye ne-coenzyme ezindleleni ezahlukene ze-metabolic. Ilawula futhi ihlanganyele ezinqubweni ezahlukene zebhayoloji. Ama-enzyme angaphezu kuka-300 ancike ku-NAD+ ukuze asebenze.

I-NAD+isifinyezo sesiNgisi se-Nicotinamide adenine dinucleotide. Igama layo eliphelele ngesiShayina yi-nicotinamide adenine dinucleotide, noma i-Coenzyme I ngamafuphi. Njenge-coenzyme edlulisa ama-ion e-hydrogen, i-NAD+ idlala indima ezicini eziningi ze-metabolism yomuntu, okuhlanganisa i-glycolysis, i-Gluconeogenesis, umjikelezo we-tricarboxylic acid, njll. Ezinye izifundo zikhombe ukuthi ukuncipha kwe-NAD+ kuhlobene nobudala, futhi izindlela zomzimba eziqondiswa yi-NAD+ zihlobene nokuguga, izifo ze-metabolic, i-neuropathy kanye nomdlavuza, okuhlanganisa nokulawula i-homeostasis yamaseli, ama-sirtuin aziwa ngokuthi "ama-gene okuphila isikhathi eside", ukulungisa i-DNA, amaprotheni omndeni we-PARP ahlobene ne-necroptosis kanye ne-CD38 esiza ekudluliseleni kwe-calcium.

I-NAD+ isebenza njengebhasi elithwala ama-electron kusuka kwelinye i-molecule yeseli kuya kwelinye. Kanye ne-NADH, ihlanganyela ekusabeleni okuhlukahlukene kwe-metabolic ngokushintshana kwama-electron okukhiqiza i-adenosine triphosphate (ATP), i-molecule "yamandla" yomzimba.

Kalula nje, i-NAD+ ibalulekile ekugcineni impilo yomzimba kanye nokulinganisela. I-metabolism, i-redox, ukugcinwa nokulungiswa kwe-DNA, ukuzinza kwezakhi zofuzo, ukulawulwa kwe-epigenetic, njll. konke kudinga ukuhlanganyela kwe-NAD+.

Ngakho-ke, imizimba yethu inesidingo esikhulu se-NAD+. I-NAD+ iyaqhubeka nokwakheka, ihlukaniswe futhi isetshenziswe kabusha emaseli ukuze kugcinwe amazinga e-NAD+ azinzile eseli.

I-NAD+ iyisici esibalulekile somsebenzi wamaseli futhi ihilelekile ekuhlinzekweni kwamandla kanye nokulungiswa kwe-DNA, kokubili okuhlobene eduze nokuguga okunempilo.

1) Isabalala kabanzi kuwo wonke amaseli omzimba womuntu futhi ihlanganyela ezinkulungwaneni zezimpendulo ze-biocatalytic. Ingakhuthaza ukushintshwa kukashukela, amafutha nama-amino acid, futhi ihlanganyele ekwakhiweni kwamandla. I-coenzyme ebalulekile edingekayo emzimbeni womuntu.

2) I-NAD+ iyona kuphela i-substrate yama-enzyme asebenzisa i-coI (i-substrate kuphela ye-enzyme yokulungisa i-DNA i-PARP, i-substrate kuphela yeprotheni ehlala isikhathi eside i-Sirtuins, kanye ne-substrate kuphela ye-cyclic ADP ribose synthase CD38/157).

Kodwa-ke, njengoba iminyaka ikhula, izinga le-NAD+ emzimbeni liyancipha ngokushesha. Lizoncipha ngo-50% njalo eminyakeni engama-20. Cishe eminyakeni engama-40 ubudala, okuqukethwe yi-NAD+ emzimbeni womuntu kungama-25% kuphela kwalokho okwakuyikho ezinganeni.

Uma amangqamuzana omuntu engenawo i-NAD+, ukungasebenzi kahle kwe-mitochondrial kuyancishiswa, ikhono lokulungisa umonakalo we-DNA liyancishiswa, kanti umndeni we-gene protein we-Sirtuin nawo awusebenzi, njll. Lezi zici ezimbi zingaholela ekuqhekekeni kwe-apoptosis, ezifweni zabantu, ekugugeni ngisho nasekufeni.

Indima ye-NAD+ empilweni yakho iyonke

Ukulwa nokuguga

I-NAD+ igcina ukuxhumana kwamakhemikhali phakathi kwe-nucleus ne-mitochondria, futhi ukuxhumana okubuthakathaka kuyimbangela ebalulekile yokuguga kwamangqamuzana.

I-NAD+ ingasusa inani elikhulayo lamakhodi e-DNA anephutha ngesikhathi sokusebenza kweseli, igcine ukubonakaliswa okuvamile kwezakhi zofuzo, igcine ukusebenza okuvamile kwamaseli, futhi yehlise ijubane lokuguga kwamaseli abantu.

Lungisa umonakalo we-DNA

I-NAD+ iyi-substrate ebalulekile ye-enzyme yokulungisa i-DNA i-PARP, enomthelela omkhulu ekulungisweni kwe-DNA, ukubonakaliswa kwezakhi zofuzo, ukuthuthukiswa kwamaseli, ukusinda kwamaseli, ukwakhiwa kabusha kwama-chromosome, kanye nokuqina kwezakhi zofuzo.

Yenza kusebenze iphrotheni yokuphila isikhathi eside

Ama-Sirtuin avame ukubizwa ngokuthi umndeni wamaprotheni okuphila isikhathi eside futhi adlala indima ebalulekile yokulawula emisebenzini yamaseli, njengokuvuvukala, ukukhula kwamaseli, isigqi se-circadian, i-metabolism yamandla, umsebenzi we-neuronal, kanye nokumelana nokucindezeleka, kanti i-NAD+ iyi-enzyme ebalulekile yokwenziwa kwamaprotheni okuphila isikhathi eside.

Ivuselela wonke amaprotheni ayi-7 okuphila isikhathi eside emzimbeni womuntu, idlala indima ebalulekile ekumelaneni nokucindezeleka kwamangqamuzana, ukugaya amandla, ukuvimbela ukuguquka kwamangqamuzana, ukuphelelwa amandla kanye nokuguga.

Nikeza amandla

Ikhuthaza ukukhiqizwa kwamandla angaphezu kuka-95% adingekayo emisebenzini yokuphila. I-Mitochondria emangqamuzaneni abantu iyizitshalo zamandla zamaseli. I-NAD+ iyi-coenzyme ebalulekile ku-mitochondria ukukhiqiza i-molecule yamandla i-ATP, iguqula izakhamzimba zibe amandla adingwa umzimba womuntu.

Khuthaza ukuvuselelwa kwemithambo yegazi futhi ugcine ukuqina kwemithambo yegazi

Imithambo yegazi iyizicubu ezibalulekile emisebenzini yokuphila. Njengoba sikhula, imithambo yegazi ilahlekelwa kancane kancane ukuguquguquka kwayo futhi iba lukhuni, iqine, futhi ibe mincane, okubangela "i-arteriosclerosis."

I-NAD+ ingandisa umsebenzi we-elastin emithanjeni yegazi, ngaleyo ndlela igcine ukuqina kwemithambo yegazi futhi igcine impilo yemithambo yegazi.

Khuthaza i-metabolism

I-metabolism iyinhlanganisela yezindlela ezahlukahlukene zokusabela kwamakhemikhali emzimbeni. Umzimba uzoqhubeka nokushintshanisa izinto kanye namandla. Uma lokhu kushintshana kuyeka, impilo yomzimba nayo izophela.

USolwazi Anthony kanye nethimba lakhe locwaningo eNyuvesi yaseCalifornia, e-USA, bathole ukuthi i-NAD+ ingathuthukisa ngempumelelo ukwehla kokusebenza kweseli okuhambisana nokuguga, ngaleyo ndlela ithuthukise impilo yabantu futhi yandise isikhathi sokuphila.

Vikela impilo yenhliziyo

Inhliziyo iyisitho esibaluleke kakhulu kubantu, futhi izinga le-NAD+ emzimbeni lidlala indima ebalulekile ekugcineni ukusebenza kwenhliziyo okuvamile.

Ukwehla kwe-NAD+ kungase kuhlobane nokuqala kwezifo eziningi zenhliziyo, futhi inani elikhulu lezifundo eziyisisekelo nalo liqinisekisile umphumela wokwengeza i-NAD+ ezifweni zenhliziyo.

Vimbela izifo zenhliziyo nemithambo yegazi

Izifundo zibonise ukuthi cishe zonke izinhlobo eziyisikhombisa ze-sirtuin (SIRT1-SIRT7) zihlobene nokuvela kwesifo senhliziyo. Ama-Sirtuin abhekwa njengezinhloso eziqinile zokwelapha izifo zenhliziyo, ikakhulukazi i-SIRT1.

I-NAD+ yiyona kuphela isisekelo se-Sirtuins. Ukwengezwa kwe-NAD+ ngesikhathi esifanele emzimbeni womuntu kungenza umsebenzi we-subtype ngayinye ye-Sirtuins usebenze ngokugcwele, ngaleyo ndlela kuvikelwe impilo yenhliziyo nokuvimbela izifo zenhliziyo.

Khuthaza ukukhula kwezinwele

Imbangela eyinhloko yokulahlekelwa izinwele ukulahlekelwa amandla eseli likamama wezinwele, kanti ukulahlekelwa amandla eseli likamama wezinwele kungenxa yokuthi izinga le-NAD+ emzimbeni womuntu liyehla. Amaseli kamama wezinwele awanawo i-ATP eyanele yokwenza ukwakheka kwamaprotheni ezinwele, ngaleyo ndlela alahlekelwe amandla awo futhi kuholele ekulahlekelweni amandla ezinwele.

Ngakho-ke, ukwengeza i-NAD+ kungaqinisa umjikelezo we-asidi futhi kukhiqize i-ATP, ukuze amaseli omama bezinwele abe nekhono elanele lokukhiqiza iphrotheni yezinwele, ngaleyo ndlela kuthuthukiswe ukulahleka kwezinwele.

Ungathengaphi Isengezo se-Beta-NAD+ Ngokuphepha Ku-inthanethi

I-Suzhou Myland Pharm & Nutrition Inc. ingumkhiqizi obhalisiwe yi-FDA ohlinzeka ngempuphu ye-NAD+ Supplement esezingeni eliphezulu nehlanzekile.

KwaSuzhou Myland Pharm sizibophezele ekuhlinzekeni ngemikhiqizo esezingeni eliphezulu ngamanani amahle kakhulu. Impuphu yethu ye-NAD+ Supplement ihlolwe ngokucophelela ukuhlanzeka kanye namandla, okuqinisekisa ukuthi uthola isithasiselo sekhwalithi ephezulu ongasithemba. Kungakhathaliseki ukuthi ufuna ukusekela impilo yamaseli, ukukhulisa amasosha omzimba wakho noma ukuthuthukisa impilo iyonke, impuphu yethu ye-NAD+ Supplement iyisinqumo esifanele.

Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukisiwe kakhulu, i-Suzhou Myland Pharm ithuthukise imikhiqizo ehlukahlukene encintisanayo futhi yaba yinkampani yezinsizakalo zesayensi yokuphila entsha, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.

Ngaphezu kwalokho, iSuzhou Myland Pharm nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi, futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.