Igama lesayensi le-NAD yi-nicotinamide adenine dinucleotide. I-NAD+ ikhona kuwo wonke amangqamuzana omzimba wethu. Kuyi-metabolite ebalulekile kanye ne-coenzyme ezindleleni ezahlukahlukene ze-metabolic. Ilamula futhi ibambe iqhaza ezinqubweni ezihlukahlukene zezinto eziphilayo. Ngaphezu kwama-enzyme angama-300 ancike ku-NAD+ Ukusebenza. Nokho, izinga lokuqukethwe le-NAD+ alimile. Njengoba sikhula, okuqukethwe kwe-NAD+ kumaseli kuzokwehla. Ikakhulukazi ngemva kweminyaka engu-30, izinga le-NAD+ lizokwehla kakhulu, okuholela ekwehleni kwemisebenzi eminingi futhi ngaleyo ndlela kubonise izimpawu zokuguga. INicotinamide riboside chloride iwuhlobo lwevithamini B3. I-Nicotinamide riboside chloride ingaguqulwa ibe yi-NAD+ (nicotinamide adenine dinucleotide). Ingenye yezandulela ze-NAD+ ezifundwe kakhulu. Imuncwa kalula ngumzimba futhi isetshenziswe. Ucwaningo oluningi lubonise ukuthi ukugcwalisa i-NRC kungakhuphula amazinga e-NAD+, okungase kulethe izinzuzo ku-metabolic, inhliziyo nemithambo yegazi nezinhlelo zezinzwa. Kuvame ukusetshenziswa njengesengezo sokudla ukuze kuthuthukiswe impilo yonke kanye nokuphila kahle.
I-Nicotinamide riboside chloride (NRC) iphuma kuvithamini B3 kanye nento entsha ye-bioactive. Yakhiwa i-ribose ye-sugar molecule kanye nengxenye ye-vitamin B3 i-nicotinamide (eyaziwa nangokuthi i-nicotinic acid noma i-vitamin B3). Ingadliwa ngokudla inyama, inhlanzi, okusanhlamvu nokunye ukudla noma ngezithako ze-NRC.
I-Nicotinamide ribose chloride ingaguqulelwa ku-NAD+ (nicotinamide adenine dinucleotide) futhi yenze umsebenzi webhayoloji ngaphakathi kwamaseli. I-NAD+ iyi-coenzyme ebalulekile ye-intracellular ebamba iqhaza ezinqubweni ezihlukahlukene ze-metabolic yeselula, okuhlanganisa ukukhiqizwa kwamandla, ukulungiswa kwe-DNA, ukwanda kwamaseli, njll. Phakathi nenqubo yokuguga yomzimba womuntu, okuqukethwe kwe-NAD + kuncipha kancane kancane. I-Nicotinamide riboside chloride supplementation ingakhuphula izinga le-NAD+, okulindeleke ukuthi ibambezeleke ukuvela kokuguga kwamangqamuzana nezifo ezihlobene.
Ucwaningo nge-nicotinamide riboside chloride lukhombisile ukuthi inemisebenzi eminingi yebhayoloji, efana nale:
Thuthukisa i-metabolism yamandla, uthuthukise ukukhuthazela nokusebenza kokuzivocavoca;
Thuthukisa umsebenzi wezinzwa kanye nenkumbulo;
Thuthukisa ukusebenza kwamasosha omzimba.
Sekukonke, i-nicotinamide riboside chloride iyisithako esithembisayo esinomsoco esinamathemba okusebenza abanzi.
Ngaphezu kwalokho, i-nicotinamide ribose chloride nayo isetshenziswa kabanzi ocwaningweni lwesayensi. Njengento eyandulela ye-NAD+, ingasetshenziswa ukutadisha i-biosynthesis nezindlela ze-metabolic ze-NAD+ nezinye izindaba ezihlobene. Ngasikhathi sinye, i-nicotinamide riboside chloride nayo isetshenziswa njengesithako emikhiqizweni yezempilo nezimonyo ukukhuthaza impilo yamaseli nokunciphisa ukuguga kwesikhumba.
Ukuguga kuyisihloko saphakade kubantu. Ngokocwaningo lososayensi, ukuguga kwamaseli kuhlobene eduze nokwehliswa kokuqukethwe kwe-nicotinamide adenine dinucleotide (NAD). I-NAD iyisixhumanisi esibalulekile kumetabolism kanye nokulungiswa kwamaseli emzimbeni womuntu. Akukwazi nje ukubambezela ukuguga, kodwa futhi nokugcina ubungqabavu bengqamuzana nokugcina impilo engokomzimba nengokwengqondo. kodwa. Njengoba sikhula, amazinga e-NAD emizimbeni yethu ehla ngokushesha futhi ngokushesha, futhi angase ehle ngisho nangaphezu kwesigamu phakathi kweminyaka yobudala engama-40 nengama-80.
Kukhona i-enzyme ebaluleke kakhulu emzimbeni wethu, okuyingxenye eyinhloko ye-metabolism yamandla eselula. Ibaluleke kangakanani? Cishe zonke izinqubo ezigcina ukusebenza okujwayelekile komzimba, okufana ne-metabolism, ukulungiswa, nokuzivikela komzimba, zidinga ukubamba iqhaza kwale enzyme. Uma amazinga ale enzyme ehla, izimpawu eziningi nezifo ezihlobene nokuguga zingase zivele, njengezifo ze-metabolic, ubuthakathaka bokuzivikela komzimba, ukuncipha kwengqondo, njll. Le enzyme ebalulekile inegama elide: i-nicotinamide adenine dinucleotide, noma i-NAD +.
Ngamafuphi, ukuncipha kwe-NAD+ emzimbeni kusho ukuguga. Ngakho-ke, singangeza i-NAD + emzimbeni ukuze sibambezele ukuguga? Uma wengeza ngokuqondile i-NAD+, umzimba womuntu ngeke ukwazi ukuwumunca, futhi uzoba nemiphumela emibi kakhulu. Ngakho-ke, abantu baphendule ukunaka kwabo entweni eyandulela i-NAD+: nicotinamide ribose chloride (NRC).
INicotinamide riboside chloride iwuhlobo lwevithamini B3 futhi ingesinye sezandulela ze-NAD+ ezifundwa kakhulu. Imuncwa kalula futhi isetshenziswe ngumzimba. Ucwaningo oluningi lukhombisile ukuthi ukwengeza i-NR kungakhuphula amazinga e-NAD+, okungase kulethe izinzuzo ezinhlelweni ze-metabolic, zenhliziyo nemithambo yegazi.
Igama elithi "anti-aging" lithola i-rap embi. Kuzwakala sengathi sizama ukumisa okuthile osekuqhubeka, noma asikwazi ukwamukela izingxenye zethu okufanele sizithande. Kodwa iqiniso liwukuthi izinguquko ze-metabolic zenzeka ngaphansi kwesikhumba ngaphambi kokuba sibone imiphumela yokuguga. Ukukhetha ukubhekana nempilo yethu ngaphakathi nangaphandle kungase kube yilokho kanye esikudingayo ukuze sithuthukise indlela esiguga ngayo.
Eqinisweni, enye yezimpawu zokuguga inqubo eyaziwa ngokuthi "ukungasebenzi kahle kwe-mitochondrial," igama elibhekisela ekulahlekelweni okujwayelekile kwamandla nokusebenza kahle kwamaseli ethu ngokuhamba kwesikhathi. Lokhu kungase kube esinye sezizathu zokuthi kungani siguga. Uma i-mitochondria isenhliziyweni yokuguga kwethu, kufanelekile ukuphenya ngazo zonke izindlela ukuze igcinwe isebenza isikhathi eside ngangokunokwenzeka.
Funda nge-mitochondria.
Cishe ngaphakathi kuwo wonke amangqamuzana kunalawa ma-organelle amancane, amise ngendlela eyinqaba abizwa ngokuthi i-mitochondria—“isizinda samandla engqamuzana.” Lezi zitho ezincane zinesibopho sokukhiqiza amandla angama-90% emizimba yethu ewadingayo. I-Mitochondria yisizathu esikhona namuhla njengezilwane eziyinkimbinkimbi kunokuba amagciwane.
Asazi njalo ukuthi i-mitochondria ibaluleke kangakanani empilweni yethu. Indlela eyinhloko yokugcina i-mitochondria yakho iphilile i-molecule ebizwa nge-NAD+ (nicotinamide adenine dinucleotide). Amaseli ethu akhiqiza i-NAD+ ngokwemvelo futhi siyisebenzisa ngokuqhubekayo usuku lonke.
Siyazi futhi ukuthi ukunikezwa kwethu kwe-NAD+ kuyehla njengoba sikhula. Lapho abacwaningi sebebonile ukuthi i-NAD+ ingase ibambe ukhiye wokugcina amangqamuzana ethu enempilo, bashaya amakhala ukuze bathole indlela yokuwasebenzisa ngokugcwele.
Abacwaningi sebeyazi kakade ukuthi amavithamini amabili aqala inqubo yamakhemikhali yokwandisa i-NAD+: i-niacin ne-niacinamide. Lokhu kwatholakala ngawo-1930 ukwelapha i-pellagra, ukuntuleka kwevithamini B3 okungaba yingozi.
I-Niacin yayizophinde ibe ukwelashwa kwe-cholesterol ephezulu ngawo-1950. Kodwa-ke, kutholakale ukuthi ukusebenzisa imithamo ephezulu ye-niacin ngezinye izikhathi kungabangela ukuguquguquka kwesikhumba okucasulayo kokubili okucasulayo nokungabonakali.
I-Niacinamide ayikubangeli ukuguquguquka kwesikhumba futhi ngokwembono inganikeza izinzuzo eziningi ezifanayo, kodwa ivimbela ukwenziwa kusebenze kwamaprotheni abalulekile akhuthaza ukulungisa amaseli abizwa ngokuthi ama-sirtuin. Ayikho i-niacinamide noma i-niacin eyaphumelela ngendlela abacwaningi ababenethemba ngayo.
Nakuba la mavithamini amabili engozandulela we-NAD+, awasona isixazululo esifanelekile. Ngenxa yemiphumela engemihle ye-niacin nokusebenza okuhlobene kwe-nicotinamide, abacwaningi abakabi naso isithasiselo sevithamini esanele sokukhulisa amazinga e-NAD+.
Ukutholwa kwe-nicotinamide riboside.
Olunye uhlobo lwevithamini B3 olubizwa nge-nicotinamide riboside lwatholakala ku-yeast ngeminyaka yawo-1940. Kodwa kwaze kwafika ekuqaleni kwawo-2000 lapho ososayensi baqala khona ukubona amandla aleli vithamini wesithathu, B3, ukuthi angagcini nje ngokukhulisa i-NAD+ kodwa futhi athuthukise impilo yomuntu. Ngo-2004, ithimba labacwaningi baseDartmouth College lathola ukuthi i-nicotinamide riboside, njengomfowabo kavithamini B3, iyisandulela se-NAD+.
Ithimba labacwaningi eliholwa uDkt. Charles Brenner lithole ukuthi i-nicotinamide riboside yandisa i-NAD+ kumagundane, futhi amagundane ahlangabezane nenani lezinzuzo zezempilo ngenxa yalokho.
Amagundane abonise yonke into kusukela ekuthuthukisweni kukashukela egazini kanye namazinga e-cholesterol kuya ekunciphiseni ukulimala kwezinzwa kanye nokumelana nokuzuza isisindo. UDkt. Charles Brenner uthole le miphumela ikhuthaza kangangokuthi wathatha isinyathelo esilandelayo ukuze aqonde okushiwo i-nicotinamide riboside empilweni yomuntu.
Ngo-2014, uDkt. Brenner waba ngumuntu wokuqala ukuthatha i-nicotinamide riboside njengesithasiselo. Imiphumela ikhuthaza ngokufanayo. Lolu hlobo olungaziwa lwevithamini B3 lwandise kakhulu amazinga akhe e-NAD+ ngokuphepha, ngokushesha, futhi ngaphandle kwemiphumela emibi.
INicotinamide riboside isebenzisa indlela eyingqayizivele ukukhiqiza i-NAD+ okungekho enye i-vitamin B3 eyisebenzisayo.
I-Nicotinamide riboside ingaphinda isebenze ama-sirtuin avuselela amaseli. Njengoba sikhula, lawa ma-sirtuin asebenza isikhathi esengeziwe ukuze asize amaseli ukuthi ahlale eqinile.
Ukuhlala unempilo njengoba ukhula akusoze kwaba lula njengevithamini eyodwa, ngisho neyokuthembisa njenge-nicotinamide riboside. Kukhona izifundo ezingaphezu kwe-100 eziphenya i-nicotinamide riboside, eziningi zazo ezikhombisa ukuthi amazinga e-NAD+ akhuphuka ahlotshaniswa nempilo ye-metabolic kanye nemisipha kumagundane. Ucwaningo olwengeziwe luyaqhubeka ukuze kuqondwe indima ye-NAD+ ekusekeleni ezinye izinselele zezempilo ezihlobene nobudala, okuhlanganisa ukuncipha kokusebenza kwesibindi, ukuzuza isisindo, amazinga e-insulin nokusebenza kobuchopho kumagundane.
Iyini i-NAD?
I-NAD+ iyi-coenzyme I, okuyi-coenzyme edlulisa ama-proton (ngokunembe kakhudlwana, ama-hydrogen ion) futhi ibamba iqhaza emisebenzini eminingi ye-physiological efana ne-cell metabolism, ukuhlanganiswa kwamandla, kanye nokulungiswa kwe-DNA. I-NAD+ iwumsoco odingekayo ekusebenzeni kweprotein ye-Sirtuin, ebizwa ngokuthi "isici sokuphila isikhathi eside" ngososayensi. Ikakhulukazi, ingakwazi ukugcina ubude bama-telomere abalulekile, ibambezele inqubo yokuguga futhi yandise isikhathi sokuphila.
I-NAD+ ingaphinde ikhuthaze ukulungiswa kwezakhi zofuzo futhi ibambezele ukuguga kwamaseli. I-NAD+ ikhuthaza ukuvuselelwa kwamaseli futhi imelana nezifo zamasosha omzimba. I-NAD+ ithuthukisa ukuzinza kwe-chromosome futhi yehlisa ubungozi bomdlavuza.
Bangabangane abakhulu bama-enzyme, abasiza ekufutheni "imishini yamaselula" edala amandla adingekayo kuwo wonke umsebenzi omkhulu emzimbeni wakho ezingeni lamaselula.
Kungani i-NAD+ ibalulekile?
Ngenxa yendima yayo ebalulekile ekukhiqizeni amandla eselula, ukuntuleka kwe-NAD+ emzimbeni wakho kwenza imisebenzi eminingi yomzimba ingabi namsebenzi. Ngaphandle kwe-NAD, amaphaphu akho ngeke akwazi ukudonsa umoya-mpilo, inhliziyo yakho ngeke ikwazi ukumpompa igazi, nama-synapses akho obuchopho ngeke avuthe.
I-NAD+ iphinde isize ekukhuthazeni ukulungiswa kwe-DNA kanye nokulawula ukusebenza kwamaseli ngokusebenzisa ama-sirtuin nama-poly(ADP-ribose) polymerases (PARPs), okubalulekile ekulawuleni izimpendulo zamaselula ezithukweni ezifana nokudla ngokweqile, ukuphuza utshwala, ukuphazamiseka kokulala, namaphethini okuhlala. Ama-enzyme.
I-NAD+ nokuguga
Ucwaningo olwenziwe ngo-2012 yithimba loMnyango Wezemithi eNyuvesi yaseNew South Wales lubonise ukuthi i-NAD metabolism ihlotshaniswa neminyaka. Ucwaningo lubonisa ukuthi amazinga e-NAD + ezicutshini zesikhumba somuntu ehla aze afike ku-50% phakathi kweminyaka yobudala engama-40 nengama-60, nokuthi ukuncipha kwe-NAD + kungase kudlale indima ebalulekile enqubweni yokuguga.
"Ukuhlobana okunamandla okungekuhle kubonwe phakathi kwamazinga e-NAD+ nobudala kubesilisa nabesifazane," kusho abacwaningi ephepheni.
Ukwengeza, i-NAD ihileleke ekuphefumuleni kwamaselula, ikakhulukazi ku-mitochondria, futhi inomthelela empilweni yonke ye-mitochondrial. Kunentshisekelo eqinile yesayensi ekubandakanyekeni kwe-NAD ekungasebenzi kahle kwe-mitochondrial, okungenye yezimpawu zokuguga.
Eminyakeni yamuva nje, ucwaningo lugxile ekuqondeni indima ye-NAD ekubhekaneni nalokhu kuncipha kokusebenza okuhlobene nobudala.
INicotinamide Ribose Chloride inyusa amazinga e-NAD+.
I-NR iyisandulela se-NAD, okusho ukuthi "iyindawo yokwakha" okwenziwa ngayo ama-molecule e-NAD+. Yatholwa ngo-2004 njengesandulela sevithamini ku-NAD+, okuyenza ibe ngenye yempumelelo yakamuva ocwaningweni lwe-NAD+.
I-NR iyivithamini eyenzeka ngokwemvelo kanye nohlobo lwenoveli lwevithamini B3, kodwa ukusetshenziswa kwayo njengesengezo kuthinteke kabi amavithamini "okuguga okunempilo". Isebenza kahle kakhulu ekwandiseni i-NAD, iyenze ibe ngenye yezindlela zokungenelela ezijabulisa kakhulu ezisombululweni zokuguga ezinempilo.
I-NR ingakhuphula ngempumelelo amazinga e-NAD+. Ukuhlolwa komtholampilo okushicilelwe ku-Scientific Reports kubonise ukuthi kwenyuse i-NAD+ kufika ku-50% ngemva kwamasonto amabili ukuyiphuza.
Nakuba ukwesekwa kwe-NR kufakazelwe ngokomtholampilo ukuthi kwenyusa amazinga e-NAD+, ukwengezwa kwe-NAD+ njengesithako esizimele akusebenzi kangako.
I-NAD+ iyi-molecule enkulu kakhulu futhi ayikwazi ukungena kumaseli ngokuqondile. Kunalokho, umzimba wakho kufanele uwuhlephule ube yizicucu ezincane ngaphambi kokuba uwele ulwelwesi lweseli. Lezi zingxenye zihlanganiswa kabusha ngaphakathi kwebhethri.
I-Nicotinamide riboside (NR) kanye i-nicotinamide riboside chloride (NRC) zombili izinhlobo zikavithamini B3, owaziwa nangokuthi i-niacin. I-Vitamin B3 iyisakhi esibalulekile esidlala indima ebalulekile emisebenzini ehlukahlukene yomzimba, okuhlanganisa ukukhiqizwa kwamandla, ukulungiswa kwe-DNA, kanye ne-cell metabolism. Kokubili i-NR ne-NRC zingamanduleli we-nicotinamide adenine dinucleotide (NAD+), i-coenzyme ehilelekile ezinqubweni ezihlukahlukene zebhayoloji, njengokulawula ukukhiqizwa kwamandla eselula nokusekela ukulungiswa kwe-DNA.
I-Nicotinamide riboside (NR) iwuhlobo lukavithamini B3 oseluthole ukunakwa ngezakhiwo zalo ezingase zibe khona zokulwa nokuguga kanye nokukhuthaza amandla. Kuyinhlanganisela eyenzeka ngokwemvelo etholakala ngamanani amancane kokunye ukudla, kodwa futhi iyatholakala njengesengezo sokudla. I-NR yaziwa ngamandla ayo okukhulisa amazinga e-NAD+ emzimbeni, nawo angasekela umsebenzi we-mitochondrial, athuthukise ukukhiqizwa kwamandla eselula, futhi angase anikeze isivikelo ekwehleni okuhlobene nobudala.
I-Nicotinamide riboside chloride (NRC), ngakolunye uhlangothi, iwuhlobo lukasawoti lwe-NR futhi luvame ukusetshenziswa ezithasiselweni zokudla. Ukwengeza i-chloride ku-NR kukhiqiza i-NRC, okukholakala ukuthi ithuthukisa ukuqina kwe-compound kanye nokuba khona kwe-bioavailability. Lokhu kusho ukuthi i-NRC ingase ibe nokumuncwa okungcono futhi isetshenziswe emzimbeni kune-NR iyodwa futhi ingase ibe nomthelela osobala kumazinga e-NAD+ kanye nokusebenza kweselula.
Omunye umehluko omkhulu phakathi kwe-NR ne-NRC ukwakheka kwawo kwamakhemikhali. I-NR iwuhlobo oluyisisekelo lwale nhlanganisela, kuyilapho i-NRC iyinguqulo eguquliwe ene-chloride eyengeziwe. Lokhu kuguqulwa kuhloselwe ukwandisa ukunyibilika kwenhlanganisela kanye nokutholakala kwe-bioavailability, okwenza kube lula ngomzimba ukumunca futhi ukusebenzise.
Mayelana nezinzuzo zabo zezempilo ezingaba khona, i-NR ne-NRC kucatshangwa ukuthi inemiphumela efanayo ngenxa yekhono labo lokukhulaNAD+amazinga. Le miphumela ingase ihlanganise ukusebenza okuthuthukisiwe kwe-mitochondrial, ukuthuthukiswa kwamandla okuguquguquka kwe-metabolism, kanye nokusekelwa okungaba khona kwempilo yeselula iyonke. Kodwa-ke, ukusebenzisa i-NRC esithasiselweni kungase kulethe inzuzo eyengeziwe yokumuncwa nokusetshenziswa okungcono, okungase kuphumele ezinzuzweni ezigqame kakhulu uma kuqhathaniswa nokusebenzisa i-NR kuphela.
1. Thuthukisa ukukhiqizwa kwamandla kwamaselula
Enye yezinzuzo eziphawuleka kakhulu zei-nicotinamide riboside chloride indima yayo ekuthuthukiseni ukukhiqizwa kwamandla kwamaselula. I-NR ingumanduleli we-nicotinamide adenine dinucleotide (NAD+), i-coenzyme edlala indima ekukhiqizweni kwe-adenosine triphosphate (ATP), imali eyinhloko yengqamuzana yamandla. indima ebalulekile. Njengoba sikhula, amazinga e-NAD+ ayancipha, okuholela ekwehleni kokukhiqizwa kwamandla amaselula. Ngokufaka i-NR, kukholakala ukuthi amazinga e-NAD+ angaphinda agcwaliswe, ngaleyo ndlela asekele ukuqina kwe-cell metabolism.
2. Umsebenzi we-Mitochondrial neminyaka yokuphila
I-Mitochondria yimithombo yamandla yeseli, enesibopho sokukhiqiza amandla nokulawula izinqubo zamaselula. Ucwaningo lubonisa ukuthi iNicotinamide Riboside Chloride ingasekela umsebenzi we-mitochondrial ngokuthuthukisa i-biogenesis ye-mitochondria entsha futhi ikhulise ukusebenza kahle kwayo. Lokhu kunomthelela empilweni yonke kanye nokuguga okunempilo, njengoba i-mitochondria esebenza kahle ibalulekile ekugcineni impilo yeselula nokuqina.
3. Ukulawulwa kwempilo ye-Metabolic nesisindo
I-NAD+ iyi-coenzyme, noma i-accessory molecule, ebandakanyeka ekuphenduleni okuningi kwezinto eziphilayo. Ucwaningo lwakamuva luthole ukuthi i-nicotinamide ribose supplementation ingavuselela ngempumelelo i-NAD+ metabolism kubantu abadala abanempilo ephakathi nabadala. Akukhona nje kuphela ukuthi izithasiselo ze-NR zabekezelelwa kahle abahlanganyeli, kungenzeka zisize ekunciphiseni umfutho wegazi nokuqina kwe-arterial. Ukushoda kwe-NAD+ kuyimbangela evamile yokuguga nezifo eziningi, futhi ucwaningo lubonisa ukuthi ukubuyisela amazinga e-NAD+ kunenani elikhulu lokwelapha nokondleka.
Ngokwandisa amazinga e-NAD+, i-nicotinamide ribose izuzisa ukulawulwa kwe-metabolic, izinqolobane zamandla, ukuhlanganiswa kwe-DNA, neminye imisebenzi yomzimba.
Ukwengeza, ucwaningo luye lwabonisa ukuthi ukwesekwa kwe-NR kungathuthukisa ukuzwela kwe-insulin, kunciphise ukuvuvukala, futhi kuthuthukise ukuguquguquka kwe-metabolic. Le miphumela ingaba yinzuzo ikakhulukazi kubantu abafuna ukulawula isisindo sabo futhi basekele impilo yonke ye-metabolic.
4. Ukusebenza kwengqondo kanye nempilo yobuchopho
Njengesandulela se-NAD+, i-nicotinamide ribose ivikela amangqamuzana obuchopho ekucindezelekeni kwe-oxidative, okungaholela ezifweni zobuchopho ezihlobene neminyaka. Ngaphakathi kwamangqamuzana obuchopho, i-NAD+ isiza ukulawula ukukhiqizwa kwe-PGC-1-alpha, iphrotheni ebonakala isiza ukuvikela amaseli ekucindezelekeni kwe-oxidative kanye nokusebenza kabi kwe-mitochondrial.
Abacwaningi bathole ukuthi kumagundane, ukuwohloka kwe-NAD+ kudlala indima ebalulekile ku-neuroinflammation, ukulimala kwe-DNA, kanye nokuwohloka kwe-neuronal ku-Alzheimer's disease. Futhi ocwaningweni lwe-test-tube, i-nicotinamide riboside ikhuphule amazinga e-NAD+ futhi yathuthukisa kakhulu ukusebenza kwe-mitochondrial kuma-stem cells eziguli zesifo sika-Parkinson.
Ucwaningo olusafufusa luphinde lukhombe ezinzuzweni ezingaba khona zokucabanga ze-nicotinamide riboside chloride. I-NAD+ ibandakanyeka ezinqubweni ezehlukene ezihlobene nempilo yobuchopho, okuhlanganisa ukusayina kwe-neuronal, ukulungiswa kwe-DNA, nokususwa kwamaprotheni alimele. Ngokusekela amazinga e-NAD+, i-NR ingasiza ekugcineni ukusebenza kwengqondo futhi ivimbele ukwehla kwengqondo okuhlobene neminyaka.
5. Ukusebenza Kwezemidlalo Nokubuyisela
Ucwaningo lwango-2019 olushicilelwe ku-European Journal of Nutrient Impurities luthole ukuthi ukusebenzisa izithasiselo ze-nicotinamide ribose kuthuthukisa amakhono omzimba futhi kwehlise nengcindezi ye-oxidative kubantu abadala.
Abacwaningi baphethe ngokuthi ukwesekwa kwe-NR bekuzuzisa abantu abantula i-NAD+, bechaza ukuthi kungani kusebenza kakhulu kubantu abadala asebekhulile kunabantu abadala.
Abasubathi nabathandi bokuqina bangase babe nentshisekelo yokwazi ukuthi i-nicotinamide riboside chloride ingaba nomthelela omuhle ekusebenzeni nokululama komdlalo. I-NAD+ idlala indima ebalulekile ekulawuleni izinqubo zamaselula ezihilelekile ekukhiqizweni kwamandla kanye nokusebenza kwemisipha. Ngokusekela amazinga e-NAD+, i-NR ingathuthukisa ukukhuthazela, ithuthukise ukululama kwemisipha, futhi ithuthukise ukusebenza kahle komdlalo.
Ikhwalithi nobumsulwa
Lapho uthenga i-nicotinamide riboside chloride powder, ikhwalithi nobumsulwa kufanele kube yinto eza kuqala kuwe. Bheka imikhiqizo eyenziwe izinkampani ezinedumela elihle kanye nenkampani yangaphandle ehlolelwe ubumsulwa namandla. Ngokufanelekile, imikhiqizo kufanele ingabi nakungcola kanye nezigcwalisi ukuze kuqinisekiswe ukuthi uthola isengezo sekhwalithi ephezulu esiletha izinzuzo ezihlosiwe.
Umthamo kanye nokusetshenziswa
Ngaphambi kokufaka i-nicotinamide riboside chloride powder ohlelweni lwakho lwansuku zonke, kubalulekile ukuqonda umthamo ofanele nemihlahlandlela yokusebenzisa. Kubalulekile ukuqala ngomthamo ophansi futhi kancane kancane ukhuphuke njengoba kudingeka, njengoba imithamo ephezulu ayilingani nemiphumela engcono futhi ingase ibangele imiphumela emibi. Ukwengeza, sicela ucabangele ukubonisana nochwepheshe bezokunakekelwa kwempilo ukuze unqume umthamo olungele imigomo nezidingo zakho ezithile zezempilo.
Izinzuzo ezingaba khona kanye nokucatshangelwa
I-Nicotinamide Riboside Chloride Powder ivame ukuphakanyiswa ngezinzuzo zayo ezingaba khona, okuhlanganisa ukusekela amazinga wamandla, ukusebenza kwe-mitochondrial, kanye nempilo yeselula iyonke. Ucwaningo luveza ukuthi kungase kube nomthelela ekugugeni nasezifweni ezihlobene nobudala.
Ukuphepha kanye nezinyathelo zokuphepha
Njenganoma yisiphi isithasiselo, kubalulekile ukubeka phambili ukuphepha futhi uqonde izinyathelo zokuphepha ezingaba khona. Nakuba i-nicotinamide riboside chloride ngokuvamile ibekezelelwa kahle, abanye abantu bangase babe nemiphumela engemihle, njengokungakhululeki emathunjini. Ukwengeza, uma unezimo zempilo ezicashile noma uthatha imithi, qiniseka ukuthi uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa lesi sengezo ukuze uqinisekise ukuthi siphephile futhi sifanele isimo sakho siqu.
Khetha umphakeli onedumela elihle
Lapho uthenga i-Nicotinamide Riboside Chloride Powder, kubalulekile ukukhetha umphakeli onedumela elihle obeka kuqala ikhwalithi, obala, nokwaneliseka kwekhasimende. Bheka izinkampani ezihlinzeka ngemininingwane mayelana nezinqubo zazo zokukhiqiza, ukuthola, nokuhlola okuvela eceleni. Ukwengeza, cabanga ukufunda ukubuyekezwa kwamakhasimende nokufuna izincomo emithonjeni ethembekile ukuze uqinisekise ukuthi uthenga kumhlinzeki onokwethenjelwa nothembekile.
I-Suzhou Myland Pharm & Nutrition Inc. ibambe iqhaza ebhizinisini lesengezo sokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokudayisa imbewu yamagilebhisi.
Njengoba inesipiliyoni seminyaka engu-30 futhi iqhutshwa ubuchwepheshe obuphezulu kanye namasu e-R&D athuthukiswe kakhulu, inkampani ithuthukise uhla lwemikhiqizo encintisanayo futhi yaba isithasiselo sesayensi yempilo emisha, ukuhlanganisa ngokwezifiso kanye nenkampani yezinkonzo zokukhiqiza.
Ngaphezu kwalokho, iSuzhou Myland Pharm & Nutrition Inc. iphinde ibe ngumkhiqizi obhalisiwe we-FDA. Izinsiza ze-R&D zenkampani, izikhungo zokukhiqiza, namathuluzi okuhlaziya kungokwesimanjemanje futhi kunemisebenzi eminingi futhi ingakhiqiza amakhemikhali ukusuka kumamiligremu ukuya kumathani esikalini, futhi ithobelane namazinga e-ISO 9001 kanye nemininingwane yokukhiqiza ye-GMP.
Q: Iyini i-nicotinamide riboside chloride powder?
A: I-Nicotinamide Riboside Chloride Powder iwuhlobo lwevithamini B3 olucutshungulwe ukuze lukwazi ukusekela ukukhiqizwa kwamandla namangqamuzana eselula. Kuvame ukusetshenziswa njengesengezo sokudla ukuze kuthuthukiswe impilo yonke kanye nokuphila kahle.
Q: Yiziphi izinzuzo ezingaba khona ze-nicotinamide riboside chloride powder?
A: Ezinye izinzuzo ezingaba khona ze-Nicotinamide Riboside Chloride Powder zifaka phakathi ukusekela umsebenzi we-mitochondrial, ukukhuthaza ukuguga okunempilo, nokuthuthukisa ukukhuthazela nokusebenza komzimba. Kungase futhi kusize ukusekela ukusebenza kwengqondo kanye nempilo yeselula iyonke.
Q: Ngingayithenga kuphi i-nicotinamide riboside chloride powder?
A: I-Nicotinamide Riboside Chloride powder iyatholakala kubathengisi abahlukahlukene kanye nezitolo ze-inthanethi. Lapho uthenga lesi sithasiselo, kubalulekile ukukhetha umthombo ohloniphekile ukuze uqinisekise ikhwalithi nokuphepha.
Umshwana wokuzihlangula: Lesi sihloko esolwazi oluvamile kuphela futhi akufanele sithathwe njengeseluleko sezokwelapha. Olunye ulwazi lokuthunyelwe kwebhulogi luvela ku-inthanethi futhi alusebenzi. Le webhusayithi inomthwalo wemfanelo kuphela wokuhlunga, ukufometha kanye nokuhlela ama-athikili. Injongo yokudlulisa ulwazi olwengeziwe ayisho ukuthi uyavumelana nemibono yayo noma uqinisekise ubuqiniso bokuqukethwe kwayo. Hlala uthintana nochwepheshe bezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma wenze izinguquko ohlelweni lwakho lokunakekelwa kwezempilo.
Isikhathi sokuthumela: Aug-14-2024
