Igama lesayensi le-NAD yi-nicotinamide adenine dinucleotide. I-NAD+ ikhona kuwo wonke amaseli omzimba wethu. Iyi-metabolite ebalulekile kanye ne-coenzyme ezindleleni ezahlukene ze-metabolic. Ilawula futhi ihlanganyele ezinqubweni ezahlukahlukene zebhayoloji. Ama-enzyme angaphezu kuka-300 ancike ku-NAD+ Ukuze asebenze. Kodwa-ke, izinga lokuqukethwe kwe-NAD+ aliguquki. Njengoba siguga, okuqukethwe kwe-NAD+ kumaseli kuzoncipha. Ikakhulukazi ngemva kweminyaka engu-30, izinga le-NAD+ lizokwehla kakhulu, okuholela ekunciphiseni kwemisebenzi eminingi futhi ngaleyo ndlela kubonise izimpawu zokuguga. I-Nicotinamide riboside chloride iwuhlobo lwe-vitamin B3. I-Nicotinamide riboside chloride ingaguqulwa ibe yi-NAD+ (nicotinamide adenine dinucleotide). Ingenye yezinto ezandulele i-NAD+ ezifundwe kakhulu. Imuncwa kalula ngumzimba futhi isetshenziswe. Izifundo eziningi zikhombisile ukuthi ukwengeza i-NRC kungakhuphula amazinga e-NAD+, okungaletha izinzuzo ezinhlelweni ze-metabolic, zenhliziyo nezezinzwa. Ivame ukusetshenziswa njengesengezo sokudla ukukhuthaza impilo yonke kanye nenhlalakahle.
I-Nicotinamide riboside chloride (NRC) iwuhlobo lwe-vitamin B3 kanye nesithako esisha esisebenzayo. Yakhiwe yi-ribose ye-molecule kashukela kanye ne-vitamin B3 component nicotinamide (eyaziwa nangokuthi i-nicotinic acid noma i-vitamin B3). Ingadliwa ngokudla inyama, inhlanzi, okusanhlamvu nokunye ukudla noma ngezithako ze-NRC.
I-Nicotinamide ribose chloride ingaguqulwa ibe yi-NAD+ (i-nicotinamide adenine dinucleotide) futhi isebenze umsebenzi webhayoloji ngaphakathi kwamaseli. I-NAD+ iyi-coenzyme ebalulekile yangaphakathi kweseli ehlanganyela ezinqubweni ezahlukahlukene ze-metabolic yamaseli, okuhlanganisa ukukhiqizwa kwamandla, ukulungiswa kwe-DNA, ukwanda kwamaseli, njll. Ngesikhathi senqubo yokuguga komzimba womuntu, okuqukethwe yi-NAD+ kwehla kancane kancane. Ukwengezwa kwe-Nicotinamide riboside chloride kungakhuphula izinga le-NAD+, okulindeleke ukuthi kubambezele ukwenzeka kokuguga kwamaseli nezifo ezihlobene.
Ucwaningo nge-nicotinamide riboside chloride lukhombisile ukuthi inemisebenzi eminingi yebhayoloji, njenge:
Thuthukisa imetabolism yamandla, uthuthukise ukukhuthazela kanye nokusebenza kahle kokuzivocavoca;
Thuthukisa ukusebenza kwezinzwa kanye nenkumbulo;
Thuthukisa ukusebenza kwesimiso somzimba sokuzivikela.
Sekukonke, i-nicotinamide riboside chloride iyisithako esithembisayo kakhulu se-nutraceutical esinamathuba amaningi okusetshenziswa.
Ngaphezu kwalokho, i-nicotinamide ribose chloride nayo isetshenziswa kabanzi ocwaningweni lwesayensi. Njengento eyandulela i-NAD+, ingasetshenziswa ukutadisha indlela yokwenziwa kwezinto eziphilayo kanye nezindlela ze-metabolic ze-NAD+ nezinye izinkinga ezihlobene. Ngesikhathi esifanayo, i-nicotinamide riboside chloride nayo isetshenziswa njengesithako emikhiqizweni yezempilo kanye nezimonyo ukukhuthaza impilo yamaseli nokunciphisa ukuguga kwesikhumba.
Ukuguga kuyindaba ehlala njalo kubantu. Ngokusho kocwaningo olwenziwa ososayensi, ukuguga kwamangqamuzana kuhlobene kakhulu nokwehla kokuqukethwe kwe-nicotinamide adenine dinucleotide (NAD). I-NAD iyisixhumanisi esibalulekile ekusetshenzisweni kwe-metabolism kanye nokulungiswa kwamangqamuzana emzimbeni womuntu. Ayikwazi nje ukulibazisa ukuguga, kodwa futhi igcina amandla amangqamuzana futhi ilondoloze impilo yomzimba neyengqondo. Kodwa-ke, njengoba sikhula, amazinga e-NAD emizimbeni yethu ehla ngokushesha nangokushesha, futhi angase ehle ngisho nangaphezulu kwesigamu phakathi kweminyaka engama-40 no-80.
Kukhona i-enzyme ebaluleke kakhulu emzimbeni wethu, eyingxenye eyinhloko ye-metabolism yamandla eseli. Ibaluleke kangakanani? Cishe zonke izinqubo ezigcina ukusebenza okuvamile komzimba, njengokugaya ukudla, ukulungiswa, kanye nokuzivikela komzimba, zidinga ukubamba iqhaza kwale enzyme. Lapho amazinga ale enzyme ehla, izimpawu eziningi nezifo ezihlobene nokuguga zingalandela, njengezifo ze-metabolism, ukusebenza komzimba okubuthakathaka, ukwehla kwengqondo, njll. Le enzyme ebalulekile inegama elide: i-nicotinamide adenine dinucleotide, noma i-NAD+.
Ngamafuphi, ukwehla kwe-NAD+ emzimbeni kusho ukuguga. Ngakho-ke, singayinezela yini i-NAD+ emzimbeni ukuze sibambezele ukuguga? Uma ungeza i-NAD+ ngqo, umzimba womuntu ngeke ukwazi ukuyimunca, futhi izoba nemiphumela emibi kakhulu. Ngakho-ke, abantu baphendukela ekunakeni kwabo into eyandulela i-NAD+: i-nicotinamide ribose chloride (NRC).
I-Nicotinamide riboside chloride iwuhlobo lwe-vitamin B3 futhi ingenye yezandulela ze-NAD+ ezifundwe kakhulu. Imuncwa kalula futhi isetshenziswe umzimba. Izifundo eziningi zikhombisile ukuthi ukwengeza i-NR kungakhuphula amazinga e-NAD+, okungaletha izinzuzo ezinhlelweni ze-metabolic, zenhliziyo nezezinzwa.
Igama elithi “ukulwa nokuguga” lizwakala libi kakhulu. Kuzwakala sengathi sizama ukumisa into esivele iqhubeka, noma asikwazi ukwamukela izingxenye zethu okufanele sizithande. Kodwa iqiniso liwukuthi izinguquko ze-metabolic zenzeka ngaphansi kwesikhumba ngaphambi kokuba sibone imiphumela yokuguga. Ukukhetha ukubhekana nempilo yethu kusukela ngaphakathi kungaba yilokho kanye esikudingayo ukuze sithuthukise indlela esiguga ngayo.
Eqinisweni, esinye sezimpawu zokuguga inqubo eyaziwa ngokuthi "ukungasebenzi kahle kwe-mitochondrial," igama elibhekisela ekulahlekelweni kwamandla nokusebenza kahle kwamaseli ethu ngokuhamba kwesikhathi. Lokhu kungaba esinye sezizathu ezenza siguge. Uma i-mitochondria iyinhliziyo yokuguga kwethu, kufanelekile ukuphenya ngazo zonke izindlela ezingase zisebenze ukuze zihlale zisebenza isikhathi eside ngangokunokwenzeka.
Funda nge-mitochondria.
Cishe ngaphakathi kweseli ngalinye kukhona lawa ma-organelle amancane, anomumo ongavamile abizwa ngokuthi i-mitochondria—“indlu yamandla yeseli.” Lawa malungu amancane anesibopho sokukhiqiza u-90% wamandla imizimba yethu ewadingayo. Ama-mitochondria yiwona asenza sibe khona namuhla njengezilwane eziyinkimbinkimbi kunokuba sibe amabhaktheriya.
Asazi njalo ukuthi i-mitochondria ibaluleke kangakanani empilweni yethu. Indlela eyinhloko yokugcina i-mitochondria yakho iphilile i-molecule ebizwa ngokuthi i-NAD+ (i-nicotinamide adenine dinucleotide). Amaseli ethu akhiqiza i-NAD+ ngokwemvelo futhi siyisebenzisa njalo usuku lonke.
Siyazi futhi ukuthi ukutholakala kwethu kwe-NAD+ kwehla njengoba siguga. Lapho abacwaningi beqaphela ukuthi i-NAD+ ingase ibe yisihluthulelo sokugcina amangqamuzana ethu ephilile, bazama ukuthola indlela yokuyisebenzisa ngokugcwele.
Abacwaningi sebeyazi kakade ukuthi amavithamini amabili aqala inqubo yamakhemikhali yokwandisa i-NAD+: i-niacin ne-niacinamide. Lawa atholakala ngawo-1930 ukwelapha i-pellagra, ukuntuleka kwe-vitamin B3 okungaba yingozi.
I-Niacin nayo yaba ukwelashwa kwe-cholesterol ephezulu ngawo-1950. Kodwa-ke, kutholakale ukuthi ukudla imithamo ephezulu ye-niacin ngezinye izikhathi kungabangela ukucasuka kwesikhumba okucasulayo nokungabukeki kahle.
I-Niacinamide ayibangeli ukukhukhumala kwesikhumba futhi ngokombono inganikeza izinzuzo eziningi ezifanayo, kodwa ivimbela ukusebenza kwamaprotheni abalulekile akhuthaza ukulungiswa kwamaseli abizwa ngokuthi ama-sirtuins. I-niacinamide noma i-niacin azizange ziphumelele njengoba abacwaningi babenethemba.
Nakuba la mavithamini amabili eyisandulela se-NAD+, awayona ikhambi elifanele. Ngenxa yemiphumela emibi ye-niacin kanye nokusebenza kahle kwe-nicotinamide, abacwaningi abasenaso isithasiselo samavithamini esanele sokwandisa amazinga e-NAD+.
Ukutholwa kwe-nicotinamide riboside.
Olunye uhlobo lwevithamini B3 olubizwa ngokuthi i-nicotinamide riboside lwatholakala kwimvubelo ngawo-1940. Kodwa kwaze kwaba sekuqaleni kwawo-2000 lapho ososayensi baqala ukubona khona amandla ale vithamini yesithathu, i-B3, hhayi nje kuphela okwandisa i-NAD+ kodwa futhi okuthuthukisa impilo yabantu. Ngo-2004, ithimba locwaningo laseDartmouth College lathola ukuthi i-nicotinamide riboside, njengomfowabo wevithamini B3, iyisandulela se-NAD+.
Ithimba locwaningo eliholwa nguDkt. Charles Brenner lithole ukuthi i-nicotinamide riboside yandisa i-NAD+ emagundwini, futhi amagundane athole izinzuzo eziningi zezempilo ngenxa yalokho.
Amagundane abonise konke kusukela kushukela wegazi othuthukisiwe kanye namazinga e-cholesterol kuya ekunciphiseni ukulimala kwemizwa kanye nokumelana nokukhuluphala. UDkt. Charles Brenner uthole le miphumela ikhuthaza kakhulu kangangokuthi wathatha isinyathelo esilandelayo sokuqonda imiphumela ye-nicotinamide riboside empilweni yabantu.
Ngo-2014, uDkt. Brenner waba ngumuntu wokuqala ukuthatha i-nicotinamide riboside njengesengezo. Imiphumela iyakhuthaza ngokufanayo. Lolu hlobo olungaziwa lwevithamini B3 lwandise kakhulu amazinga akhe e-NAD+ ngokuphepha, ngokushesha, futhi ngaphandle kwemiphumela emibi.
I-Nicotinamide riboside isebenzisa indlela ehlukile yokukhiqiza i-NAD+ okungekho omunye uvithamini B3 oyisebenzisayo.
I-Nicotinamide riboside ingaphinde isebenze amaphrotheni akhuthaza ukulungiswa kwamaseli ama-sirtuin. Njengoba siguga, lawa ma-sirtuin asebenza isikhathi esengeziwe ukusiza amaseli ahlale eqinile.
Ukuhlala uphilile njengoba ukhula ngeke kube lula njengevithamini eyodwa, ngisho noma une-vitamin eyodwa ethembisayo njenge-nicotinamide riboside. Kunezifundo ezingaphezu kwe-100 ezihlola i-nicotinamide riboside, eziningi zazo ezibonisa ukuthi amazinga e-NAD+ akhuphukile ahlotshaniswa nempilo ye-metabolic kanye nemisipha emagundwini. Ucwaningo olwengeziwe luyaqhubeka ukuqonda indima ye-NAD+ ekusekeleni ezinye izinselele zempilo ezihlobene nokuguga, okuhlanganisa ukwehla kokusebenza kwesibindi, ukukhuluphala, amazinga e-insulin kanye nokusebenza kobuchopho emagundwini.
Kuyini i-NAD?
I-NAD+ yi-coenzyme I, okuyi-coenzyme edlulisa ama-proton (ngokunembile, ama-ion e-hydrogen) futhi ihlanganyela emisebenzini eminingi ye-physiological efana nokuguqulwa kwezinto zamaseli, ukwakheka kwamandla, kanye nokulungiswa kwe-DNA. I-NAD+ iyisakhi esidingekayo ekusebenzeni kweprotheni ye-Sirtuin, ebizwa ngokuthi "isici sobude besikhathi" ngososayensi. Ikakhulukazi, ingagcina ubude bama-telomere ayisihluthulelo, yehlise ijubane lenqubo yokuguga futhi yandise isikhathi sokuphila.
I-NAD+ ingakhuthaza ukulungiswa kwezakhi zofuzo futhi ilibazise ukuguga kwamaseli. I-NAD+ ikhuthaza ukuvuselelwa kwamaseli futhi imelana nezifo zesimiso sokuzivikela komzimba. I-NAD+ ithuthukisa ukuzinza kwama-chromosome futhi inciphisa ingozi yomdlavuza.
Bangabangane abakhulu bama-enzyme, abasiza ekuvuseleleni "imishini yeselula" edala amandla adingekayo kuyo yonke imisebenzi emikhulu emzimbeni wakho ezingeni lamaseli.
Kungani i-NAD+ ibalulekile?
Ngenxa yendima yayo ebalulekile ekukhiqizweni kwamandla eseli, ukuntuleka kwe-NAD+ emzimbeni wakho kwenza imisebenzi eminingi yomzimba ingabi namsebenzi. Ngaphandle kwe-NAD, amaphaphu akho ngeke akwazi ukungenisa umoya-mpilo, inhliziyo yakho ngeke ikwazi ukupompa igazi, futhi i-synapses yobuchopho bakho ngeke ivuthe.
I-NAD+ iphinde isize ekukhuthazeni ukulungiswa kwe-DNA nokulawula umsebenzi wamaseli ngokusebenzisana nama-sirtuin kanye nama-poly(ADP-ribose) polymerases (PARPs), abalulekile ekulawuleni izimpendulo zamaseli ezinhlamba ezifana nokudla ngokweqile, ukuphuza utshwala, ukuphazamiseka kokulala, kanye namaphethini okuhlala phansi. Ama-enzyme.
I-NAD+ kanye nokuguga
Ucwaningo olwenziwe ngo-2012 yithimba elivela eMnyangweni Wezemithi eNyuvesi yaseNew South Wales lubonise ukuthi i-metabolism ye-NAD ihlotshaniswa nobudala. Ucwaningo lubonisa ukuthi amazinga e-NAD+ ezicutshini zesikhumba somuntu ehla ngo-50% phakathi kweminyaka engama-40 nengama-60, nokuthi ukuncipha kwe-NAD+ kungadlala indima ebalulekile enkambisweni yokuguga.
"Kubonakale ukuhlobana okunamandla okungekuhle phakathi kwamazinga e-NAD+ kanye nobudala kwabesilisa nabesifazane," kusho abacwaningi kuleli phepha.
Ngaphezu kwalokho, i-NAD ihilelekile ekuphefumuleni kwamaseli, ikakhulukazi ku-mitochondria, futhi inegalelo empilweni ye-mitochondria iyonke. Kukhona isithakazelo esikhulu sesayensi ekubandakanyekeni kwe-NAD ekungasebenzi kahle kwe-mitochondria, esinye sezimpawu zokuguga.
Eminyakeni yamuva nje, ucwaningo lugxile ekuqondeni indima ye-NAD ekubhekaneni nalokhu kwehla kokusebenza okuhlobene nobudala.
I-Nicotinamide Ribose Chloride inyusa amazinga e-NAD+.
I-NR iyisandulela se-NAD, okusho ukuthi "iyibhloko yokwakha" lapho kwenziwa khona ama-molecule e-NAD+. Yatholakala ngo-2004 njengesandulela sevithamini se-NAD+, okwenza kube ngenye yezinguquko zakamuva ocwaningweni lwe-NAD+.
I-NR iyivithamini etholakala ngokwemvelo futhi uhlobo olusha lwevithamini B3, kodwa ukusetshenziswa kwayo njengesithasiselo kuye kwathinteka kabi ngamavithamini "okuguga okunempilo". Isebenza kahle kakhulu ekwandiseni i-NAD, okwenza kube ngenye yezindlela ezijabulisa kakhulu zokuxazulula izinkinga zokuguga okunempilo.
I-NR ingakhuphula amazinga e-NAD+ ngempumelelo. Ukuhlolwa kwezokwelapha okushicilelwe ku-Scientific Reports kubonise ukuthi yakhuphula i-NAD+ ngamaphesenti afinyelela ku-50 ngemva kwamasonto amabili iyisebenzisa.
Nakuba ukwengezwa kwe-NR kuye kwafakazelwa ngokwezokwelapha ukuthi kwandisa amazinga e-NAD+, ukwengezwa kwe-NAD+ njengesithako esizimele akusebenzi kangako.
I-NAD+ iyi-molecule enkulu kakhulu futhi ayikwazi ukungena ngqo kumaseli. Esikhundleni salokho, umzimba wakho kufanele uyihlukanise ibe yizicucu ezincane ngaphambi kokuba iwele ulwelwesi lweseli. Lezi zingxenye zihlanganiswa kabusha ngaphakathi kwebhethri.
I-Nicotinamide riboside (NR) kanye i-nicotinamide riboside chloride (NRC) Zombili ziyizinhlobo zevithamini B3, eyaziwa nangokuthi i-niacin. Ivithamini B3 iyisakhi esibalulekile esidlala indima ebalulekile emisebenzini eyahlukahlukene yomzimba, okuhlanganisa ukukhiqizwa kwamandla, ukulungiswa kwe-DNA, kanye nokusetshenziswa kwe-metabolism yamaseli. Zombili i-NR ne-NRC ziyizandulela ze-nicotinamide adenine dinucleotide (NAD+), i-coenzyme ehilelekile ezinqubweni ezahlukahlukene zezinto eziphilayo, njengokulawula ukukhiqizwa kwamandla amaseli nokusekela ukulungiswa kwe-DNA.
I-Nicotinamide riboside (NR) uhlobo lwe-vitamin B3 oluye lwathola ukunakwa ngenxa yezakhiwo zalo zokulwa nokuguga kanye nokukhulisa amandla. Luyinhlanganisela eyenzeka ngokwemvelo etholakala ngamanani amancane ekudleni okuthile, kodwa futhi iyatholakala njengesengezo sokudla. I-NR yaziwa ngekhono layo lokukhulisa amazinga e-NAD+ emzimbeni, okungasekela ukusebenza kwe-mitochondrial, kuthuthukise ukukhiqizwa kwamandla eseli, futhi kunganikeza isivikelo ekuwohlokeni okuhlobene nokuguga.
Ngakolunye uhlangothi, i-Nicotinamide riboside chloride (NRC) iwuhlobo lukasawoti lwe-NR futhi ivame ukusetshenziswa ezithasiselweni zokudla. Ukwengeza i-chloride ku-NR kukhiqiza i-NRC, okukholelwa ukuthi ithuthukisa ukuzinza kwe-compound kanye nokutholakala kwayo. Lokhu kusho ukuthi i-NRC ingaba nokumuncwa okungcono kanye nokusetshenziswa emzimbeni kune-NR yodwa futhi ingaba nomthelela ocacile emazingeni e-NAD+ kanye nokusebenza kweseli.
Omunye umehluko omkhulu phakathi kwe-NR ne-NRC yisakhiwo samakhemikhali sazo. I-NR iwuhlobo oluyisisekelo lwale nhlanganisela, kanti i-NRC iyinguqulo eguquliwe ene-chloride eyengeziwe. Lokhu kuguqulwa kuhloswe ukwandisa ukuncibilika kwenhlanganisela kanye nokutholakala kwayo, okwenza kube lula ngomzimba ukuyimunca nokuyisebenzisa.
Ngokuphathelene nezinzuzo zazo zezempilo ezingaba khona, i-NR kanye ne-NRC kucatshangwa ukuthi zinemiphumela efanayo ngenxa yekhono lazo lokukhulisaI-NAD+amazinga. Le miphumela ingafaka phakathi ukusebenza kwe-mitochondrial okuthuthukisiwe, ukwenziwa ngcono kwe-metabolism yamandla, kanye nokusekelwa okungenzeka kwempilo yamaseli iyonke. Kodwa-ke, ukusebenzisa i-NRC esithasiselweni kungaletha inzuzo eyengeziwe yokumuncwa nokusetshenziswa okungcono, okungenzeka kuholele ezinzuzweni ezivelele kakhulu uma kuqhathaniswa nokusebenzisa i-NR yodwa.
1. Thuthukisa ukukhiqizwa kwamandla eselula
Enye yezinzuzo eziphawuleka kakhulu ze-i-nicotinamide riboside chloride indima yayo ekuthuthukiseni ukukhiqizwa kwamandla eseli. I-NR iyisandulela se-nicotinamide adenine dinucleotide (NAD+), i-coenzyme edlala indima ekukhiqizweni kwe-adenosine triphosphate (ATP), imali yamandla eyinhloko yeseli. indima ebalulekile. Njengoba siguga, amazinga e-NAD+ ayancipha, okuholela ekunciphiseni ukukhiqizwa kwamandla eseli. Ngokunezela nge-NR, kukholelwa ukuthi amazinga e-NAD+ angagcwaliswa kabusha, ngaleyo ndlela kusekelwe ekusetshenzisweni kahle kwamandla eseli.
2. Umsebenzi we-Mitochondrial kanye nesikhathi sokuphila
Ama-Mitochondria ayizikhumulo zamandla zeseli, anesibopho sokukhiqiza amandla nokulawula izinqubo zamaseli. Ucwaningo lubonisa ukuthi i-Nicotinamide Riboside Chloride ingasekela umsebenzi we-mitochondrial ngokukhuthaza i-biogenesis ye-mitochondria entsha nokwandisa ukusebenza kwayo kahle. Lokhu kunemiphumela yesikhathi sokuphila kanye nokuguga okunempilo, njengoba i-mitochondria esebenza kahle ibalulekile ekugcineni impilo yamaseli nokuqina.
3. Impilo ye-metabolic kanye nokuphathwa kwesisindo
I-NAD+ iyi-coenzyme, noma i-molecule eyisengezo, ehilelekile ekuphenduleni okuningi kwezinto eziphilayo. Ucwaningo lwamuva nje luthole ukuthi ukwengezwa kwe-nicotinamide ribose kungavuselela ngempumelelo i-metabolism ye-NAD+ kubantu abadala abanempilo abaneminyaka ephakathi nendawo kanye nasebekhulile. Akukhona nje kuphela ukuthi izithasiselo ze-NR zabekezelelwa kahle ngabahlanganyeli, kungenzeka ukuthi zasiza ekunciphiseni umfutho wegazi kanye nokuqina kwemithambo yegazi. Ukuntuleka kwe-NAD+ kuyimbangela evamile yokuguga kanye nezifo eziningi, futhi ucwaningo lubonisa ukuthi ukubuyisela amazinga e-NAD+ kunenani elikhulu lokwelapha kanye nokudla okunempilo.
Ngokwandisa amazinga e-NAD+, i-nicotinamide ribose izuzisa ukulawulwa kwe-metabolic, izinqolobane zamandla, ukwakheka kwe-DNA, kanye neminye imisebenzi yomzimba.
Ngaphezu kwalokho, izifundo zikhombisile ukuthi ukwengezwa kwe-NR kungathuthukisa ukuzwela kwe-insulin, kunciphise ukuvuvukala, futhi kuthuthukise ukuguquguquka kwe-metabolic. Le miphumela ingaba wusizo ikakhulukazi kubantu abafuna ukulawula isisindo sabo nokusekela impilo yonke ye-metabolic.
4. Umsebenzi wokuqonda kanye nempilo yobuchopho
Njengesandulela se-NAD+, i-nicotinamide ribose ivikela amangqamuzana obuchopho ekucindezelekeni kwe-oxidative, okungaholela ezifweni zobuchopho ezihlobene nokuguga. Ngaphakathi kwamangqamuzana obuchopho, i-NAD+ isiza ukulawula ukukhiqizwa kwe-PGC-1-alpha, iphrotheni ebonakala isiza ukuvikela amangqamuzana ekucindezelekeni kwe-oxidative kanye nokusebenza kwe-mitochondrial okuphazamiseka.
Abacwaningi bathole ukuthi emagundwini, ukuncipha kwe-NAD+ kudlala indima ebalulekile ekuvuvukeni kwe-neuroinflammation, ekulimaleni kwe-DNA, kanye nokuwohloka kwe-neuronal esifweni i-Alzheimer's. Futhi ocwaningweni lwe-test-tube, i-nicotinamide riboside yandise amazinga e-NAD+ futhi yathuthukisa kakhulu umsebenzi we-mitochondrial kumaseli okuqala eziguli ezinesifo sikaParkinson.
Ucwaningo olusanda kuvela luphinde lukhombe izinzuzo ezingaba khona zokuqonda ze-nicotinamide riboside chloride. I-NAD+ ihilelekile ezinqubweni ezahlukahlukene ezihlobene nempilo yobuchopho, okuhlanganisa ukuhanjiswa kwe-neuronal, ukulungiswa kwe-DNA, kanye nokususwa kwamaprotheni alimele. Ngokusekela amazinga e-NAD+, i-NR ingasiza ekugcineni ukusebenza kokuqonda futhi ivimbele ukwehla kokuqonda okuhlobene nobudala.
5. Ukusebenza Kwezemidlalo Nokululama
Ucwaningo lwango-2019 olwanyatheliswa kuyi-European Journal of Nutrient Impurities luthole ukuthi ukusebenzisa izithasiselo ze-nicotinamide ribose kwathuthukisa amakhono omzimba futhi kunciphisa ukucindezeleka kwe-oxidative kubantu abadala.
Abacwaningi baphetha ngokuthi ukwengezwa kwe-NR kwakuzuzisa abantu abaswele i-NAD+, bachaza ukuthi kungani kusebenza kangcono kubantu abadala kunabantu abadala abasebasha.
Abasubathi nabathandi bokuqina komzimba bangaba nentshisekelo yokwazi ukuthi i-nicotinamide riboside chloride ingaba nomthelela omuhle ekusebenzeni kwezemidlalo nasekululameni. I-NAD+ idlala indima ebalulekile ekulawuleni izinqubo zamaseli ezihilelekile ekukhiqizweni kwamandla kanye nokusebenza kwemisipha. Ngokusekela amazinga e-NAD+, i-NR ingathuthukisa ukukhuthazela, ithuthukise ukululama kwemisipha, futhi ithuthukise ukusebenza kwezemidlalo jikelele.
Ikhwalithi Nobumsulwa
Uma uthenga i-nicotinamide riboside chloride powder, ikhwalithi kanye nobumsulwa kumele kube yinto eza kuqala kuwe. Funa imikhiqizo eyenziwe yizinkampani ezidumile kanye nabantu besithathu abahlolwe ubumsulwa kanye namandla. Okungcono kakhulu, imikhiqizo kufanele ingabi namagciwane kanye nama-filler ukuqinisekisa ukuthi uthola isengezo sekhwalithi ephezulu esiletha izinzuzo ezihlosiwe.
Isilinganiso kanye nokusetshenziswa
Ngaphambi kokufaka i-nicotinamide riboside chloride powder ohlelweni lwakho lwansuku zonke, kubalulekile ukuqonda umthamo ofanele kanye neziqondiso zokusebenzisa. Kubalulekile ukuqala ngomthamo ophansi bese ukhuphula kancane kancane njengoba kudingeka, njengoba umthamo ophezulu ungalingani nemiphumela engcono futhi ungabangela imiphumela emibi. Ngaphezu kwalokho, sicela ucabangele ukubonisana nochwepheshe wezempilo ukuze uthole umthamo ofanele imigomo nezidingo zakho ezithile zempilo.
Izinzuzo ezingaba khona kanye nokucatshangelwa
I-Nicotinamide Riboside Chloride Powder ivame ukunconywa ngezinzuzo zayo ezingaba khona, okuhlanganisa ukusekela amazinga wamandla, ukusebenza kwe-mitochondrial, kanye nempilo yamaseli iyonke. Ucwaningo lubonisa ukuthi ingaba nomthelela nasekugugeni nasezifweni ezihlobene nokuguga.
Ukuphepha kanye nezinyathelo zokuphepha
Njenganoma yisiphi isengezo, kubalulekile ukubeka phambili ukuphepha nokuqonda izinyathelo zokuphepha ezingaba khona. Nakuba i-nicotinamide riboside chloride ivame ukubekezelelwa kahle, abanye abantu bangase babe nemiphumela emibi emincane, njengokungakhululeki kwesisu. Ngaphezu kwalokho, uma unezinkinga zempilo eziyisisekelo noma uthatha imithi, qiniseka ukuthi uthintana nochwepheshe wezempilo ngaphambi kokusebenzisa lesi sengezo ukuqinisekisa ukuthi siphephile futhi sifanele isimo sakho.
Khetha umhlinzeki othembekile
Uma uthenga i-Nicotinamide Riboside Chloride Powder, kubalulekile ukukhetha umhlinzeki othembekile obeka phambili ikhwalithi, ukucaca, kanye nokwaneliseka kwamakhasimende. Funa izinkampani ezinikeza imininingwane mayelana nezinqubo zazo zokukhiqiza, ukuthola, kanye nokuhlolwa komuntu wesithathu. Ngaphezu kwalokho, cabanga ngokufunda ukubuyekezwa kwamakhasimende nokufuna izincomo ezivela emithonjeni ethembekile ukuqinisekisa ukuthi uthenga kumhlinzeki othembekile nothembekile.
I-Suzhou Myland Pharm & Nutrition Inc. ibilokhu ibandakanyeka ebhizinisini lezithako zokudla okunempilo kusukela ngo-1992. Yinkampani yokuqala eShayina ukuthuthukisa nokuthengisa okukhishwe kwembewu yamagilebhisi.
Njengoba ineminyaka engama-30 yesipiliyoni futhi iqhutshwa ubuchwepheshe obuphezulu kanye nesu le-R&D elithuthukisiwe kakhulu, inkampani ithuthukise imikhiqizo ehlukahlukene yokuncintisana futhi yaba yinkampani yezinsizakalo ezintsha zesayensi yokuphila, ukuhlanganiswa ngokwezifiso kanye nokukhiqiza.
Ngaphezu kwalokho, iSuzhou Myland Pharm & Nutrition Inc. nayo ingumkhiqizi obhalisiwe yi-FDA. Izinsizakusebenza ze-R&D zenkampani, izikhungo zokukhiqiza, kanye nezinsimbi zokuhlaziya zisesimanje futhi zisebenza ngezindlela eziningi futhi zingakhiqiza amakhemikhali kusukela kuma-milligram kuya kumathani ngobukhulu, futhi zihambisana nezindinganiso ze-ISO 9001 kanye nemininingwane yokukhiqiza i-GMP.
Q: Iyini i-nicotinamide riboside chloride powder?
A: I-Nicotinamide Riboside Chloride Powder iwuhlobo lwe-vitamin B3 oluye lwacwaningwa ngamandla alo okusekela ukukhiqizwa kwamandla eseli kanye ne-metabolism. Ivame ukusetshenziswa njengesengezo sokudla ukukhuthaza impilo yonke kanye nenhlalakahle.
Q: Yiziphi izinzuzo ezingaba khona ze-nicotinamide riboside chloride powder?
A: Ezinye izinzuzo ezingaba khona ze-Nicotinamide Riboside Chloride Powder zifaka phakathi ukusekela umsebenzi we-mitochondrial, ukukhuthaza ukuguga okunempilo, kanye nokuthuthukisa ukukhuthazela kanye nokusebenza ngokomzimba. Kungasiza futhi ukusekela umsebenzi wokuqonda kanye nempilo yamaseli iyonke.
U: Ngingayithenga kuphi i-nicotinamide riboside chloride powder?
A: Impuphu ye-Nicotinamide Riboside Chloride iyatholakala kubathengisi abahlukahlukene kanye nezitolo eziku-inthanethi. Uma uthenga lesi sengezo, kubalulekile ukukhetha umthombo othembekile ukuqinisekisa ikhwalithi nokuphepha.
Isixwayiso: Lesi sihloko senzelwe ulwazi olujwayelekile kuphela futhi akufanele sithathwe njenganoma yisiphi iseluleko sezokwelapha. Olunye ulwazi lweposi lebhulogi luvela kwi-inthanethi futhi alulona ochwepheshe. Le webhusayithi inesibopho sokuhlunga, ukufometha nokuhlela izihloko kuphela. Inhloso yokudlulisa ulwazi olwengeziwe akusho ukuthi uyavumelana nemibono yayo noma uqinisekisa ubuqiniso bokuqukethwe kwayo. Njalo xhumana nochwepheshe wezempilo ngaphambi kokusebenzisa noma yiziphi izithasiselo noma ukwenza izinguquko ohlelweni lwakho lokunakekelwa kwempilo.
Isikhathi sokuthunyelwe: Agasti-14-2024
