1-Methylnicotinamide Chloride Inombolo ye-CAS:1005-24-9
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | 1-Methylnicotinamide chloride |
| Elinye igama | I-N-Methylnicotinamide chloride；I-NMN-Cl；I-1-MNA chloride；i-3-carbamoyl-1-methyl-pyridinium chloride |
| Inombolo ye-CAS | 1005-24-9 |
| Ifomula yama-molecule | C7H9N2I-OCl |
| Isisindo sama-molecule | 172.61 |
| Ubumsulwa | 98.5% |
| Ukubukeka | Okumhlophe – okumhlophe qhwa, okuqinile okukristaluimpuphu |
| Ukupakisha | 1kg/isikhwama; 25kg/isigubhu |
| Isicelo | ci-hemicaleokubonakalayomi-aterials |
Isingeniso somkhiqizo
I-1-Methylnicotinamide chloride iyi-derivative ye-nicotinamide exutshwe ne-methyl, ebonakala ngesakhiwo sikasawoti we-ammonium esizinzile se-quaternary. Isebenza njengesihluthulelo esibalulekile sokufunda ngokusetshenziswa kwe-nicotinamide. Ukuncibilika kwayo emanzini okuhle kanye nokuqina kwamakhemikhali kwenza ifaneleke njengethuluzi lokucwaninga ngamakhemikhali.
I-1-MNA iyisithako esitholakala ngokwemvelo emzimbeni womuntu, esisebenza njengomkhiqizo ojwayelekile we-niacin metabolism. Njengengxenye ephakathi yale ndlela ye-metabolic, i-1-MNA icutshungulwa kabanzi yi-aldehyde oxidase ukuze ikhiqize ama-metabolite angaphansi njenge-N-methyl-2-pyridone-5-carboxamide (2PY) kanye ne-N-methyl-4-pyridone-3-carboxamide (4PY), ekugcineni akhishwa ohlelweni lomchamo.
I-1-Methylnicotinamide chloride iyi-derivative ye-nicotinamide exutshwe ne-methyl, ebonakala ngesakhiwo sikasawoti we-ammonium esizinzile se-quaternary. Isebenza njengesihluthulelo esibalulekile sokufunda ngokusetshenziswa kwe-nicotinamide. Ukuncibilika kwayo emanzini okuhle kanye nokuqina kwamakhemikhali kwenza ifaneleke njengethuluzi lokucwaninga ngamakhemikhali.
I-1-MNA iyisithako esitholakala ngokwemvelo emzimbeni womuntu, esisebenza njengomkhiqizo ojwayelekile we-niacin metabolism. Njengengxenye ephakathi yale ndlela ye-metabolic, i-1-MNA icutshungulwa kabanzi yi-aldehyde oxidase ukuze ikhiqize ama-metabolite angaphansi njenge-N-methyl-2-pyridone-5-carboxamide (2PY) kanye ne-N-methyl-4-pyridone-3-carboxamide (4PY), ekugcineni akhishwa ohlelweni lomchamo.
Isici
(1) Ukuncibilika kwamanzi: Kuncibilika kalula emanzini nasezincibilikisini eziphilayo ezihlala emanzini.
(2) Ukuzinza: Kuzinzile ngaphansi kwezimo zokushisa kwegumbi kodwa kudinga ukugcinwa ezindaweni ezingangeni umswakama.
(3) Ukuphepha: I-European Union yenze ukuhlolwa kwesayensi kwe-1-MNA njengesithako sokudla esisha. Ngokuhambisana noMthethonqubo we-EU (EC) No 258/97, i-1-MNA ibhekwa njengephephile ukusetshenziswa, kanye nokudla okuphezulu okunconywayo komuntu omdala okungu-58 mg nsuku zonke, okuhloswe kakhulu ukusetshenziswa ezithasiselo zokudla.
Izicelo
I-1-Methylnicotinamide chloride (efushaniswe ngokuthi i-MNC) iyi-methylated derivative ye-nicotinamide. Ukutholwa kwe-1-MNA kungenziwa ngezindlela ezifana ne-high-performance liquid chromatography (HPLC) kanye ne-enzyme-linked immunosorbent assay (ELISA). Ibonisa amandla okusetshenziswa emikhakheni yokudla nemikhiqizo yezempilo. Embonini yokudla, ingasebenza njenge-antioxidant ukubambezela ukushiswa kwamafutha nokugcina ikhwalithi yokudla. Ngenxa yezimfanelo zayo zesakhiwo, ingasebenza futhi njengesithako esisebenzayo ekudleni okuqiniswe ngokudla okunempilo. Ngaphezu kwalokho, i-1-MNA ibonisa imisebenzi ekulawulweni kwe-metabolic kanye nokuthuthukiswa kwezimo zomzimba, iyinika inani lokuthuthukiswa kokudla okusebenzayo kanye nezithako zokudla ezibangela izimangalo zempilo.
Ukuhlolwa kwe-EU kuphethe ngokuthi ukudla nsuku zonke okungu-58 mg we-1-MNA okuvela ezithasiselo zokudla akunakwenzeka ukuthi kuholele emiphumeleni emibi yezempilo kubantu, futhi kufakwe ngokusemthethweni kukhathalogi yokudla entsha ye-EU.
Njenge-molecule ebalulekile esebenzayo kanye nendinganiso yokubhekisela, i-1-methylnicotinamide chloride inamathemba amaningi okusetshenziswa ocwaningweni lwesayensi, ekuthuthukisweni kwemithi, kanye nasembonini yezithasiselo zokudla. Ukuhlolwa kwayo kokuphepha okuchazwe kahle kanye nemisebenzi ehlukahlukene yezinto eziphilayo kuyibeka njengesihloko esibalulekile socwaningo kanye nengxenye yezinhlelo zokusebenza ezahlukahlukene.
