O-304 Inombolo ye-CAS:1261289-04-6 Yakha imisipha futhi unciphise amafutha.
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | O-304 |
| Elinye igama | I-4-Chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]benzamide |
| Inombolo ye-CAS | 1261289-04-6 |
| Ifomula yama-molecule | C16H11Cl2N3O2S |
| Isisindo sama-molecule | 380.25 |
| Ubumsulwa | 98% |
| Ukubukeka | Impuphu emhlophe kuya kwemhlophe kakhulu |
| Ukupakisha | 1kg/isikhwama, 25kg/ibhareli |
| Isicelo | Isengezo Sokudla Izinto Ezingavuthiwe |
Isingeniso somkhiqizo
I-O-304 iyisiqalisi se-AMPK sama-molecule amancane esithuthukisa umsebenzi we-AMPK ngokuvimbela i-dephosphorylation ye-AMPK (pAMPK) ene-phosphorylated, ngaleyo ndlela yandisa amazinga e-pAMPK ngaphandle kokunciphisa amazinga e-adenosine triphosphate (ATP) angaphakathi kweseli. Inezindlela eziningi zokusebenza, okuhlanganisa ukuthuthukisa i-glucose metabolism, ukunciphisa ukumelana ne-insulin, kanye nokuvikela uhlelo lwenhliziyo nemithambo yegazi.
Isici
(1) Ukuhlanzeka okuphezulu: I-O-304 ikhiqizwa ngenqubo yokukhiqiza ehlungiwe, okufeza ukuhlanzeka okuphezulu komkhiqizo. Ukuhlanzeka okuphezulu kusho ukutholakala okungcono kwezinto eziphilayo.
(2) Umsebenzi Wezinto Eziphilayo:I-O-304 iyi-pan-activator yomlomo ye-AMPK (i-AMP-activated protein kinase). Ithuthukisa umsebenzi we-AMPK ngokuvimbela i-dephosphorylation ye-pAMPK.
Izicelo
1. Ukusebenza kwe-AMPK: I-O-304 yandisa umsebenzi we-AMPK ngokuvimbela inqubo yokususa i-phosphorylation ye-AMPK (pAMPK) ene-phosphorylated, ngaleyo ndlela ilawula ibhalansi ye-metabolism yamandla.
2. Ukuthuthukisa i-metabolism ye-glucose: Ezifundweni zezilwane, umthamo we-100 mg/kg we-O-304 usize ngempumelelo ukugcina amazinga e-glucose egazini azinzile kanye namazinga e-insulin egazini, kunciphisa kakhulu umthwalo we-metabolic obangelwa ukudla okunamafutha amaningi, kanye nokuvimbela ukuguquguquka kwe-glucose egazini kanye nokuphakama kwe-insulin okungavamile okubangelwa ukungalingani kokudla.
3. Pukuvikela ukuqina kwemithambo yegazi:I-O-304 isiza ukugcina umfutho wegazi usemazingeni anempilo, inciphisa ukucindezeleka emithanjeni yegazi, futhi ihlinzeka ngesivikelo sesikhathi eside nesithambile sezinhlelo zenhliziyo nezemithambo yegazi, isekela ukuzinza ngokomzwelo namandla aqhubekayo.
4.Ukukhuthaza ubusha obuhlala njalo:I-O-304 ihlose ngqo indlela yokubonisana ye-AMPK-mTOR, ilawula ngobuhlakani inqubo ye-autophagy yamaseli, ikhuthaza ukuguguleka kwamaprotheni asebekhulile kanye nama-lipids angajwayelekile, futhi igcine indawo yamaseli ehlanzekile futhi ephilayo, ngaleyo ndlela ibambezele ukuguga kwamaseli.
