I-BAM15A CAS No.:210302-02-6 Yakha imisipha futhi unciphise amafutha.
Amapharamitha Omkhiqizo
| Igama lomkhiqizo | I-BAM15A |
| Elinye igama | I-N5,N6-Bis(2-Chlorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine |
| Inombolo ye-CAS | 210302-02-6 |
| Ifomula yama-molecule | C16H10Cl2N6O |
| Isisindo sama-molecule | 373.2 |
| Ubumsulwa | 98% |
| Ukubukeka | Impuphu ephuzi kancane noma emhlophe |
| Ukupakisha | 1kg/isikhwama, 25kg/ibhareli |
| Isicelo | Isengezo Sokudla Izinto Ezingavuthiwe |
Isingeniso somkhiqizo
I-BAM15A iyi-modulator yesizukulwane esisha ye-mitochondrial. Njenge-uncoupler ye-proton ye-mitochondrial enhle kakhulu, ilawula ngobumnene i-gradient ye-proton kulo lonke ulwelwesi lwangaphakathi lwe-mitochondrial, ikhulisa ukusebenza kahle kwe-metabolism yamandla omzimba futhi isheshise ukuwohloka kwemvelo kwamafutha, ngaphandle kokuthinta imisipha noma isifiso sokudla esivamile.
Izifundo zangaphambi kokwelashwa ziqinisekisile ukuthi lesi sithako sisiza ekuthuthukiseni ukuqunjelwa komzimba, sithuthukise ukuzwela kwe-insulin, sinciphise ukuqongelela kwamafutha esibindini futhi sinciphise izimpendulo zokuvuvukala komzimba. Sine-bioavailability yomlomo efika ku-67% futhi sinezakhiwo ezithambile eziphephile kakhulu. Ngokungafani nezithako zendabuko ezifanayo, asibangeli ukushisa komzimba okungavamile noma ukulimala kwamangqamuzana, okwenza kube yinto eluhlaza yokudla okunempilo ephezulu yokulawula isisindo kanye nokulawula i-metabolic.
Isici
(1) Ubumsulwa obuphezulu: BAM15Aingakhiqiza imikhiqizo ehlanzekile kakhulu ngenqubo yokukhiqiza ehlungiwe. Ukuhlanzeka okuphezulu kusho ukutholakala okungcono kwezinto eziphilayo.
(2) Indlela yokuxhumanisa esebenza kahle: Njengomthwali we-proton we-mitochondrial, iphazamisa ukuthambekela kwe-proton kwe-membrane yangaphakathi ye-mitochondrial, ikhuthaza ukuguqulwa kwamandla e-oxidative kusuka kwizakhi zomzimba abe amandla okushisa kune-ATP, okuthuthukisa kakhulu ukusetshenziswa kwamandla
(3) Ukulahlekelwa amafutha okuphephile kanye nokuthuthukiswa kwe-metabolic: Ekuhlolweni kwezilwane, ukutholakala kwe-bioavailability ngomlomo kufinyelele ku-67%, kunciphisa amafutha emzimbeni ngaphezu kuka-20% ngaphandle kokunciphisa isisindo semisipha, okuthinta isifiso sokudla noma izinga lokushisa komzimba, kuyilapho kuthuthukiswa ukuzwela kwe-insulin, kunciphisa isibindi esinamafutha kanye nokuvuvukala.
(4) Inzuzo ephansi yobuthi: Uma kuqhathaniswa nezinto ezivamile zokuxhumanisa, ayikho ingozi yomkhuhlane ophezulu noma ubuthi obuvela ku-cytotoxicity. Akukho ukulimala kwezitho zomzimba noma imiphumela emibi yezinzwa.
Izicelo
1. Ukunciphisa amafutha kanye nokuthuthukiswa kwe-metabolic: Ngokuhlanganisa i-mitochondrial, kunciphisa kakhulu amafutha omzimba (kumamodeli ezilwane, amafutha omzimba ancipha ngaphezu kuka-20%), kunciphisa ushukela egazini, ukumelana ne-insulin, kanye nokuqongelela kwamafutha esibindi ngasikhathi sinye, ngaphandle kokuthinta isifiso sokudla noma isisindo semisipha;
2. Ukulwa nokuguga: Thuthukisa isisindo semisipha (ngo-8%) kanye namandla (ngo-40%) ezilwaneni ezindala, nciphisa amafutha futhi uvimbele ukuvuvukala okungapheli, futhi ulwe nokukhuluphala kwe-myogenic.
3. Ukulwa nokuvuvukala: Kunciphisa ingozi yokulimala kwezinso okubangelwa yi-sepsis (AKI), futhi kunciphisa izimpendulo zokuvuvukala komzimba ngokuvimbela ukukhiqizwa kwe-mitochondrial ROS kanye nokukhishwa kwe-mtDNA.
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